NL970027I2 - Hirudine-derivaat. - Google Patents

Hirudine-derivaat.

Info

Publication number
NL970027I2
NL970027I2 NL970027C NL970027C NL970027I2 NL 970027 I2 NL970027 I2 NL 970027I2 NL 970027 C NL970027 C NL 970027C NL 970027 C NL970027 C NL 970027C NL 970027 I2 NL970027 I2 NL 970027I2
Authority
NL
Netherlands
Prior art keywords
derivative
hirudine
thr
hirudin derivative
tyr
Prior art date
Application number
NL970027C
Other languages
English (en)
Other versions
NL970027I1 (nl
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL970027(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/hu
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NL970027I1 publication Critical patent/NL970027I1/nl
Publication of NL970027I2 publication Critical patent/NL970027I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NL970027C 1985-04-11 1997-07-23 Hirudine-derivaat. NL970027I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
DE3805540 1988-02-23

Publications (2)

Publication Number Publication Date
NL970027I1 NL970027I1 (nl) 1997-10-01
NL970027I2 true NL970027I2 (nl) 1998-04-01

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
NL970027C NL970027I2 (nl) 1985-04-11 1997-07-23 Hirudine-derivaat.

Country Status (9)

Country Link
EP (1) EP0324712B1 (nl)
AT (1) ATE87938T1 (nl)
DE (2) DE58903988D1 (nl)
DK (1) DK172350B1 (nl)
ES (1) ES2055149T3 (nl)
FI (1) FI96956C (nl)
IL (1) IL88925A (nl)
LU (1) LU90127I2 (nl)
NL (1) NL970027I2 (nl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
US5663141A (en) * 1989-12-01 1997-09-02 Basf Aktiengesellschaft Hirudin/polyalkylene glycol conjugates and hirudin muteins
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) * 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69625623T2 (de) 1996-01-31 2003-11-06 Sumitomo Bakelite Co. Ltd., Tokio/Tokyo Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
DE19944870A1 (de) 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

Also Published As

Publication number Publication date
FI96956C (fi) 1996-09-25
FI890127A (fi) 1989-07-14
DE19775033I2 (de) 2011-01-20
DK172350B1 (da) 1998-04-06
ES2055149T3 (es) 1994-08-16
DE58903988D1 (de) 1993-05-13
LU90127I2 (fr) 1997-10-06
DK13189A (da) 1989-07-14
DK13189D0 (da) 1989-01-12
EP0324712A3 (en) 1990-07-04
EP0324712B1 (de) 1993-04-07
NL970027I1 (nl) 1997-10-01
IL88925A (en) 1995-11-27
ATE87938T1 (de) 1993-04-15
FI890127A0 (fi) 1989-01-11
FI96956B (fi) 1996-06-14
EP0324712A2 (de) 1989-07-19

Similar Documents

Publication Publication Date Title
DE58903988D1 (de) Hirudin-derivat.
DE3871538D1 (de) Kraftanlage mit c02 als arbeitsfluidum.
FI873141A0 (fi) Daeggdjurs interleukin-4.
DE3876388D1 (de) Spannungsregler mit zwei eingaengen mit niedrigem spannungsverlust.
DE3785899D1 (de) Halbleiteranordnung mit stromversorgungsleiterbahnen.
DE3877326D1 (de) Leistungsversorgung.
DE3585741D1 (de) Halbleiterlaser mit verteilter rueckkopplung.
DE3682394D1 (de) Industrieller roboter mit austauschbaren modulen.
FI90667C (fi) Menetelmä valmistaa uutta ihmisen tyypin I interferoniproteiinia
DE3586157D1 (de) Schaltnetzteil mit mehreren ausgaengen.
FI99211B (fi) Menetelmä hirudiinivariantin valmistamiseksi
DE3787112D1 (de) Menschliche Pankreaselastase I.
DE3875768D1 (de) Halbleiterlaser mit verteilter rueckkopplung.
NO861635L (no) Fremgangsmaate for fremstilling av rekombinert aaa-interferon.
IT1181293B (it) Macchina per la produzione di catene ornamentali, in particolare di tipo accoppiato
NO851435L (no) Stol.
NO873059D0 (no) Dobbelt-svitsjet kraftforsyning.
NO860838L (no) Transportabelt vedproduksjonsanlegg.
DE3575227D1 (de) Kugelhaufenreaktor mit batch-betrieb.
DD223560B1 (de) Flachgriffakkordeon mit gekoppelten hilfstastenreihen
IT8619653A0 (it) Procedimento per la produzione di bussole a struttura perfezionara, per l'unione di parti in legno.
SE8702645D0 (sv) Solprocesser, vetefusion i acceleratorer, vetefusionsreaktor
SU1369026A1 (ru) ШТАММ ГРИБА Chaetomium olivaccum ДЛЯ ПОЛУЧЕНИЯ БИОПРЕПАРАТА ПРОТИВ БЕЛОЙ ГНИЛИ ПОДСОЛНЕЧНИКА
DE3863906D1 (de) Elektrolysezellen fuer die herstellung von fluor.
IT8445718A0 (it) Procedimento per la produzione industriale di pannelli a superficie visualizzante le venature del legno.