ES466793A1 - Un procedimiento para la preparacion de derivados de imida- zol, con propiedades antiartriticas. - Google Patents

Un procedimiento para la preparacion de derivados de imida- zol, con propiedades antiartriticas.

Info

Publication number
ES466793A1
ES466793A1 ES466793A ES466793A ES466793A1 ES 466793 A1 ES466793 A1 ES 466793A1 ES 466793 A ES466793 A ES 466793A ES 466793 A ES466793 A ES 466793A ES 466793 A1 ES466793 A1 ES 466793A1
Authority
ES
Spain
Prior art keywords
substituted
diaryl
imidazoles
thio
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466793A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES466793A1 publication Critical patent/ES466793A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen 4,5-diaril-2-(tio sustituido)imidazoles 1- sustituidos anti-inflamatorios y sus correspondientes sulfóxidos y sulfonas, útiles para el tratamiento de la artritis y enfermedades similares.
ES466793A 1977-02-09 1978-02-08 Un procedimiento para la preparacion de derivados de imida- zol, con propiedades antiartriticas. Expired ES466793A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76721977A 1977-02-09 1977-02-09
US05/865,831 US4182769A (en) 1977-02-09 1978-01-05 Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones

Publications (1)

Publication Number Publication Date
ES466793A1 true ES466793A1 (es) 1979-08-01

Family

ID=27117878

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466793A Expired ES466793A1 (es) 1977-02-09 1978-02-08 Un procedimiento para la preparacion de derivados de imida- zol, con propiedades antiartriticas.

Country Status (27)

Country Link
US (1) US4182769A (es)
JP (1) JPS53130665A (es)
AR (1) AR221590A1 (es)
AT (1) AT363076B (es)
AU (1) AU524360B2 (es)
CA (1) CA1107286A (es)
CH (1) CH643834A5 (es)
DE (1) DE2805166A1 (es)
DK (1) DK16878A (es)
ES (1) ES466793A1 (es)
FI (1) FI68619C (es)
FR (1) FR2380264A1 (es)
GB (1) GB1587373A (es)
GR (1) GR64157B (es)
HU (1) HU181868B (es)
IE (1) IE46454B1 (es)
IL (1) IL53996A (es)
IT (1) IT1092439B (es)
LU (1) LU79028A1 (es)
MX (1) MX5934E (es)
NL (1) NL7801454A (es)
NO (1) NO149813C (es)
NZ (1) NZ186411A (es)
PT (1) PT67625B (es)
SE (1) SE7801466L (es)
SU (1) SU867301A3 (es)
YU (1) YU28978A (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
DE2966706D1 (en) * 1978-08-10 1984-03-29 Ciba Geigy Ag Substituted anthranilic acid amides, process for their preparation, pharmaceutical compositions containing them and their preparation
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (da) * 1978-10-02 1980-04-03 Du Pont Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
IT1110282B (it) * 1979-02-19 1985-12-23 Acraf Tio-indazoli basici
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4438117A (en) 1980-09-03 1984-03-20 E. I. Du Pont De Nemours And Company 2-Substituted thio-4,5-diarylpyrimidines
US4355041A (en) * 1982-01-04 1982-10-19 E. I. Du Pont De Nemours And Company 4,5-Bis-(4-fluorophenyl)-1-(4-nitrobenzyl)-2-[((1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole, composition and use
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
ZA826501B (en) * 1982-09-06 1984-04-25 Du Pont Anti-hypertensive imidazole derivative
DE3504678A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
US5300519A (en) * 1988-07-06 1994-04-05 The University Of Sheffield Immunosuppressive agents
US5098707A (en) * 1989-07-31 1992-03-24 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5030644A (en) * 1989-07-31 1991-07-09 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
JPH03145473A (ja) * 1989-10-27 1991-06-20 Hisamitsu Pharmaceut Co Inc 新規なイミダゾール酢酸誘導体
GB9005966D0 (en) * 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
JP2002515915A (ja) * 1997-06-30 2002-05-28 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 炎症性疾患の治療で有用な２−置換イミダゾール類
FR2823747B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
US20170202818A1 (en) 2014-07-18 2017-07-20 Ohio University Methods and compositions to modify gsk-3 activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1155580A (en) * 1965-10-21 1969-06-18 Geigy Ag J R New Imidazole Derivatives their Production and Use
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
JPS5343958B2 (es) * 1972-07-29 1978-11-24

Also Published As

Publication number Publication date
IT7820079A0 (it) 1978-02-07
NL7801454A (nl) 1978-08-11
DE2805166A1 (de) 1978-08-10
NO780432L (no) 1978-08-10
PT67625B (en) 1979-07-17
GB1587373A (en) 1981-04-01
AU3309778A (en) 1979-08-16
IE780280L (en) 1978-08-09
FR2380264A1 (fr) 1978-09-08
US4182769A (en) 1980-01-08
FI780429A (fi) 1978-08-10
FI68619C (fi) 1985-10-10
FI68619B (fi) 1985-06-28
CH643834A5 (de) 1984-06-29
IT1092439B (it) 1985-07-12
PT67625A (en) 1978-03-01
MX5934E (es) 1984-08-30
CA1107286A (en) 1981-08-18
YU28978A (en) 1983-01-21
DK16878A (da) 1978-08-10
NO149813B (no) 1984-03-19
NO149813C (no) 1984-06-27
SE7801466L (sv) 1978-08-10
ATA87078A (de) 1980-12-15
GR64157B (en) 1980-02-05
IE46454B1 (en) 1983-06-15
LU79028A1 (fr) 1979-05-25
AU524360B2 (en) 1982-09-16
IL53996A (en) 1982-04-30
HU181868B (en) 1983-11-28
AT363076B (de) 1981-07-10
JPS53130665A (en) 1978-11-14
AR221590A1 (es) 1981-02-27
IL53996A0 (en) 1978-04-30
SU867301A3 (ru) 1981-09-23
NZ186411A (en) 1981-03-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202