BR9910340A - Matriz polimérica para a distribuição de um agente terapêutico ou profilático, método para a fabricação e administração da mesma - Google Patents

Matriz polimérica para a distribuição de um agente terapêutico ou profilático, método para a fabricação e administração da mesma

Info

Publication number
BR9910340A
BR9910340A BR9910340-0A BR9910340A BR9910340A BR 9910340 A BR9910340 A BR 9910340A BR 9910340 A BR9910340 A BR 9910340A BR 9910340 A BR9910340 A BR 9910340A
Authority
BR
Brazil
Prior art keywords
drug
polymeric matrix
matrix
hydrophobic
integrated
Prior art date
Application number
BR9910340-0A
Other languages
English (en)
Inventor
Howard Bernstein
Donald Chickering
Sarwat Khattak
Julie Ann Straub
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of BR9910340A publication Critical patent/BR9910340A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<B>"MATRIZ POLIMéRICA PARA A DISTRIBUIçãO DE UM AGENTE TERAPêUTICO OU PROFILáTICO, MéTODO PARA A FABRICAçãO E ADMINISTRAçãO DA MESMA"<D>. Um lipídeo ou outro composto hidrofóbico ou amfifílico (doravante coletivamente designados por "compostos hidrofóbicos") é integrado dentro de uma matriz polimérica para a distribuição de droga para alterar a cinética de liberação de droga. Em incorporações nas quais a droga é solúvel em água, a droga é liberada ao longo de períodos de tempo mais longos se comparados à liberação a partir de uma matriz polimérica que não incorpora o composto hidrofóbico no material polimérico. Em contraste com os métodos nos quais um surfactante ou lipídeo é adicionado a um excipiente, o composto hidrofóbico é efetivamente integrado dentro da matriz polimérica, modificando desta forma a difusão de água para dentro da micropartícula e a difusão de droga solubilizada para fora da matriz. O composto hidrofóbico integrado também prolonga a degradação de polímeros hidroliticamente instáveis formando a matriz, retardando ainda mais a liberação de droga encapsulada.
BR9910340-0A 1998-04-30 1999-03-08 Matriz polimérica para a distribuição de um agente terapêutico ou profilático, método para a fabricação e administração da mesma BR9910340A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8363698P 1998-04-30 1998-04-30
US09/255,179 US6423345B2 (en) 1998-04-30 1999-02-22 Matrices formed of polymer and hydrophobic compounds for use in drug delivery
PCT/US1999/005187 WO1999056731A1 (en) 1998-04-30 1999-03-08 Matrices formed of polymer and hydrophobic compounds for use in drug delivery

Publications (1)

Publication Number Publication Date
BR9910340A true BR9910340A (pt) 2001-01-09

Family

ID=26769533

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910340-0A BR9910340A (pt) 1998-04-30 1999-03-08 Matriz polimérica para a distribuição de um agente terapêutico ou profilático, método para a fabricação e administração da mesma

Country Status (19)

Country Link
US (5) US6423345B2 (pt)
EP (1) EP1073422B1 (pt)
JP (1) JP5153032B2 (pt)
KR (1) KR100703051B1 (pt)
CN (1) CN1201729C (pt)
AT (1) ATE319433T1 (pt)
AU (1) AU746696B2 (pt)
BR (1) BR9910340A (pt)
CA (1) CA2329875C (pt)
DE (1) DE69930240T2 (pt)
DK (1) DK1073422T3 (pt)
ES (1) ES2259472T3 (pt)
IL (2) IL139252A0 (pt)
MX (1) MXPA00010566A (pt)
NO (1) NO324895B1 (pt)
NZ (1) NZ508470A (pt)
PL (1) PL196159B1 (pt)
PT (1) PT1073422E (pt)
WO (1) WO1999056731A1 (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170215457A1 (en) 2014-07-21 2017-08-03 Sevecom S.P.A. Powdered emulsion for animal feed
US11213052B2 (en) 2011-06-10 2022-01-04 Sevecom S.P.A. Use of emulsifiers in association with vegetable oleins in an animal feed

