DK1208211T3 - Midler og fremgangsmåder til modificering af genekspression under anvendelse af upolyadenyleret RNA - Google Patents

Midler og fremgangsmåder til modificering af genekspression under anvendelse af upolyadenyleret RNA

Info

Publication number
DK1208211T3
DK1208211T3 DK00953352T DK00953352T DK1208211T3 DK 1208211 T3 DK1208211 T3 DK 1208211T3 DK 00953352 T DK00953352 T DK 00953352T DK 00953352 T DK00953352 T DK 00953352T DK 1208211 T3 DK1208211 T3 DK 1208211T3
Authority
DK
Denmark
Prior art keywords
methods
gene expression
unpolyadenylated
modifying gene
unpolyadenylated rna
Prior art date
Application number
DK00953352T
Other languages
English (en)
Inventor
Ming-Bo Wang
Peter Waterhouse
Original Assignee
Commw Scient Ind Res Org
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23473586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1208211(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Commw Scient Ind Res Org filed Critical Commw Scient Ind Res Org
Application granted granted Critical
Publication of DK1208211T3 publication Critical patent/DK1208211T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8283Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for virus resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031Beta-glucuronidase (3.2.1.31)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK00953352T 1999-08-13 2000-08-14 Midler og fremgangsmåder til modificering af genekspression under anvendelse af upolyadenyleret RNA DK1208211T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/373,720 US6423885B1 (en) 1999-08-13 1999-08-13 Methods for obtaining modified phenotypes in plant cells
PCT/IB2000/001133 WO2001012824A1 (en) 1999-08-13 2000-08-14 Means and methods for modifying gene expression using unpolyadenylated rna

Publications (1)

Publication Number Publication Date
DK1208211T3 true DK1208211T3 (da) 2008-03-03

Family

ID=23473586

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05016726.1T DK1650306T3 (da) 1999-08-13 2000-08-14 Means and methods for modifying gene expression using unpolyadenylated RNA
DK00953352T DK1208211T3 (da) 1999-08-13 2000-08-14 Midler og fremgangsmåder til modificering af genekspression under anvendelse af upolyadenyleret RNA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05016726.1T DK1650306T3 (da) 1999-08-13 2000-08-14 Means and methods for modifying gene expression using unpolyadenylated RNA

Country Status (12)

