DK1019507T3 - Aminoterminalt afkortede RANTES som kemokinantagonister - Google Patents
Aminoterminalt afkortede RANTES som kemokinantagonisterInfo
- Publication number
- DK1019507T3 DK1019507T3 DK98951476T DK98951476T DK1019507T3 DK 1019507 T3 DK1019507 T3 DK 1019507T3 DK 98951476 T DK98951476 T DK 98951476T DK 98951476 T DK98951476 T DK 98951476T DK 1019507 T3 DK1019507 T3 DK 1019507T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- terminally truncated
- chemokine antagonists
- truncated rantes
- rantes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97116863A EP0906954A1 (fr) | 1997-09-29 | 1997-09-29 | C-C chémokine tronquée à l'aminoterminus comme antagoniste de chémokines |
EP97122471A EP0905240A1 (fr) | 1997-09-29 | 1997-12-19 | Amino-terminale tronquée C-C chemokin et d'un antagoniste chemokin |
EP98104216A EP0905241A1 (fr) | 1997-09-29 | 1998-03-10 | Amino-terminale tronquée C-C chemokine et d'un antagoniste de chemokin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1019507T3 true DK1019507T3 (da) | 2004-07-19 |
Family
ID=8227408
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98951476T DK1019507T3 (da) | 1997-09-29 | 1998-09-28 | Aminoterminalt afkortede RANTES som kemokinantagonister |
DK04007579T DK1439231T3 (da) | 1997-09-29 | 1998-09-28 | Aminoterminalt afkortede RANTES som kemokinantagonister |
DK98947553T DK1021541T3 (da) | 1997-09-29 | 1998-09-28 | Aminoterminalt trunkeret MCP-2 som chemokinantagonister |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04007579T DK1439231T3 (da) | 1997-09-29 | 1998-09-28 | Aminoterminalt afkortede RANTES som kemokinantagonister |
DK98947553T DK1021541T3 (da) | 1997-09-29 | 1998-09-28 | Aminoterminalt trunkeret MCP-2 som chemokinantagonister |
Country Status (29)
Country | Link |
---|---|
US (5) | US6905676B2 (fr) |
EP (6) | EP0906954A1 (fr) |
JP (2) | JP4230659B2 (fr) |
KR (2) | KR100542934B1 (fr) |
CN (3) | CN1233415C (fr) |
AR (2) | AR013528A1 (fr) |
AT (3) | ATE264390T1 (fr) |
AU (2) | AU750606B2 (fr) |
BG (2) | BG64679B1 (fr) |
BR (2) | BR9812394A (fr) |
CA (2) | CA2305017A1 (fr) |
CY (1) | CY1110927T1 (fr) |
CZ (2) | CZ299478B6 (fr) |
DE (3) | DE69822856T2 (fr) |
DK (3) | DK1019507T3 (fr) |
EA (2) | EA003942B1 (fr) |
EE (2) | EE200000151A (fr) |
ES (3) | ES2287601T3 (fr) |
HK (3) | HK1062637A1 (fr) |
HU (2) | HU226414B1 (fr) |
IL (2) | IL135351A (fr) |
NO (2) | NO20001584D0 (fr) |
NZ (3) | NZ516027A (fr) |
PL (2) | PL197569B1 (fr) |
PT (3) | PT1019507E (fr) |
SK (2) | SK286439B6 (fr) |
UA (2) | UA73080C2 (fr) |
WO (2) | WO1999016877A1 (fr) |
ZA (2) | ZA988675B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7067117B1 (en) | 1997-09-11 | 2006-06-27 | Cambridge University Technical Services, Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
WO1999028474A2 (fr) * | 1997-12-01 | 1999-06-10 | The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services | Variants de chemokine et leurs procedes d'utilisation |
US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
CA2387378A1 (fr) * | 1999-10-25 | 2001-05-03 | Euroscreen S.A. | Chimiokines humaines phc-1 et phc-2 traitees |
EP1167527A1 (fr) * | 2000-06-22 | 2002-01-02 | Euroscreen S.A. | Chemokines humaines tronquées: PHC-1 et PHC-2 |
AU2505601A (en) * | 1999-11-15 | 2001-05-30 | Wolf-Georg Forssmann | Novel use of hcc-2 |
CA2316405A1 (fr) * | 2000-05-26 | 2001-11-26 | Ian Clark-Lewis | Modulation de l'inflammation a l'aide de produits du type protease |
EP1176200A3 (fr) | 2000-06-20 | 2005-01-12 | Switch Biotech Aktiengesellschaft | Utilisation des polypeptides ou leurs acides nucléiques pour le diagnose ou traitement des maladies de la peau ou de la cicatrisation de blessures et leurs utilisations pour l'identification des substances pharmacologiquement actives |
UA77950C2 (en) * | 2000-10-04 | 2007-02-15 | Applied Research Systems | Use of mutants of cc chemokines for treatment of multiple sclerosis |
GB2373785A (en) * | 2001-03-28 | 2002-10-02 | Rega Inst For Medical Res | Truncating chemokines using dipeptidyl peptidase IV |
IL162600A0 (en) | 2001-12-17 | 2005-11-20 | Applied Research Systems | Cc-chemokine mutants as cc-chemokine antagonists |
WO2004104216A2 (fr) * | 2003-05-21 | 2004-12-02 | Bayer Healthcare Ag | Diagnostics et agents therapeutiques destines a des maladies liees a une dipeptidylpeptidase iv (dpp4) |
DE102005049637A1 (de) * | 2005-10-14 | 2007-04-26 | Rheinisch-Westfälische Technische Hochschule Aachen | Antagonisten gegen die Interaktion von PF4 und RANTES |
MX2010001307A (es) | 2007-08-02 | 2010-07-30 | Novimmune Sa | Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos. |
WO2011097567A1 (fr) * | 2010-02-08 | 2011-08-11 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Essai multiplexé du rantes, variants du rantes se rapportant à une maladie, et variants du rantes se rapportant à une activité enzymatique |
US9296803B2 (en) | 2010-03-11 | 2016-03-29 | Health Research, Inc. | Methods and compositions containing Fc fusion proteins for enhancing immune responses |
