DK1573006T3 - Fremstilling af IL-21 i prokaryotiske værter - Google Patents

Fremstilling af IL-21 i prokaryotiske værter

Info

Publication number
DK1573006T3
DK1573006T3 DK03810068.1T DK03810068T DK1573006T3 DK 1573006 T3 DK1573006 T3 DK 1573006T3 DK 03810068 T DK03810068 T DK 03810068T DK 1573006 T3 DK1573006 T3 DK 1573006T3
Authority
DK
Denmark
Prior art keywords
coli
preparation
expression
vectors
prokaryotic hosts
Prior art date
Application number
DK03810068.1T
Other languages
English (en)
Inventor
Chung Chang
Jeffrey D Meyer
Bruce L Zamost
Susan D Holderman
Hong Y Liu
Jongh Karen S De
Douglas C Covert
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1573006T3 publication Critical patent/DK1573006T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DK03810068.1T 2002-12-13 2003-12-12 Fremstilling af IL-21 i prokaryotiske værter DK1573006T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43345202P 2002-12-13 2002-12-13
US43344802P 2002-12-13 2002-12-13
PCT/US2003/039764 WO2004055168A2 (en) 2002-12-13 2003-12-12 Il-21 production in prokaryotic hosts

Publications (1)

Publication Number Publication Date
DK1573006T3 true DK1573006T3 (da) 2010-03-22

Family

ID=32600150

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03810068.1T DK1573006T3 (da) 2002-12-13 2003-12-12 Fremstilling af IL-21 i prokaryotiske værter

Country Status (17)

Country Link
US (4) US7250274B2 (da)
EP (1) EP1573006B1 (da)
JP (1) JP4664684B2 (da)
KR (1) KR101098897B1 (da)
AT (1) ATE448298T1 (da)
AU (1) AU2003302250B2 (da)
BR (1) BR0317243A (da)
CA (1) CA2507817C (da)
DE (1) DE60330044D1 (da)
DK (1) DK1573006T3 (da)
ES (1) ES2334127T3 (da)
IL (2) IL168697A (da)
MX (1) MXPA05006117A (da)
NO (1) NO334561B1 (da)
PL (1) PL209009B1 (da)
RU (1) RU2354703C2 (da)
WO (1) WO2004055168A2 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307024B1 (en) 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
EP1641422A4 (en) * 2003-06-19 2007-08-22 Centocor Inc ANALOGUES OF INTERLEUKINE-21
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
WO2005035565A1 (en) * 2003-10-10 2005-04-21 Novo Nordisk A/S Il-21 derivatives
EP2633866A3 (en) 2003-10-17 2013-12-18 Novo Nordisk A/S Combination therapy
CA2566745A1 (en) * 2004-05-20 2005-12-01 Zymogenetics, Inc. Methods of treating cancer using il-21 and monoclonal antibody therapy
WO2006111524A2 (en) 2005-04-18 2006-10-26 Novo Nordisk A/S Il-21 variants
CA2608579C (en) * 2005-05-26 2019-09-10 Cytos Biotechnology Ag Scalable fermentation process
RU2420308C2 (ru) * 2005-06-06 2011-06-10 Ново Нордикс А/С Стабилизированные композиции ил-21
ATE529441T1 (de) 2005-08-30 2011-11-15 Novo Nordisk As Expression von proteinen in e.coli
WO2007039147A1 (en) 2005-09-22 2007-04-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods of using il-21
ES2357152T3 (es) * 2005-10-04 2011-04-19 Zymogenetics, L.L.C. Producción y purificación de il-29.
PT1963369E (pt) * 2005-11-28 2013-05-28 Zymogenetics Inc Antagonistas de il-21
JP5401097B2 (ja) * 2005-12-23 2014-01-29 ノボ・ノルデイスク・エー／エス 分取逆相クロマトグラフィー（ｒｐｃ）を使用するタンパク質精製
DK2061897T3 (da) 2006-07-27 2020-06-02 Wyeth Llc Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
EP2109620B1 (en) * 2006-12-21 2012-08-22 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
CN101622269A (zh) * 2007-03-01 2010-01-06 诺沃-诺迪斯克有限公司 蛋白质在大肠杆菌中的表达
JP5358840B2 (ja) * 2007-11-24 2013-12-04 独立行政法人産業技術総合研究所 Ｇｆｐ（緑色蛍光蛋白質）の機能賦活・回復方法
ES2572231T3 (es) 2007-12-07 2016-05-30 Zymogenetics Inc Anticuerpos monoclonales anti-IL-21 humana
US9927440B2 (en) * 2009-11-25 2018-03-27 Duke University Protein engineering
WO2011149917A1 (en) * 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
WO2013169693A1 (en) 2012-05-09 2013-11-14 Bristol-Myers Squibb Company Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
JP6086378B2 (ja) * 2012-11-30 2017-03-01 国立大学法人お茶の水女子大学 組み換えヒト膵臓リパーゼの調製方法
JPWO2015178466A1 (ja) * 2014-05-21 2017-04-20 味の素株式会社 フィブロイン様タンパク質の製造法
RU2620073C2 (ru) * 2015-06-02 2017-05-22 Федеральное государственное бюджетное учреждение "Государственный научный центр Институт иммунологии" Федерального медико-биологического агентства России Оптимизированный ген, кодирующий рекомбинантный белок - аналог интерферона альфа-17 человека
RU2614264C2 (ru) * 2015-06-19 2017-03-24 Федеральное государственное бюджетное учреждение "Государственный научный центр Институт иммунологии" Федерального медико-биологического агентства России Оптимизированный ген, кодирующий рекомбинантный белок - аналог интерферона бета человека
RU2614124C9 (ru) * 2015-10-01 2020-04-22 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) Оптимизированный ген, кодирующий рекомбинантный белок ипфiii
JP2017110001A (ja) * 2015-12-16 2017-06-22 株式会社 資生堂 タブレット型凍結乾燥化粧料
JP6404405B1 (ja) * 2017-06-14 2018-10-10 株式会社 資生堂 タブレット型凍結乾燥化粧料
EP3643294B1 (en) * 2017-06-19 2023-11-29 Shiseido Company, Ltd. Tablet-type freeze-dried cosmetic
JP2022551195A (ja) * 2019-10-14 2022-12-07 インバイオス エン．フェー． 宿主細胞におけるバイオプロダクトの産生
CA3182002A1 (en) * 2020-06-09 2021-12-16 Charles Richardson Method of making virus-like particle

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142940C (zh) * 1996-10-04 2004-03-24 安姆根有限公司 含有mpl配体的药物组合物
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US6307024B1 (en) 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
CA2366921C (en) * 1999-03-09 2013-12-17 Zymogenetics, Inc. Novel cytokine zalpha11 ligand
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
WO2003082212A2 (en) 2002-03-27 2003-10-09 The Governement Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for treating cancer in humans
AU2003230834A1 (en) 2002-04-09 2003-10-27 Beth Israel Deaconess Medical Center, Inc. Antagonists of il-21 and modulation of il-21-mediated t cell responses
MXPA05003729A (es) 2002-10-11 2005-06-17 Novo Nordisk As Tratamiento de condiciones alergicas mediante el uso de il 21.
CN1513993A (zh) 2002-12-31 2004-07-21 北京博泰迪生物工程科技开发有限公司 中国人基因组cDNA文库白细胞介素21的编码基因序列及其蛋白质的氨基酸序列
EP1641422A4 (en) 2003-06-19 2007-08-22 Centocor Inc ANALOGUES OF INTERLEUKINE-21
JP2007512008A (ja) 2003-11-24 2007-05-17 ノボ　ノルディスク　アクティーゼルスカブ 融合タンパク質及び該タンパク質の切断方法

Also Published As

Publication number Publication date
ES2334127T3 (es) 2010-03-05
AU2003302250A1 (en) 2004-07-09
JP2006509525A (ja) 2006-03-23
EP1573006A2 (en) 2005-09-14
CA2507817C (en) 2014-04-22
IL168697A (en) 2011-10-31
WO2004055168A2 (en) 2004-07-01
US20070048842A1 (en) 2007-03-01
US7745176B2 (en) 2010-06-29
PL209009B1 (pl) 2011-07-29
WO2004055168A3 (en) 2005-06-02
US20070048798A1 (en) 2007-03-01
JP4664684B2 (ja) 2011-04-06
MXPA05006117A (es) 2005-09-30
BR0317243A (pt) 2005-11-01
KR20050090393A (ko) 2005-09-13
EP1573006B1 (en) 2009-11-11
RU2005117338A (ru) 2006-03-20
US20060134754A1 (en) 2006-06-22
DE60330044D1 (de) 2009-12-24
EP1573006A4 (en) 2006-06-14
NO334561B1 (no) 2014-04-07
KR101098897B1 (ko) 2011-12-26
US20070048263A1 (en) 2007-03-01
PL377291A1 (pl) 2006-01-23
IL198074A0 (en) 2011-08-01
AU2003302250B2 (en) 2009-08-27
RU2354703C2 (ru) 2009-05-10
NO20053385L (no) 2005-07-12
US7767199B2 (en) 2010-08-03
US7250274B2 (en) 2007-07-31
US7622561B2 (en) 2009-11-24
CA2507817A1 (en) 2004-07-01
ATE448298T1 (de) 2009-11-15

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