Country Link
US (8) US6423885B1 (da)
EP (2) EP1208211B1 (da)
AT (1) ATE378412T1 (da)
AU (1) AU783799B2 (da)
CA (1) CA2381921C (da)
CY (1) CY1107876T1 (da)
DE (1) DE60037123T2 (da)
DK (2) DK1650306T3 (da)
ES (2) ES2296632T3 (da)
NZ (1) NZ516929A (da)
PT (2) PT1650306E (da)
WO (1) WO2001012824A1 (da)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63220A (en) * 1981-07-01 1985-09-29 Yeda Res & Dev Process for production of polyacrolein microspheres
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) * 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
AU743316C (en) 1998-03-20 2005-09-15 Commonwealth Scientific And Industrial Research Organisation Control of gene expression
US8598332B1 (en) * 1998-04-08 2013-12-03 Bayer Cropscience N.V. Methods and means for obtaining modified phenotypes
US20040214330A1 (en) * 1999-04-07 2004-10-28 Waterhouse Peter Michael Methods and means for obtaining modified phenotypes
WO2000044914A1 (en) * 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US20040138168A1 (en) * 1999-04-21 2004-07-15 Wyeth Methods and compositions for inhibiting the function of polynucleotide sequences
EP2363478B1 (en) * 1999-04-21 2019-07-24 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibiting the function of polynucleotide sequences
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
GB9925459D0 (en) * 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
US20060194958A1 (en) * 1999-11-10 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
ES2629683T3 (es) 1999-11-30 2017-08-14 Mayo Foundation For Medical Education And Research B7-H1, una nueva molécula inmunorreguladora
GB2377221B (en) * 2000-03-17 2004-08-18 Benitec Australia Ltd Genetic silencing
US7691991B2 (en) * 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
US7109393B2 (en) * 2000-08-15 2006-09-19 Mendel Biotechnology, Inc. Methods of gene silencing using inverted repeat sequences
CA2433680A1 (en) * 2000-12-28 2002-08-01 Gregory M Arndt Double-stranded rna-mediated gene suppression
US7385046B2 (en) * 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
EP1229134A3 (en) * 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
ES2609014T3 (es) * 2001-07-12 2017-04-18 University Of Massachusetts Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico
US7294504B1 (en) 2001-12-27 2007-11-13 Allele Biotechnology & Pharmaceuticals, Inc. Methods and compositions for DNA mediated gene silencing
WO2003076592A2 (en) * 2002-03-06 2003-09-18 Rigel Pharmaceuticals, Inc. Novel method for delivery and intracellular synthesis of sirna molecules
JP2005519607A (ja) 2002-03-14 2005-07-07 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション 改変された遺伝子サイレンシングrnaおよびその使用
WO2004022782A2 (en) * 2002-09-04 2004-03-18 Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Compositions and methods for tissue specific or inducible inhibition of gene expression
EP1558724A4 (en) * 2002-11-01 2006-08-02 New England Biolabs Inc ORGANIC RNA SCREENING AND ITS USE IN INTERRUPTING GENE TRANSMISSION IN THE ENVIRONMENT
US20040133944A1 (en) * 2003-01-08 2004-07-08 Delta And Pine Land Company Seed oil suppression to enhance yield of commercially important macromolecules
AP2005003409A0 (en) 2003-04-09 2005-12-31 Bayer Bioscience Nv Methods and means for increasing the tolerance of plants to stress conditions.
WO2004106517A1 (en) * 2003-06-03 2004-12-09 Benitec Australia Limited Double-stranded nucleic acid
US20080131874A1 (en) * 2003-06-24 2008-06-05 Amitava Mitra Method for efficient post-transcriptional gene silencing using intrinsic direct repeat sequences and utilization thereof in functional genomics
IL157538A0 (en) 2003-08-21 2004-03-28 Bar Ilan Res & Dev Company Ltd Plant resistant to cytoplasm-feeding parasites
CA2568603A1 (en) * 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
US20060235212A1 (en) * 2004-12-22 2006-10-19 Nickolai Alexandrov Nucleic acid sequences encoding zinc finger proteins
WO2005097824A2 (en) * 2004-04-02 2005-10-20 Pioneer Hi-Bred International, Inc. Cytokinin oxidase sequences and methods of use
US20060026711A1 (en) * 2004-07-21 2006-02-02 Shihshieh Huang Non-systemic gene suppression in plants
US7595433B2 (en) 2004-09-14 2009-09-29 Ceres, Inc. Modulations of amino acid and sugar content in plants
US20060059585A1 (en) * 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
EP1810026B1 (en) * 2004-10-06 2018-04-18 Mayo Foundation For Medical Education And Research B7-h1 and pd-1 in treatment of renal cell carcinoma
US7429692B2 (en) * 2004-10-14 2008-09-30 Ceres, Inc. Sucrose synthase 3 promoter from rice and uses thereof
KR20070085421A (ko) 2004-10-21 2007-08-27 벤간자 아이엔씨 식물들의 해충들 및 병원균들에 대한 내성을 제공하기 위한방법들 및 물질들
US9758790B2 (en) 2004-12-08 2017-09-12 Ceres, Inc. Modulating the level of components within plants
WO2006062971A2 (en) * 2004-12-08 2006-06-15 Ceres Inc. Modulating plant carbon levels
WO2007087601A2 (en) * 2006-01-25 2007-08-02 Ceres, Inc. Modulating plant protein levels
WO2007089610A1 (en) * 2006-01-26 2007-08-09 Ceres, Inc. Modulating plant oil levels
BRPI0519657A2 (pt) * 2004-12-16 2009-03-03 Ceres Inc modulaÇço dos nÍveis de nitrogÊnio em plantas
EP1824967B1 (en) 2004-12-21 2014-11-05 Monsanto Technology, LLC Recombinant dna constructs and methods for controlling gene expression
US20060200878A1 (en) 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
US7335760B2 (en) * 2004-12-22 2008-02-26 Ceres, Inc. Nucleic acid sequences encoding zinc finger proteins
WO2006091676A2 (en) * 2005-02-22 2006-08-31 Ceres Inc. Modulating plant alkaloids
DE202005004135U1 (de) * 2005-03-11 2005-05-19 Klocke Verpackungs-Service Gmbh Mehrkomponentenverpackung mit Applikator
WO2006115575A1 (en) * 2005-04-20 2006-11-02 Ceres Inc. Regulatory regions from papaveraceae
US8124839B2 (en) * 2005-06-08 2012-02-28 Ceres, Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
WO2007041536A2 (en) * 2005-09-30 2007-04-12 Ceres, Inc. Modulating plant tocopherol levels
US20090178160A1 (en) * 2005-10-25 2009-07-09 Joon-Hyun Park Modulation of Triterpenoid Content in Plants
US20090215084A1 (en) * 2006-01-05 2009-08-27 Mayo Foundation For Medical Education And Research B7-h1 and b7-h4 in cancer
US20100015642A1 (en) * 2006-01-05 2010-01-21 Kwon Eugene D B7-h1 and survivin in cancer
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
WO2007120989A2 (en) * 2006-02-24 2007-10-25 Ceres, Inc. Shade regulatory regions
WO2007117693A2 (en) * 2006-04-07 2007-10-18 Ceres, Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
WO2007124361A2 (en) * 2006-04-20 2007-11-01 Mayo Foundation For Medical Education And Research Soluble b7-h1
WO2007133804A2 (en) * 2006-05-15 2007-11-22 Ceres, Inc. Modulation of oil levels in plants
WO2007147068A2 (en) * 2006-06-14 2007-12-21 Ceres, Inc. Increasing uv-b tolerance in plants
US20090320165A1 (en) * 2006-06-21 2009-12-24 Steven Craig Bobzin Modulation of protein levels in plants
US20130191941A1 (en) 2006-07-05 2013-07-25 Shing Kwok Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants
WO2008005631A2 (en) 2006-07-07 2008-01-10 Washington State University Genes encoding chavicol/eugenol synthase from the creosote bush larrea tridentata
ES2633352T3 (es) 2006-10-12 2017-09-20 Monsanto Technology Llc microARN de plantas y procedimientos de uso de los mismos
US8362322B2 (en) 2006-10-27 2013-01-29 Ceres, Inc. Modulating lignin in plants
WO2008064128A2 (en) * 2006-11-22 2008-05-29 Ceres, Inc. Broadly expressing regulatory regions
US20100151109A1 (en) * 2006-12-15 2010-06-17 Amr Saad Ragab Modulation of plant protein levels
CA2687605A1 (en) * 2007-05-21 2008-11-27 Bayer Bioscience N.V. Methods and means for producing glycoproteins with altered glycosylation pattern in higher plants
AU2008286701B2 (en) 2007-08-14 2015-02-12 Commonwealth Scientific And Industrial Research Organisation Improved gene silencing methods
