DK1465912T3 - Kimære TNF-ligander - Google Patents

Kimære TNF-ligander

Info

Publication number
DK1465912T3
DK1465912T3 DK02797229T DK02797229T DK1465912T3 DK 1465912 T3 DK1465912 T3 DK 1465912T3 DK 02797229 T DK02797229 T DK 02797229T DK 02797229 T DK02797229 T DK 02797229T DK 1465912 T3 DK1465912 T3 DK 1465912T3
Authority
DK
Denmark
Prior art keywords
tnfα
cell
sequence encoding
chimeric
subdomain
Prior art date
Application number
DK02797229T
Other languages
Danish (da)
English (en)
Inventor
Charles E Prussak
Thomas J Kipps
Mark J Cantwell
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK1465912T3 publication Critical patent/DK1465912T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK02797229T 2001-12-06 2002-12-05 Kimære TNF-ligander DK1465912T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,305 US7786282B2 (en) 2001-12-06 2001-12-06 Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
PCT/US2002/039245 WO2003050254A2 (en) 2001-12-06 2002-12-05 Novel chimeric tnf ligands

Publications (1)

Publication Number Publication Date
DK1465912T3 true DK1465912T3 (da) 2009-03-16

Family

ID=21720251

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02797229T DK1465912T3 (da) 2001-12-06 2002-12-05 Kimære TNF-ligander

Country Status (17)

Country Link
US (3) US7786282B2 (xx)
EP (1) EP1465912B9 (xx)
JP (1) JP4610194B2 (xx)
CN (1) CN1316022C (xx)
AT (1) ATE414103T1 (xx)
AU (2) AU2002362205B2 (xx)
CA (1) CA2469494A1 (xx)
CY (1) CY1110473T1 (xx)
DE (1) DE60229881D1 (xx)
DK (1) DK1465912T3 (xx)
ES (1) ES2316638T3 (xx)
HK (1) HK1070077A1 (xx)
IL (2) IL162357A0 (xx)
PT (1) PT1465912E (xx)
SI (1) SI1465912T1 (xx)
TW (1) TWI275644B (xx)
WO (1) WO2003050254A2 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20080318886A1 (en) * 2006-12-05 2008-12-25 Prussak Charles E Methods of Increasing Cancer Sensitivity to Chemotherapeutic Agents Using Chimeric ISF35
PL391627A1 (pl) * 2010-06-25 2012-01-02 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
PL219845B1 (pl) * 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
GB201406705D0 (en) 2014-04-15 2014-05-28 Univ Liverpool Fusion proteins,polynucleotides,expression vectors, and their uses
CN107615065B (zh) * 2015-03-23 2020-07-24 以埃森生物科学股份有限公司的名义经营的埃森仪器股份有限公司 对生物材料评估腺病毒或腺相关病毒的病毒类型的非缔合的病毒尺寸颗粒
US20180244750A1 (en) 2015-11-02 2018-08-30 Memgen, Llc Methods for treatment of cancer
HUP1600456A2 (en) 2016-07-19 2018-01-29 Richter Gedeon Nyrt Novel cell-based tnf-alpha binding assay
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
WO2021095012A1 (en) * 2019-11-13 2021-05-20 Crispr Therapeutics Ag Methods of manufacturing car-t cells
WO2022216565A1 (en) * 2021-04-05 2022-10-13 Implicyte, Inc. Armed chimeric oncolytic viruses
WO2024064637A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of faslg

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US209295A (en) * 1878-10-22 Improvement in water-closets
US158831A (en) * 1875-01-19 Improvement in washing-machines
US22017A (en) * 1858-11-09 Pen-fountain
DE3750056T2 (de) 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
US5095096A (en) 1987-05-29 1992-03-10 Sagami Chemical Research Center Fused protein comprising lymphotoxin
DK0491878T3 (da) 1989-08-16 1997-06-23 Chiron Corp Præparater til inhibering af proteinhormondannelse og anvendelser deraf
US5519119A (en) 1990-09-21 1996-05-21 Ishihara Sangyo Kaisha Ltd. Muteins of TNF pharmaceutical compositions and a method of making
CA2055168A1 (en) 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
US5716805A (en) 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
US5962406A (en) 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
DE69233051T2 (de) 1991-10-25 2004-03-11 Immunex Corp., Seattle Antikörper gegen CD40-L
EP1239043A3 (en) 1992-03-30 2003-01-02 Immunex Corporation Fusion proteins comprising tumour necrosis factor receptor
CZ283533B6 (cs) 1992-04-02 1998-04-15 F. Hoffmann-La Roche Ag TNF - muteiny a způsob jejich výroby
EP0615451B1 (en) 1992-05-26 2005-12-07 Immunex Corporation Novel cytokine that binds cd30
JPH07508179A (ja) 1992-08-21 1995-09-14 シェリング・コーポレーション ヒトインターロイキン−１３
WO1994004570A1 (en) 1992-08-21 1994-03-03 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
US5573924A (en) 1992-09-08 1996-11-12 Immunex Corporation CD27 ligand
DK0679191T3 (da) 1993-01-22 2004-04-13 Immunex Corp Påvisning og behandling af mutationer i et CD40-ligand-gen
US5565321A (en) 1993-01-22 1996-10-15 Immunex Corporation Detection of mutations in a CD40 ligand gene
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
US5861310A (en) 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
JPH08127594A (ja) 1993-11-10 1996-05-21 Mochida Pharmaceut Co Ltd Ｆａｓ抗原に結合する新規蛋白質およびそれをコードするＤＮＡ
AU1059095A (en) 1993-11-24 1995-06-13 Australian National University, The Treatment of viral disease with cd40l peptide
JPH09507074A (ja) 1993-12-23 1997-07-15 イミュネックス・コーポレーション Ｃｄ４０を発現する腫瘍細胞を特徴とする疾患の予防又は治療方法
ATE387458T1 (de) 1994-01-07 2008-03-15 Mochida Pharm Co Ltd Fas-antigenbindender ligand
DK0763057T3 (da) 1994-04-28 2006-03-27 Boehringer Ingelheim Pharma Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
US5606023A (en) 1994-05-24 1997-02-25 Thomas Jefferson University Mutant tumor necrosis factor proteins
US5759536A (en) 1994-05-27 1998-06-02 University Technology Corporation Use of fas ligand to supress T-lymphocyte-mediated immune responses
CA2195665A1 (en) 1994-07-22 1996-02-08 Robert Frederick Geoffrey Booth Pharmaceutical compositions comprising a chimaeric tnf binding protein
GB9425060D0 (en) 1994-12-13 1995-02-08 Univ Birmingham Carcinoma treatment
US5888764A (en) 1995-01-20 1999-03-30 Uab Research Foundation Human fas gene promoter region
US6017527A (en) 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US6016832A (en) * 1997-04-16 2000-01-25 Woodward Governor Company Valve for controlling gas mass flow
US6951919B1 (en) 1997-09-17 2005-10-04 Mochida Pharmaceutical Co., Ltd. Fas ligand derivative
US6451759B1 (en) 1998-01-14 2002-09-17 The Regents Of The University Of California Noncleavable Fas ligand
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
AU2001253426A1 (en) 2000-04-12 2001-10-30 University Of South Florida Regulation of systemic immune responses utilizing soluble cd40
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
GB2392158B (en) 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof

Also Published As

Publication number Publication date
AU2010200912A1 (en) 2010-04-01
US20110008842A1 (en) 2011-01-13
US20050048476A1 (en) 2005-03-03
EP1465912A2 (en) 2004-10-13
AU2002362205A1 (en) 2003-06-23
IL162357A0 (en) 2005-11-20
CA2469494A1 (en) 2003-06-19
WO2003050254A3 (en) 2004-03-04
ES2316638T3 (es) 2009-04-16
HK1070077A1 (en) 2005-06-10
US20120116052A1 (en) 2012-05-10
JP4610194B2 (ja) 2011-01-12
US7964712B2 (en) 2011-06-21
SI1465912T1 (sl) 2009-04-30
WO2003050254A2 (en) 2003-06-19
TWI275644B (en) 2007-03-11
ATE414103T1 (de) 2008-11-15
DE60229881D1 (de) 2008-12-24
PT1465912E (pt) 2009-02-19
EP1465912A4 (en) 2005-04-13
CN1612890A (zh) 2005-05-04
US7786282B2 (en) 2010-08-31
IL162357A (en) 2010-12-30
TW200301777A (en) 2003-07-16
JP2005511086A (ja) 2005-04-28
AU2002362205B2 (en) 2009-12-10
CN1316022C (zh) 2007-05-16
CY1110473T1 (el) 2015-04-29
EP1465912B9 (en) 2009-08-12
EP1465912B1 (en) 2008-11-12

Similar Documents

Publication Publication Date Title
HK1070077A1 (en) Chimeric tnf ligands
DK0873407T3 (da) Apo-2-ligand
IL193886A (en) Antibodies that bind to ldcam sequences
PT1015585E (pt) Homologos de ligandos de tie
DE69939732D1 (de) Apo-2 ligand
DE69833670D1 (de) Homologe des tie-rezeptortyrosinekinase liganden
ATE335735T1 (de) Imidazolyl-cyclische acetale
PT770088E (pt) Nova citoquina designada lerk-5
NO990086D0 (no) Avkortete, oppl÷selige tumornekrosefaktorreseptorer av type I og type II
NO984551D0 (no) Modulatorer av TNF-receptorforbundet faktor (TRAF), deres fremstilling og anvendelse
DE60237777D1 (de) Etzungen und verfahren zur gezielten herunterregulierung von angiogenese und zur krebstherapie
HK1162667A1 (en) Nucleolin as marker for determining the likelihood of success of endostatin cancer therapy
TW200716746A (en) Methods for identifying a compound modulating the binding between polypeptides
ATE148468T1 (de) Neue eiskernformende mikroorganismen
ATE190626T1 (de) Bindungspeptide zur interaktion mit wachstumsfaktoren als liganden des rezeptors des epidermiswachstumsfactor und des erbb-2-rezeptor
DK1255829T3 (da) Inhibitor af hepatocytvækstfaktoraktivator til anvendelse i modulation af angiogenese og kardiovaskularisering
ATE191224T1 (de) Tnf-inhibitoren
WO2001070978A3 (en) Polypeptides and nucleic acids encoding same
WO2006013462A3 (en) Growth factors nsg28, nsg30, and nsg32
WO2000024771A3 (en) Nucleic acids encoding osteoprotegerin-like proteins and methods of using same
WO2001036638A3 (en) Polypeptides and nucleic acids encoding same
WO2001044473A3 (en) Polypeptides and nucleic acids encoding same
WO2001032874A3 (en) Polypeptides and nucleic acids encoding same
WO2001036644A3 (en) Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
WO2001051632A3 (en) Odorant receptor polypeptides and nucleic acids encoding same