DK8685A - Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser - Google Patents
Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser Download PDFInfo
- Publication number
- DK8685A DK8685A DK8685A DK8685A DK8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- preparing
- hydroxylered
- 1alfa
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 229930003231 vitamin Natural products 0.000 abstract 2
- 239000011782 vitamin Substances 0.000 abstract 2
- 229940088594 vitamin Drugs 0.000 abstract 2
- 235000013343 vitamin Nutrition 0.000 abstract 2
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 208000022458 calcium metabolism disease Diseases 0.000 abstract 1
- 229960002061 ergocalciferol Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 235000001892 vitamin D2 Nutrition 0.000 abstract 1
- 239000011653 vitamin D2 Substances 0.000 abstract 1
- 150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49286383A | 1983-05-09 | 1983-05-09 | |
| US49286383 | 1983-05-09 | ||
| US60732784A | 1984-05-04 | 1984-05-04 | |
| US60732784 | 1984-05-04 | ||
| US8400714 | 1984-05-09 | ||
| PCT/US1984/000714 WO1984004527A1 (en) | 1983-05-09 | 1984-05-09 | PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK8685A true DK8685A (da) | 1985-01-08 |
| DK8685D0 DK8685D0 (da) | 1985-01-08 |
| DK171397B1 DK171397B1 (da) | 1996-10-14 |
Family
ID=27050897
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK008685A DK171397B1 (da) | 1983-05-09 | 1985-01-08 | 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater |
| DK198801845A DK172567B1 (da) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater |
| DK199101832A DK172733B1 (da) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198801845A DK172567B1 (da) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater |
| DK199101832A DK172733B1 (da) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater |
Country Status (7)
| Country | Link |
|---|---|
| JP (3) | JPH0651624B2 (da) |
| AU (1) | AU568549B2 (da) |
| CH (1) | CH665834A5 (da) |
| DE (4) | DE3490215C2 (da) |
| DK (3) | DK171397B1 (da) |
| NL (1) | NL193245C (da) |
| WO (1) | WO1984004527A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62500301A (ja) * | 1984-10-04 | 1987-02-05 | ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン | ２４―ホモビタミンｄ誘導体 |
| DE3687377T2 (de) * | 1985-01-17 | 1993-04-29 | Wisconsin Alumni Res Found | Vitamin-d-abkoemmlinge und deren herstellungsverfahren. |
| CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| JP2645130B2 (ja) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
| GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
| IN171426B (da) * | 1990-02-14 | 1992-10-10 | Wisconsin Alumni Res Found | |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| AU4645893A (en) * | 1992-06-22 | 1994-01-24 | Lunar Corporation | Oral 1alpha-hydroxyprevitamin D |
| US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| AU750451B2 (en) | 1997-02-13 | 2002-07-18 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| IL153378A0 (en) | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| WO2009111873A1 (en) | 2008-03-12 | 2009-09-17 | Cytochroma, Inc. | Stabilized 1,25-dihydroxyvitamin d2 and method of making same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
| US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
-
1984
- 1984-05-09 NL NL8420137A patent/NL193245C/nl not_active IP Right Cessation
- 1984-05-09 CH CH145/85A patent/CH665834A5/de not_active IP Right Cessation
- 1984-05-09 AU AU30115/84A patent/AU568549B2/en not_active Ceased
- 1984-05-09 DE DE3490215A patent/DE3490215C2/de not_active Expired - Lifetime
- 1984-05-09 WO PCT/US1984/000714 patent/WO1984004527A1/en not_active Ceased
- 1984-05-09 DE DE3448412A patent/DE3448412C2/de not_active Expired - Lifetime
- 1984-05-09 DE DE19843490215 patent/DE3490215T/de active Pending
- 1984-05-09 DE DE3448360A patent/DE3448360C2/de not_active Expired - Lifetime
-
1985
- 1985-01-08 DK DK008685A patent/DK171397B1/da not_active IP Right Cessation
-
1988
- 1988-04-06 DK DK198801845A patent/DK172567B1/da not_active IP Right Cessation
-
1989
- 1989-12-26 JP JP1338023A patent/JPH0651624B2/ja not_active Expired - Lifetime
- 1989-12-26 JP JP1338025A patent/JPH0610188B2/ja not_active Expired - Fee Related
- 1989-12-26 JP JP1338024A patent/JPH02288873A/ja active Granted
-
1991
- 1991-11-07 DK DK199101832A patent/DK172733B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK183291A (da) | 1991-11-07 |
| DK184588A (da) | 1988-04-06 |
| AU568549B2 (en) | 1988-01-07 |
| AU3011584A (en) | 1984-12-04 |
| JPH0651624B2 (ja) | 1994-07-06 |
| DK172567B1 (da) | 1999-01-18 |
| NL193245C (nl) | 1999-04-02 |
| DE3448360C2 (da) | 1991-10-02 |
| WO1984004527A1 (en) | 1984-11-22 |
| JPH02288873A (ja) | 1990-11-28 |
| JPH02288829A (ja) | 1990-11-28 |
| CH665834A5 (de) | 1988-06-15 |
| DK183291D0 (da) | 1991-11-07 |
| JPH02288854A (ja) | 1990-11-28 |
| DK184588D0 (da) | 1988-04-06 |
| DK8685D0 (da) | 1985-01-08 |
| DE3490215C2 (da) | 1991-07-25 |
| DE3490215T (de) | 1985-05-15 |
| JPH0339505B2 (da) | 1991-06-14 |
| NL8420137A (nl) | 1985-04-01 |
| NL193245B (nl) | 1998-12-01 |
| DE3448412C2 (da) | 1991-12-12 |
| JPH0610188B2 (ja) | 1994-02-09 |
| DK171397B1 (da) | 1996-10-14 |
| DK172733B1 (da) | 1999-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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