DK1499738T3 - Recombinase-polymerease-amplifikation - Google Patents
Recombinase-polymerease-amplifikationInfo
- Publication number
- DK1499738T3 DK1499738T3 DK03711216T DK03711216T DK1499738T3 DK 1499738 T3 DK1499738 T3 DK 1499738T3 DK 03711216 T DK03711216 T DK 03711216T DK 03711216 T DK03711216 T DK 03711216T DK 1499738 T3 DK1499738 T3 DK 1499738T3
- Authority
- DK
- Denmark
- Prior art keywords
- dna
- amplification
- recombinase
- polymerease
- polymerase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
- G06F16/90—Details of database functions independent of the retrieved data types
- G06F16/95—Retrieval from the web
- G06F16/951—Indexing; Web crawling techniques
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
- G06F16/90—Details of database functions independent of the retrieved data types
- G06F16/95—Retrieval from the web
- G06F16/957—Browsing optimisation, e.g. caching or content distillation
- G06F16/9574—Browsing optimisation, e.g. caching or content distillation of access to content, e.g. by caching
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Databases & Information Systems (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Data Mining & Analysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Polyesters Or Polycarbonates (AREA)
- Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35856302P | 2002-02-21 | 2002-02-21 | |
| PCT/US2003/005492 WO2003072805A2 (en) | 2002-02-21 | 2003-02-21 | Recombinase polymerase amplification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1499738T3 true DK1499738T3 (da) | 2008-11-17 |
Family
ID=27765964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03711216T DK1499738T3 (da) | 2002-02-21 | 2003-02-21 | Recombinase-polymerease-amplifikation |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US7270981B2 (https=) |
| EP (4) | EP1499738B1 (https=) |
| JP (4) | JP4340543B2 (https=) |
| AT (1) | ATE400663T1 (https=) |
| AU (1) | AU2003215391B2 (https=) |
| CA (1) | CA2476481C (https=) |
| DE (1) | DE60322044D1 (https=) |
| DK (1) | DK1499738T3 (https=) |
| ES (1) | ES2310237T3 (https=) |
| PT (1) | PT1499738E (https=) |
| WO (1) | WO2003072805A2 (https=) |
Families Citing this family (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2444649C (en) | 2001-04-20 | 2012-10-02 | The Penn State Research Foundation | Methods for nucleic acid manipulation |
| US7270981B2 (en) * | 2002-02-21 | 2007-09-18 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| CA2498764C (en) * | 2002-09-20 | 2015-11-10 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| US20040241732A1 (en) * | 2003-04-11 | 2004-12-02 | Chu-An Chang | Method of generating long nucleic acid molecules of defined sequence |
| JP2005110621A (ja) * | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| AU2011202896B2 (en) * | 2004-06-01 | 2012-12-06 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
| EP3985125A1 (en) * | 2004-06-01 | 2022-04-20 | Abbott Diagnostics Scarborough, Inc. | Recombinase polymerase amplification |
| AU2005250239A1 (en) | 2004-06-02 | 2005-12-15 | Alere San Diego, Inc. | 2'-nitrobenzyl-modified ribonucleotides |
| JP4534138B2 (ja) * | 2004-12-21 | 2010-09-01 | アイシン精機株式会社 | 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用 |
| WO2006081222A2 (en) * | 2005-01-25 | 2006-08-03 | Compass Genetics, Llc. | Isothermal dna amplification |
| WO2007096702A2 (en) * | 2005-07-25 | 2007-08-30 | Asm Scientific, Inc. | Methods for multiplexing recombinase polymerase amplification |
| US7368265B2 (en) * | 2006-01-23 | 2008-05-06 | Compass Genetics, Llc | Selective genome amplification |
| US8071308B2 (en) * | 2006-05-04 | 2011-12-06 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| EP3978121A1 (en) | 2006-07-19 | 2022-04-06 | BioNano Genomics, Inc. | Nanonozzle device arrays: their preparation and use for macromolecular analysis |
| EP2604344A3 (en) | 2007-03-28 | 2014-07-16 | BioNano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| US8628919B2 (en) * | 2008-06-30 | 2014-01-14 | Bionano Genomics, Inc. | Methods and devices for single-molecule whole genome analysis |
| WO2010003132A1 (en) | 2008-07-02 | 2010-01-07 | Illumina Cambridge Ltd. | Using populations of beads for the fabrication of arrays on surfaces |
| CN108467887A (zh) | 2008-11-18 | 2018-08-31 | 生物纳米基因公司 | 多核苷酸作图和测序 |
| SG183029A1 (en) | 2009-01-13 | 2012-08-30 | Fluidigm Corp | Single-cell nucleic acid analysis |