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
ES2325141T3 (es) * 1998-07-17 2009-08-26 Pacira Pharmaceuticals, Inc. Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas.
CA2362481C (en) * 1999-03-03 2008-11-04 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
WO2000052037A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
EP1642572A1 (en) * 1999-05-27 2006-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
IL146659A0 (en) * 1999-05-27 2002-07-25 Acusphere Inc Porous drug matrices and method of manufacture thereof
CN100376291C (zh) * 1999-05-27 2008-03-26 阿库斯菲尔公司 多孔药物基质及其制造方法
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
WO2001049268A1 (en) * 2000-01-05 2001-07-12 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US6589557B2 (en) * 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
US20020150621A1 (en) * 2000-10-16 2002-10-17 Kohane Daniel S. Lipid-protein-sugar particles for drug delivery
ES2243556T3 (es) 2000-10-16 2005-12-01 Conor Medsystems, Inc. Dispositivo medico expandible para proporcionar un agente beneficioso.
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
BR0210518A (pt) 2001-06-22 2004-06-22 Pfizer Prod Inc Composições farmacêuticas de dispersões de drogas e polìmeros neutros
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
AU2002335046A1 (en) * 2001-10-19 2003-05-06 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US9308220B2 (en) 2001-12-11 2016-04-12 Cosmo Technologies Limited Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
ITMI20012599A1 (it) * 2001-12-11 2003-06-11 Cosmo Spa Composizioni farmaceutiche per la somministrazione orale di eparina osuoi derivati, utili per la terapia di malattie infiammatorie dell'int
AU2003221497A1 (en) 2002-03-13 2003-09-22 Novartis Ag Pharmaceutical microparticles
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
JP2005520847A (ja) * 2002-03-20 2005-07-14 アドバンスト インハレーション リサーチ，インコーポレイテッド 肺投与用ｈＧＨ（ヒト成長ホルモン）製剤
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20040105821A1 (en) * 2002-09-30 2004-06-03 Howard Bernstein Sustained release pharmaceutical formulation for inhalation
WO2004043509A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
GB0228571D0 (en) * 2002-12-06 2003-01-15 Novartis Ag Organic compounds
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
WO2004087214A1 (en) 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
CN102772357B (zh) * 2003-03-31 2014-12-31 泰坦医药品公司 用于持续释放多巴胺受体激动剂的可植入聚合物装置
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7645474B1 (en) * 2003-07-31 2010-01-12 Advanced Cardiovascular Systems, Inc. Method and system of purifying polymers for use with implantable medical devices
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
BRPI0414907A (pt) * 2003-09-30 2006-11-07 Acusphere Inc formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물
US20050084455A1 (en) * 2003-10-16 2005-04-21 Council Of Scientific & Industrial Research Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof
US8157788B2 (en) * 2003-11-06 2012-04-17 Paolo L. Manfredi Multi-site drug delivery platform
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
EP1691786A1 (en) * 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
SI1691787T1 (sl) * 2003-12-04 2008-10-31 Pfizer Prod Inc Postopek za pripravo farmacevtskih produktov iz več delcev
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
KR20050104152A (ko) 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US7862835B2 (en) * 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
DE102005002703C5 (de) 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
EP1879552B1 (en) * 2005-03-14 2016-02-17 Biotegra, Inc. Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix
US8246984B2 (en) * 2005-12-06 2012-08-21 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
EP1978933A2 (en) * 2005-12-15 2008-10-15 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
DK1973406T3 (da) 2005-12-28 2014-06-23 Advanced Bionutrition Corp Fremføringsmiddel til probiotiske bakerier omfattende en tør blanding af polysaccharider, saccharider, polyoler i glasform
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
WO2008070118A1 (en) * 2006-12-05 2008-06-12 Landec Corporation Drug delivery
US20100004124A1 (en) * 2006-12-05 2010-01-07 David Taft Systems and methods for delivery of materials for agriculture and aquaculture
EP2117354B1 (en) * 2006-12-18 2018-08-08 Advanced BioNutrition Corp. A dry food product containing live probiotic
US10258571B2 (en) * 2007-02-12 2019-04-16 Particle Sciences, Inc. Delivery devices containing encapsulated and/or practice-bound active pharmaceutical ingredients
US20090148498A1 (en) * 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
IN266731B (pt) * 2007-05-14 2015-05-28 Sustained Nano Systems Llc
US8071119B2 (en) * 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US8101274B2 (en) * 2007-06-11 2012-01-24 Spedden Richard H Solid state membranes with surface-embedded glycosylated amphiphilic molecules and micelles formed therefrom
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
ES2630805T3 (es) * 2008-07-14 2017-08-24 Polypid Ltd. Composición de vehículo de fármaco de liberación sostenida
BRPI0910382B1 (pt) 2008-07-18 2021-07-06 Biomod Concepts Inc Artigo para aplicar um ingrediente ativo, veículo de aplicação para transferência de micropartículas a um substrato, micropartícula para liberar um ingrediente ativo e método para liberar um ingrediente ativo
KR20110042107A (ko) 2008-08-07 2011-04-22 바이오엑티브 써지컬, 아이엔씨. 의료 장치 및 이식물을 위한 줄기 세포 포획 및 고정화 코팅
CN102369105A (zh) * 2008-09-24 2012-03-07 莱斯勒斯公司 在材料中引入耐热和/或耐压生物
EP2410996B1 (en) 2009-03-27 2017-08-02 Advanced Bionutrition Corp. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
SG176253A1 (en) 2009-05-26 2011-12-29 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
CN102470105B (zh) 2009-07-14 2015-07-29 波利皮得有限公司 持续释放药物载体组合物
JP5860409B2 (ja) * 2010-01-19 2016-02-16 ポリピッド リミテッド 徐放性核酸マトリックス組成物
WO2011094469A2 (en) 2010-01-28 2011-08-04 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
JP2013526572A (ja) 2010-05-17 2013-06-24 アエリエ・ファーマシューティカルズ・インコーポレーテッド 眼治療薬の送達のための薬物送達装置
LT2603100T (lt) 2010-08-13 2018-07-25 Advanced Bionutrition Corp. Stabilizuojanti kompozicija, skirta biologinių medžiagų sausam saugojimui
JP2013538231A (ja) 2010-09-17 2013-10-10 ブラッシカ プロテクション プロダクツ リミテッド ライアビリティ カンパニー グルコシノレートによる処置のための製剤
US20140271861A1 (en) * 2011-07-27 2014-09-18 Polypid Ltd. Matrix compositions for controlled release of peptide and polypeptide molecules
CN105287431A (zh) * 2014-05-30 2016-02-03 中国科学院过程工程研究所 一种载活性药物的聚合物脂质球及其制备方法
WO2016025911A1 (en) 2014-08-14 2016-02-18 Brown University Compositions for stabilizing and delivering proteins
US10953050B2 (en) 2015-07-29 2021-03-23 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
US10327935B2 (en) * 2016-07-21 2019-06-25 Cook Medical Technologies Llc Stent graft with internal constraining mechanism
WO2019226519A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
SG11202005947RA (en) 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
WO2019222856A1 (en) 2018-05-24 2019-11-28 Nureva Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
CN112094580A (zh) * 2020-09-01 2020-12-18 杭州曦茂新材料科技有限公司 一种树脂防腐涂料及其生产方法
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409283A (en) 1943-04-21 1946-10-15 James L Hudson Coupling for plastic tubes
US3022209A (en) 1956-11-23 1962-02-20 Phillips Petroleum Co Method of welding butted pipe sections of polyethylene to form a reinforced joint
US3643805A (en) 1970-01-20 1972-02-22 Abcor Water Management Co Inc A membrane system which includes a tube sheet for securing supported membrane tubes therein
US3683960A (en) 1970-11-19 1972-08-15 Jerry Kirsch Block manifold for fluid control systems and method of making the same
