ES8302652A2 - Un procedimiento para la preparacion de derivados de pirrol - Google Patents

Un procedimiento para la preparacion de derivados de pirrol

Info

Publication number
ES8302652A2
ES8302652A2 ES499559A ES49955981A ES8302652A2 ES 8302652 A2 ES8302652 A2 ES 8302652A2 ES 499559 A ES499559 A ES 499559A ES 49955981 A ES49955981 A ES 49955981A ES 8302652 A2 ES8302652 A2 ES 8302652A2
Authority
ES
Spain
Prior art keywords
pyrroles
sulfones
diaryl
antiinflammatory
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499559A
Other languages
English (en)
Other versions
ES499559A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES499559A0 publication Critical patent/ES499559A0/es
Publication of ES8302652A2 publication Critical patent/ES8302652A2/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE PIRROL Y COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN (CERTIFICADO DE ADICION DE LA PATENTE PRINCIPAL N<002> 478.556). CARACTERIZADOS POR SER COMPUESTOS DE FORMULA GENERAL (I), DONDE R ES ALQUILO C -C ; R Y R SON, INDEPENDIENTEMENTE, 2-TIENILO,3-PIRIDILO,3-PIRIDIL-N-OXIDO O UN RADICAL DE FORMULA (II), EN DONDE Y ES R S(O)<010>-, SIENDO R METILO O ETILO, Y M ES 0, 1 O 2; Y ES H, F O CL; R ES ALQUILO C -C ; Y R ES H, ALQUILO C -C O ALILO. DE APLICACION EN LA PREPARACION DE COMPUESTOS FARMACEUTICOS, UTILIZADOS PARA EL TRATAMIENTO DE LA ARTRITIS O PARA ALIVIAR EL DOLOR EN LOS MAMIFEROS.
ES499559A 1980-02-19 1981-02-18 Un procedimiento para la preparacion de derivados de pirrol Expired ES8302652A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/122,501 US4267184A (en) 1979-02-08 1980-02-19 Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones

Publications (2)

Publication Number Publication Date
ES499559A0 ES499559A0 (es) 1983-01-01
ES8302652A2 true ES8302652A2 (es) 1983-01-01

Family

ID=22403065

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499559A Expired ES8302652A2 (es) 1980-02-19 1981-02-18 Un procedimiento para la preparacion de derivados de pirrol

Country Status (17)

Country Link
US (1) US4267184A (es)
EP (1) EP0034798B1 (es)
JP (1) JPS56150060A (es)
AT (1) AT374796B (es)
AU (1) AU540613B2 (es)
CA (1) CA1144550A (es)
DE (1) DE3170571D1 (es)
DK (1) DK448480A (es)
ES (1) ES8302652A2 (es)
FI (1) FI804028L (es)
GR (1) GR70770B (es)
NO (1) NO810547L (es)
PH (1) PH17299A (es)
PT (1) PT72087B (es)
SU (1) SU1160934A3 (es)
YU (1) YU279080A (es)
ZA (1) ZA808109B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495196A (en) * 1980-07-17 1985-01-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-pyrrole-2-methanols and method for use thereof
US4438117A (en) 1980-09-03 1984-03-20 E. I. Du Pont De Nemours And Company 2-Substituted thio-4,5-diarylpyrimidines
US4652582A (en) * 1985-01-09 1987-03-24 E. I. Du Pont De Nemours And Company Antiinflammatory-2-halo-4,5-diarylpyrroles
US5306827A (en) * 1991-12-04 1994-04-26 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents
US5284863A (en) * 1991-12-04 1994-02-08 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
US6492413B2 (en) * 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5480902A (en) * 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
US5492925A (en) 1993-08-31 1996-02-20 American Cyanamid Company Thienyl-and furylpyrrole insecticidal and acaricidal agents
US5968974A (en) * 1995-07-19 1999-10-19 Merck & Co., Inc. Method of treating colonic adenomas
US6593361B2 (en) 1995-07-19 2003-07-15 Merck & Co Inc Method of treating colonic adenomas
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
AU702887B2 (en) * 1995-10-31 1999-03-11 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
ES2208964T3 (es) * 1996-12-10 2004-06-16 G.D. SEARLE &amp; CO. Compuestos de pirrolilo substituidos para el tratamiento de la inflamacion.
WO1999033796A1 (fr) 1997-12-26 1999-07-08 Nissin Food Products Co., Ltd. Derives de 5-arylpyrrole
HRP20020440B1 (en) * 2002-05-21 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020452A2 (en) * 2002-05-23 2004-02-29 Pliva D D 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3709906A (en) * 1968-07-26 1973-01-09 Sankyo Co 2-alkyl-4,5-diphenylpyrrole derivatives
DK75779A (da) * 1978-03-13 1979-09-14 Du Pont 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse

Also Published As

Publication number Publication date
AU6403280A (en) 1981-08-27
ZA808109B (en) 1982-07-28
PT72087B (en) 1981-09-29
SU1160934A3 (ru) 1985-06-07
AU540613B2 (en) 1984-11-29
AT374796B (de) 1984-05-25
US4267184A (en) 1981-05-12
DE3170571D1 (en) 1985-06-27
NO810547L (no) 1981-08-20
JPH0250902B2 (es) 1990-11-05
ES499559A0 (es) 1983-01-01
EP0034798A2 (en) 1981-09-02
JPS56150060A (en) 1981-11-20
PT72087A (en) 1980-12-01
DK448480A (da) 1981-08-20
PH17299A (en) 1984-07-18
EP0034798A3 (en) 1981-09-09
CA1144550A (en) 1983-04-12
ATA73981A (de) 1983-10-15
EP0034798B1 (en) 1985-05-22
GR70770B (es) 1983-03-16
YU279080A (en) 1983-10-31
FI804028L (fi) 1981-08-20

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