US20110020325A1 (en) * 2008-02-29 2011-01-27 Kwon Eugene D Methods for reducing granulomatous inflammation
JP5822466B2 (ja) 2008-03-04 2015-11-24 ワシントン ステイト ユニバーシティー 種子油および膜脂質における脂肪酸不飽和化の示差的調節のための組成物および方法
AU2009273754B2 (en) 2008-07-21 2016-07-14 Commonwealth Scientific And Industrial Research Organisation Improved cottonseed oil and uses
US8419145B2 (en) * 2008-07-25 2013-04-16 Eastman Kodak Company Inkjet printhead and method of printing with multiple drop volumes
US8298794B2 (en) * 2008-10-09 2012-10-30 Ceres, Inc. Cinnamyl-alcohol dehydrogenases
US20100183633A1 (en) * 2008-12-04 2010-07-22 University Of Massachusetts Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition
US8309530B2 (en) 2009-02-04 2012-11-13 Washington State University Compositions and methods for modulating ghrelin-mediated conditions
US20100257634A1 (en) * 2009-04-03 2010-10-07 Venganza Inc. Bioassay for gene silencing constructs
EP2443234B1 (en) 2009-06-15 2018-08-15 Icon Genetics GmbH Nicotiana benthamiana plants deficient in xylosyltransferase activity
CA2782251C (en) 2009-07-20 2021-06-22 Ceres, Inc. Transgenic plants having increased biomass
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
ES2817780T3 (es) 2010-07-12 2021-04-08 The State Of Israel Ministry Of Agriculture And Rural Development Agricultural Res Organization A R Polinucleótidos aislados y métodos y plantas que usan los mismos para regular la acidez de las plantas
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
WO2012058223A1 (en) 2010-10-27 2012-05-03 Ceres, Inc. Transgenic plants having altered biomass composition
US9181532B2 (en) 2011-07-29 2015-11-10 Icon Genetics Gmbh Production of galactosylated N-glycans in plants
JP6104252B2 (ja) 2011-10-04 2017-03-29 アイコン・ジェネティクス・ゲーエムベーハー フコシルトランスフェラーゼ活性が欠損したニコチアナ・ベンサミアナ植物
WO2013067128A1 (en) 2011-11-02 2013-05-10 Ceres, Inc. Transgenic plants having increased tolerance to aluminum
US10323256B2 (en) 2011-12-09 2019-06-18 Ceres, Inc. Transgenic plants having altered biomass composition
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
EP3404103B1 (en) 2012-02-15 2021-03-24 CureVac AG Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
EP3348645B1 (en) 2012-02-15 2020-06-03 CureVac AG Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
EP3527662B1 (en) 2012-02-15 2022-01-26 CureVac AG Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
ES2654205T3 (es) 2012-03-27 2018-02-12 Curevac Ag Moléculas artificiales de ácido nucleico para la expresión mejorada de proteínas o péptidos
EP3578659B1 (en) 2012-03-27 2023-11-01 CureVac SE Artificial nucleic acid molecules for improved protein or peptide expression
CN104321432B (zh) 2012-03-27 2018-08-10 库瑞瓦格股份公司 包含5′top utr的人工核酸分子
US20150315541A1 (en) * 2012-12-13 2015-11-05 Moderna Therapeutics, Inc. Modified polynucleotides for altering cell phenotype
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3017049B1 (en) 2013-07-01 2018-08-22 Bayer CropScience NV Methods and means for modulating flowering time in monocot plants
PL3035955T3 (pl) 2013-08-21 2020-03-31 Curevac Ag Kompozycja i szczepionka do leczenia raka płuca
CA2925033A1 (en) 2013-09-24 2015-04-02 Bayer Cropscience Nv Hetero-transglycosylase and uses thereof
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052131B1 (en) 2013-10-01 2018-12-05 Mayo Foundation for Medical Education and Research Methods for treating cancer in patients with elevated levels of bim
IL307495A (en) 2013-11-07 2023-12-01 Ozgene Holdings Pty Ltd Preparations and methods for the production of genetically modified animals
US11254951B2 (en) 2014-12-30 2022-02-22 Curevac Ag Artificial nucleic acid molecules
JP6584414B2 (ja) 2013-12-30 2019-10-02 キュアバック アーゲー 人工核酸分子
RU2717986C2 (ru) 2013-12-30 2020-03-27 Куревак Аг Искусственные молекулы нуклеиновой кислоты
US9101100B1 (en) 2014-04-30 2015-08-11 Ceres, Inc. Methods and materials for high throughput testing of transgene combinations
WO2015179654A1 (en) 2014-05-22 2015-11-26 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti b7-h1 antibodies
PL3169785T3 (pl) 2014-07-15 2022-05-23 Forage Genetics International, Llc Sposób zwiększania plonu w warunkach stresu abiotycznego
US10517875B2 (en) 2014-07-23 2019-12-31 Mayo Foundation for Medical Engineering and Research Targeting DNA-PKcs and B7-H1 to treat cancer
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
WO2016113333A1 (en) 2015-01-16 2016-07-21 Bayer Cropscience Nv Leaf-preferential promoters and uses thereof
WO2016128519A1 (en) 2015-02-12 2016-08-18 Bayer Cropscience Nv Shoot apex-preferential promoters and uses thereof
CA2994588A1 (en) 2015-08-07 2017-02-16 Bayer Cropscience Nv Root-preferential and stress inducible promoter and uses thereof
WO2017075045A2 (en) 2015-10-30 2017-05-04 Mayo Foundation For Medical Education And Research Antibodies to b7-h1
BR112018069506A2 (pt) 2016-03-24 2019-01-29 Academisch Ziekenhuis Leiden métodos para transfectar plantas e para reduzir eventos de integração aleatória
AU2017249663B2 (en) 2016-04-11 2023-04-20 BASF Agricultural Solutions Seed US LLC Seed-specific and endosperm-preferential promoters and uses thereof
EP3443098A1 (en) 2016-04-11 2019-02-20 Bayer CropScience NV Seed-specific and endosperm-preferential promoters and uses thereof
DE102016015741A1 (de) 2016-04-12 2017-11-30 Kws Saat Se Kernkodierte männliche Sterilität durch Mutation in Cytochrom P450 Oxidase
DE102016106656A1 (de) 2016-04-12 2017-10-12 Kws Saat Se Kernkodierte männliche Sterilität durch Mutation in Cytochrom P450 Oxidase
AU2017249366A1 (en) 2016-04-13 2018-10-25 Bayer Cropscience Nv Seed-specific and embryo-preferential promoters and uses thereof
CN109661469A (zh) 2016-04-13 2019-04-19 巴斯夫农业种子解决方案美国有限责任公司 种子优选性和珠柄优选性启动子及其用途
WO2018170436A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil with high tolerance to downy mildew
AU2018239406A1 (en) 2017-03-23 2019-09-26 Basf Se Anther-specific promoter and uses thereof
WO2018217474A1 (en) 2017-05-24 2018-11-29 Bayer Cropscience Lp Fungal rust-inducible promoter
US11917978B2 (en) 2017-09-21 2024-03-05 The Conard Pyle Company Miniature rose plant named ‘meibenbino’
US11252928B2 (en) 2017-09-21 2022-02-22 The Condard-Pyle Company Miniature rose plant named ‘Meibenbino’
EP3502259A1 (en) 2017-12-19 2019-06-26 Universiteit Leiden A combinational strategy for reducing random integration events when transfecting plants
BR112020026543A2 (pt) 2018-06-27 2021-04-06 Basf Se Métodos para aumentar a razão de uma proteína, para aumentar a termotolerância, aumentar o rendimento, para produzir uma planta, para aumentar a termoestabilidade e produzir uma variante de proteína, variante de proteína, ácido nucleico, genes recombinantes, vetores, células, alelos nocaute e termoestável, planta, parte de planta ou semente, uso da variante de proteína, método de produção de alimentos e planta de cereal
US11473086B2 (en) 2019-06-19 2022-10-18 Ut-Battelle, Llc Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
WO2021004838A2 (en) 2019-07-05 2021-01-14 BASF Agricultural Solutions Seed US LLC Rubisco activase with reduced adp inhibition and uses thereof
CA3148950A1 (en) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
US11944063B2 (en) 2020-09-30 2024-04-02 Spring Meadow Nursery, Inc. Hydrangea ‘SMNHPH’
US11155884B1 (en) 2020-10-16 2021-10-26 Klemm & Sohn Gmbh & Co. Kg Double-flowering dwarf Calibrachoa
EP3984355B1 (en) 2020-10-16 2024-05-15 Klemm & Sohn GmbH & Co. KG Double-flowering dwarf calibrachoa
AU2022358470A1 (en) 2021-10-01 2024-04-11 Basf Se Plants with improved properties
WO2023052562A1 (en) 2021-10-01 2023-04-06 Basf Se Wheat plants with an increased yield
WO2024099765A2 (en) 2022-11-10 2024-05-16 BASF Agricultural Solutions Seed US LLC Transcription regulating nucleotide sequences and methods of use