GB1390379A (en) 1972-06-28 1975-04-09 Serck Industries Ltd Method of manufacturing hollow articles eg heat exchangers
US3776001A (en) 1973-01-16 1973-12-04 Kimberly Clark Co Self-lubricating compound for use in hygienic and medical applications, and suppositories made therefrom
US4070044A (en) 1976-01-22 1978-01-24 Phillips Petroleum Company Polymer pipe connection and method to make it
US4312687A (en) 1980-12-15 1982-01-26 Chevron Research Company Solar collector headers
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4615114A (en) 1984-03-12 1986-10-07 Asea Electric, Incorporated Method of manufacturing molded buswork for power distribution systems
US4730458A (en) * 1986-09-26 1988-03-15 The United States Of America As Represented By The United States Department Of Energy Thermal electric vapor trap arrangement and method
US5012052A (en) * 1988-03-22 1991-04-30 Indiana University Foundation Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method
US5447341A (en) 1988-06-13 1995-09-05 Metzeler Automotive Profiles Gmbh Molder rubber hose branch
CA1328550C (en) 1988-09-19 1994-04-19 Yoshinori Umezawa Method of fabricating pipe units
AU645003B2 (en) 1988-11-08 1994-01-06 Takeda Chemical Industries Ltd. Sustained release preparations
US5342628A (en) 1990-10-11 1994-08-30 Applied Medical Research, Inc. Drug diffusion polymer system and method
US5287758A (en) * 1991-01-26 1994-02-22 Behringwerke Ag Temperature controlled pipette tube
US5335944A (en) 1991-03-25 1994-08-09 Toyoda Gosei Co., Ltd. Hose coupling structure
JPH0538769A (ja) 1991-07-19 1993-02-19 Mitsutoyo Jushi Kk ブロー成形管の端部に厚肉フランジを射出成形する方法
JPH0570793A (ja) * 1991-09-10 1993-03-23 Nissei Baadeishie Kk 脂質の粒状組成物
FR2693249B1 (fr) 1992-07-03 1994-09-16 Hutchinson Procédé de raccordement de tubes ou tuyaux, raccords et dispositifs analogues obtenus par sa mise en Óoeuvre.
JP3266656B2 (ja) * 1992-08-18 2002-03-18 日清ファルマ株式会社 ビタミン含浸粒状物およびその製造方法
ES2170074T3 (es) 1992-09-10 2002-08-01 Childrens Medical Center Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales.
US5411300A (en) 1993-03-16 1995-05-02 Toyoda Gosei Co., Ltd. Hose connecting assembly
FR2710265B1 (fr) 1993-09-22 1995-10-20 Adir Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs.
DE4337492C2 (de) 1993-11-03 1999-06-02 Joerg Michael Dr Re Schierholz Verfahren zur Inkorporierung lipophiler pharmazeutisch wirksamer Substanzen in weiche Kontaktlinsen zur Erstellung ophthalmologischer kontrollierter Freisetzungssysteme mittels diffusionskontrollierter Sorption
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
CA2244742C (en) 1996-02-07 2005-08-23 Anthony Joseph Cesaroni Bonding of tubes of thermoplastic polymers
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
JP3544604B2 (ja) * 1996-12-16 2004-07-21 株式会社荏原製作所 切替式トラップ装置
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
DE19631001C1 (de) * 1996-08-01 1997-12-18 Testo Gmbh & Co Kondensatabscheider
KR0181252B1 (ko) * 1996-12-31 1999-03-20 박원훈 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
US5895695A (en) 1997-03-28 1999-04-20 Rowley; William W. Crosslinked overmolded plumbing tubes
JP3347977B2 (ja) * 1997-07-02 2002-11-20 フリヂスター株式会社 液体循環型熱電冷却・加熱装置
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6540926B2 (en) * 1997-10-02 2003-04-01 David Paul Goodrich Filter assembly
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6096178A (en) * 1998-08-24 2000-08-01 Aviv Amirav Electrolyzer device for the operation of flame ionization detectors
US6101815A (en) * 1998-11-09 2000-08-15 General Electric Company Thermo-electrical dehumidifier
US6490879B1 (en) * 2000-09-27 2002-12-10 Assist International Marketing, Inc. Water generating machine
US6427449B1 (en) * 2000-12-15 2002-08-06 Solid State Cooling Systems Compact volatile organic compound removal system
US6370884B1 (en) * 2001-03-30 2002-04-16 Maher I. Kelada Thermoelectric fluid cooling cartridge

