DK0930365T3 - Bindingsdomæner i Serrate-protein - Google Patents

Bindingsdomæner i Serrate-protein

Info

Publication number
DK0930365T3
DK0930365T3 DK99101562T DK99101562T DK0930365T3 DK 0930365 T3 DK0930365 T3 DK 0930365T3 DK 99101562 T DK99101562 T DK 99101562T DK 99101562 T DK99101562 T DK 99101562T DK 0930365 T3 DK0930365 T3 DK 0930365T3
Authority
DK
Denmark
Prior art keywords
binding domains
toporythmic protein
protein
fragment
serrate protein
Prior art date
Application number
DK99101562T
Other languages
Danish (da)
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Richard Fehon
Ilaria Rebay
Original Assignee
Univ Yale
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0930365(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Indiana University Foundation filed Critical Univ Yale
Application granted granted Critical
Publication of DK0930365T3 publication Critical patent/DK0930365T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99101562T 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein DK0930365T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (1)

Publication Number Publication Date
DK0930365T3 true DK0930365T3 (da) 2008-06-02

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner

Country Status (12)

Country Link
US (1) US5849869A (ja)
EP (4) EP0576623B2 (ja)
JP (7) JPH07503123A (ja)
AT (4) ATE397661T1 (ja)
AU (1) AU675203B2 (ja)
CA (1) CA2102208C (ja)
DE (4) DE69232832T3 (ja)
DK (4) DK0933082T3 (ja)
ES (4) ES2303363T3 (ja)
IE (2) IE85350B1 (ja)
IL (1) IL101728A (ja)
WO (1) WO1992019734A1 (ja)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
ATE442373T1 (de) 1995-06-28 2009-09-15 Imp Cancer Res Tech Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
EP0861894B1 (en) 1995-11-17 2006-03-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
AU728798B2 (en) * 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
JP3922726B2 (ja) * 1996-07-16 2007-05-30 旭化成株式会社 分化抑制剤
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US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
DE69836131T3 (de) 1997-04-04 2017-06-14 Millennium Pharmaceuticals, Inc. Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen
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US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
EP1032666A1 (en) * 1997-11-22 2000-09-06 Hyseq, Inc. A NOVEL EGF MOTIF PROTEIN OBTAINED FROM A cDNA LIBRARY OF FETAL LIVER-SPLEEN
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001288628A1 (en) * 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
JP2005511754A (ja) * 2001-12-07 2005-04-28 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 乳癌幹細胞の予測的同定および特徴づけ
AU2004256425A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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CA2612021A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2628255C (en) * 2005-10-31 2016-04-19 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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BRPI0719409A2 (pt) 2006-12-18 2014-02-11 Genentch Inc "regiões variáveis da cadeia pesada ("vh"), sequências da cadeia vh, ácido nucléico, vetor, célula, anticorpos, uso do anticorpo, método para produzir um anticorpo, anticorpo anti-notch3 e forma humanizada do anticorpo"
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
US8088617B2 (en) 2007-01-24 2012-01-03 Oncomed Pharmaceuticals, Inc. Antibodies that bind the glutamate ligand binding region of Notch1
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
CN102055023A (zh) 2007-11-12 2011-05-11 株式会社杰士汤浅国际 锂二次电池的制造方法
PL2307459T3 (pl) 2008-07-08 2015-05-29 Oncomed Pharm Inc Czynniki wiążące receptor Notch1 i sposoby ich stosowania
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
WO2010037041A2 (en) 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
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US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
WO1994013701A2 (en) * 1992-12-11 1994-06-23 The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Healthand Human Services Delta-like gene expressed in neuroendocrine tumors

Also Published As

Publication number Publication date
ES2310933T3 (es) 2009-01-16
CA2102208C (en) 2003-04-29
WO1992019734A1 (en) 1992-11-12
ATE226633T1 (de) 2002-11-15
EP0933082B1 (en) 2010-07-14
DE69233724T2 (de) 2009-04-02
IE20030774A1 (en) 2003-12-10
JP4604228B2 (ja) 2011-01-05
DE69232832T2 (de) 2003-06-18
EP0930366B1 (en) 2008-06-04
IL101728A0 (en) 1992-12-30
DE69232832D1 (de) 2002-11-28
DE69233735D1 (de) 2008-07-17
JP2007330258A (ja) 2007-12-27
DE69232832T3 (de) 2008-02-28
EP0576623A4 (en) 1995-01-18
EP0930365A3 (en) 1999-07-28
IE921367A1 (en) 1992-11-04
EP0933082A1 (en) 1999-08-04
ATE473754T1 (de) 2010-07-15
ATE386116T1 (de) 2008-03-15
ES2181674T5 (es) 2008-03-01
DK0933082T3 (da) 2010-10-25
AU1919792A (en) 1992-12-21
DK0576623T3 (da) 2003-02-24
JP2004065243A (ja) 2004-03-04
US5849869A (en) 1998-12-15
AU675203B2 (en) 1997-01-30
ES2303363T3 (es) 2008-08-01
JP2008005843A (ja) 2008-01-17
EP0930366A3 (en) 1999-07-28
DE69233724D1 (de) 2008-03-27
JPH07503123A (ja) 1995-04-06
EP0576623A1 (en) 1994-01-05
JP2011135886A (ja) 2011-07-14
ES2348919T3 (es) 2010-12-16
DK0930366T3 (da) 2008-10-13
JP2007330259A (ja) 2007-12-27
DE69233791D1 (de) 2010-08-26
JP2011155979A (ja) 2011-08-18
ATE397661T1 (de) 2008-06-15
EP0576623B2 (en) 2007-10-03
JP4430891B2 (ja) 2010-03-10
IE85350B1 (en) 2009-10-14
EP0576623B1 (en) 2002-10-23
JP4604227B2 (ja) 2011-01-05
EP0930366A2 (en) 1999-07-21
EP0930365B1 (en) 2008-02-13
IL101728A (en) 2007-08-19
CA2102208A1 (en) 1992-11-12
DK0576623T4 (da) 2008-01-02
ES2181674T3 (es) 2003-03-01
EP0930365A2 (en) 1999-07-21

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