Family Cites Families (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931397A (en) 1971-11-05 1976-01-06 Beecham Group Limited Biologically active material
US4024222A (en) 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
US4283393A (en) 1979-03-13 1981-08-11 Merck & Co., Inc. Topical application of interferon inducers
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4605394A (en) 1982-12-03 1986-08-12 Simon V. Skurkovich Methods for the treatment of pathological conditions by removing interferon from the organism
DE3208247A1 (de) 1982-03-08 1983-09-22 Philips Patentverwaltung Gmbh, 2000 Hamburg Cuvette fuer die atom-absorptions-spektrometrie
JPS5936698A (ja) 1982-08-20 1984-02-28 Science & Tech Agency B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞
NZ209840A (en) * 1983-10-17 1988-11-29 Kaji Akira A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action
US5190931A (en) 1983-10-20 1993-03-02 The Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
ATE198350T1 (de) 1983-10-20 2001-01-15 Univ New York State Res Found Regulierung der genexpression durch translationshemmung unter verwendung einer m-rns behindernden komplementären rns
US5272065A (en) * 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US5208149A (en) * 1983-10-20 1993-05-04 The Research Foundation Of State University Of New York Nucleic acid constructs containing stable stem and loop structures
US5173410A (en) 1984-02-15 1992-12-22 Lubrizol Genetics Inc. Transfer vector
US4766072A (en) * 1985-07-17 1988-08-23 Promega Corporation Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence
GB8521646D0 (en) 1985-08-30 1985-10-02 English Clays Lovering Pochin Inorganic fillers
CA1326450C (en) 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)
US6617496B1 (en) 1985-10-16 2003-09-09 Monsanto Company Effecting virus resistance in plants through the use of negative strand RNAs
GB8601680D0 (en) 1986-01-23 1986-02-26 Agricultural Genetics Co Modification of plant viruses
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5453566A (en) 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
NZ219472A (en) 1986-03-28 1990-08-28 Calgene Inc Regulation of phenotype in plant cells using dsdna constructs
US5017488A (en) * 1986-04-01 1991-05-21 University Of Medicine And Dentistry Of New Jersey Highly efficient dual T7/T3 promoter vector PJKF16 and dual SP6/T3 promoter vector PJFK15
ES2060646T3 (es) 1987-02-09 1994-12-01 Lubrizol Genetics Inc Virus rna hibrido.
PH24467A (en) 1987-03-03 1990-07-18 Hem Res Inc Synergistics interplay of lymphokines and dsrnas
US4950652A (en) 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
AU1820588A (en) 1987-07-17 1989-01-19 Hem Research, Inc. Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function
IE66830B1 (en) 1987-08-12 1996-02-07 Hem Res Inc Topically active compositions of double-stranded RNAs
IE72103B1 (en) 1987-08-12 1997-03-12 Hem Res Inc Promotion of host defense by systemic dsRNA treatment
ATE122402T1 (de) 1987-09-04 1995-05-15 Hem Pharma Corp Diagnose von mangelzuständen doppelsträngiger rns.
US5874555A (en) 1987-10-30 1999-02-23 California Institute Of Technology Triple helices and processes for making same
US4963532A (en) 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
KR970010758B1 (ko) 1987-12-15 1997-06-30 진 쉬어즈 피티와이. 리미티드 올리고리보뉴클레오티드 화합물
US5254678A (en) * 1987-12-15 1993-10-19 Gene Shears Pty. Limited Ribozymes
PH25365A (en) 1987-12-23 1991-05-13 Hem Research Rhase l inhibitor as a marker for virus infections
US5922602A (en) 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
GB8810120D0 (en) 1988-04-28 1988-06-02 Plant Genetic Systems Nv Transgenic nuclear male sterile plants
CA1320446C (en) 1988-06-20 1993-07-20 William A. Carter Modulation of lymphokine-resistant cellular states by dsrnas
EP0350151B1 (en) 1988-07-07 1994-03-30 Hem Pharmaceuticals Corp. Diagnosing and treating chronic fatigue syndrome
US5597718A (en) * 1988-10-04 1997-01-28 Agracetus Genetically engineering cotton plants for altered fiber
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5780269A (en) * 1989-02-24 1998-07-14 The University Of Medicine And Denistry Of New Jersey Hybrid molecules
US5436141A (en) 1989-02-24 1995-07-25 University Of Medicine And Dentistry Of New Jersey Method for synthesizing stable single-stranded CDNA in eukaryotes by means of a bacterial retron and products
US5405775A (en) * 1989-02-24 1995-04-11 The University Of Medicine And Dentistry Of New Jersey Retrons coding for hybrid DNA/RNA molecules
US5434070A (en) * 1989-02-24 1995-07-18 The University Of Medicine And Dentistry Of New Jersey Reverse transcriptases from Escherichia coli and Myxococcus xanthus
ES2090049T3 (es) 1989-03-16 1996-10-16 Boehringer Ingelheim Int Unidades geneticas para la inhibicion de la funcion de arn.
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5034323A (en) 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
WO1990012488A2 (en) 1989-04-05 1990-11-01 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast
AU5421090A (en) 1989-04-05 1990-11-05 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A clone of double-stranded rna virus and applications thereof
EP0473576A4 (en) 1989-05-19 1993-03-10 Hem Research, Inc. Short therapeutic dsrna of defined structure
GB8916213D0 (en) 1989-07-14 1989-08-31 Ici Plc Dna constructs,cells and plants derived therefrom
WO1991002069A1 (en) 1989-08-10 1991-02-21 Plant Genetic Systems N.V. Plants with modified flowers
US5747308A (en) 1989-10-25 1998-05-05 Celltech Therapeutics Limited Recombinant DNA method
US5939600A (en) * 1989-11-03 1999-08-17 Goldbach; Robert Willem Nucleic acids encoding tospovirus genome and expression thereof