TW201718851A (zh) * | 2015-09-18 | 2017-06-01 | 通用醫院公司 | 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途 |
CA3101052A1 (fr) | 2018-05-28 | 2019-12-05 | ORION Biotechnology Switzerland Sarl | Methodes d'inhibition de l'inflammation cerebrale |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
US11402391B2 (en) | 2020-12-21 | 2022-08-02 | Incelldx, Inc. | Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0311107A3 (fr) | 1987-10-08 | 1990-04-18 | Stichting REGA V.Z.W. | Fluoro-3'-purine-didéoxy-2',3'-ribosides actifs contre HIV |
US5739103A (en) * | 1993-11-12 | 1998-04-14 | Dana-Farber Cancer Institute | Chemokine N-terminal deletion mutations |
MX9703889A (es) * | 1994-12-08 | 1997-08-30 | Glaxo Group Ltd | Peptido rantes y fragmentos y composiciones que lo contienen, para el tratamiento de la inflamacion. |
WO1997025427A1 (fr) * | 1996-01-12 | 1997-07-17 | Genetics Institute, Inc. | Beta-chemokine, h1305 (mpc-2) |
AU733925C (en) * | 1996-03-27 | 2002-06-13 | Icos Corporation | Monocyte chemotactic protein-5 materials and methods |
FR2748938B1 (fr) * | 1996-05-22 | 1998-07-31 | Pasteur Institut | Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih |
US6168784B1 (en) * | 1997-09-03 | 2001-01-02 | Gryphon Sciences | N-terminal modifications of RANTES and methods of use |
-
1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/fr not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/fr not_active Withdrawn
-
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/fr not_active Withdrawn
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/fr active IP Right Grant
- 1998-09-28 EE EEP200000151A patent/EE200000151A/xx unknown
- 1998-09-28 EE EEP200000152A patent/EE200000152A/xx unknown
- 1998-09-28 CA CA002305017A patent/CA2305017A1/fr not_active Abandoned
- 1998-09-28 HU HU0003505A patent/HU226414B1/hu not_active IP Right Cessation
- 1998-09-28 CA CA002304827A patent/CA2304827A1/fr not_active Abandoned
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
- 1998-09-28 NZ NZ516027A patent/NZ516027A/en unknown
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
- 1998-09-28 ES ES04007579T patent/ES2287601T3/es not_active Expired - Lifetime
- 1998-09-28 EA EA200000378A patent/EA003942B1/ru not_active IP Right Cessation
- 1998-09-28 KR KR1020007003020A patent/KR100542934B1/ko not_active IP Right Cessation
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active IP Right Cessation
- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 CZ CZ20001146A patent/CZ299478B6/cs not_active IP Right Cessation
- 1998-09-28 AR ARP980104819A patent/AR013528A1/es active IP Right Grant
- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 AU AU94420/98A patent/AU750606B2/en not_active Ceased
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
- 1998-09-28 EP EP04007579A patent/EP1439231B1/fr not_active Expired - Lifetime
- 1998-09-28 SK SK450-2000A patent/SK286439B6/sk not_active IP Right Cessation
- 1998-09-28 CN CNB988095726A patent/CN1148447C/zh not_active Expired - Fee Related
- 1998-09-28 ES ES98951476T patent/ES2218860T3/es not_active Expired - Lifetime
- 1998-09-28 NZ NZ503235A patent/NZ503235A/xx unknown
- 1998-09-28 WO PCT/EP1998/006142 patent/WO1999016876A1/fr active IP Right Grant
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 DK DK04007579T patent/DK1439231T3/da active
- 1998-09-28 EP EP98947553A patent/EP1021541B1/fr not_active Expired - Lifetime
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 DE DE69838188T patent/DE69838188T2/de not_active Expired - Lifetime
- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 PT PT04007579T patent/PT1439231E/pt unknown
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
- 1998-09-28 ES ES98947553T patent/ES2215324T3/es not_active Expired - Lifetime
- 1998-09-28 EP EP98951476A patent/EP1019507B1/fr not_active Expired - Lifetime
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 JP JP2000513947A patent/JP4233214B2/ja not_active Expired - Fee Related
- 1998-09-28 CZ CZ20001147A patent/CZ299479B6/cs not_active IP Right Cessation
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 PL PL339545A patent/PL196427B1/pl not_active IP Right Cessation
- 1998-09-28 AT AT98951476T patent/ATE263242T1/de active
-
2000
- 2000-03-22 BG BG104266A patent/BG64679B1/bg unknown
- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584D0/no not_active Application Discontinuation
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
-
2001
- 2001-04-25 HK HK04105182A patent/HK1062637A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK01102962A patent/HK1032426A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK01102961A patent/HK1032425A1/xx not_active IP Right Cessation
-
2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
-
2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown
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