ES2090049T3 - Unidades geneticas para la inhibicion de la funcion de arn. - Google Patents

Unidades geneticas para la inhibicion de la funcion de arn.

Info

Publication number
ES2090049T3
ES2090049T3 ES90104701T ES90104701T ES2090049T3 ES 2090049 T3 ES2090049 T3 ES 2090049T3 ES 90104701 T ES90104701 T ES 90104701T ES 90104701 T ES90104701 T ES 90104701T ES 2090049 T3 ES2090049 T3 ES 2090049T3
Authority
ES
Spain
Prior art keywords
rna
units
inhibition
genetic
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104701T
Other languages
English (en)
Inventor
Hartmut Dr Beug
Max L Prof-Dr Birnstiel
Matthew Dr Cotten
Ernst Dr Wagner
Harald Dipl-Ing Kandolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2090049T3 publication Critical patent/ES2090049T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Abstract

LA UNIDAD CONTIENE LAS UNIDADES DE TRANSCRIPCION NECESARIAS PARA LA TRANSCRIPCION CON POLIMERASA III Y UN DNA CODIFICADOR PARA RNA INHIBIDOR, QUE SE DISPONE EN EL INTERIOR DE LA UNIDAD DE TAL MODO, QUE EL RNA TRANSCRITO SEA UNA PARTE DEL RESULTADO DE LA TRANSCRIPCION CON POLIMERASA III. CON ESTAS UNIDADES SE PUEDE OBTENER UNA MAYOR ESTABILIDAD DEL RNA INHIBIDOR SIN MERMA DE LA ACTIVIDAD. TAMBIEN SE DESCRIBEN UN PROCEDIMIENTO PARA LA INTRODUCCION DE LAS UNIDADES GENETICAS EN CELULAS, LA UTILIZACION DE ESTAS UNIDADES Y LOS PREPARADOS FARMACEUTICOS, QUE LA CONTIENEN.
ES90104701T 1989-03-16 1990-03-13 Unidades geneticas para la inhibicion de la funcion de arn. Expired - Lifetime ES2090049T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT60989 1989-03-16

Publications (1)

Publication Number Publication Date
ES2090049T3 true ES2090049T3 (es) 1996-10-16

Family

ID=3495118

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104701T Expired - Lifetime ES2090049T3 (es) 1989-03-16 1990-03-13 Unidades geneticas para la inhibicion de la funcion de arn.

Country Status (20)