HUT57265A (en) 1989-11-03 1991-11-28 Zaadunie Bv Process for producing plants of diminished infection-sensitivity
US5457189A (en) * 1989-12-04 1995-10-10 Isis Pharmaceuticals Antisense oligonucleotide inhibition of papillomavirus
US5168064A (en) 1990-04-20 1992-12-01 The Regents Of The University Of California Endo-1,4-β-glucanase gene and its use in plants
GB9009307D0 (en) 1990-04-25 1990-06-20 Ici Plc Dna,constructs,cells and plant derived therefrom
AU7906691A (en) * 1990-05-23 1991-12-10 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Adeno-associated virus (aav)-based eucaryotic vectors
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
WO1991019784A1 (en) * 1990-06-13 1991-12-26 The Trustees Of Princeton University A Lac REPRESSOR-HSV VP16 CHIMERIC TRANSCRIPTIONAL ACTIVATOR PROTEIN SYSTEM FUNCTIONING IN TRANSFECTED MAMMALIAN CELLS
US5580767A (en) 1990-08-14 1996-12-03 Isis Pharmaceuticals, Inc. Inhibition of influenza viruses by antisense oligonucleotides
DE4027616A1 (de) * 1990-08-31 1992-03-05 Boehringer Mannheim Gmbh Verfahren zur bestimmung von polymerase-aktivitaet
MX9100993A (es) 1990-09-10 1992-05-04 Us Agriculture Secuencia de adn aislado y enzima acido 1-aminociclopropan-1-carboxilico sintasa,recombinante
US5306862A (en) * 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
SE467358B (sv) 1990-12-21 1992-07-06 Amylogene Hb Genteknisk foeraendring av potatis foer bildning av staerkelse av amylopektintyp
SE467160B (sv) 1990-12-21 1992-06-01 Amylogene Hb Genetisk foeraendring av potatis foer bildning av staerkelse av amylostyp
PT100052A (pt) 1991-01-25 1993-03-31 Us Biochemical Corp Regulacao da translacao do acido nucleico
GB9105383D0 (en) * 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
GB9106713D0 (en) 1991-03-28 1991-05-15 Ici Plc Dna,dna constructs,cells and plants derived therefrom
EP0513884A1 (en) 1991-04-16 1992-11-19 Mogen International N.V. Male-sterile plants, methods for obtaining male-sterile plants and recombinant DNA for use therein
WO1992018522A1 (en) 1991-04-18 1992-10-29 The Salk Institute For Biological Studies Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
GB9109063D0 (en) 1991-04-26 1991-06-12 Ici Plc Modification of lignin synthesis in plants
WO1992021757A1 (en) 1991-05-30 1992-12-10 Plant Genetic Systems, N.V. Nematode-responsive plant promoters
JP3087246B2 (ja) 1991-07-11 2000-09-11 インターナショナル フラワー ディベロップメンツ プロプライアタリー リミティド フラボノイド経路の酵素をコードする遺伝子配列及びその使用
US6010908A (en) 1992-08-21 2000-01-04 The Regents Of The University Of California Gene therapy by small fragment homologous replacement
US5714323A (en) * 1991-08-30 1998-02-03 The University Of Medecine And Dentistry Of New Jersey Over expression of single-stranded molecules
CA2073630C (en) 1991-08-30 2007-12-11 Atsushi Ohshima Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor
US5354854A (en) * 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
HU218897B (hu) 1991-11-20 2000-12-28 Mogen International N. V. Növényi parazita nematódokra csökkentett fogékonyságú növények és eljárás az előállításukra
FR2685346B1 (fr) * 1991-12-18 1994-02-11 Cis Bio International Procede de preparation d'arn double-brin, et ses applications.
ES2166361T3 (es) 1992-02-19 2002-04-16 State Of Oregon Acting By & Th Produccion de plantas resistentes a los virus a traves de la introduccion de rna viral intraducible de sentido positivo.
DE4208107A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Pseudorabies-virus (prv)-polynukleotide und ihre verwendung zur herstellung von virusresistenten eukaryotischen zellen
US5593874A (en) * 1992-03-19 1997-01-14 Monsanto Company Enhanced expression in plants
US5496698A (en) * 1992-08-26 1996-03-05 Ribozyme Pharmaceuticals, Inc. Method of isolating ribozyme targets
GB9210273D0 (en) 1992-05-13 1992-07-01 Ici Plc Dna
US5693535A (en) 1992-05-14 1997-12-02 Ribozyme Pharmaceuticals, Inc. HIV targeted ribozymes
US6451603B1 (en) * 1992-06-29 2002-09-17 Gene Shears Pty. Limited Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens
AU4770093A (en) 1992-07-02 1994-01-31 Hybridon, Inc. Self-stabilized oligonucleotides as therapeutic agents
EP0606454A1 (en) 1992-07-30 1994-07-20 Keygene N.V. Dna constructs, cells and plants derived therefrom
CA2106260A1 (en) * 1992-09-17 1994-03-18 Robert M. Kotin Human adeno-associated virus integration site dna and uses thereof
WO1994007367A1 (en) 1992-09-29 1994-04-14 Apollon, Inc. Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids
CA2146113A1 (en) 1992-10-15 1994-10-15 Adrianus Johannes Van Tunen Genetic moderation of restoration or plant phenotypes
US6872872B1 (en) * 1992-11-17 2005-03-29 E. I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
US6372965B1 (en) 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
ZA939767B (en) 1993-01-21 1994-09-14 Univ North Carolina State Nematode-resistant transgenic plants
US7205457B1 (en) 1993-02-05 2007-04-17 Monsanto Technology Llc Altered linolenic and linoleic acid content in plants
US6069298A (en) * 1993-02-05 2000-05-30 Regents Of The University Of Minnesota Methods and an acetyl CoA carboxylase gene for conferring herbicide tolerance and an alteration in oil content of plants
EP0620281A3 (en) * 1993-03-31 1995-05-03 Mitsubishi Corp Oilseed plants producing valuable seeds with modified amino acid and fatty acid compositions.
WO1994029465A1 (en) 1993-06-08 1994-12-22 Nunhems Zaden B.V. Process for generating male sterile plants
US5739309A (en) 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
KR960704034A (ko) 1993-07-19 1996-08-31 다니엘 엘. 캐시앙 단백질 생산, 세포 증식 및(또는) 전염병 병원균의 증식에 대한 올리고뉴클레오티드 저해의 향상법(Enhancement of Oligonucleotide Inhibition of Protein Production, Cell Proliferation, and/or Multiplication of Infectious Disease Pathogens)
