DK1273574T3 - Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidin - Google Patents
Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidinInfo
- Publication number
- DK1273574T3 DK1273574T3 DK02022777T DK02022777T DK1273574T3 DK 1273574 T3 DK1273574 T3 DK 1273574T3 DK 02022777 T DK02022777 T DK 02022777T DK 02022777 T DK02022777 T DK 02022777T DK 1273574 T3 DK1273574 T3 DK 1273574T3
- Authority
- DK
- Denmark
- Prior art keywords
- dichloropyrimidine
- dihydroxypyrimidine
- phosgene
- phenyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9408270A GB9408270D0 (en) | 1994-04-26 | 1994-04-26 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1273574T3 true DK1273574T3 (da) | 2006-02-13 |
Family
ID=10754155
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02022777T DK1273574T3 (da) | 1994-04-26 | 1995-03-27 | Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidin |
DK95912362T DK0757678T3 (da) | 1994-04-26 | 1995-03-27 | Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95912362T DK0757678T3 (da) | 1994-04-26 | 1995-03-27 | Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidin |
Country Status (20)
Country | Link |
---|---|
US (1) | US5750694A (fr) |
EP (2) | EP1273574B1 (fr) |
JP (1) | JP3688295B2 (fr) |
CN (2) | CN1140512C (fr) |
AT (2) | ATE240301T1 (fr) |
BR (1) | BR9507481A (fr) |
CA (1) | CA2182522C (fr) |
CZ (1) | CZ289265B6 (fr) |
DE (2) | DE69534576T2 (fr) |
DK (2) | DK1273574T3 (fr) |
ES (2) | ES2251555T3 (fr) |
GB (1) | GB9408270D0 (fr) |
HU (1) | HU220374B (fr) |
IL (1) | IL113143A (fr) |
PL (1) | PL182718B1 (fr) |
RO (1) | RO117450B1 (fr) |
RU (1) | RU2156240C2 (fr) |
SK (1) | SK137196A3 (fr) |
TW (1) | TW388759B (fr) |
WO (1) | WO1995029166A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT402818B (de) * | 1995-06-02 | 1997-09-25 | Chemie Linz Gmbh | Verfahren zur herstellung von reinem 4,6-dichlorpyrimidin |
DE19531299A1 (de) * | 1995-08-25 | 1997-02-27 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidinen |
US6160117A (en) * | 1997-11-06 | 2000-12-12 | Zeneca Limited | Chemical process |
AU2801500A (en) * | 1999-02-05 | 2000-08-25 | Syngenta Participations Ag | Method of producing substituted pyrimidine derivatives |
DE19929353A1 (de) * | 1999-06-26 | 2000-12-28 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin |
DE19929350A1 (de) * | 1999-06-26 | 2000-12-28 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin mit Säurechloriden |
DE19935322A1 (de) | 1999-07-28 | 2001-02-01 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin mit Phosgen |
DE19938500A1 (de) | 1999-08-13 | 2001-02-15 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin mit Schwefel- und Phosphorverbindungen |
US20020042514A1 (en) * | 2000-06-26 | 2002-04-11 | Doyle Timothy John | Synthesis of chlorinated pyrimidines |
US6608199B2 (en) | 2000-07-07 | 2003-08-19 | Syngenta Limited | Synthesis of chlorinated pyrimidines |
US6982331B2 (en) * | 2001-06-08 | 2006-01-03 | Syngenta Crop Protection, Inc. | Synthesis of chlorinated pyrimidines |
DE10226220A1 (de) * | 2002-06-13 | 2003-12-24 | Bayer Cropscience Ag | Verfahren zur Herstellung von 4,6-Dichlor-5-fluorpyrimidin |
