AU568549B2 - Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds - Google Patents

Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds

Info

Publication number
AU568549B2
AU568549B2 AU30115/84A AU3011584A AU568549B2 AU 568549 B2 AU568549 B2 AU 568549B2 AU 30115/84 A AU30115/84 A AU 30115/84A AU 3011584 A AU3011584 A AU 3011584A AU 568549 B2 AU568549 B2 AU 568549B2
Authority
AU
Australia
Prior art keywords
vitamin
dihydroxy
compound
trans
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU30115/84A
Other languages
English (en)
Other versions
AU3011584A (en
Inventor
Hector F. Deluca
Heinrich K. Schnoes
Rafal R. Sicinski
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU3011584A publication Critical patent/AU3011584A/en
Application granted granted Critical
Publication of AU568549B2 publication Critical patent/AU568549B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AU30115/84A 1983-05-09 1984-05-09 Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds Ceased AU568549B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US492863 1983-05-09
US60732784A 1984-05-04 1984-05-04
US607327 1984-05-04

Publications (2)

Publication Number Publication Date
AU3011584A AU3011584A (en) 1984-12-04
AU568549B2 true AU568549B2 (en) 1988-01-07

Family

ID=27050897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30115/84A Ceased AU568549B2 (en) 1983-05-09 1984-05-09 Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds

Country Status (7)

Country Link
JP (3) JPH02288873A (fr)
AU (1) AU568549B2 (fr)
CH (1) CH665834A5 (fr)
DE (4) DE3490215C2 (fr)
DK (3) DK171397B1 (fr)
NL (1) NL193245C (fr)
WO (1) WO1984004527A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU594662B2 (en) * 1985-01-17 1990-03-15 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197949A1 (fr) * 1984-10-04 1986-10-22 Wisconsin Alumni Research Foundation Derives de vitamine d et leurs procedes de preparation
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
CA1341408C (fr) * 1988-08-02 2002-12-10 Charles W. Bishop Methode de prevention et de traitement de la perte de masse osseuse
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171449B (fr) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
ES2170069T3 (es) * 1992-06-22 2002-08-01 Bone Care Int Inc 1-alfa-hidroxiprevitamina d para administracion oral.
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6929797B2 (en) 1997-02-13 2005-08-16 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
US20090233889A1 (en) 2008-03-12 2009-09-17 Uttam Saha Stabilized 1,25-dihydroxyvitamin d2 and method of making same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU594662B2 (en) * 1985-01-17 1990-03-15 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same

Also Published As

Publication number Publication date
DK8685D0 (da) 1985-01-08
DE3490215T (de) 1985-05-15
AU3011584A (en) 1984-12-04
JPH02288873A (ja) 1990-11-28
DK171397B1 (da) 1996-10-14
WO1984004527A1 (fr) 1984-11-22
DE3448412C2 (fr) 1991-12-12
DK172567B1 (da) 1999-01-18
DK184588D0 (da) 1988-04-06
DE3448360C2 (fr) 1991-10-02
DK183291A (da) 1991-11-07
NL8420137A (nl) 1985-04-01
NL193245B (nl) 1998-12-01
JPH02288829A (ja) 1990-11-28
DK172733B1 (da) 1999-06-21
DK183291D0 (da) 1991-11-07
DE3490215C2 (fr) 1991-07-25
DK184588A (da) 1988-04-06
NL193245C (nl) 1999-04-02
CH665834A5 (de) 1988-06-15
JPH0651624B2 (ja) 1994-07-06
JPH0610188B2 (ja) 1994-02-09
DK8685A (da) 1985-01-08
JPH02288854A (ja) 1990-11-28
JPH0339505B2 (fr) 1991-06-14

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired