ES484196A1 - Un procedimiento para la preparacion de derivados de pirrol - Google Patents

Un procedimiento para la preparacion de derivados de pirrol

Info

Publication number
ES484196A1
ES484196A1 ES484196A ES484196A ES484196A1 ES 484196 A1 ES484196 A1 ES 484196A1 ES 484196 A ES484196 A ES 484196A ES 484196 A ES484196 A ES 484196A ES 484196 A1 ES484196 A1 ES 484196A1
Authority
ES
Spain
Prior art keywords
pyrroles
sulfones
diaryl
thio
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484196A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES484196A1 publication Critical patent/ES484196A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1. Un procedimiento para la preparación de derivados de pirrol de fórmula: **(Fórmula-01)** donde R1 es alquilo C1-C4, mono- o poli-fluoralquilo C1-C4 o alilo; R2 y R3, independientemente son 2-tienilo, 3-piridilo, 3- piridil-N-óxido o **(Fórmula-02)** Y1 es alquilo C1-C4, alcoxi C1-C4, F, C1, Br, H o (R5)2N, donde R5 es metilo o etilo; Y2 es H, F o Cl; R4 es H o alquilo C1-C3; R6 es H, alquilo C1-C4, alilo, -CH2CH2N(R7)2, -CHOR9, 2- tetrahidropiranilo, 2-tetrahidrofuranilo, -CR10 **(Fórmula-03)** -CN(R11)2, alquilsulfonilo C1-C4 o -COR10; R7 es H, metilo o etilo; R8 es H o metilo; R9 es alquilo C1-C3, bencilo, -CH2CH2OCH3 o -CR10; R10 es alquilo C1-C4 o bencilo; R11 es metilo o etilo; X es O o S; Y3 es H, F, C1, Br, alquilo C1-C4 o nitro y n es 0,1 ó 2; con la condición de que, cuando Y1 e Y2 son ambos H, R1 es CF3; o sus sales de adición farmacéuticamente aceptables donde por lo menos uno de los radicales R2 ó R3 es 3-piridilo, Y1 es (R5)2N ó R6 es -CH2CH2N(R7)2.
ES484196A 1978-03-13 1979-09-14 Un procedimiento para la preparacion de derivados de pirrol Expired ES484196A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88633778A 1978-03-13 1978-03-13
US97220178A 1978-12-28 1978-12-28
US1025979A 1979-02-08 1979-02-08

Publications (1)

Publication Number Publication Date
ES484196A1 true ES484196A1 (es) 1980-05-16

Family

ID=27359191

Family Applications (2)

Application Number Title Priority Date Filing Date
ES478556A Expired ES478556A1 (es) 1978-03-13 1979-03-12 Un procedimiento para la preparacion de derivados de pirrol.
ES484196A Expired ES484196A1 (es) 1978-03-13 1979-09-14 Un procedimiento para la preparacion de derivados de pirrol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES478556A Expired ES478556A1 (es) 1978-03-13 1979-03-12 Un procedimiento para la preparacion de derivados de pirrol.

Country Status (17)

Country Link
EP (1) EP0005156B1 (es)
JP (1) JPS54141766A (es)
AR (2) AR225739A1 (es)
AU (1) AU527243B2 (es)
CA (1) CA1126275A (es)
DE (1) DE2963707D1 (es)
DK (1) DK75779A (es)
ES (2) ES478556A1 (es)
FI (1) FI790852A (es)
GR (1) GR66513B (es)
IL (1) IL56856A (es)
MX (1) MX5685E (es)
NO (1) NO790821L (es)
NZ (1) NZ189881A (es)
PH (1) PH14378A (es)
PT (1) PT69336A (es)
YU (1) YU58979A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267184A (en) * 1979-02-08 1981-05-12 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones
DK350280A (da) * 1979-08-27 1981-02-28 Du Pont Fremgangsmaade til fremstilling af 4,5-diaryl-alfapolyfluoralkyl-1h-pyrrol-2-methanoler og 1-(4,5-diaryl-1h-pyrrol-2-yl)-polyfluoralkanoner
US4267190A (en) * 1980-04-18 1981-05-12 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols
EP0044485A1 (en) * 1980-07-21 1982-01-27 E.I. Du Pont De Nemours And Company Antiinflammatory 2,3-diaryl-5(2,2,2-trifluoro-1-(trifluoromethyl)-ethyl)-1H-pyrroles
DE3317653A1 (de) * 1983-05-14 1984-11-15 Gödecke AG, 1000 Berlin 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende
US5306827A (en) * 1991-12-04 1994-04-26 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents
US5492925A (en) * 1993-08-31 1996-02-20 American Cyanamid Company Thienyl-and furylpyrrole insecticidal and acaricidal agents
FR2874012B1 (fr) * 2004-08-09 2008-08-22 Sanofi Synthelabo Derives de pyrrole, leur preparation et leur utlisation en therapeutique
US8822694B2 (en) 2009-02-25 2014-09-02 Takeda Pharmaceutical Company Limited Process for producing pyrrole compound

Also Published As

Publication number Publication date
NO790821L (no) 1979-09-14
DE2963707D1 (en) 1982-11-04
YU58979A (en) 1983-04-30
DK75779A (da) 1979-09-14
PH14378A (en) 1981-06-17
CA1126275A (en) 1982-06-22
ES478556A1 (es) 1979-12-16
AR225739A1 (es) 1982-04-30
PT69336A (en) 1979-04-01
MX5685E (es) 1983-12-09
IL56856A (en) 1982-09-30
FI790852A (fi) 1979-09-14
AU4504079A (en) 1979-09-20
AR224276A1 (es) 1981-11-13
AU527243B2 (en) 1983-02-24
EP0005156A1 (en) 1979-11-14
GR66513B (es) 1981-03-24
NZ189881A (en) 1981-02-11
JPS54141766A (en) 1979-11-05
IL56856A0 (en) 1979-05-31
EP0005156B1 (en) 1982-09-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000403