DK1434779T3 - Tværbundne glycopeptid-cephalosporinantibiotika - Google Patents

Tværbundne glycopeptid-cephalosporinantibiotika

Info

Publication number
DK1434779T3
DK1434779T3 DK02769054T DK02769054T DK1434779T3 DK 1434779 T3 DK1434779 T3 DK 1434779T3 DK 02769054 T DK02769054 T DK 02769054T DK 02769054 T DK02769054 T DK 02769054T DK 1434779 T3 DK1434779 T3 DK 1434779T3
Authority
DK
Denmark
Prior art keywords
compounds
cross
linked glycopeptide
cephalosporin antibiotics
antibiotics
Prior art date
Application number
DK02769054T
Other languages
English (en)
Inventor
Paul Fatheree
Daniel D Long
Daniel Marquess
Edmund J Moran
Martin S Linsell
Matthew B Nodwell
S Derek Turner
James Aggen
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of DK1434779T3 publication Critical patent/DK1434779T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/40Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK02769054T 2001-10-12 2002-10-11 Tværbundne glycopeptid-cephalosporinantibiotika DK1434779T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32888901P 2001-10-12 2001-10-12

Publications (1)

Publication Number Publication Date
DK1434779T3 true DK1434779T3 (da) 2006-01-30

Family

ID=23282891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02769054T DK1434779T3 (da) 2001-10-12 2002-10-11 Tværbundne glycopeptid-cephalosporinantibiotika

Country Status (30)

Country Link
US (11) US6974797B2 (da)
EP (1) EP1434779B1 (da)
JP (3) JP4249023B2 (da)
KR (1) KR100888660B1 (da)
CN (2) CN100358901C (da)
AT (1) ATE314376T1 (da)
AU (1) AU2002332111B2 (da)
BR (2) BR0213154A (da)
CA (1) CA2463544C (da)
CO (1) CO5580782A2 (da)
DE (1) DE60208404T2 (da)
DK (1) DK1434779T3 (da)
EA (1) EA007001B1 (da)
ES (1) ES2254738T3 (da)
HK (1) HK1066007A1 (da)
HR (1) HRP20040243B1 (da)
HU (1) HU230158B1 (da)
IL (2) IL160846A0 (da)
IS (1) IS2422B (da)
MX (1) MXPA04003273A (da)
NO (1) NO334092B1 (da)
NZ (1) NZ531576A (da)
PL (1) PL209757B1 (da)
RS (1) RS50888B (da)
SI (1) SI1434779T1 (da)
SK (1) SK2052004A3 (da)
TW (1) TWI335332B (da)
UA (1) UA80098C2 (da)
WO (1) WO2003031449A2 (da)
ZA (1) ZA200402732B (da)

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TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
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ES2335013T3 (es) * 2003-05-23 2010-03-18 Theravance, Inc. Antibioticos de glucopeptido-cefalosporina reticulados.
DE602004012269T2 (de) 2003-07-11 2009-04-30 Theravance, Inc., South San Francisco Quervernetzte glycopeptid-cephalosporin-antibiotika
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US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
EP2970164B1 (en) * 2013-03-13 2017-05-03 Theravance Biopharma Antibiotics IP, LLC Crystalline form of a substituted thiazolylacetic acid triethylamine salt
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US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US10943049B2 (en) * 2018-09-28 2021-03-09 Taiwan Semiconductor Manufacturing Co., Ltd. Rule check violation prediction systems and methods
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
TW202404581A (zh) 2022-05-25 2024-02-01 美商醫肯納腫瘤學公司 Mek抑制劑及其用途

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ES2335013T3 (es) 2003-05-23 2010-03-18 Theravance, Inc. Antibioticos de glucopeptido-cefalosporina reticulados.
DE602004012269T2 (de) 2003-07-11 2009-04-30 Theravance, Inc., South San Francisco Quervernetzte glycopeptid-cephalosporin-antibiotika
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Also Published As

Publication number Publication date
HK1066007A1 (en) 2005-03-11
US20080108558A1 (en) 2008-05-08
US6974797B2 (en) 2005-12-13
DE60208404T2 (de) 2006-07-27
CN1329397C (zh) 2007-08-01
US7655621B2 (en) 2010-02-02
CA2463544A1 (en) 2003-04-17
CN100358901C (zh) 2008-01-02
CA2463544C (en) 2011-03-29
HRP20040243B1 (en) 2008-07-31
HUP0401596A3 (en) 2013-06-28
US20080194464A1 (en) 2008-08-14
HUP0401596A2 (hu) 2004-12-28
YU29504A (sh) 2006-08-17
BR0213154A (pt) 2004-08-10
WO2003031449A3 (en) 2003-08-28
PL368451A1 (en) 2005-03-21
SK2052004A3 (en) 2004-10-05
US20080039611A1 (en) 2008-02-14
ES2254738T3 (es) 2006-06-16
US8557978B2 (en) 2013-10-15
US20120214967A1 (en) 2012-08-23
JP2009143962A (ja) 2009-07-02
AU2002332111B2 (en) 2008-04-17
NO20041912L (no) 2004-05-10
US20100197569A1 (en) 2010-08-05
RS50888B (sr) 2010-08-31
US7728127B2 (en) 2010-06-01
TWI335332B (en) 2011-01-01
JP4249023B2 (ja) 2009-04-02
IS7172A (is) 2004-03-04
PL209757B1 (pl) 2011-10-31
JP2009040795A (ja) 2009-02-26
EA200400530A1 (ru) 2004-08-26
CN1568325A (zh) 2005-01-19
NZ531576A (en) 2006-10-27
ZA200402732B (en) 2005-05-25
US20050239691A1 (en) 2005-10-27
WO2003031449A2 (en) 2003-04-17
US7601690B2 (en) 2009-10-13
JP2005507907A (ja) 2005-03-24
BRPI0213154B1 (pt) 2018-01-16
CN1781916A (zh) 2006-06-07
EP1434779A2 (en) 2004-07-07
HU230158B1 (hu) 2015-09-28
US7341993B2 (en) 2008-03-11
EP1434779B1 (en) 2005-12-28
JP4445028B2 (ja) 2010-04-07
KR20050035122A (ko) 2005-04-15
EA007001B1 (ru) 2006-06-30
IL160846A0 (en) 2004-08-31
US20080051577A1 (en) 2008-02-28
UA80098C2 (en) 2007-08-27
DE60208404D1 (de) 2006-02-02
US7612037B2 (en) 2009-11-03
US20030130173A1 (en) 2003-07-10
US7713931B2 (en) 2010-05-11
KR100888660B1 (ko) 2009-03-13
NO334092B1 (no) 2013-12-09
US8044195B2 (en) 2011-10-25
US7649080B2 (en) 2010-01-19
US20080194465A1 (en) 2008-08-14
US7553962B2 (en) 2009-06-30
MXPA04003273A (es) 2004-07-08
HRP20040243A2 (en) 2004-08-31
US20080039374A1 (en) 2008-02-14
ATE314376T1 (de) 2006-01-15
IL160846A (en) 2010-05-17
CO5580782A2 (es) 2005-11-30
IS2422B (is) 2008-10-15
SI1434779T1 (sl) 2006-06-30
US20080045721A1 (en) 2008-02-21

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