| US8685648B2 (en) | 2009-02-03 | 2014-04-01 | Biohelix Corporation | Endonuclease-enhanced helicase-dependent amplification |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US9334531B2 (en) * | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US20100299773A1 (en) * | 2009-05-20 | 2010-11-25 | Monsanto Technology Llc | Methods and compositions for selecting an improved plant |
| JP5847076B2 (ja) | 2009-05-20 | 2016-01-20 | バイオサイト インコーポレイテッド | Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質 |
| EP2438196B1 (en) * | 2009-06-05 | 2016-12-21 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| US8586362B2 (en) | 2009-06-10 | 2013-11-19 | Wisconsin Alumni Research Foundation | Method for DNA double-strand break repair in vitro and applications thereof |
| NO329699B1 (no) * | 2009-06-16 | 2010-12-06 | Agr Cannseal As | Brønnverktøy og fremgangsmåte for in situ innføring av et behandlingsfluid i et ringrom i en brønn |
| WO2011047223A1 (en) | 2009-10-16 | 2011-04-21 | Monsanto Technology Llc | Methods of polynucleotide detection |
| GB0922097D0 (en) | 2009-12-17 | 2010-02-03 | Atlas Genetics Ltd | Microbial assay |
| WO2011106368A2 (en) | 2010-02-23 | 2011-09-01 | Illumina, Inc. | Amplification methods to minimise sequence specific bias |
| US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
| NZ610129A (en) | 2010-10-04 | 2014-08-29 | Genapsys Inc | Systems and methods for automated reusable parallel biological reactions |
| US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
| CN103270173B (zh) | 2010-10-12 | 2017-11-21 | 孟山都技术公司 | 对应于转基因事件mon87712的大豆植物和种子及其检测方法 |
| JP5932832B2 (ja) | 2010-12-17 | 2016-06-08 | モンサント テクノロジー エルエルシー | 植物細胞の適格性を改善する方法 |
| EP2694666B1 (en) | 2011-04-07 | 2018-05-23 | Alere San Diego, Inc. | Monitoring recombinase polymerase amplification mixtures |
| WO2012149193A2 (en) | 2011-04-29 | 2012-11-01 | Monsanto Technology Llc | Diagnostic molecular markers for seed lot purity traits in soybeans |
| US9708672B2 (en) | 2011-05-02 | 2017-07-18 | Nutech Ventures | Plants with useful traits and related methods |
| US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
| KR101940833B1 (ko) | 2011-05-27 | 2019-01-21 | 제납시스 인크. | 유전자 및 생물학적 분석을 위한 시스템 및 방법 |
| US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
| EP3228713A1 (en) | 2011-06-30 | 2017-10-11 | Monsanto Technology LLC | Alfalfa plant and seed corresponding to transgenic event kk 179-2 and methods for detection thereof |
| US9670540B2 (en) | 2011-07-21 | 2017-06-06 | Cornell University | Methods and devices for DNA sequencing and molecular diagnostics |
| HUE059863T2 (hu) | 2011-08-31 | 2023-01-28 | Seminis Vegetable Seeds Inc | Eljárás és készítmények görögdinnye keménységhez |
| US9352312B2 (en) | 2011-09-23 | 2016-05-31 | Alere Switzerland Gmbh | System and apparatus for reactions |
| CN106591103B (zh) | 2011-12-01 | 2021-06-04 | 吉纳普赛斯股份有限公司 | 用于高效电子测序与检测的系统和方法 |
| JP5958034B2 (ja) * | 2012-04-11 | 2016-07-27 | 富士レビオ株式会社 | 分子ビーコン型プローブを用いた標的核酸の検出方法 |
| SG10201802883UA (en) | 2012-04-19 | 2018-05-30 | Life Technologies Corp | Nucleic acid amplification |
| EP3461910B1 (en) | 2012-04-19 | 2020-08-26 | Life Technologies Corporation | Nucleic acid amplification |
| EP2859111B1 (en) | 2012-06-08 | 2020-07-08 | Ionian Technologies, LLC | Nucleic acid amplifications |
| DE102012014981B3 (de) | 2012-07-26 | 2013-07-18 | Sartorius Stedim Biotech Gmbh | Verfahren zur Differenzierung zwischen lebenden und toten Zellen |
| CN107760772B (zh) | 2012-08-24 | 2022-02-01 | 生命技术公司 | 用于核酸配对末端测序的方法、组合物、系统、仪器和试剂盒 |
| WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| US10314253B2 (en) | 2012-12-04 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and compositions for watermelon sex expression |
| US10294489B2 (en) | 2013-03-15 | 2019-05-21 | Board Of Trustees Of Southern Illinois University | Soybean resistant to cyst nematodes |
| US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
| CN116334193A (zh) | 2013-03-15 | 2023-06-27 | 赛拉诺斯知识产权有限责任公司 | 核酸扩增 |
| EP2971141B1 (en) | 2013-03-15 | 2018-11-28 | Genapsys, Inc. | Systems for biological analysis |
| US20140302504A1 (en) | 2013-03-15 | 2014-10-09 | Theranos, Inc. | Nucleic Acid Amplification |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| SG11201507273SA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nucleic acid amplification |
| US10059999B2 (en) | 2013-06-10 | 2018-08-28 | Monsanto Technology Llc | Molecular markers associated with soybean tolerance to low iron growth conditions |
| EP3041957A4 (en) | 2013-09-04 | 2017-03-29 | Fluidigm Corporation | Proximity assays for detecting nucleic acids and proteins in a single cell |
| CN103421777B (zh) * | 2013-09-11 | 2015-05-13 | 北京市农林科学院林业果树研究所 | 无需pcr仪的侧翼核酸序列快速准确扩增方法及应用 |
| US10767188B2 (en) | 2013-09-25 | 2020-09-08 | Nutech Ventures | Methods and compositions for obtaining useful plant traits |
| NZ630628A (en) | 2013-10-08 | 2015-04-24 | Seminis Vegetable Seeds Inc | Methods and compositions for peronospora resistance in spinach |
| CN105611827A (zh) | 2013-10-09 | 2016-05-25 | 孟山都技术公司 | 转基因玉米事件mon87403和其检测方法 |
| CN105722977A (zh) | 2013-10-30 | 2016-06-29 | 绿色生活生物技术有限责任公司 | 用于柑橘绿化枯萎病的发病定量系统和治疗方法 |
| NZ718164A (en) | 2013-11-27 | 2017-04-28 | Seminis Vegetable Seeds Inc | Disease resistance loci in onion |
| WO2015089238A1 (en) | 2013-12-11 | 2015-06-18 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
| EP3102691B1 (en) | 2014-02-03 | 2019-09-11 | Thermo Fisher Scientific Baltics UAB | Method for controlled dna fragmentation |
| WO2015127248A1 (en) | 2014-02-21 | 2015-08-27 | Syngenta Participations Ag | Genetic loci associated with increased fertility in maize |
| NZ630710A (en) | 2014-02-27 | 2016-03-31 | Seminis Vegetable Seeds Inc | Compositions and methods for peronospora resistance in spinach |
| EP3556864B1 (en) | 2014-04-18 | 2020-12-09 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
| GB201410022D0 (en) * | 2014-06-05 | 2014-07-16 | Orion Diagnostica Oy | Method |
| WO2015191815A1 (en) | 2014-06-13 | 2015-12-17 | Life Technologies Corporation | Multiplex nucleic acid amplification |
| US10316369B2 (en) | 2014-06-27 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and assays for male sterile watermelon |
| US10364458B2 (en) | 2014-07-16 | 2019-07-30 | Tangen Biosciences, Inc. | Isothermal methods for amplifying nucleic acid samples |
| KR102126641B1 (ko) | 2014-09-29 | 2020-06-24 | 일루미나 케임브리지 리미티드 | 재조합효소 돌연변이체 |
| EP3005862A1 (en) | 2014-10-10 | 2016-04-13 | Seminis Vegetable Seeds, Inc. | Melon plants with improved disease tolerance |
| EP3215260B1 (en) | 2014-11-03 | 2020-01-15 | Tangen Biosciences Inc. | Apparatus and method for cell, spore, or virus capture and disruption |
| UA126271C2 (uk) | 2015-04-28 | 2022-09-14 | Монсанто Текнолоджі Елелсі | Спосіб одержання вкорочених рослин кукурудзи |
| US10415101B2 (en) | 2015-04-30 | 2019-09-17 | Monsanto Technology Llc | Methods for producing canola plants with clubroot resistance and compositions thereof |
| JP6822974B2 (ja) | 2015-05-29 | 2021-01-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | シトラコン酸無水物によって微生物を不活性化する方法 |
| EP3307908B1 (en) | 2015-06-09 | 2019-09-11 | Life Technologies Corporation | Methods for molecular tagging |
| US10767189B2 (en) | 2015-08-18 | 2020-09-08 | Monsanto Technology Llc | Methods for producing cotton plants with enhanced drought tolerance and compositions thereof |
| US10448595B2 (en) | 2015-09-03 | 2019-10-22 | Seminis Vegetable Seeds, Inc. | Downy mildew resistant lettuce plants |
| US10858709B2 (en) | 2015-09-10 | 2020-12-08 | Monsanto Technology Llc | Methods for producing corn plants with downy mildew resistance and compositions thereof |
| GB201519565D0 (en) | 2015-11-05 | 2015-12-23 | Alere San Diego Inc | Sample preparation device |
| ES3063374T3 (en) | 2015-10-30 | 2026-04-16 | Abbott Diagnostics Scarborough Inc | Determination of polymorphisms using isothermal nucleic acid amplification |
| US20180363037A1 (en) | 2015-12-09 | 2018-12-20 | Life Technologies Corporation | Detection and quantification of nucleic acid molecules associated with a surface |
| BR112018012039A2 (pt) | 2015-12-18 | 2018-12-04 | Monsanto Technology Llc | métodos para produção de plantas de milho com resistência à helmintosporiose e composições dos mesmos |
| US10329601B2 (en) | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| WO2017121836A1 (en) | 2016-01-15 | 2017-07-20 | Thermo Fisher Scientific Baltics Uab | Thermophilic dna polymerase mutants |
| WO2017147486A1 (en) | 2016-02-26 | 2017-08-31 | Alere San Diego Inc. | Redox labeled oligonucleotide probes and their use |
| CA3016582A1 (en) | 2016-03-04 | 2017-09-08 | Alere San Diego, Inc. | Automated nested recombinase polymerase amplification |
