DK1114817T3 - Substituerede benzylaminopiperidinforbindelser - Google Patents

Substituerede benzylaminopiperidinforbindelser

Info

Publication number
DK1114817T3
DK1114817T3 DK01108350T DK01108350T DK1114817T3 DK 1114817 T3 DK1114817 T3 DK 1114817T3 DK 01108350 T DK01108350 T DK 01108350T DK 01108350 T DK01108350 T DK 01108350T DK 1114817 T3 DK1114817 T3 DK 1114817T3
Authority
DK
Denmark
Prior art keywords
compounds
substituted
substituted benzylaminopiperidine
benzylaminopiperidine compounds
benzylaminopiperidine
Prior art date
Application number
DK01108350T
Other languages
Danish (da)
English (en)
Inventor
Kunio Satake
Yuji Shishido
Hiroaki Wakabayashi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK1114817T3 publication Critical patent/DK1114817T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01108350T 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser DK1114817T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24
EP96914375A EP0861235B1 (en) 1995-08-24 1996-06-10 Substituted benzylaminopiperidine compounds

Publications (1)

Publication Number Publication Date
DK1114817T3 true DK1114817T3 (da) 2004-04-26

Family

ID=11004362

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96914375T DK0861235T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser
DK01108350T DK1114817T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK96914375T DK0861235T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Country Status (42)

Country Link
US (1) US6506775B1 (zh)
EP (2) EP1114817B1 (zh)
JP (1) JP3084069B2 (zh)
KR (1) KR100288673B1 (zh)
CN (1) CN1153764C (zh)
AP (1) AP643A (zh)
AR (1) AR006305A1 (zh)
AT (2) ATE258166T1 (zh)
AU (1) AU702698B2 (zh)
BG (1) BG64126B1 (zh)
BR (1) BR9609989A (zh)
CA (1) CA2227814C (zh)
CO (1) CO4480738A1 (zh)
CZ (1) CZ297543B6 (zh)
DE (2) DE69616817T2 (zh)
DK (2) DK0861235T3 (zh)
DZ (1) DZ2086A1 (zh)
ES (2) ES2163017T3 (zh)
HK (1) HK1014935A1 (zh)
HR (1) HRP960386B1 (zh)
HU (1) HU225480B1 (zh)
IL (1) IL119078A (zh)
IS (1) IS1947B (zh)
MA (1) MA23961A1 (zh)
MX (1) MX9801467A (zh)
MY (1) MY114800A (zh)
NO (1) NO310720B1 (zh)
NZ (1) NZ308207A (zh)
OA (1) OA10666A (zh)
PE (2) PE20010700A1 (zh)
PL (1) PL186773B1 (zh)
PT (2) PT861235E (zh)
RO (1) RO119299B1 (zh)
RU (1) RU2152930C2 (zh)
SI (2) SI1114817T1 (zh)
SK (1) SK282925B6 (zh)
TN (1) TNSN96107A1 (zh)
TR (1) TR199800300T1 (zh)
TW (1) TW340842B (zh)
UA (1) UA48981C2 (zh)
WO (1) WO1997008144A1 (zh)
YU (1) YU49122B (zh)

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TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
GEP20043224B (en) * 1999-05-06 2004-04-26 Pfizer Prod Inc Substituted Benzolactam Compounds
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
CA2374643C (en) 1999-05-21 2006-02-14 Pfizer Products Inc. 1-trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives as substance p antagonists
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
AU2004232799A1 (en) 2003-04-18 2004-11-04 Eli Lilly And Company (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists
MXPA06013484A (es) * 2004-05-21 2007-01-23 Pfizer Prod Inc Metabolitos de (+)-(2s, 3s)-3-(2- metoxi-5- trifluorometoxibencilamino) -2-fenil- piperidina.
EP1778639B1 (en) 2004-07-15 2015-09-02 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
KR20080044840A (ko) 2005-07-15 2008-05-21 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
AU2007300627B2 (en) 2006-09-22 2012-02-16 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2008204380B2 (en) 2007-01-10 2013-08-15 Msd Italia S.R.L. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
CA2682727C (en) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Indoledione derivative
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CA2717509A1 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
JP5511080B2 (ja) 2008-03-31 2014-06-04 興和株式会社 1,3−ジヒドロイソベンゾフラン誘導体
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-([1,2,4]트리아졸로[1,5-α]피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
MX2012004377A (es) 2009-10-14 2012-06-01 Merck Sharp & Dohme Piperidinas sustituidas que aumentan la actividad de p53 y sus usos.
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
EP3330377A1 (en) 2010-08-02 2018-06-06 Sirna Therapeutics, Inc. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
EP2606134B1 (en) 2010-08-17 2019-04-10 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
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RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
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UA39168C2 (uk) * 1991-06-20 2001-06-15 Пфайзер, Інк. Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі
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Also Published As

