DE69432867D1 - Zubereitung mit gesteuerter freisetzung - Google Patents
Zubereitung mit gesteuerter freisetzungInfo
- Publication number
- DE69432867D1 DE69432867D1 DE69432867T DE69432867T DE69432867D1 DE 69432867 D1 DE69432867 D1 DE 69432867D1 DE 69432867 T DE69432867 T DE 69432867T DE 69432867 T DE69432867 T DE 69432867T DE 69432867 D1 DE69432867 D1 DE 69432867D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- active compound
- polymer matrix
- controlled release
- microspheres
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPM249293 | 1993-11-18 | ||
AUPM249293 | 1993-11-18 | ||
PCT/AU1994/000708 WO1995013798A1 (en) | 1993-11-18 | 1994-11-17 | Controlled release preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432867D1 true DE69432867D1 (de) | 2003-07-31 |
DE69432867T2 DE69432867T2 (de) | 2004-04-22 |
Family
ID=3777364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432867T Expired - Lifetime DE69432867T2 (de) | 1993-11-18 | 1994-11-17 | Zubereitung mit gesteuerter freisetzung |
Country Status (9)
Country | Link |
---|---|
US (1) | US5932248A (de) |
EP (1) | EP0727984B1 (de) |
JP (1) | JP4619457B2 (de) |
CN (1) | CN1139380A (de) |
AT (1) | ATE243501T1 (de) |
AU (1) | AU693821B2 (de) |
CA (1) | CA2176933A1 (de) |
DE (1) | DE69432867T2 (de) |
WO (1) | WO1995013798A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2775435B1 (fr) * | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
WO1999049908A1 (en) | 1998-03-31 | 1999-10-07 | University Of Cincinnati | Temperature controlled solute delivery system |
CA2248592A1 (en) * | 1998-08-31 | 2000-02-29 | Christopher D. Batich | Microspheres for use in the treatment of cancer |
CN1230152C (zh) * | 1999-02-03 | 2005-12-07 | 鲍德杰克特研究有限公司 | 水凝胶颗粒制剂 |
WO2000053160A1 (en) * | 1999-03-08 | 2000-09-14 | Powderject Research Limited | Delivery of microparticle formulations using needleless syringe device for sustained-release of bioactive compounds |
AU777620B2 (en) * | 1999-04-09 | 2004-10-21 | Jessie L.S. Au | Methods and compositions for enhancing delivery of therapeutic agents to tissues |
JP2001031577A (ja) * | 1999-07-16 | 2001-02-06 | Fujibio Co Ltd | キチン・キトサンによるシスプラチンの副作用防止方法及びそのための配合剤 |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US20030206958A1 (en) * | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
KR100872884B1 (ko) * | 2000-03-24 | 2008-12-10 | 바이오스피어 메디칼 인코포레이티드 | 능동 색전화용 미소구 |
AUPR098300A0 (en) * | 2000-10-25 | 2000-11-16 | Sirtex Medical Limited | Polymer based radionuclide containing microspheres |
DE60138641D1 (de) | 2000-10-27 | 2009-06-18 | Baxter Healthcare Sa | Herstellung von mikrokügelchen |
AU3104102A (en) * | 2000-12-18 | 2002-07-01 | Univ Texas | Local regional chemotherapy and radiotherapy using in situ hydrogel |
DK1418890T3 (da) * | 2001-08-16 | 2008-08-11 | Baxter Int | Drivmiddel-baserede mikropartikelformuleringer |
US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
WO2003020242A1 (en) * | 2001-08-29 | 2003-03-13 | Srl Technologies, Inc. | Sustained release preparations |
US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
US8685427B2 (en) * | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
US8920826B2 (en) | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
DE602004014101D1 (de) * | 2003-02-12 | 2008-07-10 | Biocompatibles Uk Ltd | Zusammensetzungen für die chemoembolotherapie solider tumoren |