| AU2017241670B2 (en) | 2016-03-28 | 2020-10-08 | Illumina, Inc. | Recombinase mutants |
| US11299777B2 (en) | 2016-04-04 | 2022-04-12 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| US9617587B1 (en) | 2016-04-04 | 2017-04-11 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| US11268117B2 (en) | 2016-06-10 | 2022-03-08 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
| US10544456B2 (en) | 2016-07-20 | 2020-01-28 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
| WO2018031874A1 (en) | 2016-08-11 | 2018-02-15 | Monsanto Technology Llc | Methods and compositions for producing corn plants with resistance to late wilt |
| WO2018053174A1 (en) | 2016-09-15 | 2018-03-22 | Abbott Laboratories | Devices and methods for sample analysis |
| AU2017232187B2 (en) | 2016-09-30 | 2023-11-09 | Seminis Vegetable Seeds, Inc. | Xanthomonas resistant brassica oleracea plants |
| WO2018071522A1 (en) | 2016-10-11 | 2018-04-19 | Life Technologies Corporation | Rapid amplification of nucleic acids |
| CN106701738B (zh) * | 2016-11-10 | 2020-05-08 | 中国科学院成都生物研究所 | 一种等温解开双链dna及制备单链dna的方法 |
| BR112019017947A2 (pt) | 2017-02-28 | 2020-05-19 | Alere San Diego Inc | dispositivo microfluídico, leitor configurado para recebê-lo e método |
| GB2578038B (en) | 2017-06-16 | 2022-11-23 | Life Technologies Corp | Control nucleic acids, and compositions, kits, and uses thereof |
| EP3645710A1 (en) | 2017-06-26 | 2020-05-06 | Thermo Fisher Scientific Baltics Uab | Thermophilic dna polymerase mutants |
| KR20200083444A (ko) | 2017-08-31 | 2020-07-08 | 아이오니안 테크놀로지스, 엘엘씨 | 호흡기 세포융합 바이러스 종의 니킹 및 연장 증폭 반응(near) |
| BR112020005121A2 (pt) | 2017-09-14 | 2020-09-24 | Alere San Diego Inc. | detecção de amplificação pela polimerase recombinase usando sonda de duplo hapteno |
| CA3076378A1 (en) | 2017-09-21 | 2019-03-28 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
| US12226745B2 (en) | 2017-11-07 | 2025-02-18 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| EP4310196A3 (en) | 2017-11-07 | 2024-04-24 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| CN108034763B (zh) * | 2017-12-21 | 2021-10-22 | 北京卓诚惠生生物科技股份有限公司 | 检测甲型肝炎和戊型肝炎病毒的引物、探针及试剂盒 |
| US10597714B2 (en) | 2017-12-29 | 2020-03-24 | Clear Labs, Inc. | Automated priming and library loading device |
| US10246704B1 (en) | 2017-12-29 | 2019-04-02 | Clear Labs, Inc. | Detection of microorganisms in food samples and food processing facilities |
| EP3731959B1 (en) | 2017-12-29 | 2025-10-08 | Clear Labs, Inc. | Automated priming and library loading device |
| US11268102B2 (en) | 2018-05-16 | 2022-03-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for identifying and selecting brachytic locus in solanaceae |
| AU2019287163B2 (en) | 2018-06-12 | 2025-08-21 | Keygene N.V. | Nucleic acid amplification method |
| CN108410954A (zh) * | 2018-07-10 | 2018-08-17 | 默禾医疗科技（上海）有限公司 | 一种室温扩增反应体系中反应缓冲液的制配方法 |
| WO2020018824A1 (en) | 2018-07-19 | 2020-01-23 | Ultima Genomics, Inc. | Nucleic acid clonal amplification and sequencing methods, systems, and kits |
| US20210388431A1 (en) * | 2018-10-29 | 2021-12-16 | Igor V. Kutyavin | Thermokinetically balanced isothermal amplification of nucleic acid sequences |
| SG11202012748TA (en) | 2018-12-14 | 2021-01-28 | Illumina Cambridge Ltd | Decreasing phasing with unlabeled nucleotides during sequencing |
| SG11202012746XA (en) | 2018-12-17 | 2021-01-28 | Illumina Cambridge Ltd | Compositions for use in polyunucleotide sequencing |
| CN112654714B (zh) | 2018-12-17 | 2024-10-11 | 伊卢米纳剑桥有限公司 | 用于测序的引物寡核苷酸 |
| AU2020208190B2 (en) | 2019-01-15 | 2022-07-28 | Seminis Vegetable Seeds, Inc. | Green bean plants with improved disease resistance |
| EP3963103B1 (en) | 2019-05-03 | 2024-02-28 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| US20220259641A1 (en) * | 2019-07-17 | 2022-08-18 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Amplification assay for the detection of anaplasma phagocytophilum |
| JP7675700B2 (ja) | 2019-08-21 | 2025-05-13 | ライフ テクノロジーズ コーポレーション | シーケンシングのためのシステムおよび方法 |
| SG10202008262UA (en) | 2019-09-26 | 2021-04-29 | Seminis Vegetable Seeds Inc | Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1 |
| GB201916379D0 (en) | 2019-11-11 | 2019-12-25 | Biocrucible Ltd | Biochemical reaction methods and reagents |
| WO2021226754A1 (zh) * | 2020-05-09 | 2021-11-18 | 杭州梓晶生物有限公司 | 一种病毒重组酶-聚合酶扩增检测方法 |
