DK1073422T3 - Matricer dannet af polymere og hydrofobe forbindelser til anvendelse ved lægemiddelaflevering - Google Patents

Matricer dannet af polymere og hydrofobe forbindelser til anvendelse ved lægemiddelaflevering

Info

Publication number
DK1073422T3
DK1073422T3 DK99911269T DK99911269T DK1073422T3 DK 1073422 T3 DK1073422 T3 DK 1073422T3 DK 99911269 T DK99911269 T DK 99911269T DK 99911269 T DK99911269 T DK 99911269T DK 1073422 T3 DK1073422 T3 DK 1073422T3
Authority
DK
Denmark
Prior art keywords
drug
hydrophobic
polymeric
matrix
integrated
Prior art date
Application number
DK99911269T
Other languages
English (en)
Inventor
Howard Bernstein
Donald Chickering
Sarwat Khattak
Julie Straub
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Application granted granted Critical
Publication of DK1073422T3 publication Critical patent/DK1073422T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK99911269T 1998-04-30 1999-03-08 Matricer dannet af polymere og hydrofobe forbindelser til anvendelse ved lægemiddelaflevering DK1073422T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8363698P 1998-04-30 1998-04-30
US09/255,179 US6423345B2 (en) 1998-04-30 1999-02-22 Matrices formed of polymer and hydrophobic compounds for use in drug delivery

Publications (1)

Publication Number Publication Date
DK1073422T3 true DK1073422T3 (da) 2006-07-03

Family

ID=26769533

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99911269T DK1073422T3 (da) 1998-04-30 1999-03-08 Matricer dannet af polymere og hydrofobe forbindelser til anvendelse ved lægemiddelaflevering

Country Status (19)