Country Link
EP (1) EP0387775B1 (es)
JP (1) JP3330930B2 (es)
KR (1) KR900014591A (es)
AT (1) ATE140961T1 (es)
AU (1) AU637354B2 (es)
CA (1) CA2012312C (es)
DD (1) DD297838A5 (es)
DE (1) DE59010432D1 (es)
DK (1) DK0387775T3 (es)
ES (1) ES2090049T3 (es)
FI (1) FI105103B (es)
GR (1) GR3020935T3 (es)
HU (2) HU215187B (es)
IE (1) IE74850B1 (es)
IL (1) IL93754A (es)
NO (1) NO306623B1 (es)
NZ (1) NZ232917A (es)
PT (1) PT93440B (es)
RU (1) RU2136751C1 (es)
ZA (1) ZA901973B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013641A1 (en) * 1989-05-10 1990-11-15 Sloan-Kettering Institute For Cancer Research Stably transformed eucaryotic cells comprising a foreign transcribable dna under the control of a pol iii promoter
DE4091533T (es) * 1989-08-31 1992-01-30
JP2507895B2 (ja) * 1989-12-19 1996-06-19 工業技術院長 リボザイムの新規合成系
WO1991019789A1 (en) * 1990-06-19 1991-12-26 Commonwealth Scientific And Industrial Research Organisation Endonucleases
US6008343A (en) * 1990-06-19 1999-12-28 Gene Shears Pty. Ltd. Nucleotide based endonucleases
PL169576B1 (pl) * 1990-10-12 1996-08-30 Max Planck Gesellschaft Sposób wytwarzania czasteczki RNA o aktywnosci katalitycznej PL PL
DE4104186A1 (de) * 1991-02-12 1992-08-13 Genentech Inc Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
FR2687411A1 (fr) * 1992-02-13 1993-08-20 Nice Sophia Antipolis Universi Vecteur comportant un gene viral transcrit par l'arn polymerase iii, et procede de production intracellulaire d'arn.
WO1993022433A2 (de) * 1992-04-28 1993-11-11 Frank Andreas Harald Meyer Medikament zur gentherapeutischen behandlung von menschen, tieren und pflanzen, insbesondere zur blockierung der virenvermehrung und der tumorgene sowie verfahren zur herstellung des medikaments
US5610052A (en) * 1992-08-26 1997-03-11 Ribozyme Pharmaceuticals Inc. Enzymatic RNA with activity to ras
AU687001B2 (en) * 1992-05-14 1998-02-19 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting cancer development
US5989906A (en) * 1992-05-14 1999-11-23 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
WO1993024133A1 (en) * 1992-05-27 1993-12-09 City Of Hope CHIMERIC tRNALYS-RIBOZYME MOLECULES
US5827935A (en) * 1992-05-27 1998-10-27 City Of Hope Chimeric tRNAlys -ribozyme molecules
DE69333937T2 (de) * 1992-06-29 2006-08-31 Gene Shears Pty. Ltd. Nukleinsäuren und sie verwendende verfahren zur bekämpfung viraler pathogene
WO1994013798A1 (en) * 1992-12-16 1994-06-23 Bergmann Johanna E Agents for the prevention and treatment of human alzheimer's disease
ATE250670T1 (de) * 1993-07-06 2003-10-15 Univ Nice Sophia Antipolis Vektor, enthält ein bei arn-polymerase-iii transcriptes virus-gen
US5837503A (en) * 1993-07-07 1998-11-17 Universite De Nice-Sophia-Antipolis Vector containing viral gene transcribed by RNA polymerase III and methods for use
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
CA2157015A1 (en) * 1994-01-24 1995-07-27 John J. Rossi Inhibitors and target molecule co-localization
DE4424761C1 (de) * 1994-07-04 1995-06-08 Max Planck Gesellschaft Expressionskassette für die Antisense- und die Ribozym-Expression
WO1996040906A1 (en) 1995-06-07 1996-12-19 Commonwealth Scientific And Industrial Research Organisation Optimized minizymes and miniribozymes and uses thereof
FR2755976B1 (fr) * 1996-11-15 1999-01-15 Idm Immuno Designed Molecules Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
US6057156A (en) * 1997-01-31 2000-05-02 Robozyme Pharmaceuticals, Inc. Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
WO1999020753A2 (en) * 1997-10-21 1999-04-29 Ribozyme Pharmaceuticals, Inc. Peptide bond formation using nucleic acid catalysts
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
KR101085210B1 (ko) 1998-03-20 2011-11-21 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 유전자 발현 조절방법
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
AU776150B2 (en) 1999-01-28 2004-08-26 Medical College Of Georgia Research Institute, Inc. Composition and method for (in vivo) and (in vitro) attenuation of gene expression using double stranded RNA
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1229134A3 (en) 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods

Also Published As

Publication number Publication date
HU215187B (hu) 1998-10-28
DE59010432D1 (de) 1996-09-05
HU211868A9 (en) 1995-12-28
DD297838A5 (de) 1992-01-23
CA2012312A1 (en) 1990-09-16
NO306623B1 (no) 1999-11-29
NO901213L (no) 1990-09-17
FI901296A0 (fi) 1990-03-15
GR3020935T3 (en) 1996-12-31
AU637354B2 (en) 1993-05-27
EP0387775A1 (de) 1990-09-19
NZ232917A (en) 1997-07-27
IE900931L (en) 1990-09-16
RU2136751C1 (ru) 1999-09-10
DK0387775T3 (da) 1996-11-04
ATE140961T1 (de) 1996-08-15
HUT54206A (en) 1991-01-28
HU901584D0 (en) 1990-06-28
ZA901973B (en) 1991-11-27
JPH03130080A (ja) 1991-06-03
NO901213D0 (no) 1990-03-15
PT93440B (pt) 2001-07-31
CA2012312C (en) 2001-08-14
EP0387775B1 (de) 1996-07-31
IL93754A0 (en) 1990-12-23
PT93440A (pt) 1990-11-07
FI105103B (fi) 2000-06-15
JP3330930B2 (ja) 2002-10-07
AU5130190A (en) 1990-11-01
KR900014591A (ko) 1990-10-24
IL93754A (en) 1995-12-31
IE74850B1 (en) 1997-08-13

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