Publication number Publication date
HUP9901159A2 (hu) 1999-07-28
EP1114817B1 (en) 2004-01-21
NO310720B1 (no) 2001-08-20
EP1114817A1 (en) 2001-07-11
ATE208377T1 (de) 2001-11-15
IL119078A0 (en) 1996-11-14
AP643A (en) 1998-04-24
SI1114817T1 (en) 2004-06-30
HRP960386A2 (en) 1998-04-30
CA2227814A1 (en) 1997-03-06
CA2227814C (en) 2002-12-31
DK0861235T3 (da) 2001-12-27
WO1997008144A1 (en) 1997-03-06
TR199800300T1 (xx) 1998-06-22
PE1398A1 (es) 1998-02-27
CZ297543B6 (cs) 2007-02-07
DE69631390D1 (de) 2004-02-26
AU5776996A (en) 1997-03-19
CN1193961A (zh) 1998-09-23
US6506775B1 (en) 2003-01-14
HK1014935A1 (en) 1999-10-08
DE69631390T2 (de) 2004-11-25
IS4644A (is) 1997-12-30
DZ2086A1 (fr) 2002-07-22
NO980751D0 (no) 1998-02-23
ATE258166T1 (de) 2004-02-15
OA10666A (en) 2002-11-25
RU2152930C2 (ru) 2000-07-20
SK282925B6 (sk) 2003-01-09
MA23961A1 (fr) 1997-04-01
BR9609989A (pt) 1999-07-06
YU47896A (sh) 1998-12-23
JP3084069B2 (ja) 2000-09-04
PL325332A1 (en) 1998-07-20
UA48981C2 (uk) 2002-09-16
AP9600850A0 (en) 1996-10-31
CZ52198A3 (cs) 1999-01-13
TNSN96107A1 (fr) 2005-03-15
DE69616817D1 (de) 2001-12-13
AU702698B2 (en) 1999-03-04
SK20798A3 (en) 1999-03-12
HUP9901159A3 (en) 2000-05-29
TW340842B (en) 1998-09-21
HRP960386B1 (en) 2002-04-30
MY114800A (en) 2003-01-31
HU225480B1 (en) 2006-12-28
AR006305A1 (es) 1999-08-25
NZ308207A (en) 1998-07-28
EP0861235A1 (en) 1998-09-02
ES2211684T3 (es) 2004-07-16
PT861235E (pt) 2002-03-28
EP0861235B1 (en) 2001-11-07
IL119078A (en) 2003-11-23
PT1114817E (pt) 2004-05-31
MX9801467A (es) 1998-05-31
RO119299B1 (ro) 2004-07-30
CO4480738A1 (es) 1997-07-09
IS1947B (is) 2004-10-13
BG64126B1 (bg) 2004-01-30
YU49122B (sh) 2004-03-12
KR100288673B1 (ko) 2001-05-02
CN1153764C (zh) 2004-06-16
PL186773B1 (pl) 2004-02-27
ES2163017T3 (es) 2002-01-16
KR19990044077A (ko) 1999-06-25
SI0861235T1 (en) 2002-04-30
PE20010700A1 (es) 2001-07-09
NO980751L (no) 1998-02-23
BG102288A (en) 1998-09-30
DE69616817T2 (de) 2002-04-04
JPH10510554A (ja) 1998-10-13

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