Country Link
US (5) US6423345B2 (da)
EP (1) EP1073422B1 (da)
JP (1) JP5153032B2 (da)
KR (1) KR100703051B1 (da)
CN (1) CN1201729C (da)
AT (1) ATE319433T1 (da)
AU (1) AU746696B2 (da)
BR (1) BR9910340A (da)
CA (1) CA2329875C (da)
DE (1) DE69930240T2 (da)
DK (1) DK1073422T3 (da)
ES (1) ES2259472T3 (da)
IL (2) IL139252A0 (da)
MX (1) MXPA00010566A (da)
NO (1) NO324895B1 (da)
NZ (1) NZ508470A (da)
PL (1) PL196159B1 (da)
PT (1) PT1073422E (da)
WO (1) WO1999056731A1 (da)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6277413B1 (en) * 1998-07-17 2001-08-21 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
JP4936595B2 (ja) * 1999-03-03 2012-05-23 イーライ リリー アンド カンパニー ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物
CN1345333A (zh) 1999-03-03 2002-04-17 伊莱利利公司 棘白菌素/糖类复合物
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
CN100376291C (zh) * 1999-05-27 2008-03-26 阿库斯菲尔公司 多孔药物基质及其制造方法
EP1642572A1 (en) * 1999-05-27 2006-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
IL146659A0 (en) 1999-05-27 2002-07-25 Acusphere Inc Porous drug matrices and method of manufacture thereof
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
CA2395132A1 (en) * 2000-01-05 2001-07-12 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US6589557B2 (en) * 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
WO2002032398A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for drug delivery
AU2001294634B2 (en) 2000-10-16 2006-07-06 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
ATE444060T1 (de) * 2001-06-22 2009-10-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
WO2003035051A2 (en) * 2001-10-19 2003-05-01 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US9308220B2 (en) 2001-12-11 2016-04-12 Cosmo Technologies Limited Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
ITMI20012599A1 (it) * 2001-12-11 2003-06-11 Cosmo Spa Composizioni farmaceutiche per la somministrazione orale di eparina osuoi derivati, utili per la terapia di malattie infiammatorie dell'int
US20050152980A1 (en) 2002-03-13 2005-07-14 Michael Ausborn Pharmeutical microparticles
WO2003079991A2 (en) * 2002-03-20 2003-10-02 Advanced Inhalation Research, Inc. Method for administration of growth hormone via pulmonary delivery
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20040105821A1 (en) * 2002-09-30 2004-06-03 Howard Bernstein Sustained release pharmaceutical formulation for inhalation
AU2003291470A1 (en) * 2002-11-08 2004-06-03 Innovational Holdings, Llc Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
GB0228571D0 (en) * 2002-12-06 2003-01-15 Novartis Ag Organic compounds
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
AU2004226327A1 (en) 2003-03-28 2004-10-14 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
US20050031667A1 (en) 2003-03-31 2005-02-10 Patel Rajesh A. Implantable polymeric device for sustained release of dopamine agonist
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
US7645474B1 (en) * 2003-07-31 2010-01-12 Advanced Cardiovascular Systems, Inc. Method and system of purifying polymers for use with implantable medical devices
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
CN1856296A (zh) * 2003-09-30 2006-11-01 阿库斯菲尔公司 可注射的、口服、或局部用缓释药物制剂
JP4235226B2 (ja) * 2003-10-10 2009-03-11 サムヤン コーポレイション 両親媒性ブロック共重合体及びそれを含む薬剤送達用高分子組成物
US20050084455A1 (en) * 2003-10-16 2005-04-21 Council Of Scientific & Industrial Research Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof
US8157788B2 (en) * 2003-11-06 2012-04-17 Paolo L. Manfredi Multi-site drug delivery platform
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417338A (pt) * 2003-12-04 2007-04-17 Pfizer Prod Inc formas de dosagem de azitromicina multiparticulada por processos a base de lìquido
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
BRPI0417360A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc método para a preparação de multiparticulados farmacêuticos
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
CA2549225A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
KR20050104152A (ko) 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US7862835B2 (en) * 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
DE102005002703C5 (de) 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
JP5178506B2 (ja) * 2005-03-14 2013-04-10 バイオベンション ホールディングス リミテッド ドラッグデリバリー組成物と関連する方法
EP1959961A2 (en) * 2005-12-06 2008-08-27 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
WO2007070843A2 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
EP1973406B1 (en) 2005-12-28 2014-03-12 Advanced Bionutrition Corporation A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US20100004124A1 (en) * 2006-12-05 2010-01-07 David Taft Systems and methods for delivery of materials for agriculture and aquaculture
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
WO2008070118A1 (en) * 2006-12-05 2008-06-12 Landec Corporation Drug delivery
WO2008076975A1 (en) 2006-12-18 2008-06-26 Advanced Bionutrition Corporation A dry food product containing live probiotic
EP3391874A3 (en) * 2007-02-12 2019-04-24 Particle Sciences, Inc. Delivery devices containing encapsulated and/or particle- bound active pharmaceutical ingredients
US8071119B2 (en) * 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
IN266731B (da) * 2007-05-14 2015-05-28 Sustained Nano Systems Llc
US20090148498A1 (en) * 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US8101274B2 (en) * 2007-06-11 2012-01-24 Spedden Richard H Solid state membranes with surface-embedded glycosylated amphiphilic molecules and micelles formed therefrom
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US8877242B2 (en) * 2008-07-14 2014-11-04 Polypid Ltd. Sustained-release drug carrier composition
RU2018129725A (ru) * 2008-07-18 2019-03-20 Байомод Консептс Инк. Изделия, высвобождающие активный ингредиент
WO2010017459A1 (en) 2008-08-07 2010-02-11 Bioactive Surgical, Inc> Stem cell capture and immobilization coatings for medical devices and implants
US11028454B2 (en) * 2008-09-24 2021-06-08 Resilux Incorporation of thermo-resistant and/or pressure-resistant organisms in materials
CA2756883C (en) 2009-03-27 2018-01-09 Advanced Bionutrition Corp. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
