DK1240157T3 - Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning - Google Patents

Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning

Info

Publication number
DK1240157T3
DK1240157T3 DK00983349T DK00983349T DK1240157T3 DK 1240157 T3 DK1240157 T3 DK 1240157T3 DK 00983349 T DK00983349 T DK 00983349T DK 00983349 T DK00983349 T DK 00983349T DK 1240157 T3 DK1240157 T3 DK 1240157T3
Authority
DK
Denmark
Prior art keywords
indol
benzyl
substituted
acid derivatives
glyoxylic acid
Prior art date
Application number
DK00983349T
Other languages
Danish (da)
English (en)
Inventor
Eckhard Guenther
Peter Emig
Dietmar Reichert
Baut Guillaume Le
Bernd Nickel
Gerald Bacher
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Application granted granted Critical
Publication of DK1240157T3 publication Critical patent/DK1240157T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
DK00983349T 1999-12-23 2000-12-19 Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning DK1240157T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
DK1240157T3 true DK1240157T3 (da) 2004-06-14

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00983349T DK1240157T3 (da) 1999-12-23 2000-12-19 Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning

Country Status (31)

Country Link
US (1) US6432987B2 (ko)
EP (1) EP1240157B1 (ko)
JP (1) JP2003519137A (ko)
KR (1) KR100747425B1 (ko)
CN (1) CN1283637C (ko)
AR (1) AR027098A1 (ko)
AT (1) ATE259364T1 (ko)
AU (1) AU772745B2 (ko)
BG (1) BG106924A (ko)
BR (1) BR0016712A (ko)
CA (1) CA2395259A1 (ko)
CO (1) CO5251472A1 (ko)
CZ (1) CZ20022094A3 (ko)
DE (2) DE19962300A1 (ko)
DK (1) DK1240157T3 (ko)
ES (1) ES2215768T3 (ko)
HK (1) HK1054038B (ko)
HU (1) HUP0203716A3 (ko)
IL (1) IL150235A0 (ko)
MX (1) MXPA02006229A (ko)
NO (1) NO324750B1 (ko)
NZ (2) NZ533731A (ko)
PL (1) PL195014B1 (ko)
PT (1) PT1240157E (ko)
RU (1) RU2266280C2 (ko)
SK (1) SK8752002A3 (ko)
TR (1) TR200400601T4 (ko)
TW (1) TWI284128B (ko)
UA (1) UA75060C2 (ko)
WO (1) WO2001047913A2 (ko)
ZA (1) ZA200204896B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
RU2327696C2 (ru) * 2003-06-05 2008-06-27 Центарис Гмбх Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
SG146624A1 (en) 2003-09-11 2008-10-30 Kemia Inc Cytokine inhibitors
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
ES2644450T3 (es) 2004-12-31 2017-11-29 Dr. Reddy's Laboratories Ltd. Nuevos derivados de bencilamina como inhibidores de CETP
WO2006099256A2 (en) * 2005-03-11 2006-09-21 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
JP5406716B2 (ja) 2006-08-07 2014-02-05 アイアンウッド ファーマシューティカルズ インコーポレイテッド インドール化合物
EP2091532A1 (en) * 2006-11-28 2009-08-26 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP3563842A1 (en) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
MX352074B (es) 2011-09-27 2017-11-08 Dr Reddys Laboratories Ltd Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
KR100362864B1 (ko) * 1994-02-22 2003-04-16 메렐 파마슈티칼스 인크. 에스트로겐관련신생물및질환의치료에유용한신규인돌유도체
ES2179088T3 (es) * 1994-04-01 2003-01-16 Lilly Co Eli Inhibidores de flsa2 1h-indol-3-glioxilamida.
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
EP0987250A4 (en) * 1997-02-20 2000-12-06 Shionogi & Co INDOLDICARBONIC ACID DERIVATIVES
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
WO1999009978A1 (en) * 1997-08-28 1999-03-04 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
WO1999016453A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
EP1039911B1 (en) * 1997-10-27 2005-05-25 Eli Lilly And Company MORPHOLINO-N-ETHYL ESTER PRODRUGS OF INDOLE sPLA 2 INHIBITORS
WO1999021545A1 (en) * 1997-10-27 1999-05-06 Eli Lilly And Company ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS
CA2309135A1 (en) * 1997-10-27 1999-05-06 Michael Lyle Denney N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
AU1405899A (en) * 1997-11-14 1999-06-07 Eli Lilly And Company Treatment for alzheimer's disease
WO1999043654A2 (en) * 1998-02-25 1999-09-02 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
JP3842043B2 (ja) * 1998-04-28 2006-11-08 エルビオン アクチエンゲゼルシャフト 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
BR9910095A (pt) * 1998-05-01 2000-12-26 Lilly Co Eli Compostos inibidores de spla2 para tratamento de doença
DE69921314T2 (de) * 1998-05-01 2006-02-09 Eli Lilly And Co., Indianapolis INHIBITORISCHE ESTER FÜR sPLA 2
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
CA2395259A1 (en) 2001-07-05
IL150235A0 (en) 2002-12-01
US6432987B2 (en) 2002-08-13
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20
WO2001047913A2 (de) 2001-07-05
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
PL355684A1 (en) 2004-05-17
DE50005284D1 (de) 2004-03-18
DE19962300A1 (de) 2001-06-28
BR0016712A (pt) 2002-09-03
CN1283637C (zh) 2006-11-08
CO5251472A1 (es) 2003-02-28
RU2002120462A (ru) 2004-01-10
JP2003519137A (ja) 2003-06-17
AU2011901A (en) 2001-07-09
HUP0203716A2 (hu) 2003-03-28
CZ20022094A3 (cs) 2002-10-16
UA75060C2 (en) 2006-03-15
NO20023039L (no) 2002-08-09
PL195014B1 (pl) 2007-07-31
TWI284128B (en) 2007-07-21
PT1240157E (pt) 2004-06-30
HK1054038B (zh) 2007-04-13
CN1420880A (zh) 2003-05-28
ZA200204896B (en) 2002-12-20
HK1054038A1 (en) 2003-11-14
NO20023039D0 (no) 2002-06-21
EP1240157B1 (de) 2004-02-11
NZ533731A (en) 2005-03-24
NO324750B1 (no) 2007-12-03
KR100747425B1 (ko) 2007-08-09
HUP0203716A3 (en) 2004-05-28
ATE259364T1 (de) 2004-02-15
AR027098A1 (es) 2003-03-12
NZ519977A (en) 2004-08-27
US20010014690A1 (en) 2001-08-16
WO2001047913A3 (de) 2002-04-25
ES2215768T3 (es) 2004-10-16
TR200400601T4 (tr) 2004-04-21
BG106924A (bg) 2003-04-30
AU772745B2 (en) 2004-05-06
EP1240157A2 (de) 2002-09-18

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