DK8685A - METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS - Google Patents
METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS Download PDFInfo
- Publication number
- DK8685A DK8685A DK8685A DK8685A DK8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- preparing
- hydroxylered
- 1alfa
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Previously unknown derivatives of vitamin D2 and, more especially, 1α,25-dihydroxylated compounds of the vitamin D series. A process is also provided for preparing these derivatives, as are certain intermediates for this. The invention provides 1α,25- dihydroxyvitamin D2 derivatives, and acylates thereof, which can be used as replacement for vitamin D3 or D2, or for various of the known vitamin metabolites of the vitamins, for their various purposes for remedying pathological states in connection with calcium metabolism and bone diseases which are associated therewith.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49286383A | 1983-05-09 | 1983-05-09 | |
US49286383 | 1983-05-09 | ||
US60732784A | 1984-05-04 | 1984-05-04 | |
US60732784 | 1984-05-04 | ||
PCT/US1984/000714 WO1984004527A1 (en) | 1983-05-09 | 1984-05-09 | PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS |
US8400714 | 1984-05-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK8685D0 DK8685D0 (en) | 1985-01-08 |
DK8685A true DK8685A (en) | 1985-01-08 |
DK171397B1 DK171397B1 (en) | 1996-10-14 |
Family
ID=27050897
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK008685A DK171397B1 (en) | 1983-05-09 | 1985-01-08 | 24-Epi-1alpha,25-dihydroxylated vitamin D2 derivatives, and preparations for pharmaceutical use which comprises these derivatives |
DK198801845A DK172567B1 (en) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
DK199101832A DK172733B1 (en) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198801845A DK172567B1 (en) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
DK199101832A DK172733B1 (en) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
Country Status (7)
Country | Link |
---|---|
JP (3) | JPH0610188B2 (en) |
AU (1) | AU568549B2 (en) |
CH (1) | CH665834A5 (en) |
DE (4) | DE3448360C2 (en) |
DK (3) | DK171397B1 (en) |
NL (1) | NL193245C (en) |
WO (1) | WO1984004527A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002078A1 (en) * | 1984-10-04 | 1986-04-10 | Wisconsin Alumni Research Foundation | Vitamin d derivatives and methods for preparing same |
DE3687377T2 (en) * | 1985-01-17 | 1993-04-29 | Wisconsin Alumni Res Found | VITAMIN-D-COMBINATIONS AND THEIR PRODUCTION METHOD. |
CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
JP2645130B2 (en) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | Steroid derivatives |
GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
IN171426B (en) * | 1990-02-14 | 1992-10-10 | Wisconsin Alumni Res Found | |
CA2116238C (en) * | 1992-06-22 | 2007-09-04 | Joyce C. Knutson | Oral 1 .alpha.-hydroxyprevitamin d |
US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
AU750451B2 (en) | 1997-02-13 | 2002-07-18 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
JP5492099B2 (en) | 2008-03-12 | 2014-05-14 | シトクロマ インコーポレイテッド | Stabilized 1,25-dihydroxyvitamin D2 and process for producing the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
-
1984
- 1984-05-09 CH CH145/85A patent/CH665834A5/en not_active IP Right Cessation
- 1984-05-09 DE DE3448360A patent/DE3448360C2/de not_active Expired - Lifetime
- 1984-05-09 DE DE19843490215 patent/DE3490215T/en active Pending
- 1984-05-09 NL NL8420137A patent/NL193245C/en not_active IP Right Cessation
- 1984-05-09 WO PCT/US1984/000714 patent/WO1984004527A1/en active Application Filing
- 1984-05-09 DE DE3490215A patent/DE3490215C2/de not_active Expired - Lifetime
- 1984-05-09 DE DE3448412A patent/DE3448412C2/de not_active Expired - Lifetime
- 1984-05-09 AU AU30115/84A patent/AU568549B2/en not_active Ceased
-
1985
- 1985-01-08 DK DK008685A patent/DK171397B1/en not_active IP Right Cessation
-
1988
- 1988-04-06 DK DK198801845A patent/DK172567B1/en not_active IP Right Cessation
-
1989
- 1989-12-26 JP JP1338025A patent/JPH0610188B2/en not_active Expired - Fee Related
- 1989-12-26 JP JP1338023A patent/JPH0651624B2/en not_active Expired - Lifetime
- 1989-12-26 JP JP1338024A patent/JPH02288873A/en active Granted
-
1991
- 1991-11-07 DK DK199101832A patent/DK172733B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH665834A5 (en) | 1988-06-15 |
WO1984004527A1 (en) | 1984-11-22 |
DK171397B1 (en) | 1996-10-14 |
AU568549B2 (en) | 1988-01-07 |
DK172733B1 (en) | 1999-06-21 |
JPH02288873A (en) | 1990-11-28 |
DE3448360C2 (en) | 1991-10-02 |
DK184588A (en) | 1988-04-06 |
DE3490215C2 (en) | 1991-07-25 |
NL193245C (en) | 1999-04-02 |
DK8685D0 (en) | 1985-01-08 |
JPH0651624B2 (en) | 1994-07-06 |
JPH02288854A (en) | 1990-11-28 |
NL8420137A (en) | 1985-04-01 |
DE3448412C2 (en) | 1991-12-12 |
JPH02288829A (en) | 1990-11-28 |
JPH0610188B2 (en) | 1994-02-09 |
NL193245B (en) | 1998-12-01 |
DE3490215T (en) | 1985-05-15 |
AU3011584A (en) | 1984-12-04 |
DK183291D0 (en) | 1991-11-07 |
DK172567B1 (en) | 1999-01-18 |
JPH0339505B2 (en) | 1991-06-14 |
DK183291A (en) | 1991-11-07 |
DK184588D0 (en) | 1988-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
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