BG106924A - Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие - Google Patents

Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие Download PDF

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Publication number
BG106924A
BG106924A BG106924A BG10692402A BG106924A BG 106924 A BG106924 A BG 106924A BG 106924 A BG106924 A BG 106924A BG 10692402 A BG10692402 A BG 10692402A BG 106924 A BG106924 A BG 106924A
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BG
Bulgaria
Prior art keywords
group
cooh
acid
residue
amino
Prior art date
Application number
BG106924A
Other languages
Bulgarian (bg)
English (en)
Inventor
Eckhard Gunther
Peter Emig
Dietmar Reichert
Baut Guillaume Le
Bernd Nickel
Gerald Bacher
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BG106924A publication Critical patent/BG106924A/bg

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
BG106924A 1999-12-23 2002-07-16 Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие BG106924A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
BG106924A true BG106924A (bg) 2003-04-30

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106924A BG106924A (bg) 1999-12-23 2002-07-16 Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие

Country Status (31)

Country Link
US (1) US6432987B2 (ko)
EP (1) EP1240157B1 (ko)
JP (1) JP2003519137A (ko)
KR (1) KR100747425B1 (ko)
CN (1) CN1283637C (ko)
AR (1) AR027098A1 (ko)
AT (1) ATE259364T1 (ko)
AU (1) AU772745B2 (ko)
BG (1) BG106924A (ko)
BR (1) BR0016712A (ko)
CA (1) CA2395259A1 (ko)
CO (1) CO5251472A1 (ko)
CZ (1) CZ20022094A3 (ko)
DE (2) DE19962300A1 (ko)
DK (1) DK1240157T3 (ko)
ES (1) ES2215768T3 (ko)
HK (1) HK1054038B (ko)
HU (1) HUP0203716A3 (ko)
IL (1) IL150235A0 (ko)
MX (1) MXPA02006229A (ko)
NO (1) NO324750B1 (ko)
NZ (2) NZ519977A (ko)
PL (1) PL195014B1 (ko)
PT (1) PT1240157E (ko)
RU (1) RU2266280C2 (ko)
SK (1) SK8752002A3 (ko)
TR (1) TR200400601T4 (ko)
TW (1) TWI284128B (ko)
UA (1) UA75060C2 (ko)
WO (1) WO2001047913A2 (ko)
ZA (1) ZA200204896B (ko)

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DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
RS20050901A (en) * 2003-06-05 2007-12-31 Zentaris Gmbh., Indole derivatives with apoptosis- inducing effect
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
BRPI0414313A (pt) 2003-09-11 2006-11-07 Kemia Inc inibidores de citocinas
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US9040558B2 (en) 2004-12-31 2015-05-26 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
EP1865949B1 (en) * 2005-03-11 2012-11-14 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8884020B2 (en) * 2006-08-07 2014-11-11 Ironwood Pharmaceuticals, Inc. Indole compounds
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物

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AU665690B2 (en) * 1992-05-08 1996-01-11 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
ATE170839T1 (de) * 1994-02-22 1998-09-15 Merrell Pharma Inc Indolderivate zur behandlung von östrogenabhängigen neoplasmen und krankheiten
HUT72048A (en) * 1994-04-01 1996-03-28 Lilly Co Eli 1h-indole-3-glyoxylamide spla2 inhibitors and pharmaceutical compositions containing these compounds
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
CA2279211A1 (en) * 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
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WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
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DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
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KR20010071197A (ko) * 1998-05-01 2001-07-28 피터 지. 스트링거 ｓＰＬＡ2 억제제 에스테르
ID27153A (id) * 1998-05-01 2001-03-08 Lilly Co Eli Senyawa inhibitor spla2 untuk mengobati penyakit
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TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
DE50005284D1 (de) 2004-03-18
IL150235A0 (en) 2002-12-01
NO20023039D0 (no) 2002-06-21
US20010014690A1 (en) 2001-08-16
AU2011901A (en) 2001-07-09
ZA200204896B (en) 2002-12-20
CN1283637C (zh) 2006-11-08
CO5251472A1 (es) 2003-02-28
BR0016712A (pt) 2002-09-03
HUP0203716A3 (en) 2004-05-28
CZ20022094A3 (cs) 2002-10-16
UA75060C2 (en) 2006-03-15
ES2215768T3 (es) 2004-10-16
RU2002120462A (ru) 2004-01-10
TR200400601T4 (tr) 2004-04-21
PL195014B1 (pl) 2007-07-31
HK1054038A1 (en) 2003-11-14
DE19962300A1 (de) 2001-06-28
KR100747425B1 (ko) 2007-08-09
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
US6432987B2 (en) 2002-08-13
AR027098A1 (es) 2003-03-12
NZ519977A (en) 2004-08-27
HUP0203716A2 (hu) 2003-03-28
PT1240157E (pt) 2004-06-30
CA2395259A1 (en) 2001-07-05
DK1240157T3 (da) 2004-06-14
ATE259364T1 (de) 2004-02-15
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20
EP1240157B1 (de) 2004-02-11
CN1420880A (zh) 2003-05-28
WO2001047913A2 (de) 2001-07-05
JP2003519137A (ja) 2003-06-17
PL355684A1 (en) 2004-05-17
AU772745B2 (en) 2004-05-06
TWI284128B (en) 2007-07-21
WO2001047913A3 (de) 2002-04-25
NZ533731A (en) 2005-03-24
EP1240157A2 (de) 2002-09-18
NO20023039L (no) 2002-08-09
HK1054038B (zh) 2007-04-13
NO324750B1 (no) 2007-12-03

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