CN1321986C (zh) * | 2005-06-20 | 2007-06-20 | 江苏省激素研究所有限公司 | 制备4,6-二氯嘧啶的方法 |
US10018782B2 (en) | 2015-05-28 | 2018-07-10 | Corning Optical Communications LLC | Optical fiber stripping methods and apparatus |
CN105859637A (zh) * | 2016-05-13 | 2016-08-17 | 安徽广信农化股份有限公司 | 4,6-二氯嘧啶的合成及工艺优化 |
CN105859636A (zh) * | 2016-05-13 | 2016-08-17 | 安徽广信农化股份有限公司 | 一种以4,6-二羟基嘧啶为中间体的4,6-二氯嘧啶的合成方法 |
CN105906570A (zh) * | 2016-05-13 | 2016-08-31 | 安徽广信农化股份有限公司 | 一种4,6-二氯嘧啶的合成工艺 |
CN106187913A (zh) * | 2016-07-19 | 2016-12-07 | 安徽广信农化股份有限公司 | 一种改进后的4,6‑二氯嘧啶的生产工艺 |
CN106045917A (zh) * | 2016-07-19 | 2016-10-26 | 安徽广信农化股份有限公司 | 一步法制备4,6‑二氯嘧啶的合成工艺 |
CN108178748B (zh) * | 2018-01-19 | 2021-04-06 | 和记黄埔医药(上海)有限公司 | 4,6-二氯嘧啶-5-甲腈的合成方法 |
CN109516958B (zh) * | 2018-12-26 | 2020-12-08 | 杭州布朗生物医药科技有限公司 | 一种2,4-二氯嘧啶及其衍生物的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1310810A (fr) * | 1960-11-26 | 1962-11-30 | Basf Ag | Procédé pour la production de composés chlorés hétérocycliques |
DE3220105A1 (de) * | 1982-05-28 | 1983-12-01 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung in (alpha)-stellung chlorierten stickstoff-heterocyclen |
DE3228712A1 (de) * | 1982-07-31 | 1984-02-02 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4,5,6-tetrachlorpyrimidin |
DE3431698A1 (de) * | 1984-08-29 | 1986-03-13 | Bayer Ag, 5090 Leverkusen | 5,5-dichlor-4,5-dihydro-6-hydroxy-2-trichlormethyl-pyrimidin-4-on, ein verfahren zu seiner herstellung und seine verwendung |
DE3441789A1 (de) * | 1984-11-15 | 1986-05-15 | Bayer Ag, 5090 Leverkusen | 5,6-dichlor-4-hydroxy-2-trichlormethylpyrimidin |
DE3441935A1 (de) * | 1984-11-16 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-dihydroxypyrimidinen |
GB8916698D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Novel process |
DE4222518A1 (de) * | 1992-07-09 | 1994-01-13 | Bayer Ag | Verfahren zur Hertellung von 5-(Trifluormethyl)-uracil und die neuen Verbindungen 2,4-Dichlor-5-trichlormethyl-pyrimidin und 2,4-Difluor-5-trifluormethyl-pyrimidin |
GB9220585D0 (en) * | 1992-09-30 | 1992-11-11 | Smithkline Beecham Plc | Pharmaceuticals |
CN1082031A (zh) * | 1993-05-20 | 1994-02-16 | 郑州市孝义制药厂 | 磺胺间甲氧嘧啶的制备方法 |
DE4408404A1 (de) * | 1994-03-12 | 1995-09-14 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Chlorpyrimidinen |
-
1994
- 1994-04-26 GB GB9408270A patent/GB9408270D0/en active Pending
-
1995
- 1995-03-27 EP EP02022777A patent/EP1273574B1/fr not_active Expired - Lifetime
- 1995-03-27 JP JP52742695A patent/JP3688295B2/ja not_active Expired - Fee Related
- 1995-03-27 US US08/669,568 patent/US5750694A/en not_active Expired - Lifetime
- 1995-03-27 CA CA002182522A patent/CA2182522C/fr not_active Expired - Lifetime
- 1995-03-27 BR BR9507481A patent/BR9507481A/pt not_active Application Discontinuation
- 1995-03-27 DE DE69534576T patent/DE69534576T2/de not_active Expired - Lifetime
- 1995-03-27 AT AT95912362T patent/ATE240301T1/de active
- 1995-03-27 AT AT02022777T patent/ATE308526T1/de active
- 1995-03-27 WO PCT/GB1995/000676 patent/WO1995029166A1/fr active IP Right Grant