EP0637582A1 (en) * 1993-08-06 1995-02-08 Sumitomo Chemical Company, Limited A propriolate ester compound, an acaricide containing the same as an active ingredient and an acaricidal method
US5514546A (en) 1993-09-01 1996-05-07 Research Corporation Technologies, Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US5808036A (en) 1993-09-01 1998-09-15 Research Corporation Technologies Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
GB9318927D0 (en) 1993-09-13 1993-10-27 Zeneca Ltd Regulation of senescence
EP1584682B1 (en) 1993-09-20 2009-07-15 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5858981A (en) 1993-09-30 1999-01-12 University Of Pennsylvania Method of inhibiting phagocytosis
GB9320548D0 (en) 1993-10-06 1993-11-24 Sandoz Ltd Improvements in or relating to organic compounds
US5624803A (en) 1993-10-14 1997-04-29 The Regents Of The University Of California In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5578716A (en) 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
US5908779A (en) 1993-12-01 1999-06-01 University Of Connecticut Targeted RNA degradation using nuclear antisense RNA
FR2714383B1 (fr) 1993-12-29 1996-02-09 Centre Nat Rech Scient Contrôle de l'expression de gènes.
PT1298208E (pt) 1994-01-05 2006-10-31 Gene Shears Pty Ltd Ribozimas que abordam selectivamente uma sequencia tat do hiv
US5849991A (en) * 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
CA2183992A1 (en) 1994-02-23 1995-08-31 Dan T. Stinchcomb Method and reagent for inhibiting the expression of disease related genes
US5686649A (en) * 1994-03-22 1997-11-11 The Rockefeller University Suppression of plant gene expression using processing-defective RNA constructs
US5631148A (en) 1994-04-22 1997-05-20 Chiron Corporation Ribozymes with product ejection by strand displacement
US6054299A (en) * 1994-04-29 2000-04-25 Conrad; Charles A. Stem-loop cloning vector and method
US6146886A (en) * 1994-08-19 2000-11-14 Ribozyme Pharmaceuticals, Inc. RNA polymerase III-based expression of therapeutic RNAs
CA2199820A1 (en) 1994-09-12 1996-03-21 Kevin J. Scanlon Modulation of drug radiation resistant genes
WO1996035706A1 (en) 1995-05-11 1996-11-14 Hybridon, Inc. Pyrimidine targeting hairpin triplex-forming oligonucleotides
US5691140A (en) 1995-05-18 1997-11-25 New England Biolabs, Inc. Bidirectional in vitro transcription vectors utilizing a single RNA polymerase for both directions
US5693773A (en) 1995-06-07 1997-12-02 Hybridon Incorporated Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidines
JPH11510376A (ja) 1995-06-30 1999-09-14 ディーエヌエー プラント テクノロジー コーポレイション 遅発成熟性トマト
FR2737501B1 (fr) * 1995-07-31 1997-10-24 Transgene Sa Nouveaux virus auxiliaires pour la preparation de vecteurs viraux recombinants
EP0850318A1 (en) 1995-09-13 1998-07-01 Chiron Corporation Method and construct for screening for inhibitors of transcriptional activation
AU7366296A (en) 1995-09-20 1997-04-09 Worcester Foundation For Biomedical Research, Inc. Antisense oligonucleotide chemotherapy for benign hyperplasia or cancer of the prostate
JPH09110894A (ja) 1995-10-17 1997-04-28 Soyaku Gijutsu Kenkyusho:Kk ハイブリッドdna/rnaオリゴヌクレオチド及び抗ウイルス剤
US5773692A (en) 1995-12-12 1998-06-30 Her Majesty The Queen In Right Of Canada, As Represented By Agriculture And Agri-Food Canada Anti-sense RNA for CAB transcript to reduce chlorophyll content in plants
CA2279673A1 (en) 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acids for therapeutic and diagnostic uses
IT1283876B1 (it) 1996-01-12 1998-05-07 Univ Roma Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare
EP0880598A4 (en) * 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US5891855A (en) * 1996-02-12 1999-04-06 The Scripps Research Institute Inhibitors of leaderless protein export
JP3847366B2 (ja) 1996-02-22 2006-11-22 アンジェスMg株式会社 アンチセンスオリゴヌクレオチドを用いた固定性分裂終了細胞増殖剤
AU2089197A (en) 1996-03-13 1997-10-01 National Research Council Of Canada Process of raising squalene levels in plants and dna sequences used therefor
EP0888452B1 (en) * 1996-03-15 2004-02-11 Munin Corporation Human cyr61, an extracellular matrix signalling molecule
US6022863A (en) 1996-05-21 2000-02-08 Yale University Regulation of gene expression
IL127162A (en) 1996-05-24 2007-07-24 Biogen Idec Inc Kidney injury related molecules
US5994526A (en) * 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
AU725002B2 (en) 1996-06-21 2000-10-05 Plant Genetic Systems N.V. Gene expression in plants
US5879906A (en) * 1996-06-26 1999-03-09 Cambia Biosystems Llc Glucuronide repressors and uses thereof
US5952546A (en) * 1996-06-27 1999-09-14 Dna Plant Technology Corporation Delayed ripening tomato plants with T-DNA bearing a truncated ACC2 synthase gene
US5850026A (en) 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
WO1998000110A1 (en) * 1996-07-03 1998-01-08 University Of Pittsburgh Emulsion formulations for hydrophilic active agents
DE69734589T2 (de) * 1996-08-02 2006-08-10 Genesense Technologies Inc., Markham Antitumor antisense sequenzen gegen h1 und r2 verbindungen von ribonukleotide reductase
DE19631919C2 (de) 1996-08-07 1998-07-16 Deutsches Krebsforsch Anti-Sinn-RNA mit Sekundärstruktur
US5747338A (en) 1996-08-15 1998-05-05 Chiron Corporation Method and construct for screening for inhibitors of transcriptional activation
US6225290B1 (en) 1996-09-19 2001-05-01 The Regents Of The University Of California Systemic gene therapy by intestinal cell transformation
US5814500A (en) 1996-10-31 1998-09-29 The Johns Hopkins University School Of Medicine Delivery construct for antisense nucleic acids and methods of use
GB9703146D0 (en) 1997-02-14 1997-04-02 Innes John Centre Innov Ltd Methods and means for gene silencing in transgenic plants
