YU29504A - Unakrsno vezani glikopeptidno-cefalosporinski antibiotici - Google Patents

Unakrsno vezani glikopeptidno-cefalosporinski antibiotici

Info

Publication number
YU29504A
YU29504A YU29504A YUP29504A YU29504A YU 29504 A YU29504 A YU 29504A YU 29504 A YU29504 A YU 29504A YU P29504 A YUP29504 A YU P29504A YU 29504 A YU29504 A YU 29504A
Authority
YU
Yugoslavia
Prior art keywords
compounds
cross
linked glycopeptide
cephalosporin antibiotics
antibiotics
Prior art date
Application number
YU29504A
Other languages
English (en)
Inventor
Paul Fatheree
Martin Linsell
Daniel Long
Daniel Marquess
Edmund Moran
Matthew Nodwell
Derek Turner
James Aggen
Original Assignee
Theravance Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc. filed Critical Theravance Inc.
Publication of YU29504A publication Critical patent/YU29504A/sh
Publication of RS50888B publication Critical patent/RS50888B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Ovaj pronalazak obezbedjuje nova unakrsno vezana glikopeptidno-cefalosporinska jedinjenja i njihove farmaceutski prihvatljive soli koji su korisni kao antibiotici. Ovaj pronalazak takodje obezbedjuje farmaceutske kompozicije koje sdrže ovakva jedinjenja; metode lečenja bakterijske infekcije kod sisara koji koriste ovakva jedinjenja i postupke i intermedijere korisne za dobijanje takvih jedinjenja.[This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
YUP-295/04A 2001-10-12 2002-10-11 Unakrsno vezani glikopeptidno-cefalosporinski antibiotici RS50888B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32888901P 2001-10-12 2001-10-12

Publications (2)

Publication Number Publication Date
YU29504A true YU29504A (sh) 2006-08-17
RS50888B RS50888B (sr) 2010-08-31

Family

ID=23282891

Country Status (30)

Country Link
US (11) US6974797B2 (sh)
EP (1) EP1434779B1 (sh)
JP (3) JP4249023B2 (sh)
KR (1) KR100888660B1 (sh)
CN (2) CN1329397C (sh)
AT (1) ATE314376T1 (sh)
AU (1) AU2002332111B2 (sh)
BR (2) BR0213154A (sh)
CA (1) CA2463544C (sh)
CO (1) CO5580782A2 (sh)
DE (1) DE60208404T2 (sh)
DK (1) DK1434779T3 (sh)
EA (1) EA007001B1 (sh)
ES (1) ES2254738T3 (sh)
HK (1) HK1066007A1 (sh)
HR (1) HRP20040243B1 (sh)
HU (1) HU230158B1 (sh)
IL (2) IL160846A0 (sh)
IS (1) IS2422B (sh)
MX (1) MXPA04003273A (sh)
NO (1) NO334092B1 (sh)
NZ (1) NZ531576A (sh)
PL (1) PL209757B1 (sh)
RS (1) RS50888B (sh)
SI (1) SI1434779T1 (sh)
SK (1) SK2052004A3 (sh)
TW (1) TWI335332B (sh)
UA (1) UA80098C2 (sh)
WO (1) WO2003031449A2 (sh)
ZA (1) ZA200402732B (sh)

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TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
TWI325323B (en) 2002-05-24 2010-06-01 Theravance Inc Cross-linked glycopeptide-cephalosporin antibiotics
DE602004024393D1 (de) * 2003-05-23 2010-01-14 Theravance Inc Quervernetzte glycopeptid-cephalosporin-antibiotika
WO2005005436A2 (en) * 2003-07-11 2005-01-20 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
KR100808414B1 (ko) * 2004-06-08 2008-02-29 엘지전자 주식회사 이동단말의 클라이언트 세션 복구방법
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
JP6151257B2 (ja) 2011-09-09 2017-06-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺内感染症の治療方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
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CA2902724A1 (en) * 2013-03-13 2014-10-09 Theravance Biopharma Antibiotics Ip, Llc Crystalline form of a substituted thiazolylacetic acid triethylamine salt
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US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
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TW202404581A (zh) 2022-05-25 2024-02-01 美商醫肯納腫瘤學公司 Ｍｅｋ抑制劑及其用途

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Also Published As

Publication number Publication date
US20050239691A1 (en) 2005-10-27
NO334092B1 (no) 2013-12-09
SI1434779T1 (sl) 2006-06-30
KR100888660B1 (ko) 2009-03-13
US20080108558A1 (en) 2008-05-08
EP1434779A2 (en) 2004-07-07
US6974797B2 (en) 2005-12-13
CN1329397C (zh) 2007-08-01
US20100197569A1 (en) 2010-08-05
HUP0401596A2 (hu) 2004-12-28
IL160846A (en) 2010-05-17
DE60208404D1 (de) 2006-02-02
HRP20040243B1 (en) 2008-07-31
JP2009143962A (ja) 2009-07-02
RS50888B (sr) 2010-08-31
US20080194465A1 (en) 2008-08-14
PL209757B1 (pl) 2011-10-31
EA200400530A1 (ru) 2004-08-26
ES2254738T3 (es) 2006-06-16
US7649080B2 (en) 2010-01-19
CN1781916A (zh) 2006-06-07
CA2463544C (en) 2011-03-29
DE60208404T2 (de) 2006-07-27
CN1568325A (zh) 2005-01-19
ATE314376T1 (de) 2006-01-15
US20080039611A1 (en) 2008-02-14
IL160846A0 (en) 2004-08-31
US7601690B2 (en) 2009-10-13
NZ531576A (en) 2006-10-27
HUP0401596A3 (en) 2013-06-28
HRP20040243A2 (en) 2004-08-31
US7553962B2 (en) 2009-06-30
US20080194464A1 (en) 2008-08-14
CA2463544A1 (en) 2003-04-17
TWI335332B (en) 2011-01-01
WO2003031449A2 (en) 2003-04-17
CO5580782A2 (es) 2005-11-30
BR0213154A (pt) 2004-08-10
IS7172A (is) 2004-03-04
US7713931B2 (en) 2010-05-11
US8557978B2 (en) 2013-10-15
US7612037B2 (en) 2009-11-03
US20120214967A1 (en) 2012-08-23
ZA200402732B (en) 2005-05-25
NO20041912L (no) 2004-05-10
US20080039374A1 (en) 2008-02-14
MXPA04003273A (es) 2004-07-08
CN100358901C (zh) 2008-01-02
US7655621B2 (en) 2010-02-02
US20080051577A1 (en) 2008-02-28
HK1066007A1 (en) 2005-03-11
US7728127B2 (en) 2010-06-01
US8044195B2 (en) 2011-10-25
JP4445028B2 (ja) 2010-04-07
SK2052004A3 (en) 2004-10-05
IS2422B (is) 2008-10-15
KR20050035122A (ko) 2005-04-15
PL368451A1 (en) 2005-03-21
EP1434779B1 (en) 2005-12-28
HU230158B1 (hu) 2015-09-28
EA007001B1 (ru) 2006-06-30
US20030130173A1 (en) 2003-07-10
UA80098C2 (en) 2007-08-27
AU2002332111B2 (en) 2008-04-17
US20080045721A1 (en) 2008-02-21
JP2009040795A (ja) 2009-02-26
BRPI0213154B1 (pt) 2018-01-16
WO2003031449A3 (en) 2003-08-28
JP4249023B2 (ja) 2009-04-02
JP2005507907A (ja) 2005-03-24
US7341993B2 (en) 2008-03-11
DK1434779T3 (da) 2006-01-30

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