DK1133522T3 - Antagonistiske analoger af GH-RH, der inhiberer IGF-I og -II - Google Patents

Antagonistiske analoger af GH-RH, der inhiberer IGF-I og -II

Info

Publication number
DK1133522T3
DK1133522T3 DK99963962T DK99963962T DK1133522T3 DK 1133522 T3 DK1133522 T3 DK 1133522T3 DK 99963962 T DK99963962 T DK 99963962T DK 99963962 T DK99963962 T DK 99963962T DK 1133522 T3 DK1133522 T3 DK 1133522T3
Authority
DK
Denmark
Prior art keywords
inhibit igf
antagonistic analogs
antagonistic
analogs
igf
Prior art date
Application number
DK99963962T
Other languages
Danish (da)
English (en)
Inventor
Andrew V Schally
Jozsef Varga
Marta Zarandi
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Application granted granted Critical
Publication of DK1133522T3 publication Critical patent/DK1133522T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK99963962T 1998-11-25 1999-11-23 Antagonistiske analoger af GH-RH, der inhiberer IGF-I og -II DK1133522T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/199,381 US6057422A (en) 1998-11-25 1998-11-25 Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Publications (1)

Publication Number Publication Date
DK1133522T3 true DK1133522T3 (da) 2006-11-06

Family

ID=22737273

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99963962T DK1133522T3 (da) 1998-11-25 1999-11-23 Antagonistiske analoger af GH-RH, der inhiberer IGF-I og -II

Country Status (29)

Country Link
US (2) US6057422A (no)
EP (1) EP1133522B1 (no)
JP (1) JP2002530432A (no)
KR (1) KR100629013B1 (no)
CN (1) CN100422211C (no)
AR (1) AR022392A1 (no)
AT (1) ATE332310T1 (no)
AU (1) AU757222B2 (no)
BG (1) BG65137B1 (no)
BR (1) BR9915512A (no)
CA (1) CA2351665C (no)
CO (1) CO5180565A1 (no)
CZ (1) CZ20011794A3 (no)
DE (1) DE69932255T2 (no)
DK (1) DK1133522T3 (no)
ES (1) ES2264279T3 (no)
HK (1) HK1036461A1 (no)
HU (1) HUP0105094A3 (no)
IL (1) IL142899A0 (no)
NO (1) NO20012489L (no)
NZ (1) NZ511307A (no)
PL (1) PL197471B1 (no)
PT (1) PT1133522E (no)
RU (1) RU2235099C2 (no)
SK (1) SK7252001A3 (no)
TR (1) TR200101492T2 (no)
TW (1) TW585873B (no)
UA (1) UA68407C2 (no)
WO (1) WO2000031136A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412477A4 (en) * 2001-07-12 2005-12-14 Exelixis Inc GLYPICANS (GPC) USEFUL AS MODIFIERS OF IRRTK AND P21 MECHANISMS, METHODS OF USE THEREOF
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
JP2006504694A (ja) * 2002-09-18 2006-02-09 サントル・オスピタリエ・ドゥ・リュニヴェルシテ・ドゥ・モントリオール・（シー・エイチ・ユー・エム） Ｇｈｒｈ類似体
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
CA2718146C (en) * 2008-03-28 2016-09-20 The University Of Miami Novel n- and c-terminal substituted antagonistic analogs of gh-rh
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
US20110171191A1 (en) 2008-06-12 2011-07-14 Syntaxin Limited Suppression of neuroendocrine diseases
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
US8227421B2 (en) 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
BR112013027150A2 (pt) 2011-04-21 2017-06-06 Theratechnologies Inc thera
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
US10350273B2 (en) 2014-11-12 2019-07-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment of hormonal disorders of growth
EP3920961A4 (en) 2019-02-08 2022-12-14 United States Government as represented by the Department of Veterans Affairs GROWTH HORMONE RELEASING HORMONE ANTAGONISTS AND THEIR USES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
EP0527914A4 (en) * 1990-05-04 1993-08-11 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity

Also Published As

Publication number Publication date
IL142899A0 (en) 2002-04-21
BG65137B1 (bg) 2007-03-30
NZ511307A (en) 2005-01-28
US7026281B1 (en) 2006-04-11
EP1133522B1 (en) 2006-07-05
KR20010101079A (ko) 2001-11-14
JP2002530432A (ja) 2002-09-17
DE69932255T2 (de) 2007-05-31
SK7252001A3 (en) 2002-02-05
BG105638A (en) 2002-01-31
KR100629013B1 (ko) 2006-09-26
PL349877A1 (en) 2002-09-23
CO5180565A1 (es) 2002-07-30
TW585873B (en) 2004-05-01
CA2351665C (en) 2008-09-02
US6057422A (en) 2000-05-02
HUP0105094A2 (hu) 2002-04-29
CZ20011794A3 (cs) 2002-02-13
WO2000031136A1 (en) 2000-06-02
WO2000031136A9 (en) 2001-07-19
RU2235099C2 (ru) 2004-08-27
NO20012489D0 (no) 2001-05-21
UA68407C2 (en) 2004-08-16
AU2029100A (en) 2000-06-13
ATE332310T1 (de) 2006-07-15
EP1133522A1 (en) 2001-09-19
PL197471B1 (pl) 2008-04-30
HK1036461A1 (en) 2002-01-04
TR200101492T2 (tr) 2001-11-21
CA2351665A1 (en) 2000-06-02
CN1328570A (zh) 2001-12-26
AR022392A1 (es) 2002-09-04
ES2264279T3 (es) 2006-12-16
NO20012489L (no) 2001-07-04
DE69932255D1 (de) 2006-08-17
CN100422211C (zh) 2008-10-01
HUP0105094A3 (en) 2002-05-28
PT1133522E (pt) 2006-11-30
BR9915512A (pt) 2001-08-07
AU757222B2 (en) 2003-02-06

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