| WO2021228839A1 (en) | 2020-05-11 | 2021-11-18 | Deutsches Krebsforschungszentrum | Polynucleotide detection by cas nucleases |
| AU2021204717A1 (en) | 2020-07-15 | 2022-02-03 | Seminis Vegetable Seeds, Inc. | Green Bean Plants with Improved Disease Resistance |
| EP4243986A1 (en) | 2020-11-16 | 2023-09-20 | Life Technologies Corporation | System and method for sequencing |
| US20240182990A1 (en) | 2021-03-09 | 2024-06-06 | Etablissement Français Du Sang | Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination |
| CA3218077A1 (en) | 2021-04-29 | 2022-11-03 | Abbott Laboratories | Systems and methods for pooling samples for high-throughput analysis |
| CN113891944A (zh) * | 2021-06-24 | 2022-01-04 | 黄婉秋 | 检测病原体rna、及动物或人类基因rna的试剂盒及其应用 |
| GB202110485D0 (en) | 2021-07-21 | 2021-09-01 | Dnae Diagnostics Ltd | Compositions, kits and methods for sequencing target polynucleotides |
| US20250269368A1 (en) | 2021-07-21 | 2025-08-28 | Dnae Group Holdings Limited | Method and system comprising a cartridge for sequencing target polynucleotides |
| GB202110479D0 (en) | 2021-07-21 | 2021-09-01 | Dnae Diagnostics Ltd | Compositions, kits and methods for sequencing target polynucleotides |
| WO2023014222A1 (en) | 2021-08-03 | 2023-02-09 | Wageningen Universiteit | Argonaute-based nucleic acid detection system |
| US12480157B2 (en) | 2021-09-30 | 2025-11-25 | Illumina, Inc. | Polynucleotide sequencing |
| CN114237548B (zh) * | 2021-11-22 | 2023-07-18 | 南京大学 | 基于非易失性存储器阵列的复数点乘运算的方法及系统 |
| CN114085891A (zh) | 2021-11-23 | 2022-02-25 | 广州达安基因股份有限公司 | 基于重组酶聚合酶扩增技术的逆转录扩增系统和方法 |
| CN113981045B (zh) | 2021-11-23 | 2025-09-16 | 广州达安基因股份有限公司 | 制备恒温扩增混合酶系的方法 |
| US20230193310A1 (en) | 2021-12-10 | 2023-06-22 | Seminis Vegetabe Seeds, Inc. | Lettuce plants having resistance to downy mildew |
| WO2023250288A2 (en) | 2022-06-21 | 2023-12-28 | Seminis Vegetable Seeds, Inc. | Novel qtls conferring resistance to cucumber mosaic virus |
| EP4565720A1 (en) | 2022-08-04 | 2025-06-11 | Abbott Laboratories | Assays for detecting monkeypox virus |
| JP2025533369A (ja) | 2022-09-29 | 2025-10-07 | イルミナ インコーポレイテッド | 動的光学システム較正 |
| AU2024202284B2 (en) | 2023-04-14 | 2025-08-14 | Seminis Vegetable Seeds, Inc. | Methods and compositions for Peronospora resistance in spinach |
| WO2025049450A1 (en) | 2023-08-28 | 2025-03-06 | Abbott Molecular, Inc. | Assays for detecting bk virus (bkv) |
| WO2025049451A1 (en) | 2023-08-28 | 2025-03-06 | Abbott Molecular, Inc. | Assays for detecting cytomegalovirus (cmv) or epstein-bar virus (ebv) |
| WO2025111147A1 (en) | 2023-11-21 | 2025-05-30 | Abbott Laboratories | Two-dimensional matrix droplet array |
| US20250215491A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Sequencing with single-stranded binding proteins |
| WO2025144744A1 (en) | 2023-12-29 | 2025-07-03 | Life Technologies Corporation | Enrichment of clonal substrates |
| WO2025188823A1 (en) | 2024-03-07 | 2025-09-12 | Illumina, Inc. | Immersion microscopy arrangement for sequencing system with rapid scanning |
| WO2025244815A1 (en) | 2024-05-21 | 2025-11-27 | Illumina, Inc. | Flow cell assemblies and related systems and methods |
| WO2026050593A2 (en) | 2024-08-30 | 2026-03-05 | Illumina, Inc. | Apparatus and method to mitigate thermally induced aberrations in immersion optical system |
| WO2026059922A1 (en) | 2024-09-10 | 2026-03-19 | Illumina, Inc. | Molecular deduplication analysis methods |
| US20260071285A1 (en) | 2024-09-11 | 2026-03-12 | Seminis Vegetable Seeds, Inc. | Novel qtls conferring resistance to cucurbit aphid-borne yellow virus |
| WO2026073129A1 (en) | 2024-09-30 | 2026-04-02 | Illumina, Inc. | Targeted variant calling using target enrichment sequencing data |
| WO2026076044A1 (en) | 2024-10-03 | 2026-04-09 | Illumina, Inc. | Read-level methylation detection |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US603585A (en) | 1898-05-03 | cbowell | ||
| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5635347A (en) * | 1986-04-30 | 1997-06-03 | Igen, Inc. | Rapid assays for amplification products |
| US5418149A (en) | 1990-07-24 | 1995-05-23 | Hoffmann-La Roche Inc. | Reduction of non-specific amplification glycosylase using DUTP and DNA uracil |
| US5858652A (en) * | 1988-08-30 | 1999-01-12 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
| GB8903627D0 (en) | 1989-02-17 | 1989-04-05 | Unilever Plc | Assays |
| CA2035010C (en) * | 1990-01-26 | 1996-12-10 | Keith C. Backman | Method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions |
| US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
| US5273881A (en) * | 1990-05-07 | 1993-12-28 | Daikin Industries, Ltd. | Diagnostic applications of double D-loop formation |
| ATE153707T1 (de) * | 1990-05-07 | 1997-06-15 | Daikin Ind Ltd | Diagnostische anwendungen der bildung von doppelten d-loops. |
| US5223414A (en) * | 1990-05-07 | 1993-06-29 | Sri International | Process for nucleic acid hybridization and amplification |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5556751A (en) | 1991-04-25 | 1996-09-17 | Amoco Corporation | Selective amplification system using Q-β replicase |
| EP0524349A1 (en) * | 1991-07-08 | 1993-01-27 | Opticon Sensors Europe B.V. | Dual-focus scanner and such a scanner used as wandtype symbol code reader |
| EP0543484B1 (en) * | 1991-08-30 | 2001-01-31 | Research Development Corporation of Japan | A method of DNA amplification |
| US5733733A (en) | 1992-08-04 | 1998-03-31 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| US5614389A (en) | 1992-08-04 | 1997-03-25 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| US5834202A (en) | 1992-08-04 | 1998-11-10 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| CA2122203C (en) | 1993-05-11 | 2001-12-18 | Melinda S. Fraiser | Decontamination of nucleic acid amplification reactions |
| FR2708288B1 (fr) * | 1993-07-26 | 1995-09-01 | Bio Merieux | Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé. |
| US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5705366A (en) | 1994-09-15 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor |
| US5656430A (en) | 1995-06-07 | 1997-08-12 | Trevigen, Inc. | Oscillating signal amplifier for nucleic acid detection |
| US5916779A (en) | 1995-09-21 | 1999-06-29 | Becton, Dickinson And Company | Strand displacement amplification of RNA targets |
| US5731150A (en) | 1995-11-01 | 1998-03-24 | Chiron Diagnostic Corporation | IS6110 based molecular detection of mycobacterium tuberculosis |
| US5985561A (en) * | 1996-06-03 | 1999-11-16 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | FC receptor polymorphism |
| US5853990A (en) * | 1996-07-26 | 1998-12-29 | Edward E. Winger | Real time homogeneous nucleotide assay |
| CA2263815A1 (en) * | 1996-08-29 | 1998-03-05 | Koji Kigawa | Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using reca-like recombinase |
| WO1998045474A1 (en) | 1997-04-04 | 1998-10-15 | Innogenetics N.V. | Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions |
| US6245506B1 (en) | 1997-07-30 | 2001-06-12 | Bbi Bioseq, Inc. | Integrated sequencing device |
| US7175982B1 (en) | 1998-04-22 | 2007-02-13 | Enterprise Ireland (T/A BioResearch Ireland) | Method for the characterization of nucleic acid molecules involving generation of extendible upstream DNA fragments resulting from the cleavage of nucleic acid at an abasic site |
| WO1999060158A1 (en) | 1998-05-19 | 1999-11-25 | Laboratory Of Molecular Biophotonics | Solid phase for detecting nucleic acid and method for detecting nucleic acid |
| US6140054A (en) * | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
| US6087112A (en) * | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| WO2000041524A2 (en) | 1999-01-11 | 2000-07-20 | President And Fellows Of Harvard College | Isothermal amplification of dna |
| WO2000046408A1 (en) | 1999-02-04 | 2000-08-10 | Sloan-Kettering Institute For Cancer Research | Process for dna replication |
| US6699693B1 (en) * | 1999-02-04 | 2004-03-02 | Sloan-Kettering Institute For Cancer Research | Process for DNA replication |
| US6387621B1 (en) | 1999-04-27 | 2002-05-14 | University Of Utah Research Foundation | Automated analysis of real-time nucleic acid amplification |
| US6509157B1 (en) * | 1999-11-05 | 2003-01-21 | Roche Molecular Systems, Inc | 3 blocked nucleic acid amplification primers |
| NO314091B1 (no) * | 2000-01-12 | 2003-01-27 | Biotec Pharmacon Asa | Varmelabil uracil-DNA-glykosylase, DNA-sekvens som koder for enzymet, mikroorganisme som inneholder DNA-sekvensen, samt anvendelse av enzymet |
| AU2001243670A1 (en) | 2000-03-20 | 2001-10-03 | Maxygen, Inc. | Method for generating recombinant dna molecules in complex mixtures |
| EP1278889B1 (en) | 2000-03-29 | 2006-07-26 | LGC Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
| US20020061530A1 (en) | 2000-07-31 | 2002-05-23 | Belotserkovskii Boris P. | Enhanced targeting of DNA sequences by recombinase protein and single-stranded homologous DNA probes using DNA analog activation |
| IE20000887A1 (en) | 2000-11-03 | 2002-12-11 | Univ College Cork Nat Univ Ie | Method for the amplification and optional characterisation of nucleic acids |
| US6379899B1 (en) * | 2001-03-13 | 2002-04-30 | Discoverx | Isothermal exponential RNA amplification in complex mixtures |
| CA2444649C (en) | 2001-04-20 | 2012-10-02 | The Penn State Research Foundation | Methods for nucleic acid manipulation |
| EP1275735A1 (en) | 2001-07-11 | 2003-01-15 | Roche Diagnostics GmbH | Composition and method for hot start nucleic acid amplification |
| WO2003008624A2 (en) | 2001-07-15 | 2003-01-30 | Keck Graduate Institute | Nucleic acid amplification using nicking agents |
| US20030138800A1 (en) | 2001-07-15 | 2003-07-24 | Keck Graduate Institute | Exponential amplification of nucleic acids using nicking agents |
| EA006066B1 (ru) | 2001-08-20 | 2005-08-25 | Такара Био Инк. | Способы амплификации нуклеиновых кислот |
| AU2002341898A2 (en) | 2001-09-28 | 2003-04-07 | University Of Delaware | Polymorphism detection and separation |
| KR100445560B1 (ko) | 2001-10-31 | 2004-08-21 | (주)바이오넥스 | 핵산 또는 생물학적 물질을 분리하기 위한 키트의 제조방법과, 그 방법에 의해 제조된 키트와, 그 키트를사용하는 장치 |
| US7244562B2 (en) * | 2001-11-01 | 2007-07-17 | Gene Check, Inc. | RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| US7270981B2 (en) | 2002-02-21 | 2007-09-18 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) * | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US20040137456A1 (en) * | 2002-04-04 | 2004-07-15 | Hiroki Yokota | Method for identifying and characterizing individual dna molecules |
| US20030228611A1 (en) | 2002-05-01 | 2003-12-11 | President And Fellows Of Harvard College | Nucleic acid memory device |
| US6713262B2 (en) | 2002-06-25 | 2004-03-30 | Agilent Technologies, Inc. | Methods and compositions for high throughput identification of protein/nucleic acid binding pairs |
| US20060160078A1 (en) | 2002-07-12 | 2006-07-20 | Cardy Donald L N | Lateral flow assay device and method |
| US20040038213A1 (en) | 2002-08-06 | 2004-02-26 | Kwon Jai W. | Genotyping by in situ PCR amplification of a polynucleotide in a tissue biopsy |
| EP1543154A4 (en) | 2002-08-21 | 2006-08-16 | Epoch Biosciences Inc | ASSAY WITH ENDONUCLEASE FOR ABASIC SPOTS |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| CA2498764C (en) | 2002-09-20 | 2015-11-10 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| EP1613768A4 (en) * | 2003-03-11 | 2006-05-31 | Gene Check Inc | RECA-SUPPORTED ALLELSPECIFIC OLIGONUCLEOTIDE EXTENSION PROCESS |
| DE10315640A1 (de) | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung |
| JP2005110621A (ja) * | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| CA2497324A1 (en) | 2004-02-17 | 2005-08-17 | Affymetrix, Inc. | Methods for fragmenting and labelling dna |
| EP3985125A1 (en) * | 2004-06-01 | 2022-04-20 | Abbott Diagnostics Scarborough, Inc. | Recombinase polymerase amplification |
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| WO2006040187A2 (en) | 2004-10-11 | 2006-04-20 | Epigenomics Ag | A method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids |
| JP2008520245A (ja) | 2004-11-23 | 2008-06-19 | ワン，シャオ・ビン | 切断−増幅法による核酸多様性の検出 |
| EP1896610A2 (en) | 2005-05-03 | 2008-03-12 | Handylab, Inc. | Lyophilized pellets |
| US20070042427A1 (en) | 2005-05-03 | 2007-02-22 | Micronics, Inc. | Microfluidic laminar flow detection strip |
| CA2609218C (en) | 2005-05-26 | 2016-10-11 | Human Genetic Signatures Pty Ltd | Isothermal strand displacement amplification using primers containing a non-regular base |
| WO2007008997A2 (en) | 2005-07-12 | 2007-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Template specific inhibition of pcr |
| WO2007096702A2 (en) | 2005-07-25 | 2007-08-30 | Asm Scientific, Inc. | Methods for multiplexing recombinase polymerase amplification |
| US8071308B2 (en) * | 2006-05-04 | 2011-12-06 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| CA2687375C (en) | 2007-05-18 | 2017-08-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primers and probes for the detection of streptococcus pneumoniae |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| ES2320840B1 (es) | 2007-11-27 | 2010-07-01 | Nelson Alfonso Egued | Tubo humectador de doble camara. |
| JP2009139487A (ja) | 2007-12-04 | 2009-06-25 | Nippon Sheet Glass Co Ltd | 正立等倍レンズアレイプレート |
| JP5847076B2 (ja) | 2009-05-20 | 2016-01-20 | バイオサイト インコーポレイテッド | Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質 |
| EP2438196B1 (en) | 2009-06-05 | 2016-12-21 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| EP2859111B1 (en) | 2012-06-08 | 2020-07-08 | Ionian Technologies, LLC | Nucleic acid amplifications |
-
2003
- 2003-02-21 US US10/371,641 patent/US7270981B2/en not_active Expired - Lifetime
- 2003-02-21 CA CA2476481A patent/CA2476481C/en not_active Expired - Lifetime
- 2003-02-21 DK DK03711216T patent/DK1499738T3/da active
- 2003-02-21 AT AT03711216T patent/ATE400663T1/de active
- 2003-02-21 EP EP03711216A patent/EP1499738B1/en not_active Expired - Lifetime
- 2003-02-21 JP JP2003571485A patent/JP4340543B2/ja not_active Expired - Lifetime
- 2003-02-21 EP EP08012222.9A patent/EP1992706B1/en not_active Expired - Lifetime
- 2003-02-21 DE DE60322044T patent/DE60322044D1/de not_active Expired - Lifetime
- 2003-02-21 AU AU2003215391A patent/AU2003215391B2/en not_active Expired
- 2003-02-21 EP EP10180775.8A patent/EP2290096B1/en not_active Expired - Lifetime
- 2003-02-21 EP EP11184367.8A patent/EP2428588B1/en not_active Expired - Lifetime
- 2003-02-21 WO PCT/US2003/005492 patent/WO2003072805A2/en not_active Ceased
- 2003-02-21 PT PT03711216T patent/PT1499738E/pt unknown
- 2003-02-21 ES ES03711216T patent/ES2310237T3/es not_active Expired - Lifetime
-
2007
- 2007-08-13 US US11/893,113 patent/US7485428B2/en not_active Expired - Lifetime
-
2009
- 2009-01-30 US US12/322,354 patent/US20090325165A1/en not_active Abandoned
- 2009-02-06 JP JP2009026788A patent/JP4448188B2/ja not_active Expired - Lifetime
- 2009-12-07 JP JP2009278020A patent/JP5271244B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-30 US US12/799,786 patent/US20110065106A1/en not_active Abandoned
-
2011
- 2011-07-28 US US13/192,806 patent/US8460875B2/en not_active Expired - Fee Related
-
2012
- 2012-09-14 JP JP2012203178A patent/JP2012249637A/ja not_active Withdrawn
-
2013
- 2013-06-06 US US13/911,268 patent/US9340825B2/en not_active Expired - Fee Related
-
2016
- 2016-04-15 US US15/099,754 patent/US20170044598A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60322044D1 (de) | Rekombinase-polymerase-amplifikation | |
| WO2005118853A3 (en) | Recombinase polymerase amplification | |
| EP2272952B8 (en) | Thermostable or thermoactive DNA polymerase with attenuated 3'-5' exonuclease activity | |
| WO2008051530A3 (en) | Polymerase enzymes and reagents for enhanced nucleic acid sequencing | |
| DK1218542T3 (da) | Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser | |
| EP1484416A3 (en) | Method of identifying and quantifying specific fungi and bacteria | |
| WO2009092035A3 (en) | Methods and compositions for the analysis of biological molecules | |
| WO2005089508A3 (en) | Dna sequence detection by limited primer extension | |
| AU6846698A (en) | Method of nucleic acid amplification | |
| ATE481503T1 (de) | Verfahren zur genotypisierung von antigenen von blutzellen und ein kit zur genotypisierung | |
| DE60112746D1 (de) | Kälteempfindliche dna-polymerasemutanten | |
| WO2004074503A3 (en) | Nucleic acid sequencing methods, kits and reagents | |
| WO2007004057A3 (en) | Chromosome conformation capture-on-chip (4c) assay | |
| ATE476523T1 (de) | Verfahren zur genomamplifikation | |
| ATE361377T1 (de) | Leistungstarke verknüpfung von nukleinsäuresegmenten | |
| ATE541056T1 (de) | Verwendung von dna-polymerasen wie exoribonukleasen | |
| SG11201809242VA (en) | Method for increasing mutation introduction efficiency in genome sequence modification technique, and molecular complex to be used therefor | |
| WO2003048308A3 (en) | Thermus brockianus nucleic acid polymerases | |
| WO2005054270A3 (en) | Identification and design of sirna molecules | |
| WO2003027258A3 (en) | RECOMBINANT DNA PROCESSES USING A dNTP MIXTURE CONTAINING MODIFIED NUCLEOTIDES | |
| WO2006030455A8 (en) | Dna polymerases having strand displacement activity | |
| WO2011104695A3 (en) | Detection of kras mutation in exon 2 by allele specific real time quantitative pcr (as-qpcr) | |
| ATE493512T1 (de) | Zusammensetzung zur verstärkung von nukleinsäuren | |
| WO2003048310A3 (en) | Thermus oshimai nucleic acid polymerases | |
| AU2003257177A1 (en) | Improved compositions for in vitro amplification of nucleic acids |