BR0113192A - Complexos contendo perfluoralquila com radicais de açúcar, processos para a sua preparação e sua aplicação - Google Patents

Complexos contendo perfluoralquila com radicais de açúcar, processos para a sua preparação e sua aplicação

Info

Publication number
BR0113192A
BR0113192A BR0113192-3A BR0113192A BR0113192A BR 0113192 A BR0113192 A BR 0113192A BR 0113192 A BR0113192 A BR 0113192A BR 0113192 A BR0113192 A BR 0113192A
Authority
BR
Brazil
Prior art keywords
perfluoralkyl
processes
preparation
application
complexes containing
Prior art date
Application number
BR0113192-3A
Other languages
English (en)
Inventor
Johannes Platzek
Peter Mareski
Ulrich Niedballa
Bernd Raduechel
Hanns-Joachim Weinmann
Bernd Misselwitz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0113192A publication Critical patent/BR0113192A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPLEXOS CONTENDO PERFLUORALQUILA COM RADICAIS DE AçúCAR, PROCESSOS PARA A SUA PREPARAçãO E SUA APLICAçãO". A invenção refere-se a complexos contendo perfluoralquila com radicais de açúcar da fórmula geral (I), na qual R representa um mono- ou oligossacarídeo ligado através da posição 1-OH ou 1-SH, R~ f~ representa uma cadeia de carbono perfluoralquila, K representa um complexo de metal e Y e Z representam grupos ligadores, são adequados para a linfografia endovenosa, para o diagnóstico do tumor e para a formação de imagem do infarto e necrose.
BR0113192-3A 2000-08-11 2001-07-23 Complexos contendo perfluoralquila com radicais de açúcar, processos para a sua preparação e sua aplicação BR0113192A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040381A DE10040381C1 (de) 2000-08-11 2000-08-11 Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
PCT/EP2001/008499 WO2002014309A1 (de) 2000-08-11 2001-07-23 Perfluoralkylhaltige komplexe mit zuckerresten, verfahren zu deren herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
BR0113192A true BR0113192A (pt) 2003-07-15

Family

ID=7652861

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113192-3A BR0113192A (pt) 2000-08-11 2001-07-23 Complexos contendo perfluoralquila com radicais de açúcar, processos para a sua preparação e sua aplicação

Country Status (31)

Country Link
EP (1) EP1307446B1 (pt)
JP (1) JP2004506631A (pt)
KR (1) KR100820387B1 (pt)
CN (1) CN1249058C (pt)
AR (1) AR035579A1 (pt)
AT (1) ATE293623T1 (pt)
AU (2) AU2001289729B2 (pt)
BG (1) BG107540A (pt)
BR (1) BR0113192A (pt)
CA (1) CA2418790A1 (pt)
CZ (1) CZ2003340A3 (pt)
DE (2) DE10040381C1 (pt)
DK (1) DK1307446T3 (pt)
EE (1) EE200300059A (pt)
ES (1) ES2240517T3 (pt)
HK (1) HK1062016A1 (pt)
HR (1) HRP20030172A2 (pt)
HU (1) HUP0300744A3 (pt)
IL (1) IL154328A0 (pt)
MX (1) MXPA03001285A (pt)
NO (1) NO20030648L (pt)
NZ (1) NZ524079A (pt)
PL (1) PL360359A1 (pt)
PT (1) PT1307446E (pt)
RU (1) RU2280644C2 (pt)
SK (1) SK1542003A3 (pt)
TW (1) TWI243170B (pt)
UA (1) UA75364C2 (pt)
WO (1) WO2002014309A1 (pt)
YU (1) YU10403A (pt)
ZA (1) ZA200301948B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE10260372B4 (de) 2002-12-13 2007-01-04 Schering Ag Kernspintomographievorrichtung und Verfahren zur ortsaufgelösten Bilddarstellung
EP1904462A2 (de) * 2005-07-15 2008-04-02 Bayer Schering Pharma Aktiengesellschaft Perfluoralkylhaltige komplexe, verfahren zu deren herstellung, sowie deren verwendung
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
BRPI0717395A2 (pt) * 2006-10-25 2013-10-15 Koninkl Philips Electronics Nv Composto para diagnosticar câncer de próstata em um indivíduo humano ou animal, composição farmacêutica, e, uso de um composto ou uma composição
DE102008024976A1 (de) 2008-05-23 2009-12-17 Marvis Technologies Gmbh Medizinisches Instrument
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
EP2450067A1 (en) 2010-10-18 2012-05-09 MaRVis Technologies GmbH Medical device
EP2484388A1 (en) 2011-02-05 2012-08-08 MaRVis Technologies GmbH Implantable or insertable MRI-detectable medical device having a coating comprising paramagnetic ions and a process for preparing it
EP2692365A1 (en) 2012-08-03 2014-02-05 MaRVis Medical GmbH Implantable or insertable MRI-detectable medical device having a coating comprising paramagnetic ions and a process for preparing it
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10975060B2 (en) 2016-11-28 2021-04-13 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
AU623901B2 (en) * 1988-01-26 1992-05-28 Nycomed As Paramagnetic compounds comprising chelating moiety, linker group macro molecule and paramagnetic metal
EP0497926B1 (en) * 1989-10-23 1998-06-03 Nycomed Salutar, Inc. Multi-site metal chelating agents
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
ZA958789B (en) * 1994-10-21 1996-05-29 Nihon Mediphysics Co Ltd Diagnostic imaging agent
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
DE19758105A1 (de) * 1997-12-18 1999-06-24 Schering Ag Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung

Also Published As

Publication number Publication date
CA2418790A1 (en) 2003-02-07
DK1307446T3 (da) 2005-08-15
CN1468234A (zh) 2004-01-14
AU2001289729B2 (en) 2006-11-16
AU8972901A (en) 2002-02-25
EP1307446A1 (de) 2003-05-07
TWI243170B (en) 2005-11-11
DE50105965D1 (de) 2005-05-25
NZ524079A (en) 2005-10-28
SK1542003A3 (en) 2003-10-07
UA75364C2 (en) 2006-04-17
EP1307446B1 (de) 2005-04-20
HUP0300744A3 (en) 2009-01-28
NO20030648L (no) 2003-04-11
DE10040381C1 (de) 2002-06-06
MXPA03001285A (es) 2004-05-17
HRP20030172A2 (en) 2005-04-30
HUP0300744A2 (hu) 2003-09-29
IL154328A0 (en) 2003-09-17
CN1249058C (zh) 2006-04-05
PL360359A1 (en) 2004-09-06
YU10403A (sh) 2006-05-25
PT1307446E (pt) 2005-08-31
ES2240517T3 (es) 2005-10-16
WO2002014309A1 (de) 2002-02-21
HK1062016A1 (en) 2004-10-15
NO20030648D0 (no) 2003-02-10
RU2280644C2 (ru) 2006-07-27
CZ2003340A3 (cs) 2003-09-17
ATE293623T1 (de) 2005-05-15
BG107540A (bg) 2003-11-28
EE200300059A (et) 2004-12-15
KR100820387B1 (ko) 2008-04-08
KR20030024855A (ko) 2003-03-26
AR035579A1 (es) 2004-06-16
JP2004506631A (ja) 2004-03-04
ZA200301948B (en) 2004-06-25

Similar Documents

Publication Publication Date Title
BR0113192A (pt) Complexos contendo perfluoralquila com radicais de açúcar, processos para a sua preparação e sua aplicação
BR0112104A (pt) Processos para tratamento de doenças reumáticas usando uma molécula de ctla4 solúvel
ATE114459T1 (de) Polyasparaginsäurederivate als überzugsmittel für arzneiformen und lebensmittel.
EP1079859A4 (en) BIFUNCTIONAL MOLECULES AND THERAPIES THEREOF.
EA200301159A1 (ru) Цитотоксические иммуноконъюгаты антитела к cd44
BRPI0413326A (pt) métodos para tratar doença cardiovasculares empregando-se uma molécula ctla4 solúvel
AR048035A1 (es) Conjugados de almidon de hidroxialquilo y una proteina, preparados por aminacion reductora
PT952218E (pt) Molécula de cadeia simples para a ligação múltipla a antigénios, sua produção e utilização
KR910700076A (ko) 가교된 항체(Cross-linked antibodies)와 그들의 제조방법
UA86768C2 (ru) ХИМЕРНОЕ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ПОЛУЧЕННОЕ ИЗ МЫШИНОГО АНТИИДИОТИПИЧНОГО МОНОКЛОНАЛЬНОГО АНТИТЕЛА 1Е10, КОТОРОЕ РАСПОЗНАЕТ МЫШИНОЕ MAbР3
DE60206272D1 (de) Chelatorkonjugate mit verbesserten eigenschaften
BR0213112A (pt) Fecho para um recipiente de múltiplas câmaras, e, recipiente de múltiplas câmaras e fecho
AU2002339007A1 (en) Preparation of cholecystokinin agonists and antagonists, and their therapeutic and diagnostic use
EP1667716B8 (en) Cytotoxicity mediation of cells evidencing surface expression of cd44
DE69225542D1 (de) Carboxymethylmannoglukan und derivate davon
DE60328789D1 (de) Shiga-toxin-untereinheit b als vektor für die tumordiagnose und zur arzneimttelverabreichung an gb3-exprimierenden tumoren
BR0113187A (pt) Complexos que contêm perfluoralquila com radicais polares, processo para preparação dos mesmos e seu respectivo uso
BRPI0407031A (pt) Composições e métodos para tratamento de câncer empregando igsf9 e liv-1
ATE306283T1 (de) Biotin-derivate und ihre konjugaten mit chelatierungsmitteln
Rao et al. Design, synthesis and DNA interactions of a chimera between a platinum complex and an IHF mimicking peptide
BR9712546A (pt) Adjuvante, notadamente sob a forma de uma emulsão contendo um cátion metálico trivalente e composição vacinal que a compreende
PT1399142E (pt) Utilizacao de acetil-l-carnitina em associacao com biotina para o tratamento de doentes com diabetes mellitus insulino-resistente do tipo 2
BR0310027A (pt) Métodos de empregar uma combinação de uma 3-heteroaril-2-indolinona e um inibidor de ciclooxigenase-2 para o tratamento de neoplasia
NO20000694D0 (no) FremgangsmÕte for fremstilling av kontrastmidler som i utstrakt grad er fri for bivirkninger
PL348645A1 (en) Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A, 9A E 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.