DK0918746T3 - Immunterapeutiske midler og deres anvendelse til reduktion af cytokinniveauer - Google Patents

Immunterapeutiske midler og deres anvendelse til reduktion af cytokinniveauer

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Publication number
DK0918746T3
DK0918746T3 DK97936479T DK97936479T DK0918746T3 DK 0918746 T3 DK0918746 T3 DK 0918746T3 DK 97936479 T DK97936479 T DK 97936479T DK 97936479 T DK97936479 T DK 97936479T DK 0918746 T3 DK0918746 T3 DK 0918746T3
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Prior art keywords
carbon atoms
alkyl
substituted
amino
cyano
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DK97936479T
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Danish (da)
English (en)
Inventor
George W Muller
Mary Shire
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Celgene Corp
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Publication of DK0918746T3 publication Critical patent/DK0918746T3/da

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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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DK97936479T 1996-08-12 1997-08-11 Immunterapeutiske midler og deres anvendelse til reduktion af cytokinniveauer DK0918746T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69559996A 1996-08-12 1996-08-12
PCT/US1997/014098 WO1998006692A1 (en) 1996-08-12 1997-08-11 Novel immunotherapeutic agents and their use in the reduction of cytokine levels

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DK0918746T3 true DK0918746T3 (da) 2003-08-04

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US (6) US5929117A (cs)
EP (2) EP1361210B1 (cs)
JP (2) JP4214537B2 (cs)
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CN1228080A (zh) 1999-09-08
US6262101B1 (en) 2001-07-17
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RU2188819C2 (ru) 2002-09-10
HUP9904569A2 (hu) 2000-05-28
FI990180A7 (fi) 1999-03-08
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KR20050074648A (ko) 2005-07-18
FI990180A0 (fi) 1999-02-01
US20010056107A1 (en) 2001-12-27
DE69720735D1 (de) 2003-05-15
PT918746E (pt) 2003-08-29
JP4214537B2 (ja) 2009-01-28
SK17799A3 (en) 1999-11-08
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DE69720735T2 (de) 2004-03-04
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FI990180L (fi) 1999-03-08
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