DE69832993D1 - Arginin deiminase aus mycoplasma arthirtidis und sie enthaltende polymerkonjugate - Google Patents

Arginin deiminase aus mycoplasma arthirtidis und sie enthaltende polymerkonjugate

Info

Publication number
DE69832993D1
DE69832993D1 DE69832993T DE69832993T DE69832993D1 DE 69832993 D1 DE69832993 D1 DE 69832993D1 DE 69832993 T DE69832993 T DE 69832993T DE 69832993 T DE69832993 T DE 69832993T DE 69832993 D1 DE69832993 D1 DE 69832993D1
Authority
DE
Germany
Prior art keywords
adi
arginine deiminase
polymer conjugates
mycoplasma
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69832993T
Other languages
English (en)
Other versions
DE69832993T2 (de
Inventor
David Ray Filpula
Maoliang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of DE69832993D1 publication Critical patent/DE69832993D1/de
Application granted granted Critical
Publication of DE69832993T2 publication Critical patent/DE69832993T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69832993T 1997-01-31 1998-01-27 Arginin deiminase aus mycoplasma arthirtidis und sie enthaltende polymerkonjugate Expired - Lifetime DE69832993T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/792,283 US5804183A (en) 1997-01-31 1997-01-31 Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
US792283 1997-01-31
PCT/US1998/001635 WO1998033519A1 (en) 1997-01-31 1998-01-27 Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same

Publications (2)

Publication Number Publication Date
DE69832993D1 true DE69832993D1 (de) 2006-02-02
DE69832993T2 DE69832993T2 (de) 2006-09-07

Family

ID=25156365

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69832993T Expired - Lifetime DE69832993T2 (de) 1997-01-31 1998-01-27 Arginin deiminase aus mycoplasma arthirtidis und sie enthaltende polymerkonjugate

Country Status (9)

Country Link
US (3) US5804183A (de)
EP (1) EP1011717B1 (de)
JP (1) JP4126097B2 (de)
AT (1) ATE314086T1 (de)
AU (1) AU6047598A (de)
DE (1) DE69832993T2 (de)
DK (1) DK1011717T3 (de)
ES (1) ES2255147T3 (de)
WO (1) WO1998033519A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635462B1 (en) * 1997-05-12 2003-10-21 Phoenix Pharmacologies, Inc. Mutated form of arginine deiminase
US6183738B1 (en) * 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
JP2004515232A (ja) * 2000-11-28 2004-05-27 フエニツクス・フアーマコロジクス・インコーポレーテツド 修飾されたアルギニンデイミナーゼ
US6645739B2 (en) * 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
AU2003282883B2 (en) * 2002-11-18 2008-12-04 Polaris Group Methods for inhibiting viral replication in vivo
FR2884717B1 (fr) * 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
WO2007130453A2 (en) * 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
JP2009044997A (ja) * 2007-08-20 2009-03-05 Sony Corp ビリルビンオキシダーゼ（ｂｏｄ）の被覆方法
EP2295560A1 (de) 2009-09-14 2011-03-16 RWTH Aachen University Zielgerichtete Evolution von Arginindeiminase zur erhöhten Aktivität im physiologischen pH
USRE48805E1 (en) 2013-03-06 2021-11-02 Vision Global Holdings Ltd. Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
US9255262B2 (en) * 2013-03-06 2016-02-09 Vision Global Holdings Ltd. Albumin-binding arginine deminase and the use thereof
KR102263038B1 (ko) 2013-03-15 2021-06-14 티디더블유 그룹 암치료를 위한 ａｄｉ-ｐｅｇ 20 항체에 대해 감소된 교차반응성을 지니는 아르기닌 탈이민효소
SG11201607736UA (en) 2014-03-18 2016-10-28 Tdw Group Engineered chimeric pegylated adi and methods of use
AU2015317848B2 (en) 2014-09-16 2021-04-22 Polaris Group Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment
WO2017041051A1 (en) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
EP3449935A1 (de) 2017-08-31 2019-03-06 Erytech Pharma In erythrozyten eingekapselte arginin-deiminase und deren verwendung zur behandlung von krebs und arginase-1-mangel
WO2019042628A1 (en) 2017-08-31 2019-03-07 Erytech Pharma ARGININE DEIMINASE ENCAPSULATED WITHIN ERYTHROCYTES AND THEIR USE IN THE TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY
CN114514239A (zh) * 2019-08-01 2022-05-17 北卡罗来纳查佩尔山大学 用于结合抗体并抑制中和抗体的组合物和方法
CA3128035A1 (en) 2020-08-13 2022-02-13 Bioasis Technologies, Inc. Combination therapies for delivery across the blood brain barrier
JP2024505948A (ja) * 2021-02-03 2024-02-08 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル タンパク質ｍ類似体及び融合タンパク質、並びに抗体機能を阻害するためのそれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPH0253490A (ja) * 1988-08-16 1990-02-22 Agency Of Ind Science & Technol アルギニン・デイミナーゼ遺伝子
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
JP2900279B2 (ja) * 1989-08-02 1999-06-02 株式会社ジャパンエナジー 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤
JP3209338B2 (ja) * 1990-09-10 2001-09-17 株式会社ジャパンエナジー ポリエチレングリコール修飾アルギニンデイミナーゼおよびその製造法
US5372942A (en) * 1992-02-10 1994-12-13 Coriell Institute For Medical Research Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
US5349001A (en) * 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

Also Published As

Publication number Publication date
EP1011717B1 (de) 2005-12-28
AU6047598A (en) 1998-08-25
JP4126097B2 (ja) 2008-07-30
US6132713A (en) 2000-10-17
WO1998033519A1 (en) 1998-08-06
ES2255147T3 (es) 2006-06-16
ATE314086T1 (de) 2006-01-15
DE69832993T2 (de) 2006-09-07
US5916793A (en) 1999-06-29
US5804183A (en) 1998-09-08
EP1011717A1 (de) 2000-06-28
DK1011717T3 (da) 2006-05-15
JP2001512965A (ja) 2001-08-28
EP1011717A4 (de) 2003-02-19

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