ES2643148T3 (es) 2009-05-26 2017-11-21 Advanced Bionutrition Corporation Composición en polvo seco estable que comprende microorganismos biológicamente activos y/o materiales bioactivos y métodos de producción
JP5738856B2 (ja) 2009-07-14 2015-06-24 ポリピッド リミテッド 徐放性薬物担体組成物
US8795726B2 (en) 2010-01-19 2014-08-05 Polypid Ltd. Sustained-release nucleic acid matrix compositions
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
AR080073A1 (es) 2010-01-28 2012-03-14 Advanced Bionutrition Corp Composicion vitrea seca que comprende un material bioactivo
JP2013526572A (ja) 2010-05-17 2013-06-24 アエリエ・ファーマシューティカルズ・インコーポレーテッド 眼治療薬の送達のための薬物送達装置
CN104147605A (zh) 2010-08-13 2014-11-19 高级生物营养公司 用于生物材料的干的贮存稳定用组合物及其制备方法
JP2013538231A (ja) 2010-09-17 2013-10-10 ブラッシカ プロテクション プロダクツ リミテッド ライアビリティ カンパニー グルコシノレートによる処置のための製剤
ITMI20111050A1 (it) 2011-06-10 2012-12-11 Sevecom Spa Uso di emulsionanti in associazione con oleine vegetali in un alimento per animali.
US20140271861A1 (en) * 2011-07-27 2014-09-18 Polypid Ltd. Matrix compositions for controlled release of peptide and polypeptide molecules
CN105287431A (zh) * 2014-05-30 2016-02-03 中国科学院过程工程研究所 一种载活性药物的聚合物脂质球及其制备方法
PE20170138A1 (es) 2014-07-21 2017-03-16 Sevecom Spa Emulsionante en polvo para alimentos para animales
WO2016025911A1 (en) 2014-08-14 2016-02-18 Brown University Compositions for stabilizing and delivering proteins
MY194231A (en) 2015-07-29 2022-11-23 Advanced Bionutrition Corp Stable dry probiotic compositions for special dietary uses
US10327935B2 (en) * 2016-07-21 2019-06-25 Cook Medical Technologies Llc Stent graft with internal constraining mechanism
CA3087238A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
EP3801378A4 (en) 2018-05-24 2022-02-23 Celanese EVA Performance Polymers LLC IMPLANTABLE DEVICE FOR THE DELAYED RELEASE OF A MACROMOLECULAR DRUG COMPOUND
CN112094580A (zh) * 2020-09-01 2020-12-18 杭州曦茂新材料科技有限公司 一种树脂防腐涂料及其生产方法
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409283A (en) 1943-04-21 1946-10-15 James L Hudson Coupling for plastic tubes
US3022209A (en) 1956-11-23 1962-02-20 Phillips Petroleum Co Method of welding butted pipe sections of polyethylene to form a reinforced joint
US3643805A (en) 1970-01-20 1972-02-22 Abcor Water Management Co Inc A membrane system which includes a tube sheet for securing supported membrane tubes therein
US3683960A (en) 1970-11-19 1972-08-15 Jerry Kirsch Block manifold for fluid control systems and method of making the same
GB1390379A (en) 1972-06-28 1975-04-09 Serck Industries Ltd Method of manufacturing hollow articles eg heat exchangers
US3776001A (en) 1973-01-16 1973-12-04 Kimberly Clark Co Self-lubricating compound for use in hygienic and medical applications, and suppositories made therefrom
US4070044A (en) 1976-01-22 1978-01-24 Phillips Petroleum Company Polymer pipe connection and method to make it
US4312687A (en) 1980-12-15 1982-01-26 Chevron Research Company Solar collector headers
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4615114A (en) 1984-03-12 1986-10-07 Asea Electric, Incorporated Method of manufacturing molded buswork for power distribution systems
US4730458A (en) * 1986-09-26 1988-03-15 The United States Of America As Represented By The United States Department Of Energy Thermal electric vapor trap arrangement and method
US5012052A (en) * 1988-03-22 1991-04-30 Indiana University Foundation Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method
US5447341A (en) 1988-06-13 1995-09-05 Metzeler Automotive Profiles Gmbh Molder rubber hose branch
CA1328550C (en) 1988-09-19 1994-04-19 Yoshinori Umezawa Method of fabricating pipe units
NZ231281A (en) 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
US5342628A (en) 1990-10-11 1994-08-30 Applied Medical Research, Inc. Drug diffusion polymer system and method
US5287758A (en) * 1991-01-26 1994-02-22 Behringwerke Ag Temperature controlled pipette tube
US5335944A (en) 1991-03-25 1994-08-09 Toyoda Gosei Co., Ltd. Hose coupling structure
JPH0538769A (ja) 1991-07-19 1993-02-19 Mitsutoyo Jushi Kk ブロー成形管の端部に厚肉フランジを射出成形する方法
JPH0570793A (ja) * 1991-09-10 1993-03-23 Nissei Baadeishie Kk 脂質の粒状組成物
FR2693249B1 (fr) 1992-07-03 1994-09-16 Hutchinson Procédé de raccordement de tubes ou tuyaux, raccords et dispositifs analogues obtenus par sa mise en Óoeuvre.
JP3266656B2 (ja) * 1992-08-18 2002-03-18 日清ファルマ株式会社 ビタミン含浸粒状物およびその製造方法
EP1132080A3 (en) 1992-09-10 2001-10-17 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5411300A (en) 1993-03-16 1995-05-02 Toyoda Gosei Co., Ltd. Hose connecting assembly
FR2710265B1 (fr) 1993-09-22 1995-10-20 Adir Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs.
DE4337492C2 (de) 1993-11-03 1999-06-02 Joerg Michael Dr Re Schierholz Verfahren zur Inkorporierung lipophiler pharmazeutisch wirksamer Substanzen in weiche Kontaktlinsen zur Erstellung ophthalmologischer kontrollierter Freisetzungssysteme mittels diffusionskontrollierter Sorption
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
EP0879135B1 (en) 1996-02-07 2002-06-12 Anthony Joseph Cesaroni Bonding of tubes of thermoplastic polymers
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
JP3544604B2 (ja) * 1996-12-16 2004-07-21 株式会社荏原製作所 切替式トラップ装置
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
DE19631001C1 (de) * 1996-08-01 1997-12-18 Testo Gmbh & Co Kondensatabscheider
KR0181252B1 (ko) * 1996-12-31 1999-03-20 박원훈 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
US5895695A (en) 1997-03-28 1999-04-20 Rowley; William W. Crosslinked overmolded plumbing tubes
JP3347977B2 (ja) * 1997-07-02 2002-11-20 フリヂスター株式会社 液体循環型熱電冷却・加熱装置
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6540926B2 (en) * 1997-10-02 2003-04-01 David Paul Goodrich Filter assembly
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6096178A (en) * 1998-08-24 2000-08-01 Aviv Amirav Electrolyzer device for the operation of flame ionization detectors
US6101815A (en) * 1998-11-09 2000-08-15 General Electric Company Thermo-electrical dehumidifier
US6490879B1 (en) * 2000-09-27 2002-12-10 Assist International Marketing, Inc. Water generating machine
US6427449B1 (en) * 2000-12-15 2002-08-06 Solid State Cooling Systems Compact volatile organic compound removal system
US6370884B1 (en) * 2001-03-30 2002-04-16 Maher I. Kelada Thermoelectric fluid cooling cartridge

