DK169873B1 - Beta-D-phenyl-thioxylosidderivater, fremgangsmåde og thiophenolderivater til fremstilling deraf, samt et terapeutisk middel og anvendelse af beta-D-phenyl-thioxylosidderivaterne - Google Patents
Beta-D-phenyl-thioxylosidderivater, fremgangsmåde og thiophenolderivater til fremstilling deraf, samt et terapeutisk middel og anvendelse af beta-D-phenyl-thioxylosidderivaterne Download PDFInfo
- Publication number
- DK169873B1 DK169873B1 DK239788A DK239788A DK169873B1 DK 169873 B1 DK169873 B1 DK 169873B1 DK 239788 A DK239788 A DK 239788A DK 239788 A DK239788 A DK 239788A DK 169873 B1 DK169873 B1 DK 169873B1
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- DK
- Denmark
- Prior art keywords
- preparation
- derivatives
- phenyl
- formula
- xylopyranoside
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 75
- 238000000034 method Methods 0.000 title claims description 31
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical class SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 title claims description 13
- 230000008569 process Effects 0.000 title claims description 7
- 239000003814 drug Substances 0.000 title claims description 4
- 229940124597 therapeutic agent Drugs 0.000 title claims description 4
- 125000005843 halogen group Chemical group 0.000 claims abstract description 6
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 5
- 125000002252 acyl group Chemical group 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 96
- -1 4- ((4-nitrophenyl) hydroxymethyl) phenyl Chemical group 0.000 claims description 32
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 18
- 239000012429 reaction media Substances 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 13
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- 239000002253 acid Substances 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
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- 238000003786 synthesis reaction Methods 0.000 claims description 3
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8706237 | 1987-05-04 | ||
| FR8706237A FR2614893B1 (fr) | 1987-05-04 | 1987-05-04 | Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK239788D0 DK239788D0 (da) | 1988-05-03 |
| DK239788A DK239788A (da) | 1988-11-05 |
| DK169873B1 true DK169873B1 (da) | 1995-03-20 |
Family
ID=9350723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK239788A DK169873B1 (da) | 1987-05-04 | 1988-05-03 | Beta-D-phenyl-thioxylosidderivater, fremgangsmåde og thiophenolderivater til fremstilling deraf, samt et terapeutisk middel og anvendelse af beta-D-phenyl-thioxylosidderivaterne |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US4877808A (de) |
| EP (1) | EP0290321B1 (de) |
| JP (1) | JPH07103144B2 (de) |
| KR (1) | KR960015109B1 (de) |
| CN (1) | CN1020614C (de) |
| AT (1) | ATE68000T1 (de) |
| AU (1) | AU602210B2 (de) |
| CA (1) | CA1323373C (de) |
| CZ (1) | CZ278365B6 (de) |
| DD (1) | DD269852A5 (de) |
| DE (1) | DE3865230D1 (de) |
| DK (1) | DK169873B1 (de) |
| ES (1) | ES2026669T3 (de) |
| FI (1) | FI87655C (de) |
| FR (1) | FR2614893B1 (de) |
| GR (1) | GR3003415T3 (de) |
| HU (1) | HU203362B (de) |
| IE (1) | IE61386B1 (de) |
| IL (1) | IL86133A (de) |
| MA (1) | MA21260A1 (de) |
| NO (1) | NO167035C (de) |
| NZ (1) | NZ224447A (de) |
| OA (1) | OA08840A (de) |
| PT (1) | PT87382B (de) |
| SK (1) | SK297988A3 (de) |
| SU (1) | SU1567124A3 (de) |
| TN (1) | TNSN88041A1 (de) |
| YU (1) | YU46711B (de) |
| ZA (1) | ZA883031B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246961A (en) * | 1988-10-18 | 1993-09-21 | Fournier Industrie Et Sante | β-d-phenylthioxylosides, and their use as therapeutic agents |
| IE63544B1 (en) * | 1988-10-18 | 1995-05-17 | Fournier Ind & Sante | Novel Beta-d-phenylthioxylosides their method of preparation and their use in therapy |
| FR2648819B1 (fr) * | 1989-06-21 | 1994-11-25 | Fournier Innovation Synergie | Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique |
| FR2659659B1 (fr) * | 1990-03-16 | 1995-03-10 | Fournier Ind & Sante | Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| FR2652353B1 (fr) * | 1989-09-22 | 1994-02-11 | Fournier Industrie Sante | Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| EP0421829B1 (de) * | 1989-09-22 | 1994-11-09 | Fournier Industrie Et Sante | Benzopyranon-beta-D-thioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung |
| FR2660313B1 (fr) * | 1990-04-02 | 1992-07-03 | Fournier Ind & Sante | Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| FR2688221B1 (fr) * | 1992-03-09 | 1994-05-20 | Fournier Industrie Sante | Estratrienol-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| WO1994020116A1 (en) * | 1993-03-10 | 1994-09-15 | University Of Alabama Research Foundation | Artificial primers for glycogen synthesis |
| HUP9601756A3 (en) * | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
| HUP9603341A3 (en) * | 1996-12-04 | 1999-05-28 | Richter Gedeon Vegyeszet | Glucosides as blood-clotting-inhibitors and pharmaceutical compositions containing them |
| ATE226956T1 (de) * | 1998-06-24 | 2002-11-15 | Fournier Ind & Sante | Alpha-d-xylose verbindungen, herstellung und verwendung als arzneimitteln |
| US6291433B1 (en) | 1999-06-11 | 2001-09-18 | Fournier Industrie Et Sante | Derivatives of α-D-Thioxyloside and their use against atheroma |
| BR0307266A (pt) * | 2002-01-31 | 2004-12-07 | Morphochem Ag Komb Chemie | Compostos que inibem a atividade do fator xa |
| DE10300049A1 (de) * | 2003-01-03 | 2004-07-15 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Faktor VIIa inhibieren |
| FR2860234B1 (fr) * | 2003-09-25 | 2005-12-23 | Fournier Lab Sa | Nouveaux derives 666 du thioxylose |
| FR2883561B1 (fr) * | 2005-03-25 | 2009-03-20 | Fournier S A Sa Lab | Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique |
| FR2903698B1 (fr) * | 2006-07-13 | 2009-01-30 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose. |
| FR2906247B1 (fr) * | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
| FR2906248B1 (fr) | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3243425A (en) * | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
| US3949002A (en) * | 1970-11-13 | 1976-04-06 | Imperial Chemical Industries Limited | Process for producing sulfone containing thiophenols |
| GB1585962A (en) * | 1976-10-14 | 1981-03-11 | Lilly Industries Ltd | Benzophenone derivatives |
| FR2492830A1 (fr) * | 1980-10-29 | 1982-04-30 | Sori Soc Rech Ind | Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique |
| FR2549476B1 (fr) * | 1983-07-20 | 1986-04-25 | Rech Ind | Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique |
| US4515782A (en) * | 1983-08-29 | 1985-05-07 | American Cyanamid Company | Substituted phenyl-1-thio(poly-O-sulfo)-α(or β)-D-glucopyranosides |
| DE3725640A1 (de) * | 1987-08-03 | 1989-02-23 | Bayer Ag | Verfahren zur herstellung von thiophenolen und neue thiophenole |
-
1987
- 1987-05-04 FR FR8706237A patent/FR2614893B1/fr not_active Expired
-
1988
- 1988-04-20 IL IL86133A patent/IL86133A/xx not_active IP Right Cessation
- 1988-04-25 US US07/185,422 patent/US4877808A/en not_active Expired - Fee Related
- 1988-04-26 CA CA000565129A patent/CA1323373C/en not_active Expired - Fee Related
- 1988-04-27 AT AT88401030T patent/ATE68000T1/de not_active IP Right Cessation
- 1988-04-27 DE DE8888401030T patent/DE3865230D1/de not_active Expired - Fee Related
- 1988-04-27 EP EP88401030A patent/EP0290321B1/de not_active Expired - Lifetime
- 1988-04-27 ES ES198888401030T patent/ES2026669T3/es not_active Expired - Lifetime
- 1988-04-27 AU AU15219/88A patent/AU602210B2/en not_active Ceased
- 1988-04-27 JP JP63107482A patent/JPH07103144B2/ja not_active Expired - Lifetime
- 1988-04-28 ZA ZA883031A patent/ZA883031B/xx unknown
- 1988-05-02 FI FI882043A patent/FI87655C/fi not_active IP Right Cessation
- 1988-05-02 MA MA21501A patent/MA21260A1/fr unknown
- 1988-05-02 NZ NZ224447A patent/NZ224447A/xx unknown
- 1988-05-02 TN TNTNSN88041A patent/TNSN88041A1/fr unknown
- 1988-05-02 NO NO881921A patent/NO167035C/no unknown
- 1988-05-02 PT PT87382A patent/PT87382B/pt not_active IP Right Cessation
- 1988-05-03 OA OA59342A patent/OA08840A/xx unknown
- 1988-05-03 CN CN88102569A patent/CN1020614C/zh not_active Expired - Fee Related
- 1988-05-03 SK SK2979-88A patent/SK297988A3/sk unknown
- 1988-05-03 DK DK239788A patent/DK169873B1/da not_active IP Right Cessation
- 1988-05-03 IE IE132488A patent/IE61386B1/en not_active IP Right Cessation
- 1988-05-03 SU SU884355706A patent/SU1567124A3/ru active
- 1988-05-03 HU HU882258A patent/HU203362B/hu not_active IP Right Cessation
- 1988-05-03 CZ CS882979A patent/CZ278365B6/cs unknown
- 1988-05-03 DD DD88315327A patent/DD269852A5/de not_active IP Right Cessation
- 1988-05-04 KR KR1019880005172A patent/KR960015109B1/ko not_active IP Right Cessation
- 1988-05-04 YU YU86988A patent/YU46711B/sh unknown
-
1989
- 1989-06-27 US US07/371,775 patent/US4996347A/en not_active Expired - Fee Related
-
1991
- 1991-12-20 GR GR91402113T patent/GR3003415T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |