WO1999061010A3 - Treatment of infertility with cam-increasing compounds alone or in combination with at least one meiosis-stimulating compound - Google Patents

Treatment of infertility with cam-increasing compounds alone or in combination with at least one meiosis-stimulating compound Download PDF

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Publication number
WO1999061010A3
WO1999061010A3 PCT/EP1999/003138 EP9903138W WO9961010A3 WO 1999061010 A3 WO1999061010 A3 WO 1999061010A3 EP 9903138 W EP9903138 W EP 9903138W WO 9961010 A3 WO9961010 A3 WO 9961010A3
Authority
WO
WIPO (PCT)
Prior art keywords
meiosis
stimulating compound
infertility
treatment
combination
Prior art date
Application number
PCT/EP1999/003138
Other languages
French (fr)
Other versions
WO1999061010A2 (en
Inventor
Christa Hegele-Hartung
Quoc-Lam Cam
Original Assignee
Schering Ag
Hegele Hartung Christa
Cam Quoc Lam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Hegele Hartung Christa, Cam Quoc Lam filed Critical Schering Ag
Priority to JP2000550470A priority Critical patent/JP2002516272A/en
Priority to EP99939972A priority patent/EP1098652A2/en
Priority to KR1020007013278A priority patent/KR20010043828A/en
Priority to AU54089/99A priority patent/AU5408999A/en
Priority to CA002333320A priority patent/CA2333320A1/en
Publication of WO1999061010A2 publication Critical patent/WO1999061010A2/en
Publication of WO1999061010A3 publication Critical patent/WO1999061010A3/en
Priority to NO20005954A priority patent/NO20005954D0/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a pharmaceutical composition comprising c-AMP-increasing compounds in low dose and at least one meiosis-stimulating compound for the treatment of infertility and to the use of low dose c-AMP-increasing compounds alone or in combination with at least one meiosis-stimulating compound to increase the rate of fertilization in a mammal and for the preparation of medicaments. The preferred c-AMP-increasing compound is Hypoxanthine. The meiosis-stimulating compound is FF-MAS (4,4-dimethyl-5alpha-cholest-8,14,24-trien-3beta-ol).
PCT/EP1999/003138 1998-05-26 1999-05-07 Treatment of infertility with cam-increasing compounds alone or in combination with at least one meiosis-stimulating compound WO1999061010A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000550470A JP2002516272A (en) 1998-05-26 1999-05-07 Fertility treatment with a compound that increases cAMP alone or in combination with at least one compound that stimulates meiosis
EP99939972A EP1098652A2 (en) 1998-05-26 1999-05-07 Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound
KR1020007013278A KR20010043828A (en) 1998-05-26 1999-05-07 Treatment of Infertility with cAMP-Increasing Compounds Alone or in Combination with at Least One Meiosis-Stimulating Compound
AU54089/99A AU5408999A (en) 1998-05-26 1999-05-07 Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound
CA002333320A CA2333320A1 (en) 1998-05-26 1999-05-07 Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound
NO20005954A NO20005954D0 (en) 1998-05-26 2000-11-24 Treatment of infertility with cAMP-increasing compounds alone or in combination with at least one meiosis stimulant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98250177.7 1998-05-26
EP98250177 1998-05-26

Publications (2)

Publication Number Publication Date
WO1999061010A2 WO1999061010A2 (en) 1999-12-02
WO1999061010A3 true WO1999061010A3 (en) 2000-04-27

Family

ID=8234594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003138 WO1999061010A2 (en) 1998-05-26 1999-05-07 Treatment of infertility with cam-increasing compounds alone or in combination with at least one meiosis-stimulating compound

Country Status (7)

Country Link
EP (1) EP1098652A2 (en)
JP (1) JP2002516272A (en)
KR (1) KR20010043828A (en)
AU (1) AU5408999A (en)
CA (1) CA2333320A1 (en)
NO (1) NO20005954D0 (en)
WO (1) WO1999061010A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL202224B1 (en) 1999-09-16 2009-06-30 Novo Nordisk As Composition for ivf
US6544166B1 (en) 1999-11-25 2003-04-08 Groendahl Christian Treatment of human infertility
WO2001038493A1 (en) * 1999-11-25 2001-05-31 Novo Nordisk A/S Treatment of human infertility
WO2001062258A2 (en) * 2000-02-25 2001-08-30 Schering Aktiengesellschaft Improvement of implantation rate using ff-mas
AU3376501A (en) * 2000-02-25 2001-09-03 Novo Nordisk A/S Improvement of implantation rate
WO2001076360A2 (en) * 2000-04-06 2001-10-18 Novo Nordisk A/S Synchronization of the cytoplasmatic and the nuclear maturation of oocytes in vitro
EP1147774A1 (en) * 2000-04-20 2001-10-24 Stichting Dienst Landbouwkundig Onderzoek Method for improving the quality of sperm for artificial insemination of animals
MXPA02011271A (en) * 2000-05-18 2003-04-25 Schering Ag Fertilization of aged oocytes.
EP1245572A1 (en) 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation
KR20040075004A (en) * 2001-12-14 2004-08-26 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Method of inducing ovulation using non-polypeptide camp level modulator
WO2003070766A2 (en) * 2002-02-22 2003-08-28 Novo Nordisk A/S A transducer of mas signalling
EP2750692B1 (en) 2011-08-30 2016-08-03 Centre National De La Recherche Scientifique Protein complex comprising mcm8 and mcm9 proteins and their use
GB201117453D0 (en) * 2011-10-10 2011-11-23 Univ Dundee Improved sperm function/activity
CN108531447B (en) * 2018-04-13 2021-11-23 上海市生物医药技术研究院 Compound for regulating sperm motility and assisted reproduction and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0196530A2 (en) * 1985-03-26 1986-10-08 CTA Finanz AG Agent and process for increasing growth, for optimizing fertility and for stimulating the immune system in humans and animals
WO1996000235A1 (en) * 1994-06-23 1996-01-04 Novo Nordisk A/S Sterol derivatives used for regulation of meiosis
WO1996027658A1 (en) * 1995-03-06 1996-09-12 Novo Nordisk A/S Stimulation of meiosis
WO1998004366A1 (en) * 1996-07-26 1998-02-05 Cauldron Limited Partnership Removal of material by radiation applied at an oblique angle
US5882928A (en) * 1997-03-11 1999-03-16 Oocytechs Research Corporation In vitro maturation and fertilization of mammalian oocytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0196530A2 (en) * 1985-03-26 1986-10-08 CTA Finanz AG Agent and process for increasing growth, for optimizing fertility and for stimulating the immune system in humans and animals
WO1996000235A1 (en) * 1994-06-23 1996-01-04 Novo Nordisk A/S Sterol derivatives used for regulation of meiosis
WO1996027658A1 (en) * 1995-03-06 1996-09-12 Novo Nordisk A/S Stimulation of meiosis
WO1998004366A1 (en) * 1996-07-26 1998-02-05 Cauldron Limited Partnership Removal of material by radiation applied at an oblique angle
US5882928A (en) * 1997-03-11 1999-03-16 Oocytechs Research Corporation In vitro maturation and fertilization of mammalian oocytes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BYSKOV A G ET AL: "CHEMICAL STRUCTURE OF STEROLS THAT ACTIVATE OOCYTE MEIOSIS", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 374, no. 6522, 6 April 1995 (1995-04-06), pages 559 - 562, XP002043016, ISSN: 0028-0836 *
CARROLL J ET AL: "Effect of dibutyryl cyclic adenosine monophosphate on granulosa cell proliferation, oocyte growth and meiotic maturation in isolated mouse primary ovarian follicles cultured in collagen gels.", JOURNAL OF REPRODUCTION AND FERTILITY, (1991 MAY) 92 (1) 197-207., XP000874962 *
DIENHART, MARY K. ET AL: "Cyclic AMP reversal of hypoxanthine-arrested preimplantation mouse embryos is EDTA-dependent", ZYGOTE (1996), 4(2), 129-137, XP000874771 *
HARADA, M. ET AL: "Bovine oocytes from early antral follicles grow to meiotic competence in vitro: Effect of FSH and hypoxanthine.", THERIOGENOLOGY, (1997) VOL. 48, NO. 5, PP. 743-755., XP000874856 *
OTTESEN, JAN L. ET AL: "The effect of meiosis activating sterol (MAS) and some oxysterols on the resumption of meiosis in mouse oocytes cultured in vitro.", BIOLOGY OF REPRODUCTION, (1997) VOL. 56, NO. SUPPL. 1, PP. 97. MEETING INFO.: THIRTIETH ANNUAL MEETING OF THE SOCIETY FOR THE STUDY OF REPRODUCTION PORTLAND, OREGON, USA AUGUST 2-5, 1997, XP000874956 *
RUAN, BENFANG ET AL: "Sterols affecting meiosis: novel chemical syntheses and the biological activity and spectral properties of the synthetic sterols", J. LIPID RES. (1998), 39(10), 2005-2020, XP000874959 *
WARIKOO P K ET AL: "Hypoxanthine and cyclic adenosine 5'-monophosphate maintain meiotic arrest of rhesus monkey oocytes in vitro.", FERTILITY AND STERILITY, (1989 MAY) 51 (5) 886-9., XP000874960 *
WIERSMA A ET AL: "SPECIFIC PHOSPHODIESTERASE 3 INHIBITORS PREVENT THE RESUMPTION OF MEIOSIS IN MOUSE OOCYTES IN VITRO", BIOLOGY OF REPRODUCTION,US,ORLANDO, FL, vol. 56, no. SUPPL. 01, 1997, pages 91, XP000874782, ISSN: 0006-3363 *
WIERSMA, A. ET AL: "Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents", J. CLIN. INVEST. (1998), 102(3), 532-537, XP000874944 *

Also Published As

Publication number Publication date
WO1999061010A2 (en) 1999-12-02
NO20005954L (en) 2000-11-24
AU5408999A (en) 1999-12-13
KR20010043828A (en) 2001-05-25
JP2002516272A (en) 2002-06-04
EP1098652A2 (en) 2001-05-16
NO20005954D0 (en) 2000-11-24
CA2333320A1 (en) 1999-12-02

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