- 1995-03-27 SK SK1371-96A patent/SK137196A3/sk unknown
- 1995-03-27 CN CNB951927639A patent/CN1140512C/zh not_active Expired - Lifetime
- 1995-03-27 IL IL11314395A patent/IL113143A/en not_active IP Right Cessation
- 1995-03-27 DK DK02022777T patent/DK1273574T3/da active
- 1995-03-27 ES ES02022777T patent/ES2251555T3/es not_active Expired - Lifetime
- 1995-03-27 ES ES95912362T patent/ES2199983T3/es not_active Expired - Lifetime
- 1995-03-27 PL PL95317019A patent/PL182718B1/pl not_active IP Right Cessation
- 1995-03-27 CZ CZ19963126A patent/CZ289265B6/cs not_active IP Right Cessation
- 1995-03-27 RO RO96-02019A patent/RO117450B1/ro unknown
- 1995-03-27 EP EP95912362A patent/EP0757678B1/fr not_active Expired - Lifetime
- 1995-03-27 DK DK95912362T patent/DK0757678T3/da active
- 1995-03-27 RU RU96122489/04A patent/RU2156240C2/ru not_active IP Right Cessation
- 1995-03-27 CN CN200310120681.7A patent/CN1255388C/zh not_active Expired - Lifetime
- 1995-03-27 DE DE69530765T patent/DE69530765T2/de not_active Expired - Lifetime
- 1995-03-27 HU HU9602912A patent/HU220374B/hu unknown
- 1995-03-30 TW TW084103063A patent/TW388759B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1273574T3 (da) | Fremgangsmåde til fremstilling af 4,6-dichlorpyrimidin | |
DK0574597T3 (da) | Fremgangsmåde til fremstilling af brosluttede chirale metallocenkatalysatorer af bisindenyltypen | |
DK0629609T3 (da) | Fremgangsmåde til fremstilling af alkoxyiminoacetamidderivater og et mellemprodukt dertil | |
CA2083913A1 (fr) | Piperazinyl- et piperidinylcyclohexanols | |
RU96122489A (ru) | Способ получения 4,6-дихлорпиримидина | |
EP1468990A4 (fr) | Derive de piperazine | |
DK0464604T3 (da) | 1-indolylalkyl-4-(alkoxypyrimidinyl)piperaziner | |
NZ503912A (en) | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists | |
DK0549886T3 (da) | Fremgangsmåde til fremstilling af Pyrrolo(2,3-d)pyrimidiner | |
ES2087936T3 (es) | Benceno, piridina y derivado de pirimidina. | |
DK0537611T3 (da) | Fremgangsmåde til fremstilling af substituerede N-(aryl)-1,2,4-triazolopyrimidin-2-sulfonamider | |
DK0763024T3 (da) | Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater | |
ES2120498T3 (es) | Nuevo compuesto tetraciclico. | |
KR930019646A (ko) | 설포닐우레아의 제조방법 | |
ATE123025T1 (de) | 2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica. | |
DK0583637T3 (da) | Fremgangsmåde til fremstilling af isocyanater ved dekomponering af N,N,N-trisubstituerede urinstoffer | |
DK0856509T3 (da) | Fremgangsmåde til fremstilling af diacylimider | |
FI915025A0 (fi) | 8-azabicyklo(3,2,1) oktylalkyltiazolidinoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. | |
KR970021065A (ko) | 화학적 방법 | |
DK0521766T3 (da) | Hidtil ukendt fremgangsmåde til syntese af enantiomerer af 3-aminochromanderivater | |
DK0802193T3 (da) | Fremgangsmåde til fremstilling af substituerede pyrimidiner | |
AU588248B2 (en) | Benzoylphenylureas | |
ES2077697T3 (es) | Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos. | |
EP0165032A3 (fr) | Dihydropyridines anti-ischémiques et antihypertensives | |
ES2059928T3 (es) | Ciclopropanotiocarboxiamidas. |