IL53996A - 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL53996A IL53996A IL53996A IL5399678A IL53996A IL 53996 A IL53996 A IL 53996A IL 53996 A IL53996 A IL 53996A IL 5399678 A IL5399678 A IL 5399678A IL 53996 A IL53996 A IL 53996A
- Authority
- IL
- Israel
- Prior art keywords
- fluoroalkylthio
- diphenyl
- substituted
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76721977A | 1977-02-09 | 1977-02-09 | |
US05/865,831 US4182769A (en) | 1977-02-09 | 1978-01-05 | Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones |
Publications (2)
Publication Number | Publication Date |
---|---|
IL53996A0 IL53996A0 (en) | 1978-04-30 |
IL53996A true IL53996A (en) | 1982-04-30 |
Family
ID=27117878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL53996A IL53996A (en) | 1977-02-09 | 1978-02-08 | 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (27)
Country | Link |
---|---|
US (1) | US4182769A (es) |
JP (1) | JPS53130665A (es) |
AR (1) | AR221590A1 (es) |
AT (1) | AT363076B (es) |
AU (1) | AU524360B2 (es) |
CA (1) | CA1107286A (es) |
CH (1) | CH643834A5 (es) |
DE (1) | DE2805166A1 (es) |
DK (1) | DK16878A (es) |
ES (1) | ES466793A1 (es) |
FI (1) | FI68619C (es) |
FR (1) | FR2380264A1 (es) |
GB (1) | GB1587373A (es) |
GR (1) | GR64157B (es) |
HU (1) | HU181868B (es) |
IE (1) | IE46454B1 (es) |
IL (1) | IL53996A (es) |
IT (1) | IT1092439B (es) |
LU (1) | LU79028A1 (es) |
MX (1) | MX5934E (es) |
NL (1) | NL7801454A (es) |
NO (1) | NO149813C (es) |
NZ (1) | NZ186411A (es) |
PT (1) | PT67625B (es) |
SE (1) | SE7801466L (es) |
SU (1) | SU867301A3 (es) |
YU (1) | YU28978A (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
EP0008072B1 (de) * | 1978-08-10 | 1984-02-22 | Ciba-Geigy Ag | Substituierte Anthranilsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Herstellung |
US4308277A (en) * | 1978-08-10 | 1981-12-29 | Ciba-Geigy Corporation | 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same |
US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
DK337779A (da) * | 1978-10-02 | 1980-04-03 | Du Pont | Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler |
DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
IT1110282B (it) * | 1979-02-19 | 1985-12-23 | Acraf | Tio-indazoli basici |
DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US4438117A (en) | 1980-09-03 | 1984-03-20 | E. I. Du Pont De Nemours And Company | 2-Substituted thio-4,5-diarylpyrimidines |
US4355041A (en) * | 1982-01-04 | 1982-10-19 | E. I. Du Pont De Nemours And Company | 4,5-Bis-(4-fluorophenyl)-1-(4-nitrobenzyl)-2-[((1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole, composition and use |
US4503065A (en) * | 1982-08-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl 1-2-halo imidazoles |
ZA826501B (en) * | 1982-09-06 | 1984-04-25 | Du Pont | Anti-hypertensive imidazole derivative |
DE3504678A1 (de) * | 1985-02-12 | 1986-08-14 | A. Nattermann & Cie GmbH, 5000 Köln | Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung |
DE3508665A1 (de) * | 1985-03-12 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Heterocyclische sulfide und ihre anwendung als immunmodulatoren |
US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
US4780470A (en) * | 1986-08-19 | 1988-10-25 | Smithkline Beckman Corporation | Inhibition of interleukin-1 by monocytes and/or macrophages |
US5300519A (en) * | 1988-07-06 | 1994-04-05 | The University Of Sheffield | Immunosuppressive agents |
US5098707A (en) * | 1989-07-31 | 1992-03-24 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
US5030644A (en) * | 1989-07-31 | 1991-07-09 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
JPH03145473A (ja) * | 1989-10-27 | 1991-06-20 | Hisamitsu Pharmaceut Co Inc | 新規なイミダゾール酢酸誘導体 |