CN106344968B (zh) * | 2003-02-12 | 2019-09-24 | 生物相容英国有限公司 | 组合物在制备用于在实体瘤的患者进行栓塞治疗中在循环系统中形成栓塞的药物中的用途 |
US20040161466A1 (en) | 2003-02-14 | 2004-08-19 | Biocompatibles Uk Limited | Chemoembolisation |
US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
RU2426590C2 (ru) * | 2003-07-18 | 2011-08-20 | Бакстер Интернэшнл Инк. | Способы изготовления, применение и композиции небольших сферических частиц, приготовленных регулируемым фазовым разделением |
JP2007508240A (ja) * | 2003-07-22 | 2007-04-05 | バクスター・インターナショナル・インコーポレイテッド | 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法 |
WO2005087193A2 (en) * | 2004-03-11 | 2005-09-22 | Biocompatibles Uk Limited | Chemoembolisation involving an anthracycline compound |
US20060141046A1 (en) * | 2004-05-06 | 2006-06-29 | Ivrea Pharmaceuticals, Inc. | Particles for the delivery of active agents |
EP1742612A2 (de) * | 2004-05-06 | 2007-01-17 | Ivrea Pharmaceuticals, Inc. | Partikel zur wirkstofffreisetzung |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
US8333995B2 (en) | 2004-05-12 | 2012-12-18 | Baxter International, Inc. | Protein microspheres having injectable properties at high concentrations |
MXPA06012989A (es) * | 2004-05-12 | 2007-06-12 | Baxter Int | Microesferas de acidos nucleicos, produccion y suministro de las mismas. |
PT1765294E (pt) * | 2004-05-12 | 2008-12-30 | Baxter Healthcare Sa | Microesferas de ácido nucleico, sua produção e entrega |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
AU2006241145B2 (en) * | 2005-04-27 | 2011-04-28 | Baxter Healthcare S. A. | Surface-modified microparticles and methods of forming and using the same |
CN101237857A (zh) | 2005-05-09 | 2008-08-06 | 生物领域医疗公司 | 使用微球和非离子型造影剂的组合物和方法 |
US8343546B2 (en) * | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
CN101405051A (zh) * | 2006-03-21 | 2009-04-08 | 阿尔扎公司 | 用于药物电转运的可水化聚合酯基质 |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
EP2056883B1 (de) | 2006-08-04 | 2021-09-22 | Baxter International Inc. | Zusammensetzung auf mikrokügelchenbasis zur vorbeugung und/oder abwendung einer neuerkrankung an autoimmunem diabetes |
CZ2006505A3 (cs) * | 2006-08-09 | 2008-04-09 | Zentiva, A. S. | Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy |
CZ298945B6 (cs) * | 2006-09-18 | 2008-03-19 | Zentiva, A. S. | Polymerní lécivo a zpusob jeho výroby |
CA2663589A1 (en) * | 2006-10-06 | 2008-05-22 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
US20080255181A1 (en) * | 2006-12-15 | 2008-10-16 | University Of Heidelberg | Methods for treating podocyte-related disorders |
KR101389376B1 (ko) * | 2007-02-23 | 2014-04-29 | 에스케이케미칼주식회사 | 제 8 인자 및 그의 유도체의 제조 및 정제 방법 |
US8568777B2 (en) * | 2007-03-30 | 2013-10-29 | Monosol Rx, Llc | Packaged film dosage unit containing a complexate |
JP2008120838A (ja) * | 2008-02-21 | 2008-05-29 | Medgel Corp | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8540667B2 (en) * | 2008-11-12 | 2013-09-24 | Sanovas, Inc. | Multi-balloon catheter for extravasated drug delivery |
US8226601B2 (en) | 2008-11-12 | 2012-07-24 | Sanovas, Inc. | Resector balloon system |
US20160074581A1 (en) | 2014-09-17 | 2016-03-17 | Lawrence J. Gerrans | Modulated Drug Delivery |
US8597239B2 (en) | 2011-03-01 | 2013-12-03 | Sanovas, Inc. | Abrading balloon catheter for extravasated drug delivery |
US9499605B2 (en) | 2011-03-03 | 2016-11-22 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