Also Published As

Publication number Publication date
NO324895B1 (no) 2007-12-27
ES2259472T3 (es) 2006-10-01
IL139252A0 (en) 2001-11-25
ATE319433T1 (de) 2006-03-15
AU2995499A (en) 1999-11-23
NZ508470A (en) 2003-02-28
CN1301150A (zh) 2001-06-27
JP5153032B2 (ja) 2013-02-27
WO1999056731A1 (en) 1999-11-11
US20070104656A1 (en) 2007-05-10
NO20005452L (no) 2000-12-29
AU746696B2 (en) 2002-05-02
EP1073422B1 (en) 2006-03-08
DE69930240D1 (de) 2006-05-04
US20010000470A1 (en) 2001-04-26
BR9910340A (pt) 2001-01-09
JP2002513752A (ja) 2002-05-14
CN1201729C (zh) 2005-05-18
CA2329875C (en) 2003-09-16
PL343691A1 (en) 2001-08-27
DE69930240T2 (de) 2006-11-23
US7160557B2 (en) 2007-01-09
US20010043948A1 (en) 2001-11-22
US20010000230A1 (en) 2001-04-12
US7052719B2 (en) 2006-05-30
MXPA00010566A (es) 2002-04-24
US20030147962A1 (en) 2003-08-07
PL196159B1 (pl) 2007-12-31
US6423345B2 (en) 2002-07-23
EP1073422A1 (en) 2001-02-07
US6689390B2 (en) 2004-02-10
KR20010043136A (ko) 2001-05-25
KR100703051B1 (ko) 2007-04-05
CA2329875A1 (en) 1999-11-11
NO20005452D0 (no) 2000-10-27
IL139252A (en) 2006-10-31
PT1073422E (pt) 2006-05-31

Similar Documents

Publication Publication Date Title
DK1073422T3 (da) Matricer dannet af polymere og hydrofobe forbindelser til anvendelse ved lægemiddelaflevering
CY1117889T1 (el) Πολυμερες γαλακτικου οξεος και διεργασια για την παραγωγη αυτου
WO2001058474A3 (en) Microencapsulation and sustained release of biologically active agent
DE69432867D1 (de) Zubereitung mit gesteuerter freisetzung
BR9808933A (pt) Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo
NO20001042D0 (no) Oftalmiske preparater med forsinket frigivelse inneholdende vannoppløselige medikamenter
CA2455680A1 (en) Ophthalmic depot formulations for periocular or subconjunctival administration
CA2346341A1 (en) Encapsulated chemicals for use in controlled time release applications and methods
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
WO1999036099A8 (fr) Compositions a liberation controlee, leur procede de fabrication et leur utilisation
CA2322315A1 (en) Fast disintegrating tablets
IL64298A0 (en) Pharmaceutical compositions for the sustained release of hormonally active polypeptides
NO964939D0 (no) Fremgangsmåte for fremstilling av virkestoffpreparater i form av en fast lösning av virkestoffet i en polymermatriks, samt virkestoffpreparater fremstilt ved hjelp av denne fremgangsmåte
FI970934A0 (fi) Implantoitava valukappale vaikuttavien aineiden annostelemiseksi kasveihin
EP1258254A4 (en) COMPOSITIONS FOR DELAYED DELIVERY OF PHYSIOLOGICALLY ACTIVE COMPOUNDS THAT ARE LOW WATER-SOLUBLE, METHOD FOR THE PRODUCTION AND USE THEREOF
DK0904063T3 (da) Fremgangsmåde til fremstilling af mikropartikler
ATE364403T1 (de) Retardtablette hergestellt aus linearen wasserunlöslichen polysacchariden
NO972068D0 (no) Farmasöytisk sammensetning basert på stabiliserte lipofile matriser for kontrollert frigiving av aktive prinsipper
CA2273272A1 (en) Immediate release drug delivery forms
WO2001089477A3 (en) Controlled release of materials from polymer matrices
RU2000125026A (ru) Антиглаукоматозное средство