GB9005966D0 (en) * | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US6040320A (en) * | 1997-06-30 | 2000-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
FR2823747B1 (fr) * | 2001-04-24 | 2003-05-23 | Oreal | Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires |
WO2016010610A2 (en) * | 2014-07-18 | 2016-01-21 | Ohio University | Imidazole and thiazole compositions for modifying biological signaling |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6614808A (es) * | 1965-10-21 | 1967-04-24 | ||
US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
US3929807A (en) * | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
JPS5343958B2 (es) * | 1972-07-29 | 1978-11-24 |
-
1978
- 1978-01-05 US US05/865,831 patent/US4182769A/en not_active Expired - Lifetime
- 1978-01-13 DK DK16878A patent/DK16878A/da not_active Application Discontinuation
- 1978-02-06 PT PT67625A patent/PT67625B/pt unknown
- 1978-02-07 IT IT20079/78A patent/IT1092439B/it active
- 1978-02-07 CA CA296,605A patent/CA1107286A/en not_active Expired
- 1978-02-08 NZ NZ186411A patent/NZ186411A/xx unknown
- 1978-02-08 SU SU782574555A patent/SU867301A3/ru active
- 1978-02-08 SE SE7801466A patent/SE7801466L/xx unknown
- 1978-02-08 ES ES466793A patent/ES466793A1/es not_active Expired
- 1978-02-08 DE DE19782805166 patent/DE2805166A1/de not_active Withdrawn
- 1978-02-08 AT AT0087078A patent/AT363076B/de not_active IP Right Cessation
- 1978-02-08 FR FR7803517A patent/FR2380264A1/fr not_active Withdrawn
- 1978-02-08 YU YU00289/78A patent/YU28978A/xx unknown
- 1978-02-08 GB GB5097/78A patent/GB1587373A/en not_active Expired
- 1978-02-08 IE IE280/78A patent/IE46454B1/en unknown
- 1978-02-08 NL NL7801454A patent/NL7801454A/xx not_active Application Discontinuation
- 1978-02-08 IL IL53996A patent/IL53996A/xx unknown
- 1978-02-08 NO NO780432A patent/NO149813C/no unknown
- 1978-02-08 AU AU33097/78A patent/AU524360B2/en not_active Expired
- 1978-02-08 MX MX786830U patent/MX5934E/es unknown
- 1978-02-08 LU LU79028A patent/LU79028A1/xx unknown
- 1978-02-09 JP JP1304778A patent/JPS53130665A/ja active Pending
- 1978-02-09 CH CH147578A patent/CH643834A5/de not_active IP Right Cessation
- 1978-02-09 AR AR271047A patent/AR221590A1/es active
- 1978-02-09 FI FI780429A patent/FI68619C/fi not_active IP Right Cessation
- 1978-02-09 GR GR55397A patent/GR64157B/el unknown
- 1978-02-09 HU HU78DU280A patent/HU181868B/hu unknown
Also Published As
Publication number | Publication date |
---|---|
IT7820079A0 (it) | 1978-02-07 |
PT67625B (en) | 1979-07-17 |
LU79028A1 (fr) | 1979-05-25 |
US4182769A (en) | 1980-01-08 |
NL7801454A (nl) | 1978-08-11 |
FI68619C (fi) | 1985-10-10 |
IE46454B1 (en) | 1983-06-15 |
AR221590A1 (es) | 1981-02-27 |
SU867301A3 (ru) | 1981-09-23 |
NO149813B (no) | 1984-03-19 |
IL53996A0 (en) | 1978-04-30 |
FI780429A (fi) | 1978-08-10 |
CH643834A5 (de) | 1984-06-29 |
AT363076B (de) | 1981-07-10 |
PT67625A (en) | 1978-03-01 |
GB1587373A (en) | 1981-04-01 |
IE780280L (en) | 1978-08-09 |
AU3309778A (en) | 1979-08-16 |
IT1092439B (it) | 1985-07-12 |
ES466793A1 (es) | 1979-08-01 |
SE7801466L (sv) | 1978-08-10 |
CA1107286A (en) | 1981-08-18 |
HU181868B (en) | 1983-11-28 |
ATA87078A (de) | 1980-12-15 |
MX5934E (es) | 1984-08-30 |
FR2380264A1 (fr) | 1978-09-08 |
GR64157B (en) | 1980-02-05 |
YU28978A (en) | 1983-01-21 |
JPS53130665A (en) | 1978-11-14 |
DK16878A (da) | 1978-08-10 |
FI68619B (fi) | 1985-06-28 |
NO149813C (no) | 1984-06-27 |
NO780432L (no) | 1978-08-10 |
NZ186411A (en) | 1981-03-16 |
AU524360B2 (en) | 1982-09-16 |
DE2805166A1 (de) | 1978-08-10 |
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