CA2280230A1 (en) 1997-02-21 1998-08-27 Danisco A/S Antisense intron inhibition of starch branching enzyme expression
CN1226930A (zh) 1997-03-10 1999-08-25 日本烟草产业株式会社 反义核苷酸序列
GB9706381D0 (en) 1997-03-27 1997-05-14 Cambridge Advanced Tech Improvements relating to the specificity of gene expression
US7589253B2 (en) * 1997-04-15 2009-09-15 Commonwealth Scientific And Industrial Research Organisation Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism
US5942395A (en) 1997-05-09 1999-08-24 Universite De Montreal Hybrid ribozymes and methods of use
GB9710475D0 (en) 1997-05-21 1997-07-16 Zeneca Ltd Gene silencing
EP1019429A4 (en) 1997-08-20 2001-08-08 Somagenics Inc ANTISENSE THERAPEUTIC PRODUCTS WITH IMPROVED BINDING PROPERTIES AND METHODS OF USE
GB9720148D0 (en) 1997-09-22 1997-11-26 Innes John Centre Innov Ltd Gene silencing materials and methods
EP1032692A1 (en) 1997-11-18 2000-09-06 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
DE19754622A1 (de) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU743316C (en) * 1998-03-20 2005-09-15 Commonwealth Scientific And Industrial Research Organisation Control of gene expression
AUPP249298A0 (en) * 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN1202246C (zh) 1998-04-08 2005-05-18 联邦科学和工业研究组织 获得修饰表型的方法和措施
US20040214330A1 (en) 1999-04-07 2004-10-28 Waterhouse Peter Michael Methods and means for obtaining modified phenotypes
US8598332B1 (en) 1998-04-08 2013-12-03 Bayer Cropscience N.V. Methods and means for obtaining modified phenotypes
EP0959133A1 (en) 1998-05-22 1999-11-24 Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro-Dlo) A process for inhibiting expression of genes
AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP1173594B1 (en) 1999-04-20 2008-10-29 Bayer BioScience N.V. Methods for delivering inhibitory rna to plants and applications thereof
EP2363478B1 (en) 1999-04-21 2019-07-24 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibiting the function of polynucleotide sequences
US20040138168A1 (en) 1999-04-21 2004-07-15 Wyeth Methods and compositions for inhibiting the function of polynucleotide sequences
EP1196026A1 (en) 1999-06-14 2002-04-17 Exelixis, Inc. Animal models and methods for analysis of lipid metabolism and screening of pharmaceutical and pesticidal agents that modulate lipid metabolism
CN1360631A (zh) 1999-07-09 2002-07-24 美国家用产品公司 在质粒序列转录过程中防止畸变rna形成的方法和组合物
US6423885B1 (en) * 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
WO2001019857A2 (en) 1999-09-16 2001-03-22 Genoptera, Llc Facilitative transporter (ft1 and ft2) from drosophila melanogaster and uses thereof
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
WO2001037654A2 (en) 1999-11-24 2001-05-31 Dna Plant Technology Corporation METHOD OF EXPRESSING dsRNA IN PLANTS TO INHIBIT INSECT PESTS
AU2058401A (en) 1999-11-29 2001-06-04 Genoptera, Llc Nucleic acids and polypeptides of invertebrate receptors and methods of use
GB9930691D0 (en) 1999-12-24 2000-02-16 Devgen Nv Improvements relating to double-stranded RNA inhibition
GB2377221B (en) 2000-03-17 2004-08-18 Benitec Australia Ltd Genetic silencing
DK2796553T3 (da) * 2000-03-30 2019-09-30 Whitehead Inst Biomedical Res Rna-sekvensspecifikke formidlere af rna-interferens
GB2362383B (en) 2000-05-19 2003-12-31 Devgen Nv Gene expression system
US6995258B1 (en) * 2000-05-25 2006-02-07 City Of Hope Nucleolar targeting of therapeutics against HIV
HUP0302320A3 (en) 2000-06-23 2005-11-28 Pioneer Hi Bred Int Recombinant constructs and their use in reducing gene expression
US7109393B2 (en) * 2000-08-15 2006-09-19 Mendel Biotechnology, Inc. Methods of gene silencing using inverted repeat sequences
DK1407044T4 (da) 2000-12-01 2017-12-04 Max-Planck-Gesellschaft Zur Förderung Der Wss E V RNA-interferens-formidlende små RNA-molekyler
US20020150968A1 (en) * 2001-01-10 2002-10-17 Wang Peng G. Glycoconjugate and sugar nucleotide synthesis using solid supports
EP1229134A3 (en) 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
ES2609014T3 (es) 2001-07-12 2017-04-18 University Of Massachusetts Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico
WO2003023015A2 (en) 2001-09-13 2003-03-20 California Institute Of Technology Method for expression of small antiviral rna molecules within a cell
WO2003027298A1 (en) 2001-09-27 2003-04-03 Timothy Albert Holton Stem-loop vector system
US20030148519A1 (en) * 2001-11-14 2003-08-07 Engelke David R. Intracellular expression and delivery of siRNAs in mammalian cells
GB0130955D0 (en) 2001-12-24 2002-02-13 Cancer Res Ventures Expression system
US20040022748A1 (en) 2002-03-12 2004-02-05 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Method of enhancing skin lightening
JP2005519607A (ja) 2002-03-14 2005-07-07 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション 改変された遺伝子サイレンシングrnaおよびその使用
ITRM20020253A1 (it) 2002-05-08 2003-11-10 Univ Roma Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche.
US20040106566A1 (en) 2002-05-17 2004-06-03 Shi-Lung Lin RNA-splicing and processing-directed gene silencing and the relative applications thereof
AU2003297474A1 (en) 2002-12-18 2004-07-14 Salk Institute For Biological Studies Methods of inhibiting gene expression by rna interference
US20040231016A1 (en) 2003-02-19 2004-11-18 Commonwealth Scientific And Industrial Research Organization Efficient gene silencing in plants using short dsRNA sequences
CA2568603A1 (en) 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
EP2018420A4 (en) 2006-05-03 2009-06-24 Commw Scient Ind Res Org IMPROVED GENE SILENCING METHODS
US20080005034A1 (en) 2006-06-09 2008-01-03 General Instrument Corporation Method and Apparatus for Efficient Use of Trusted Third Parties for Additional Content-Sharing Security
JP5929429B2 (ja) 2012-03-30 2016-06-08 東京エレクトロン株式会社 成膜装置

