DK169473B1 - Substituerede 2-phenyl-4-quinolin-carboxylsyrer og fremgangsmåde til deres fremstilling - Google Patents
Substituerede 2-phenyl-4-quinolin-carboxylsyrer og fremgangsmåde til deres fremstilling Download PDFInfo
- Publication number
- DK169473B1 DK169473B1 DK482688A DK482688A DK169473B1 DK 169473 B1 DK169473 B1 DK 169473B1 DK 482688 A DK482688 A DK 482688A DK 482688 A DK482688 A DK 482688A DK 169473 B1 DK169473 B1 DK 169473B1
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- Prior art keywords
- hydroxy
- biphenyl
- acid
- fluoro
- phenyl
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- YTRMTPPVNRALON-UHFFFAOYSA-N 2-phenyl-4-quinolinecarboxylic acid Chemical class N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=CC=C1 YTRMTPPVNRALON-UHFFFAOYSA-N 0.000 title claims description 3
- 238000000034 method Methods 0.000 title description 9
- 238000002360 preparation method Methods 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 31
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- -1 phenoxy, phenylthio Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
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- 239000001257 hydrogen Substances 0.000 claims description 7
- 239000011541 reaction mixture Substances 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
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- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 206010043778 thyroiditis Diseases 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/090,996 US4847381A (en) | 1987-08-31 | 1987-08-31 | 2-Phenyl-4-quinoline carboxylic acids |
| US9099687 | 1987-08-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK482688D0 DK482688D0 (da) | 1988-08-30 |
| DK482688A DK482688A (da) | 1989-03-01 |
| DK169473B1 true DK169473B1 (da) | 1994-11-07 |
Family
ID=22225261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK482688A DK169473B1 (da) | 1987-08-31 | 1988-08-30 | Substituerede 2-phenyl-4-quinolin-carboxylsyrer og fremgangsmåde til deres fremstilling |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4847381A (xx) |
| EP (1) | EP0305952B1 (xx) |
| JP (1) | JP2760379B2 (xx) |
| KR (1) | KR970005909B1 (xx) |
| AR (1) | AR245698A1 (xx) |
| AT (1) | ATE90079T1 (xx) |
| AU (1) | AU613661B2 (xx) |
| CA (1) | CA1333606C (xx) |
| CS (1) | CS274434B2 (xx) |
| DD (1) | DD282225A5 (xx) |
| DE (1) | DE3881456T2 (xx) |
| DK (1) | DK169473B1 (xx) |
| ES (1) | ES2058191T3 (xx) |
| FI (1) | FI92692C (xx) |
| GR (1) | GR3008033T3 (xx) |
| HU (1) | HU202498B (xx) |
| IE (1) | IE65148B1 (xx) |
| IL (1) | IL87457A (xx) |
| NO (1) | NO174961C (xx) |
| NZ (1) | NZ225924A (xx) |
| PH (1) | PH26258A (xx) |
| PL (1) | PL156232B1 (xx) |
| PT (1) | PT88365B (xx) |
| ZA (1) | ZA886443B (xx) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968701A (en) * | 1988-04-26 | 1990-11-06 | E. I. Du Pont De Nemours And Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
| US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
| US5409886A (en) * | 1993-02-18 | 1995-04-25 | Mitsui Toatsu Chemicals, Incorporated | 3-pyrroline-2-one derivatives and herbicidal compositions containing same |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| US5578609A (en) * | 1994-03-25 | 1996-11-26 | The Dupont Merck Pharmaceutical Company | 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents |
| ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| AU757059B2 (en) | 1997-06-19 | 2003-01-30 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US6376670B1 (en) | 1997-06-19 | 2002-04-23 | Sepracor Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| WO1999038846A1 (en) * | 1998-01-30 | 1999-08-05 | Procept, Inc. | Immunosuppressive agents |
| SE9901366D0 (sv) * | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
| US20020121638A1 (en) * | 2000-06-30 | 2002-09-05 | Vladimir Grushin | Electroluminescent iridium compounds with fluorinated phenylpyridines, phenylpyrimidines, and phenylquinolines and devices made with such compounds |
| WO2009016812A1 (ja) * | 2007-07-27 | 2009-02-05 | Kowa Company, Ltd. | ２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤 |
| KR20160079123A (ko) | 2013-11-22 | 2016-07-05 | 젠자임 코포레이션 | 신경변성 질병을 치료하기 위한 신규한 방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776290A (en) * | 1957-01-01 | Hydroxy cevchoninates and carboxylic | ||
| US2008923A (en) * | 1931-07-09 | 1935-07-23 | Graham Patmore L | Cinchoninic acid salts of piperazines |
| US2077903A (en) * | 1933-12-15 | 1937-04-20 | Gen Aniline Works Inc | Process of preparing 3-amino-quinolines |
| US2486440A (en) * | 1946-01-10 | 1949-11-01 | Gen Aniline & Film Corp | Production of phenazonium dyestuff images |
| BE502610A (xx) * | 1950-04-18 | |||
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
| DE1049701B (xx) * | 1957-02-21 | |||
| FR6592M (xx) * | 1967-10-31 | 1968-12-30 | ||
| BE794945A (fr) * | 1972-02-04 | 1973-08-02 | Sandoz Sa | Application de derives de la quinoleine pour stabiliser des matieres organiques contre les effets de la lumiere ultraviolette |
| US4009020A (en) * | 1975-05-06 | 1977-02-22 | Amchem Products, Inc. | Method of regulating plant growth |
| SU1109402A1 (ru) * | 1982-10-12 | 1984-08-23 | Предприятие П/Я Р-6496 | Способ получени производных 2-(хинолил-4)-5-арилоксазола |
| US4680299A (en) * | 1984-04-30 | 1987-07-14 | E.I. Du Pont De Nemours And Company | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof |
| ZA845594B (en) * | 1983-07-22 | 1986-03-26 | Du Pont | Phenylquinolinecarboxylic acids and derivatives as antitumor agents |
-
1987
- 1987-08-31 US US07/090,996 patent/US4847381A/en not_active Expired - Lifetime
-
1988
- 1988-08-15 IL IL8745788A patent/IL87457A/en not_active IP Right Cessation
- 1988-08-24 NZ NZ225924A patent/NZ225924A/en unknown
- 1988-08-29 CA CA000575951A patent/CA1333606C/en not_active Expired - Fee Related
- 1988-08-29 PT PT88365A patent/PT88365B/pt not_active IP Right Cessation
- 1988-08-29 AT AT88114061T patent/ATE90079T1/de active
- 1988-08-29 ES ES88114061T patent/ES2058191T3/es not_active Expired - Lifetime
- 1988-08-29 PH PH37473A patent/PH26258A/en unknown
- 1988-08-29 DE DE88114061T patent/DE3881456T2/de not_active Expired - Fee Related
- 1988-08-29 EP EP88114061A patent/EP0305952B1/en not_active Expired - Lifetime
- 1988-08-30 DK DK482688A patent/DK169473B1/da not_active IP Right Cessation
- 1988-08-30 JP JP63213853A patent/JP2760379B2/ja not_active Expired - Lifetime
- 1988-08-30 AU AU21678/88A patent/AU613661B2/en not_active Ceased
- 1988-08-30 NO NO883865A patent/NO174961C/no not_active IP Right Cessation
- 1988-08-30 AR AR88311798A patent/AR245698A1/es active
- 1988-08-30 ZA ZA886443A patent/ZA886443B/xx unknown
- 1988-08-30 KR KR1019880011111A patent/KR970005909B1/ko not_active IP Right Cessation
- 1988-08-30 HU HU884489A patent/HU202498B/hu not_active IP Right Cessation
- 1988-08-30 IE IE262888A patent/IE65148B1/en not_active IP Right Cessation
- 1988-08-30 FI FI883997A patent/FI92692C/fi not_active IP Right Cessation
- 1988-08-31 CS CS587588A patent/CS274434B2/cs unknown
- 1988-08-31 PL PL1988274471A patent/PL156232B1/pl unknown
- 1988-08-31 DD DD88319347A patent/DD282225A5/de not_active IP Right Cessation
-
1993
- 1993-06-03 GR GR930400370T patent/GR3008033T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |