DK1478629T3 - N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler - Google Patents
N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midlerInfo
- Publication number
- DK1478629T3 DK1478629T3 DK03743112T DK03743112T DK1478629T3 DK 1478629 T3 DK1478629 T3 DK 1478629T3 DK 03743112 T DK03743112 T DK 03743112T DK 03743112 T DK03743112 T DK 03743112T DK 1478629 T3 DK1478629 T3 DK 1478629T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxazolidinone
- carboxamides
- aryl
- derivatives
- antibacterial agents
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35949502P | 2002-02-25 | 2002-02-25 | |
PCT/US2003/003125 WO2003072553A1 (en) | 2002-02-25 | 2003-02-24 | N-aryl-2-oxazolidinone-5-carboxamides and their derivates and their use as antibacterials |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1478629T3 true DK1478629T3 (da) | 2007-01-29 |
Family
ID=27766097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03743112T DK1478629T3 (da) | 2002-02-25 | 2003-02-24 | N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler |
Country Status (36)
Country | Link |
---|---|
US (1) | US6919329B2 (sh) |
EP (1) | EP1478629B1 (sh) |
JP (1) | JP2005524660A (sh) |
KR (1) | KR100613532B1 (sh) |
CN (1) | CN1639135A (sh) |
AP (1) | AP1902A (sh) |
AR (1) | AR038536A1 (sh) |
AT (1) | ATE342258T1 (sh) |
AU (1) | AU2003210807A1 (sh) |
BR (1) | BR0307924A (sh) |
CA (1) | CA2476038A1 (sh) |
CO (1) | CO5611128A2 (sh) |
CY (1) | CY1105797T1 (sh) |
DE (1) | DE60308998T2 (sh) |
DK (1) | DK1478629T3 (sh) |
EA (1) | EA007490B1 (sh) |
EC (1) | ECSP045245A (sh) |
ES (1) | ES2271615T3 (sh) |
GE (1) | GEP20074198B (sh) |
HR (1) | HRP20040717A2 (sh) |
IS (1) | IS7376A (sh) |
MA (1) | MA27180A1 (sh) |
MX (1) | MXPA04008205A (sh) |
MY (1) | MY135233A (sh) |
NO (1) | NO20044062L (sh) |
NZ (1) | NZ534521A (sh) |
OA (1) | OA12779A (sh) |
PL (1) | PL372461A1 (sh) |
PT (1) | PT1478629E (sh) |
SI (1) | SI1478629T1 (sh) |
TN (1) | TNSN04163A1 (sh) |
TW (1) | TW200305568A (sh) |
UA (1) | UA80112C2 (sh) |
WO (1) | WO2003072553A1 (sh) |
YU (1) | YU72804A (sh) |
ZA (1) | ZA200406362B (sh) |
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AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
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JP2008521792A (ja) * | 2004-11-29 | 2008-06-26 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗菌薬としてのジアゼピンオキサゾリジノン |
EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
AU2006215399B2 (en) | 2005-02-18 | 2010-12-09 | Astrazeneca Ab | Antibacterial piperidine derivatives |
AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
EP1874782A1 (en) | 2005-04-15 | 2008-01-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
JP5534497B2 (ja) | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス,インコーポレイテッド | トリアゾール類の合成方法 |
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CA2614105A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents |
WO2007004032A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidiones containing cyclobutane as antibacterial agents |
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EP2009012B1 (en) * | 2006-03-31 | 2014-06-25 | Research Foundation Itsuu Laboratory | Novel compound having heterocyclic ring |
JP5187901B2 (ja) * | 2006-08-30 | 2013-04-24 | 塩野義製薬株式会社 | ヒドラジンアミド誘導体 |
JP5207382B2 (ja) * | 2006-08-30 | 2013-06-12 | 塩野義製薬株式会社 | ウレア誘導体 |
CN101720325B (zh) * | 2007-08-06 | 2013-04-24 | 上海盟科药业有限公司 | 用于治疗细菌感染的抗菌邻-氟苯基噁唑烷酮 |
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US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
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MA33092B1 (fr) * | 2009-02-03 | 2012-03-01 | Trius Therapeutics | Forme cristalline du dihydrogénophosphate de (r)-3-(4-(2-(2-méthyltétrazol-5-yl)pyridin-5-yl)-3-fluorophényl)-5-hydroxyméthyl oxazolidin-2-one |
US8906913B2 (en) | 2009-06-26 | 2014-12-09 | Panacea Biotec Limited | Azabicyclohexanes |
WO2012007500A2 (de) | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
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AU764184B2 (en) * | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
CN1311787A (zh) | 1998-06-05 | 2001-09-05 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物 |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
BR0007918A (pt) | 1999-02-01 | 2001-10-23 | Upjohn Co | Processo para preparar oxazolidinonas cìclicas contendo flúor e enxofre |
ATE246189T1 (de) | 1999-05-27 | 2003-08-15 | Upjohn Co | Bizyklische oxazolidinone als antibakterielle mittel |
GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
CA2389482A1 (en) | 1999-12-21 | 2001-06-28 | Jackson B. Hester, Jr. | Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
GB0100110D0 (en) | 2001-01-04 | 2001-02-14 | Univ Leeds | Modulation of calcium channel activity |
GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
AU2002354579A1 (en) | 2001-07-12 | 2003-01-29 | Pharmacia And Upjohn Company | Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound |
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2003
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2004
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2006
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