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213052B2 (en) 2011-06-10 2022-01-04 Sevecom S.P.A. Use of emulsifiers in association with vegetable oleins in an animal feed
US20170215457A1 (en) 2014-07-21 2017-08-03 Sevecom S.P.A. Powdered emulsion for animal feed
US11185092B2 (en) 2014-07-21 2021-11-30 Sevecom S.P.A. Powdered emulsion for animal feed

Also Published As

Publication number Publication date
NO324895B1 (no) 2007-12-27
US6423345B2 (en) 2002-07-23
JP5153032B2 (ja) 2013-02-27
CN1201729C (zh) 2005-05-18
DE69930240D1 (de) 2006-05-04
MXPA00010566A (es) 2002-04-24
IL139252A (en) 2006-10-31
US20010000470A1 (en) 2001-04-26
US7160557B2 (en) 2007-01-09
US20010043948A1 (en) 2001-11-22
DE69930240T2 (de) 2006-11-23
CN1301150A (zh) 2001-06-27
PL343691A1 (en) 2001-08-27
KR20010043136A (ko) 2001-05-25
US7052719B2 (en) 2006-05-30
US6689390B2 (en) 2004-02-10
AU2995499A (en) 1999-11-23
ES2259472T3 (es) 2006-10-01
JP2002513752A (ja) 2002-05-14
AU746696B2 (en) 2002-05-02
US20070104656A1 (en) 2007-05-10
CA2329875C (en) 2003-09-16
US20010000230A1 (en) 2001-04-12
WO1999056731A1 (en) 1999-11-11
CA2329875A1 (en) 1999-11-11
EP1073422A1 (en) 2001-02-07
PT1073422E (pt) 2006-05-31
EP1073422B1 (en) 2006-03-08
NZ508470A (en) 2003-02-28
NO20005452L (no) 2000-12-29
IL139252A0 (en) 2001-11-25
PL196159B1 (pl) 2007-12-31
NO20005452D0 (no) 2000-10-27
DK1073422T3 (da) 2006-07-03
ATE319433T1 (de) 2006-03-15
US20030147962A1 (en) 2003-08-07
KR100703051B1 (ko) 2007-04-05

Similar Documents

Publication Publication Date Title
BR9910340A (pt) Matriz polimérica para a distribuição de um agente terapêutico ou profilático, método para a fabricação e administração da mesma
Ogawa et al. Controlled-release of leuprolide acetate from polylactic acid or copoly (lactic/glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer
CA2455680A1 (en) Ophthalmic depot formulations for periocular or subconjunctival administration
Hatefi et al. Biodegradable injectable in situ forming drug delivery systems
US4474752A (en) Drug delivery system utilizing thermosetting gels
KR100685303B1 (ko) 조금 녹는 약물 및 불용물의 제어방출용 위체류성 경구 약물제형
CA1224148A (en) Drug delivery system utilizing thermosetting gels
WO2002015877A8 (en) Methods and compositions for targeted delivery
CA2339482A1 (en) Composite hydrogel drug delivery systems
JPH07507548A (ja) 生物分解性放出制御溶融紡糸デリバリーシステム
BR0009213A (pt) Processos e composições para tratamento de tumores sólidos
ES2094781T3 (es) Composicion farmaceutica de microparticulas con liberacion controlada y su proceso de preparacion.
KR100289471B1 (ko) 휀타닐계마취제의이식형서방성제제
CA2534997A1 (en) Methods for administering aripiprazole
ATE421318T1 (de) Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
IL134703A (en) Process for controlling the loading of a biologically active agent into a liposome
DE69009743D1 (de) Dosierungsform für dauerverabreichung.
KR20000069800A (ko) 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
AR020780A1 (es) Composicion farmaceutica de liberacion sostenida, y metodo para liberar un agente farmaceuticamente activo
KR100709015B1 (ko) 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
AU5673399A (en) Compositions and methods for treating intracellular infections
EP0873751A2 (en) Pharmaceutical product for application to uterus mucosa
WO2005120435A3 (fr) Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc)
EP0608306B1 (en) Peroral drug delivery system
CN112741801A (zh) 一种新型卡波非聚合物及其给药系统

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA A INT.CI8:A61K 9/22; A61K 9/52; A61K 47/12; A61K 47/14; A61K 47/38; A61K 47/42

Ipc: A61K 9/22 (2008.04), A61K 9/52 (2008.04), A61K 47/

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 18A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]