DK1307446T3 - Perfluoralkylholdige komplekser med sukkerrester, fremgangsmåde til deres fremstilling og deres anvendelse - Google Patents

Perfluoralkylholdige komplekser med sukkerrester, fremgangsmåde til deres fremstilling og deres anvendelse

Info

Publication number
DK1307446T3
DK1307446T3 DK01969481T DK01969481T DK1307446T3 DK 1307446 T3 DK1307446 T3 DK 1307446T3 DK 01969481 T DK01969481 T DK 01969481T DK 01969481 T DK01969481 T DK 01969481T DK 1307446 T3 DK1307446 T3 DK 1307446T3
Authority
DK
Denmark
Prior art keywords
perfluoroalkyl
preparation
sugar residues
containing complexes
complexes
Prior art date
Application number
DK01969481T
Other languages
Danish (da)
English (en)
Inventor
Johannes Platzek
Ulrich Niedballa
Bernd Raduechel
Hanns-Joachim Weinmann
Bernd Misselwitz
Peter Mareski
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1307446T3 publication Critical patent/DK1307446T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01969481T 2000-08-11 2001-07-23 Perfluoralkylholdige komplekser med sukkerrester, fremgangsmåde til deres fremstilling og deres anvendelse DK1307446T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040381A DE10040381C1 (de) 2000-08-11 2000-08-11 Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
PCT/EP2001/008499 WO2002014309A1 (fr) 2000-08-11 2001-07-23 Complexes perfluoroalkyles a residus saccharides, leur procede de fabrication et leur utilisation

Publications (1)

Publication Number Publication Date
DK1307446T3 true DK1307446T3 (da) 2005-08-15

Family

ID=7652861

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01969481T DK1307446T3 (da) 2000-08-11 2001-07-23 Perfluoralkylholdige komplekser med sukkerrester, fremgangsmåde til deres fremstilling og deres anvendelse

Country Status (31)

Country Link
EP (1) EP1307446B1 (fr)
JP (1) JP2004506631A (fr)
KR (1) KR100820387B1 (fr)
CN (1) CN1249058C (fr)
AR (1) AR035579A1 (fr)
AT (1) ATE293623T1 (fr)
AU (2) AU2001289729B2 (fr)
BG (1) BG107540A (fr)
BR (1) BR0113192A (fr)
CA (1) CA2418790A1 (fr)
CZ (1) CZ2003340A3 (fr)
DE (2) DE10040381C1 (fr)
DK (1) DK1307446T3 (fr)
EE (1) EE200300059A (fr)
ES (1) ES2240517T3 (fr)
HK (1) HK1062016A1 (fr)
HR (1) HRP20030172A2 (fr)
HU (1) HUP0300744A3 (fr)
IL (1) IL154328A0 (fr)
MX (1) MXPA03001285A (fr)
NO (1) NO20030648L (fr)
NZ (1) NZ524079A (fr)
PL (1) PL360359A1 (fr)
PT (1) PT1307446E (fr)
RU (1) RU2280644C2 (fr)
SK (1) SK1542003A3 (fr)
TW (1) TWI243170B (fr)
UA (1) UA75364C2 (fr)
WO (1) WO2002014309A1 (fr)
YU (1) YU10403A (fr)
ZA (1) ZA200301948B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE10260372B4 (de) 2002-12-13 2007-01-04 Schering Ag Kernspintomographievorrichtung und Verfahren zur ortsaufgelösten Bilddarstellung
EP1904462A2 (fr) * 2005-07-15 2008-04-02 Bayer Schering Pharma Aktiengesellschaft Complexes perfluoro-alkyles, leur procede de production et leur utilisation
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
BRPI0717395A2 (pt) * 2006-10-25 2013-10-15 Koninkl Philips Electronics Nv Composto para diagnosticar câncer de próstata em um indivíduo humano ou animal, composição farmacêutica, e, uso de um composto ou uma composição
DE102008024976A1 (de) 2008-05-23 2009-12-17 Marvis Technologies Gmbh Medizinisches Instrument
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
EP2450067A1 (fr) 2010-10-18 2012-05-09 MaRVis Technologies GmbH Dispositif médical
EP2484388A1 (fr) 2011-02-05 2012-08-08 MaRVis Technologies GmbH Dispositif médical implantable ou insérable détectable par IRM doté d'un revêtement comportant des ions paramagnétiques et son procédé de préparation
EP2692365A1 (fr) 2012-08-03 2014-02-05 MaRVis Medical GmbH Dispositif médical implantable ou insérable détectable par IRM doté dýun revêtement comportant des ions paramagnétiques et son procédé de préparation
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
US10975060B2 (en) 2016-11-28 2021-04-13 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
AU623901B2 (en) * 1988-01-26 1992-05-28 Nycomed As Paramagnetic compounds comprising chelating moiety, linker group macro molecule and paramagnetic metal
EP0497926B1 (fr) * 1989-10-23 1998-06-03 Nycomed Salutar, Inc. Agents chelateurs metalliques multi-sites
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
ZA958789B (en) * 1994-10-21 1996-05-29 Nihon Mediphysics Co Ltd Diagnostic imaging agent
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
DE19758105A1 (de) * 1997-12-18 1999-06-24 Schering Ag Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung

Also Published As

Publication number Publication date
CA2418790A1 (fr) 2003-02-07
CN1468234A (zh) 2004-01-14
AU2001289729B2 (en) 2006-11-16
AU8972901A (en) 2002-02-25
EP1307446A1 (fr) 2003-05-07
TWI243170B (en) 2005-11-11
DE50105965D1 (de) 2005-05-25
NZ524079A (en) 2005-10-28
SK1542003A3 (en) 2003-10-07
UA75364C2 (en) 2006-04-17
EP1307446B1 (fr) 2005-04-20
HUP0300744A3 (en) 2009-01-28
NO20030648L (no) 2003-04-11
DE10040381C1 (de) 2002-06-06
MXPA03001285A (es) 2004-05-17
HRP20030172A2 (en) 2005-04-30
HUP0300744A2 (hu) 2003-09-29
BR0113192A (pt) 2003-07-15
IL154328A0 (en) 2003-09-17
CN1249058C (zh) 2006-04-05
PL360359A1 (en) 2004-09-06
YU10403A (sh) 2006-05-25
PT1307446E (pt) 2005-08-31
ES2240517T3 (es) 2005-10-16
WO2002014309A1 (fr) 2002-02-21
HK1062016A1 (en) 2004-10-15
NO20030648D0 (no) 2003-02-10
RU2280644C2 (ru) 2006-07-27
CZ2003340A3 (cs) 2003-09-17
ATE293623T1 (de) 2005-05-15
BG107540A (bg) 2003-11-28
EE200300059A (et) 2004-12-15
KR100820387B1 (ko) 2008-04-08
KR20030024855A (ko) 2003-03-26
AR035579A1 (es) 2004-06-16
JP2004506631A (ja) 2004-03-04
ZA200301948B (en) 2004-06-25

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