DK171397B1 - 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater - Google Patents

24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater Download PDF

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Publication number
DK171397B1
DK171397B1 DK008685A DK8685A DK171397B1 DK 171397 B1 DK171397 B1 DK 171397B1 DK 008685 A DK008685 A DK 008685A DK 8685 A DK8685 A DK 8685A DK 171397 B1 DK171397 B1 DK 171397B1
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DK
Denmark
Prior art keywords
vitamin
dihydroxyvitamin
hydroxyvitamin
epi
dihydroxy
Prior art date
Application number
DK008685A
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Danish (da)
English (en)
Other versions
DK8685A (da
DK8685D0 (da
Inventor
Hector F Deluca
Heinrich K Schnoes
Rafal R Sicinski
Yoko Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK8685A publication Critical patent/DK8685A/da
Publication of DK8685D0 publication Critical patent/DK8685D0/da
Application granted granted Critical
Publication of DK171397B1 publication Critical patent/DK171397B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK008685A 1983-05-09 1985-01-08 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater DK171397B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US49286383 1983-05-09
US60732784A 1984-05-04 1984-05-04
US60732784 1984-05-04
PCT/US1984/000714 WO1984004527A1 (fr) 1983-05-09 1984-05-09 PROCEDE DE PREPARATION DE LA VITAMINE D21alpha,25-DIHYDROXYLEE ET DES COMPOSES APPARENTES
US8400714 1984-05-09

Publications (3)

Publication Number Publication Date
DK8685A DK8685A (da) 1985-01-08
DK8685D0 DK8685D0 (da) 1985-01-08
DK171397B1 true DK171397B1 (da) 1996-10-14

Family

ID=27050897

Family Applications (3)

Application Number Title Priority Date Filing Date
DK008685A DK171397B1 (da) 1983-05-09 1985-01-08 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater
DK198801845A DK172567B1 (da) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater
DK199101832A DK172733B1 (da) 1983-05-09 1991-11-07 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK198801845A DK172567B1 (da) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater
DK199101832A DK172733B1 (da) 1983-05-09 1991-11-07 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater

Country Status (7)

Country Link
JP (3) JPH0610188B2 (fr)
AU (1) AU568549B2 (fr)
CH (1) CH665834A5 (fr)
DE (4) DE3490215T (fr)
DK (3) DK171397B1 (fr)
NL (1) NL193245C (fr)
WO (1) WO1984004527A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8520265A (nl) * 1984-10-04 1986-09-01 Wisconsin Alumni Res Found Derivaten van vitamine d en werkwijzen voor het bereiden daarvan.
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
CA1341408C (fr) * 1988-08-02 2002-12-10 Charles W. Bishop Methode de prevention et de traitement de la perte de masse osseuse
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171426B (fr) * 1990-02-14 1992-10-10 Wisconsin Alumni Res Found
CA2116238C (fr) * 1992-06-22 2007-09-04 Joyce C. Knutson 1 .alpha.-hydroxyprevitamine d par voie orale
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
PL336231A1 (en) 1997-02-13 2000-06-19 Bone Care International System for aimed therapeutic delivery of vitamin d compounds
ES2575003T3 (es) 2008-03-12 2016-06-23 Opko Ireland Global Holdings, Limited 1,25-Dihidroxivitamina D2 estabilizada y método de preparación de la misma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
WO1984004527A1 (fr) 1984-11-22
DK184588D0 (da) 1988-04-06
DK172733B1 (da) 1999-06-21
JPH02288873A (ja) 1990-11-28
DK8685A (da) 1985-01-08
NL193245C (nl) 1999-04-02
JPH02288829A (ja) 1990-11-28
JPH0339505B2 (fr) 1991-06-14
DK183291A (da) 1991-11-07
JPH0610188B2 (ja) 1994-02-09
DE3490215T (de) 1985-05-15
DE3490215C2 (fr) 1991-07-25
NL8420137A (nl) 1985-04-01
DK172567B1 (da) 1999-01-18
DK183291D0 (da) 1991-11-07
AU3011584A (en) 1984-12-04
DK8685D0 (da) 1985-01-08
DE3448412C2 (fr) 1991-12-12
AU568549B2 (en) 1988-01-07
DE3448360C2 (fr) 1991-10-02
DK184588A (da) 1988-04-06
CH665834A5 (de) 1988-06-15
JPH0651624B2 (ja) 1994-07-06
NL193245B (nl) 1998-12-01
JPH02288854A (ja) 1990-11-28

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