DK1025211T3 - Hyaluronansyntasegen og anvendelser deraf - Google Patents

Hyaluronansyntasegen og anvendelser deraf

Info

Publication number
DK1025211T3
DK1025211T3 DK98957450T DK98957450T DK1025211T3 DK 1025211 T3 DK1025211 T3 DK 1025211T3 DK 98957450 T DK98957450 T DK 98957450T DK 98957450 T DK98957450 T DK 98957450T DK 1025211 T3 DK1025211 T3 DK 1025211T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
hyaluronan synthase
synthase gene
hyaluronan
synthase
Prior art date
Application number
DK98957450T
Other languages
Danish (da)
English (en)
Inventor
Paul H Weigel
Paul Deangelis
Kshama Kumari
Original Assignee
Univ Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oklahoma filed Critical Univ Oklahoma
Application granted granted Critical
Publication of DK1025211T3 publication Critical patent/DK1025211T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK98957450T 1997-10-31 1998-10-30 Hyaluronansyntasegen og anvendelser deraf DK1025211T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6443597P 1997-10-31 1997-10-31
US17885198A 1998-10-26 1998-10-26
EP98957450A EP1025211B1 (en) 1997-10-31 1998-10-30 Hyaluronan synthase gene and uses thereof
PCT/US1998/023153 WO1999023227A2 (en) 1997-10-31 1998-10-30 Hyaluronan synthase gene and uses thereof

Publications (1)

Publication Number Publication Date
DK1025211T3 true DK1025211T3 (da) 2005-04-04

Family

ID=26744517

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98957450T DK1025211T3 (da) 1997-10-31 1998-10-30 Hyaluronansyntasegen og anvendelser deraf

Country Status (13)

Country Link
US (10) US6833264B1 (ja)
EP (2) EP1025211B1 (ja)
JP (1) JP4731013B2 (ja)
KR (1) KR20010031682A (ja)
CN (1) CN1322121C (ja)
AT (1) ATE284954T1 (ja)
AU (2) AU762036B2 (ja)
BR (1) BR9814834B1 (ja)
CA (1) CA2307842C (ja)
DE (1) DE69828193T2 (ja)
DK (1) DK1025211T3 (ja)
ES (1) ES2235378T3 (ja)
WO (1) WO1999023227A2 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
ES2235378T3 (es) * 1997-10-31 2005-07-01 The Board Of Regents Of The University Of Oklahoma Gen de la hialuronan sintasa y usos del mismo.
CN101275143A (zh) * 1998-04-02 2008-10-01 俄克拉何马大学董事会 编码透明质酸合酶的核酸及其应用方法
US7060469B2 (en) * 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US7534589B2 (en) * 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
AU2008200910C1 (en) * 2001-12-21 2012-11-22 Novozymes A/S Methods for producing hyaluronan in a recombinant host cell
AU2002366711C1 (en) 2001-12-21 2009-01-22 Novozymes A/S Methods for producing hyaluronan in a recombinant host cell
US9733625B2 (en) * 2006-03-20 2017-08-15 General Electric Company Trip optimization system and method for a train
JP4402588B2 (ja) * 2002-06-20 2010-01-20 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ ２価の塩を使用する凝集法
CN1833026A (zh) 2003-07-31 2006-09-13 东洋纺织株式会社 生产透明质酸的植物
EP1640457A1 (de) * 2004-09-23 2006-03-29 Bayer CropScience GmbH Verfahren und Mittel zur Herstellung von Hyaluronan
JP4948412B2 (ja) 2004-09-23 2012-06-06 バイエル・クロップサイエンス・アーゲー ヒアルロナンを製造するための方法および手段
JP2008526693A (ja) * 2005-01-03 2008-07-24 ノボザイムス バイオポリマー アクティーゼルスカブ 保湿及び抗−しわ性質を有するヒアルロン酸画分
JP2006204260A (ja) * 2005-01-31 2006-08-10 Toyobo Co Ltd ヒアルロン酸合成酵素及びその遺伝子
CA2620210A1 (en) 2005-08-25 2007-03-01 Toyo Boseki Kabushiki Kaisha Plant producing hyaluronic acid
EP1772052A1 (de) * 2005-10-05 2007-04-11 Bayer CropScience GmbH Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
JP2009509557A (ja) * 2005-10-05 2009-03-12 バイエル・クロップサイエンス・アーゲー 改善されたヒアルロン酸産生方法および手段
WO2007039315A1 (de) * 2005-10-05 2007-04-12 Bayer Cropscience Ag Pflanzen mit gesteigerter produktion von hyaluronan ii
AU2006298961B2 (en) * 2005-10-05 2013-05-02 Bayer Intellectual Property Gmbh Plants with increased hyaluronan production
JP2007174957A (ja) * 2005-12-27 2007-07-12 Toyobo Co Ltd ヒアルロン酸生産酵母
JP2009545637A (ja) 2006-08-04 2009-12-24 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 分岐ヒアルロン酸及びその製造方法
EP2405009B1 (en) * 2007-03-29 2016-08-03 Futuragene Israel Ltd. Transgenic plants containing soluble cell wall polysaccharides
WO2009026635A1 (en) * 2007-08-31 2009-03-05 The University Of Queensland Production of hyaluronic acid
WO2009077399A1 (en) 2007-12-19 2009-06-25 Evonik Goldschmidt Gmbh Crosslinked hyaluronic acid in emulsion
CA2835016A1 (en) 2011-05-30 2012-12-06 Novozymes Biopharma Dk A/S Spray drying of high molecular weight hyaluronic acid
CA2847328A1 (en) 2011-09-02 2013-03-07 Novozymes Biopharma Dk A/S Oral formulations containing hyaluronic acid for sustained drug release
WO2014100837A1 (en) 2012-12-17 2014-06-26 Bui The Duy Computer aided implantation of body implants
WO2014143990A1 (en) * 2013-03-15 2014-09-18 NuTech Medical, Inc. Preparations derived from placental materials of making and using same
KR102135044B1 (ko) * 2018-12-10 2020-07-17 대화제약 주식회사 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법
RU2719140C1 (ru) 2019-07-26 2020-04-17 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624011A5 (ja) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DE3160929D1 (en) 1980-04-17 1983-10-27 Ciba Geigy Ag Phenyl ureas
US4517295A (en) 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
CA1167797A (en) 1983-06-30 1984-05-22 Herbert E. Gladish Air conveyor components
JPS6060177A (ja) 1983-09-12 1985-04-06 Hiroyuki Yugawa 冷却用寒剤
US4511478A (en) 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
US4983392A (en) 1983-11-14 1991-01-08 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
US4615697A (en) 1983-11-14 1986-10-07 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
NO161573C (no) 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
US4708861A (en) 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
JPS60251898A (ja) 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
FR2569724B1 (fr) 1984-09-04 1991-02-08 Chisso Corp Procede pour la preparation d'acide hyaluronique
JPS6163294A (ja) * 1984-09-05 1986-04-01 Chisso Corp 発酵法によるヒアルロン酸の製造法
US5171689A (en) 1984-11-08 1992-12-15 Matsushita Electric Industrial Co., Ltd. Solid state bio-sensor
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
US4780414A (en) 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
IT1208514B (it) 1985-03-19 1989-07-10 Eniricerche Spa Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis.
JPS61267189A (ja) 1985-05-22 1986-11-26 株式会社東芝 結束装置付入金集計機
JPS6232893A (ja) 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPS6394988A (ja) 1986-10-08 1988-04-26 Meiji Seika Kaisha Ltd ヒアルロン酸の製造法
JPH072117B2 (ja) 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
EP0265578A1 (en) 1986-10-30 1988-05-04 Jan-Olof Eriksson A non-abrasive polish or cleaning composition and process for its preparation
US4822867A (en) 1987-02-02 1989-04-18 Semih Erhan Protein polymer grafts
JPH02193818A (ja) 1989-01-23 1990-07-31 Okura Yusoki Co Ltd パレット荷積み装置
US5015577A (en) 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
FR2652736A1 (fr) 1989-10-06 1991-04-12 Neftel Frederic Dispositif implantable d'evaluation du taux de glucose.
JP2986519B2 (ja) 1990-07-24 1999-12-06 生化学工業株式会社 燐脂質結合グリコサミノグリカン
JPH04124854A (ja) 1990-09-17 1992-04-24 Nikko Kyodo Co Ltd 半導体装置の製造方法
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
JPH04134854A (ja) 1990-09-26 1992-05-08 Shimadzu Corp Ｉｃチップ間配線方法
JPH04158798A (ja) 1990-10-19 1992-06-01 Tdk Corp 酵素活性の測定方法
JPH0630605B2 (ja) 1990-10-23 1994-04-27 チッソ株式会社 ヒアルロン酸ナトリウム水溶液の製造法
IT1250421B (it) 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5217743A (en) 1992-02-07 1993-06-08 Paradigm Biotechnologies Partnership Biomaterials of enhanced biocompatibility
US5621089A (en) 1992-05-27 1997-04-15 Novo Nordisk Biotech, Inc. Nucleic acid constructs for the production of a Bacillus alkaline protease
IT1260153B (it) * 1992-06-19 1996-03-28 Michael O'regan Individuazione di un frammento di dna codificante l'enzima acido ialuronico sintetasi (has) e della sua sequenza nucleotidica
WO1995022316A1 (en) 1994-02-17 1995-08-24 New York Blood Center, Inc. Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use
IT1268954B1 (it) 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5473034A (en) 1994-03-18 1995-12-05 Hyogo Prefectural Government Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
EP0804582A1 (en) 1994-05-16 1997-11-05 The Uab Research Foundation $i(STREPTOCOCCUS PNEUMONIAE) CAPSULAR POLYSACCHARIDE GENES AND FLANKING REGIONS
SE9401806D0 (sv) 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6951743B2 (en) * 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
JPH0838336A (ja) 1994-08-01 1996-02-13 Matsushita Electric Ind Co Ltd 電気カーペット用カバー
CN1161060A (zh) * 1994-09-12 1997-10-01 M·G·伯杰龙 用于微生物学实验室日常诊断中迅速检测和鉴别临床样品中普通细菌病原体和抗生素抗性基因之特异性和通用性探针及扩增引物
US5831057A (en) * 1995-10-05 1998-11-03 Cold Spring Harbor Laboratory Associative learning and the linotte gene
EE9800160A (et) 1995-11-28 1998-12-15 Genvec, Inc. Vektorid ja meetodid geenide ülekandmiseks rakkudesse
WO1997020061A1 (en) * 1995-11-30 1997-06-05 The Scripps Research Institute Synthesis of hyaluronic acid
SE9504304D0 (sv) 1995-11-30 1995-11-30 Sandvik Ab Coated milling insert
US6423514B1 (en) 1996-04-22 2002-07-23 Millennium Pharmaceuticals, Inc. Mammalian hyaluronan synthases, nucleic acids and uses thereof
US5610241A (en) 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6602693B1 (en) * 1996-07-03 2003-08-05 Clear Solutions Biotech, Inc. Gene encoding hyaluronan synthase
US6492150B1 (en) 1996-07-03 2002-12-10 Clear Colutions Biotech, Inc. Gene encoding hyaluronan synthase
CN101113436B (zh) 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
ES2235378T3 (es) 1997-10-31 2005-07-01 The Board Of Regents Of The University Of Oklahoma Gen de la hialuronan sintasa y usos del mismo.
US7223571B2 (en) 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
WO2000027437A2 (en) 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20080108110A1 (en) 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7060469B2 (en) 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US6987023B2 (en) 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
US20060105431A1 (en) 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US7534589B2 (en) 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
AU2002366711C1 (en) 2001-12-21 2009-01-22 Novozymes A/S Methods for producing hyaluronan in a recombinant host cell
WO2006033693A2 (en) 2004-06-30 2006-03-30 Deangelis Paul L Methods of selectively treating diseases with specific glycosaminoglycan polymers

