BRPI0518062A - uso de um modulador de pde4, ou um sal, solvato, ou estereoisÈmero farmaceuticamente aceitável do mesmo, e, composição farmacêutica - Google Patents
uso de um modulador de pde4, ou um sal, solvato, ou estereoisÈmero farmaceuticamente aceitável do mesmo, e, composição farmacêuticaInfo
- Publication number
- BRPI0518062A BRPI0518062A BRPI0518062-7A BRPI0518062A BRPI0518062A BR PI0518062 A BRPI0518062 A BR PI0518062A BR PI0518062 A BRPI0518062 A BR PI0518062A BR PI0518062 A BRPI0518062 A BR PI0518062A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- pde4 modulator
- stereoisomer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
USO DE UM MODULADOR DE PDE4, OU UM SAL, SOLVATO, OU ESTEREOISÈMERO FARMACEUTICAMENTE ACEITáVEL DO MESMO, E, COMPOSIçãO FARMACêUTICA. A invenção refere-se a métodos para tratar, prevenir e/ou controlar um dano/lesão no sistema nervoso central e síndromes relacionadas. Métodos específicos compreendem a administração de um modulador de PDE4 sozinho ou em combinação com um segundo agente ativo. Revela-se também composiçóes farmacêuticas, formas de dosagem unitária simples, e kits vantajosos para uso em métodos da invenção.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62380304P | 2004-10-28 | 2004-10-28 | |
PCT/US2005/038861 WO2006050057A2 (en) | 2004-10-28 | 2005-10-26 | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518062A true BRPI0518062A (pt) | 2008-10-28 |
Family
ID=36319648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518062-7A BRPI0518062A (pt) | 2004-10-28 | 2005-10-26 | uso de um modulador de pde4, ou um sal, solvato, ou estereoisÈmero farmaceuticamente aceitável do mesmo, e, composição farmacêutica |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060106085A1 (pt) |
EP (1) | EP1811992A2 (pt) |
JP (1) | JP2008518924A (pt) |
KR (1) | KR20070085454A (pt) |
CN (1) | CN101309585A (pt) |
AR (1) | AR052223A1 (pt) |
AU (1) | AU2005302523A1 (pt) |
BR (1) | BRPI0518062A (pt) |
CA (1) | CA2585423A1 (pt) |
IL (1) | IL182825A0 (pt) |
MX (1) | MX2007005040A (pt) |
PE (1) | PE20061167A1 (pt) |
WO (1) | WO2006050057A2 (pt) |
ZA (1) | ZA200704251B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
AU2006304787A1 (en) * | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
EP2038279A2 (en) * | 2006-06-06 | 2009-03-25 | Avigen, Inc. | Substituted pyrazolo [1,5- alpha] pyridine compounds and their methods of use |
CN101925596B (zh) * | 2008-01-24 | 2014-05-28 | 默克专利有限公司 | 用于治疗糖尿病的β-氨基酸衍生物 |
US9757355B2 (en) | 2011-01-10 | 2017-09-12 | Celgene Corporation | Oral dosage forms of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide |
US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
US10011611B2 (en) | 2015-08-14 | 2018-07-03 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
US20220098257A1 (en) * | 2019-01-23 | 2022-03-31 | Path Therapeutics, Inc. | Methods of Treating Epilepsy via Phosphodiesterase 4 (PDE4) Inhibition |
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-
2005
- 2005-10-26 EP EP05814094A patent/EP1811992A2/en not_active Withdrawn
- 2005-10-26 AU AU2005302523A patent/AU2005302523A1/en not_active Abandoned
- 2005-10-26 KR KR1020077011855A patent/KR20070085454A/ko not_active Application Discontinuation
- 2005-10-26 CA CA002585423A patent/CA2585423A1/en not_active Abandoned
- 2005-10-26 WO PCT/US2005/038861 patent/WO2006050057A2/en active Application Filing
- 2005-10-26 MX MX2007005040A patent/MX2007005040A/es not_active Application Discontinuation
- 2005-10-26 JP JP2007539148A patent/JP2008518924A/ja not_active Abandoned
- 2005-10-26 BR BRPI0518062-7A patent/BRPI0518062A/pt not_active IP Right Cessation
- 2005-10-26 CN CNA2005800452239A patent/CN101309585A/zh active Pending
- 2005-10-26 ZA ZA200704251A patent/ZA200704251B/xx unknown
- 2005-10-27 US US11/262,374 patent/US20060106085A1/en not_active Abandoned
- 2005-10-27 AR ARP050104509A patent/AR052223A1/es not_active Application Discontinuation
- 2005-10-28 PE PE2005001269A patent/PE20061167A1/es not_active Application Discontinuation
-
2007
- 2007-04-26 IL IL182825A patent/IL182825A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007005040A (es) | 2007-06-19 |
EP1811992A2 (en) | 2007-08-01 |
WO2006050057A2 (en) | 2006-05-11 |
AU2005302523A1 (en) | 2006-05-11 |
KR20070085454A (ko) | 2007-08-27 |
JP2008518924A (ja) | 2008-06-05 |
PE20061167A1 (es) | 2006-11-08 |
AR052223A1 (es) | 2007-03-07 |
ZA200704251B (en) | 2008-11-26 |
CA2585423A1 (en) | 2006-05-11 |
IL182825A0 (en) | 2007-09-20 |
US20060106085A1 (en) | 2006-05-18 |
CN101309585A (zh) | 2008-11-19 |
WO2006050057A3 (en) | 2008-07-10 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |