ES8900018A1 - Procedimiento para la fabricacion de derivados aminoalcoholes peptidicos inhibidores de la renina y de las proteasas acidas - Google Patents

Procedimiento para la fabricacion de derivados aminoalcoholes peptidicos inhibidores de la renina y de las proteasas acidas

Info

Publication number
ES8900018A1
ES8900018A1 ES552407A ES552407A ES8900018A1 ES 8900018 A1 ES8900018 A1 ES 8900018A1 ES 552407 A ES552407 A ES 552407A ES 552407 A ES552407 A ES 552407A ES 8900018 A1 ES8900018 A1 ES 8900018A1
Authority
ES
Spain
Prior art keywords
rennin
inhibitor
amino alcohol
preparation process
alcohol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552407A
Other languages
English (en)
Other versions
ES552407A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Sanofi SA
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8502763A external-priority patent/FR2577931B1/fr
Priority claimed from FR8511728A external-priority patent/FR2585708B1/fr
Application filed by Sanofi SA, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Sanofi SA
Publication of ES552407A0 publication Critical patent/ES552407A0/es
Publication of ES8900018A1 publication Critical patent/ES8900018A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE TRATA DE UN AMINOALCOHOL DE FORMULA (I) CON EL ESTER DE ALQUILO INFERIOR DEL ACIDO AMINADO DE FORMULA (II) A UNA TEMPERATURA ENTRE *FORMULA* Y PRESION ATMOSFERICA, SE PROCEDE PROGRESIVAMENTE A TEMPERATURA AMBIENTE A ALARGAR LA CADENA PEPTIDICA PARA OBTENER DERIVADOS AMINOALCOHOLES PEPTIDICOS DE FORMULA (III). ESTE PRODUCTO TIENE ACCION ANHIBIDORA SOBRE PROTESTAS ACIDAS ESPECIALMENTE DE LA ACTIVIDAD RENINA PLASTICA HUMANA Y APLICACION TERAPEUTICA CONTRA HIPERTENSION ARTERIAL, ULCERA GASTRODUODENAL Y AFECCIONES INFLAMATORIAS. *FORMULA*
ES552407A 1985-02-26 1986-02-26 Procedimiento para la fabricacion de derivados aminoalcoholes peptidicos inhibidores de la renina y de las proteasas acidas Expired ES8900018A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8502763A FR2577931B1 (fr) 1985-02-26 1985-02-26 Derives aminodiols peptidiques inhibiteurs de la renine et des proteases acides, leur procede de preparation et leur application en therapeutique
FR8511728A FR2585708B1 (fr) 1985-07-31 1985-07-31 Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES552407A0 ES552407A0 (es) 1988-11-16
ES8900018A1 true ES8900018A1 (es) 1988-11-16

Family

ID=26224394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES552407A Expired ES8900018A1 (es) 1985-02-26 1986-02-26 Procedimiento para la fabricacion de derivados aminoalcoholes peptidicos inhibidores de la renina y de las proteasas acidas

Country Status (9)

Country Link
EP (1) EP0214209A1 (es)
KR (1) KR860006487A (es)
AU (1) AU587426B2 (es)
DK (1) DK89286A (es)
ES (1) ES8900018A1 (es)
GR (1) GR860532B (es)
NZ (1) NZ215282A (es)
PT (1) PT82077B (es)
WO (1) WO1986004901A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
IL83663A0 (en) * 1986-10-27 1988-01-31 Robins Co Inc A H Preparation of 3-pyrrolidinols
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions
DE3721855A1 (de) * 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
DE4136443A1 (de) * 1991-11-06 1993-05-13 Boehringer Ingelheim Int Expression der reifen proteinase 2a, ihre partielle reinigung und bereitstellung kompetitiv wirkender substrate
ZA991319B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia.
TW536538B (en) 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
EP1346983A3 (en) * 1998-02-20 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia
AU2013295391B2 (en) * 2012-07-24 2018-03-08 Merck Patent Gmbh Hydroxystatin derivatives for treatment of arthrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate

Also Published As

Publication number Publication date
DK89286A (da) 1986-08-27
DK89286D0 (da) 1986-02-26
ES552407A0 (es) 1988-11-16
GR860532B (en) 1986-06-24
PT82077A (fr) 1986-03-01
AU587426B2 (en) 1989-08-17
AU5410086A (en) 1986-09-04
KR860006487A (ko) 1986-09-11
PT82077B (fr) 1987-09-25
NZ215282A (en) 1989-08-29
WO1986004901A1 (fr) 1986-08-28
EP0214209A1 (fr) 1987-03-18

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