Also Published As

Publication number Publication date
US20180179549A1 (en) 2018-06-28
CA2381921A1 (en) 2001-02-22
ES2387393T3 (es) 2012-09-21
EP1208211A4 (en) 2003-08-27
DK1650306T3 (da) 2012-08-13
EP1650306B1 (en) 2012-06-06
AU6586300A (en) 2001-03-13
NZ516929A (en) 2004-01-30
ATE378412T1 (de) 2007-11-15
PT1208211E (pt) 2008-02-13
US20030165894A1 (en) 2003-09-04
US8334374B2 (en) 2012-12-18
PT1650306E (pt) 2012-08-06
US20120270315A1 (en) 2012-10-25
CY1107876T1 (el) 2013-06-19
US6423885B1 (en) 2002-07-23
US9708621B2 (en) 2017-07-18
US8183217B2 (en) 2012-05-22
CA2381921C (en) 2017-12-12
WO2001012824A1 (en) 2001-02-22
ES2296632T3 (es) 2008-05-01
AU783799B2 (en) 2005-12-08
EP1208211A1 (en) 2002-05-29
US20120210469A1 (en) 2012-08-16
EP1650306A2 (en) 2006-04-26
DE60037123T2 (de) 2009-05-07
US20160355833A1 (en) 2016-12-08
US7138565B2 (en) 2006-11-21
US20070056057A1 (en) 2007-03-08
DE60037123D1 (de) 2007-12-27
US20050251877A1 (en) 2005-11-10
WO2001012824A8 (en) 2001-06-07
US9399777B2 (en) 2016-07-26
EP1650306A3 (en) 2006-05-03
EP1208211B1 (en) 2007-11-14
US10190127B2 (en) 2019-01-29

Similar Documents

Publication Publication Date Title
DK1208211T3 (da) Midler og fremgangsmåder til modificering af genekspression under anvendelse af upolyadenyleret RNA
WO2004035765A3 (en) Double-stranded rna structures and constructs, and methods for generating and using the same
US20180245075A1 (en) Integrated system for programmable dna methylation
WO2004011624A3 (en) Double stranded rna structures and constructs, and methods for generating and using the same
NO20025402L (no) Modifiserte ES-celler og ES-cellespesifikke gener
PL1824977T3 (pl) Promotorowy kwas nukleinowy pochodzący z rodzaju Corynebacterium, kaseta ekspresyjna zawierająca promotor i wektor, komórka gospodarza zawierająca wektor i sposób ekspresji genu z użyciem komórki
RU2006140084A (ru) СИСТЕМА ЭКСПРЕССИИ ДЛЯ ПОЛУЧЕНИЯ СЛИТНЫХ БЕЛКОВ IL-15/Fc И ЕЕ ПРИМЕНЕНИЕ
NZ538852A (en) Selection and isolation of living cells using mRNA-binding probes
Mironova et al. A single-cell view of tissue regeneration in plants
DE602005024868D1 (de) Neuer l-lysin-induzierbarer promotor
ZA200501454B (en) Isolation and cloning of dna from uncultivated organism
WO1999023216A3 (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Zhou et al. Optical Control of Base Editing and Transcription through Light‐Activated Guide RNA
WO2001085909A3 (en) Development of plant based biological sensors and novel disease resistance strategies
WO2000015772A3 (en) Recombinant protein production in urine
WO2004029301A3 (en) Method for assaying replication of hbv and testing susceptibility to drugs
MXPA02012557A (es) Composiciones y metodos para la modificacion de la expresion del gen.
WO2001079512A3 (en) Vector and method for targeted replacement and disruption of an integrated dna sequence
WO2001068807A8 (en) Identification of in vivo dna binding loci of chromatin proteins using a tethered nucleotide modification enzyme
Chen et al. A medium‐scale assay for enhancer validation in amniotes
WO2003093414A3 (en) Transgenic animal model for spliceosome-mediated rna trans-splicing
CN106191125A (zh) 一种基于热诱导miR30‑shRNA敲低鱼类基因表达的方法
Omachi et al. Comparative analysis and rational design of dCas9-VP64 variants for CRISPR activation
WO2004099386A3 (en) Gene silencing by systemic rna interference
DeLuca et al. CRISPR Library Screening in Cultured Cardiomyocytes