Also Published As

Publication number Publication date
US7153677B2 (en) 2006-12-26
ATE284954T1 (de) 2005-01-15
US20060216794A1 (en) 2006-09-28
US20030082780A1 (en) 2003-05-01
US6833264B1 (en) 2004-12-21
US20060216808A1 (en) 2006-09-28
BR9814834B1 (pt) 2011-08-23
AU1370699A (en) 1999-05-24
CN1322121C (zh) 2007-06-20
CA2307842A1 (en) 1999-05-14
US20050202540A1 (en) 2005-09-15
DE69828193D1 (de) 2005-01-20
BR9814834A (pt) 2001-07-17
CA2307842C (en) 2010-10-19
EP1025211B1 (en) 2004-12-15
US7166450B2 (en) 2007-01-23
EP1522579A2 (en) 2005-04-13
EP1522579A3 (en) 2007-11-07
WO1999023227A3 (en) 1999-08-19
US20060013829A1 (en) 2006-01-19
US6991921B2 (en) 2006-01-31
WO1999023227A9 (en) 2000-07-13
AU2003248204A1 (en) 2003-10-30
WO1999023227A2 (en) 1999-05-14
DE69828193T2 (de) 2005-12-01
US7087413B2 (en) 2006-08-08
KR20010031682A (ko) 2001-04-16
JP4731013B2 (ja) 2011-07-20
ES2235378T3 (es) 2005-07-01
US20060018924A1 (en) 2006-01-26
US20030073221A1 (en) 2003-04-17
EP1025211A2 (en) 2000-08-09
JP2001521741A (ja) 2001-11-13
US7109011B2 (en) 2006-09-19
US7141409B2 (en) 2006-11-28
US20060216793A1 (en) 2006-09-28
US7504246B2 (en) 2009-03-17
CN1283224A (zh) 2001-02-07
US7115405B2 (en) 2006-10-03
AU762036B2 (en) 2003-06-19
US20070087416A1 (en) 2007-04-19
US7060466B2 (en) 2006-06-13

Similar Documents

Publication Publication Date Title
DK1025211T3 (da) Hyaluronansyntasegen og anvendelser deraf
HK1013847A1 (en) Gdf-1 and uog-1 proteins
DE60033138D1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
AU1672388A (en) Expression of human proapolipoprotein a-i
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
ZA967173B (en) Purified coprinus laccases and nucleic acids and encoding same
DE69930955D1 (de) Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren
DE69832993D1 (de) Arginin deiminase aus mycoplasma arthirtidis und sie enthaltende polymerkonjugate
NZ510356A (en) Molecules designated LDCAM
ATE501254T1 (de) P- selectin ligandenprotein
NO177570C (no) Fremgangsmåte ved fremstilling av peptider med fibronektinbindende egenskaper, mikroorganisme og DNA-sekvens som koder for peptider med fibronektinbindende egenskaper
FI961202A (fi) Grb3-3-geeni, sen variantteja ja niiden käyttöjä
EP0719862A3 (en) A regulatory factor for expression of nitrilase gene and a gene thereof
WO1995030001A3 (en) Novel p-selectin ligand protein
AU2430588A (en) Mutant acidic fibroblast growth factor
AU7949991A (en) Cloned n-methylhydantoinase
AU7357294A (en) Recombinant cladosporium herbarum allergens
AU782261C (en) Novel glycosyltransferase genes
EP0713914A3 (en) A regulatory gene for the expression of nitrile hydratase gene
IL146191A0 (en) Viral expression vectors
DK551786A (da) Rekombinant-dna-sekvens, der koder for aminosyresekvenser i et toksin, expressionssystem omfattende samme og vaertsceller transformeret hermed
DK0828004T3 (da) Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær
TW342413B (en) Novel toxins isolated from Bracon Hebetor
EP0759474A3 (en) A regulatory factor involved in expression of nitrilase gene, and its gene
EP1314785A4 (en) NUCLEIC ACIDS AND PROTEINS WITH INCREASED EXPRESSION LEVELS UNDER THE EFFECT OF SALT-DRIVEN STRESS