DK8685A - METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS - Google Patents

METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS Download PDF

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Publication number
DK8685A
DK8685A DK8685A DK8685A DK8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A
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DK
Denmark
Prior art keywords
vitamin
preparing
hydroxylered
1alfa
derivatives
Prior art date
Application number
DK8685A
Other languages
Danish (da)
Other versions
DK171397B1 (en
DK8685D0 (en
Inventor
Hector F Deluca
Us Heinrich K Schnoes
Rafal R Sicinski
Yoko Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK8685D0 publication Critical patent/DK8685D0/en
Publication of DK8685A publication Critical patent/DK8685A/en
Application granted granted Critical
Publication of DK171397B1 publication Critical patent/DK171397B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Previously unknown derivatives of vitamin D2 and, more especially, 1α,25-dihydroxylated compounds of the vitamin D series. A process is also provided for preparing these derivatives, as are certain intermediates for this. The invention provides 1α,25- dihydroxyvitamin D2 derivatives, and acylates thereof, which can be used as replacement for vitamin D3 or D2, or for various of the known vitamin metabolites of the vitamins, for their various purposes for remedying pathological states in connection with calcium metabolism and bone diseases which are associated therewith.
DK008685A 1983-05-09 1985-01-08 24-Epi-1alpha,25-dihydroxylated vitamin D2 derivatives, and preparations for pharmaceutical use which comprises these derivatives DK171397B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US49286383 1983-05-09
US60732784A 1984-05-04 1984-05-04
US60732784 1984-05-04
PCT/US1984/000714 WO1984004527A1 (en) 1983-05-09 1984-05-09 PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS
US8400714 1984-05-09

Publications (3)

Publication Number Publication Date
DK8685D0 DK8685D0 (en) 1985-01-08
DK8685A true DK8685A (en) 1985-01-08
DK171397B1 DK171397B1 (en) 1996-10-14

Family

ID=27050897

Family Applications (3)

Application Number Title Priority Date Filing Date
DK008685A DK171397B1 (en) 1983-05-09 1985-01-08 24-Epi-1alpha,25-dihydroxylated vitamin D2 derivatives, and preparations for pharmaceutical use which comprises these derivatives
DK198801845A DK172567B1 (en) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives
DK199101832A DK172733B1 (en) 1983-05-09 1991-11-07 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK198801845A DK172567B1 (en) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives
DK199101832A DK172733B1 (en) 1983-05-09 1991-11-07 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives

Country Status (7)

Country Link
JP (3) JPH0610188B2 (en)
AU (1) AU568549B2 (en)
CH (1) CH665834A5 (en)
DE (4) DE3448360C2 (en)
DK (3) DK171397B1 (en)
NL (1) NL193245C (en)
WO (1) WO1984004527A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002078A1 (en) * 1984-10-04 1986-04-10 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
DE3687377T2 (en) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found VITAMIN-D-COMBINATIONS AND THEIR PRODUCTION METHOD.
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (en) * 1989-03-31 1997-08-25 日清製粉株式会社 Steroid derivatives
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171426B (en) * 1990-02-14 1992-10-10 Wisconsin Alumni Res Found
CA2116238C (en) * 1992-06-22 2007-09-04 Joyce C. Knutson Oral 1 .alpha.-hydroxyprevitamin d
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
AU750451B2 (en) 1997-02-13 2002-07-18 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
JP5492099B2 (en) 2008-03-12 2014-05-14 シトクロマ インコーポレイテッド Stabilized 1,25-dihydroxyvitamin D2 and process for producing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
CH665834A5 (en) 1988-06-15
WO1984004527A1 (en) 1984-11-22
DK171397B1 (en) 1996-10-14
AU568549B2 (en) 1988-01-07
DK172733B1 (en) 1999-06-21
JPH02288873A (en) 1990-11-28
DE3448360C2 (en) 1991-10-02
DK184588A (en) 1988-04-06
DE3490215C2 (en) 1991-07-25
NL193245C (en) 1999-04-02
DK8685D0 (en) 1985-01-08
JPH0651624B2 (en) 1994-07-06
JPH02288854A (en) 1990-11-28
NL8420137A (en) 1985-04-01
DE3448412C2 (en) 1991-12-12
JPH02288829A (en) 1990-11-28
JPH0610188B2 (en) 1994-02-09
NL193245B (en) 1998-12-01
DE3490215T (en) 1985-05-15
AU3011584A (en) 1984-12-04
DK183291D0 (en) 1991-11-07
DK172567B1 (en) 1999-01-18
JPH0339505B2 (en) 1991-06-14
DK183291A (en) 1991-11-07
DK184588D0 (en) 1988-04-06

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