ES2055149T3 - Derivado de hirudina. - Google Patents

Derivado de hirudina.

Info

Publication number
ES2055149T3
ES2055149T3 ES89710003T ES89710003T ES2055149T3 ES 2055149 T3 ES2055149 T3 ES 2055149T3 ES 89710003 T ES89710003 T ES 89710003T ES 89710003 T ES89710003 T ES 89710003T ES 2055149 T3 ES2055149 T3 ES 2055149T3
Authority
ES
Spain
Prior art keywords
hirudine
derived
thr
derivative
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89710003T
Other languages
English (en)
Inventor
Peter Dr Crause
Paul Dr Habermann
Dominique Dr Tripier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2055149(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/hu
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2055149T3 publication Critical patent/ES2055149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN DERIVADO DE HIRUDINA, CARACTERIZADO POR LA SECUENCIA DE AMINOACIDO N - TERMINAL LEU - THR - TYR - THR - ASP, MUESTRA UNA ALTA ACTIVIDAD BIOLOGICA. ESTE DERIVADO DE HIRUDINA SE PUEDE OBTENER DE FORMA MUY EFECTIVA EN LEVADURAS POR INGENIERIA GENETICA.
ES89710003T 1985-04-11 1989-01-11 Derivado de hirudina. Expired - Lifetime ES2055149T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
DE3805540 1988-02-23

Publications (1)

Publication Number Publication Date
ES2055149T3 true ES2055149T3 (es) 1994-08-16

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89710003T Expired - Lifetime ES2055149T3 (es) 1985-04-11 1989-01-11 Derivado de hirudina.

Country Status (9)

Country Link
EP (1) EP0324712B1 (es)
AT (1) ATE87938T1 (es)
DE (2) DE58903988D1 (es)
DK (1) DK172350B1 (es)
ES (1) ES2055149T3 (es)
FI (1) FI96956C (es)
IL (1) IL88925A (es)
LU (1) LU90127I2 (es)
NL (1) NL970027I2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
JP3187044B2 (ja) * 1989-12-01 2001-07-11 ビーエーエスエフ アクチェンゲゼルシャフト ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) * 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69624087T2 (de) 1996-01-31 2003-06-05 Sumitomo Bakelite Co. Ltd., Tokio/Tokyo Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
DE19944870A1 (de) 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
RU2435858C2 (ru) * 2009-10-23 2011-12-10 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pER-Hir, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СПОСОБНЫЙ К АВТОКАТАЛИТИЧЕСКОМУ РАСЩЕПЛЕНИЮ С ОБРАЗОВАНИЕМ [Leu1, Thr2]-63-ДЕСУЛЬФАТОГИРУДИНА, ШТАММ Escherichia coli ER2566/pER-Hir-ПРОДУЦЕНТ УКАЗАННОГО БЕЛКА И СПОСОБ ПОЛУЧЕНИЯ ГЕННО-ИНЖЕНЕРНОГО [Leu1, Thr2]-63-ДЕСУЛЬФАТОГИРУДИНА

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

Also Published As

Publication number Publication date
DK13189A (da) 1989-07-14
EP0324712A3 (en) 1990-07-04
EP0324712B1 (de) 1993-04-07
EP0324712A2 (de) 1989-07-19
DE19775033I2 (de) 2011-01-20
FI96956B (fi) 1996-06-14
DK172350B1 (da) 1998-04-06
DK13189D0 (da) 1989-01-12
IL88925A (en) 1995-11-27
FI890127A0 (fi) 1989-01-11
FI890127L (fi) 1989-07-14
DE58903988D1 (de) 1993-05-13
ATE87938T1 (de) 1993-04-15
NL970027I1 (nl) 1997-10-01
FI96956C (fi) 1996-09-25
NL970027I2 (nl) 1998-04-01
LU90127I2 (fr) 1997-10-06

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