TWI568453B (zh) * | 2011-11-22 | 2017-02-01 | 原創生醫股份有限公司 | 具有螯合型複合微胞之藥物載體及其應用 |
WO2014077629A1 (ko) * | 2012-11-15 | 2014-05-22 | 재단법인 유타 인하 디디에스 및 신의료기술개발공동연구소 | 알부민 및 덱스트란 설페이트를 포함하는 항암제 흡착능력이 향상된 생분해성 마이크로 비드 및 이의 제조방법 |
CN104994841B (zh) * | 2012-11-27 | 2018-11-16 | 犹他-仁荷Dds及新医疗技术开发共同研究所 | 包含阴离子性高分子的抗癌药吸附能力得到提高的生物降解性微珠及其的制备方法 |
WO2014152790A1 (en) * | 2013-03-14 | 2014-09-25 | Drexel University | Chelated drug delivery systems |
CN105960232B (zh) * | 2014-01-27 | 2019-03-08 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 亲水活性化合物的纳米包封 |
KR101614911B1 (ko) * | 2014-05-14 | 2016-04-25 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 제 1 및 제 2 생분해성 마이크로 비드를 포함하는 화학색전용 조성물 및 이의 제조방법 |
CN105125522B (zh) * | 2015-09-05 | 2018-08-21 | 四川大学 | 一种透明质酸-阳离子药物离子对微粒 |
US11246945B2 (en) * | 2019-06-07 | 2022-02-15 | National Defense Medical Center | Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer |
CN114947108A (zh) * | 2022-04-28 | 2022-08-30 | 中国农业大学 | 酪蛋白胶束精准控释组合物及其制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
FR2585246A1 (fr) * | 1985-07-26 | 1987-01-30 | Cortial | Procede d'obtention de formes pharmaceutiques solides a liberation prolongee |
US4946686A (en) * | 1987-09-24 | 1990-08-07 | Merck & Co., Inc. | Solubility modulated drug delivery system |
US5100668A (en) * | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
US5271945A (en) * | 1988-07-05 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Sustained release microcapsule for water soluble drug |
US4996047A (en) * | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
CA2014244A1 (en) * | 1989-04-13 | 1990-10-13 | Takeda Chemical Industries, Ltd. | Stabilized composition of anthracyclines |
US5288496A (en) * | 1990-05-15 | 1994-02-22 | Stolle Research & Development Corporation | Growth promoters for animals |
BR9107173A (pt) * | 1990-12-21 | 1993-11-16 | Richardson Vicks Inc | Complexos de medicamentos de poliamina e resina |
WO1992011844A1 (en) * | 1991-01-03 | 1992-07-23 | Alkermes Controlled Therapeutics, Inc. | Stabilization of proteins by cationic biopolymers |
JPH07507768A (ja) * | 1992-03-12 | 1995-08-31 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | Acth含有マイクロスフェアの制御放出 |
-
1994
- 1994-11-17 EP EP95900570A patent/EP0727984B1/de not_active Expired - Lifetime
- 1994-11-17 CN CN94194617A patent/CN1139380A/zh active Pending
- 1994-11-17 AT AT95900570T patent/ATE243501T1/de not_active IP Right Cessation
- 1994-11-17 CA CA002176933A patent/CA2176933A1/en not_active Abandoned
- 1994-11-17 WO PCT/AU1994/000708 patent/WO1995013798A1/en active IP Right Grant
- 1994-11-17 AU AU81363/94A patent/AU693821B2/en not_active Ceased
- 1994-11-17 DE DE69432867T patent/DE69432867T2/de not_active Expired - Lifetime
- 1994-11-17 US US08/648,055 patent/US5932248A/en not_active Expired - Lifetime
- 1994-11-17 JP JP51411195A patent/JP4619457B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0727984A1 (de) | 1996-08-28 |
CA2176933A1 (en) | 1995-05-26 |
US5932248A (en) | 1999-08-03 |
JPH09505059A (ja) | 1997-05-20 |
JP4619457B2 (ja) | 2011-01-26 |
CN1139380A (zh) | 1997-01-01 |
AU693821B2 (en) | 1998-07-09 |
AU8136394A (en) | 1995-06-06 |
EP0727984B1 (de) | 2003-06-25 |
ATE243501T1 (de) | 2003-07-15 |
EP0727984A4 (de) | 1997-09-10 |
WO1995013798A1 (en) | 1995-05-26 |
DE69432867T2 (de) | 2004-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |