DE602004014101D1 - Zusammensetzungen für die chemoembolotherapie solider tumoren - Google Patents

Zusammensetzungen für die chemoembolotherapie solider tumoren

Info

Publication number
DE602004014101D1
DE602004014101D1 DE602004014101T DE602004014101T DE602004014101D1 DE 602004014101 D1 DE602004014101 D1 DE 602004014101D1 DE 602004014101 T DE602004014101 T DE 602004014101T DE 602004014101 T DE602004014101 T DE 602004014101T DE 602004014101 D1 DE602004014101 D1 DE 602004014101D1
Authority
DE
Germany
Prior art keywords
chemoembolotherapy
compositions
solid tumors
polymer
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004014101T
Other languages
English (en)
Inventor
Andrew Lennard Lewis
Peter W Straford
Simon William Leppard
Brenda Hall
Fajardo Maria V Gonzalez
Pedro Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Publication of DE602004014101D1 publication Critical patent/DE602004014101D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/14—Organic medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups
DE602004014101T 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren Expired - Lifetime DE602004014101D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation
PCT/GB2004/000548 WO2004071495A1 (en) 2003-02-12 2004-02-12 Composition for chemoembolotherapy of solid tumors

Publications (1)

Publication Number Publication Date
DE602004014101D1 true DE602004014101D1 (de) 2008-07-10

Family

ID=32870779

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014101T Expired - Lifetime DE602004014101D1 (de) 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren

Country Status (9)

Country Link
EP (1) EP1592405B1 (de)
JP (2) JP4895802B2 (de)
KR (1) KR101157260B1 (de)
CN (4) CN103908704B (de)
AT (1) ATE396708T1 (de)
DE (1) DE602004014101D1 (de)
ES (1) ES2308149T3 (de)
HK (1) HK1079980B (de)
WO (1) WO2004071495A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60130743T2 (de) 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
EP1796644B1 (de) * 2004-09-07 2011-04-13 Biocompatibles UK Limited Arzneimittelabgabe aus embolischen mitteln
WO2006119968A2 (en) * 2005-05-09 2006-11-16 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
EP1978938B1 (de) * 2006-01-24 2015-09-09 Biocompatibles UK Limited Verfahren zum laden von polymerteilchen mit wirkstoffen
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US9107833B2 (en) 2006-06-22 2015-08-18 Biocompatibles Uk Limited Rehydratable pharmaceutical product
EP1985286A1 (de) 2007-04-24 2008-10-29 Biocompatibles UK Limited Mikrokügelchen zur Behandlung von Gehirntumoren
JP5302300B2 (ja) * 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
JP2010536738A (ja) * 2007-08-16 2010-12-02 バイオコンパティブルズ ユーケー リミテッド 薬剤の組み合わせの送達
CA2745238A1 (en) * 2008-12-02 2010-06-10 Biocompatibles Uk Limited Pancreatic tumour treatment
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
US20150224221A1 (en) 2012-08-31 2015-08-13 Chung-Ang University Industry-Academic Cooperation Foundation Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
CN117982687A (zh) 2013-03-15 2024-05-07 生物兼容英国有限公司 可成像栓塞微球
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2016139590A1 (en) * 2015-03-02 2016-09-09 Accurate Medical Therapeutics Ltd. Embolization particulates for occluding a blood vessel
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
CA3016293C (en) 2016-03-14 2023-10-10 Biocompatibles Uk Limited Emulsion comprising particles
EP3541368B1 (de) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Abbildbare partikel, verfahren zur herstellung und verfahren zur verwendung davon
WO2019014408A1 (en) * 2017-07-13 2019-01-17 Boston Scientific Scimed, Inc. EMBOLIC MICROSPHERES
EP3703583A4 (de) 2017-11-02 2020-12-30 Accurate Medical Therapeutics Ltd. Embolisationskatheter mit integriertem filter
US11702498B2 (en) 2018-06-29 2023-07-18 Biocompatibles Uk Limited Radiopaque polymers
US20200297635A1 (en) 2019-03-22 2020-09-24 Biocompatibles Uk Limited Embolic microspheres and methods
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
CN115484961A (zh) * 2020-02-25 2022-12-16 海必恩制药公司 环孢菌素类似物用于治疗癌症的用途
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
US20230201122A1 (en) 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom
JP3041627B2 (ja) * 1989-04-13 2000-05-15 武田薬品工業株式会社 アントラサイクリン系抗生物質の安定組成物
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
WO1995013798A1 (en) * 1993-11-18 1995-05-26 Cancer Research Institute Inc. Controlled release preparation
AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
DE60130544T2 (de) * 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
DE60129148T2 (de) * 2000-10-06 2008-02-28 Biocompatibles Uk Ltd., Farnham Zwitterionische polymere
EP1556090A1 (de) * 2002-09-25 2005-07-27 Biocompatibles UK Limited Polymerzusammensetzungen zur verabreichung an tiere

Also Published As

Publication number Publication date
CN103908704A (zh) 2014-07-09
KR101157260B1 (ko) 2012-06-15
JP4895802B2 (ja) 2012-03-14
HK1079980A1 (en) 2006-04-21
JP2006515358A (ja) 2006-05-25
CN102895662B (zh) 2017-09-12
HK1079980B (zh) 2008-11-14
JP5616251B2 (ja) 2014-10-29
JP2011178784A (ja) 2011-09-15
CN103908704B (zh) 2017-09-01
EP1592405A1 (de) 2005-11-09
CN106267325A (zh) 2017-01-04
KR20050103224A (ko) 2005-10-27
CN102895662A (zh) 2013-01-30
ATE396708T1 (de) 2008-06-15
EP1592405B1 (de) 2008-05-28
WO2004071495A1 (en) 2004-08-26
CN103393605A (zh) 2013-11-20
CN103393605B (zh) 2018-05-29
CN106267325B (zh) 2019-09-24
ES2308149T3 (es) 2008-12-01

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