DK0915835T3 - Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benze - Google Patents
Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benzeInfo
- Publication number
- DK0915835T3 DK0915835T3 DK98928291T DK98928291T DK0915835T3 DK 0915835 T3 DK0915835 T3 DK 0915835T3 DK 98928291 T DK98928291 T DK 98928291T DK 98928291 T DK98928291 T DK 98928291T DK 0915835 T3 DK0915835 T3 DK 0915835T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- amino
- dihydroxypropyl
- reaction
- triiodo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001268A IT1292037B1 (it) | 1997-05-30 | 1997-05-30 | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
| PCT/EP1998/002927 WO1998054124A1 (en) | 1997-05-30 | 1998-05-19 | A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-n,n'-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0915835T3 true DK0915835T3 (da) | 2001-02-05 |
Family
ID=11377250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98928291T DK0915835T3 (da) | 1997-05-30 | 1998-05-19 | Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benze |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5965772A (de) |
| EP (1) | EP0915835B1 (de) |
| JP (1) | JP3437584B2 (de) |
| KR (1) | KR20000029649A (de) |
| CN (1) | CN1228079A (de) |
| AT (1) | ATE198191T1 (de) |
| AU (1) | AU729759B2 (de) |
| CA (1) | CA2261656A1 (de) |
| CZ (1) | CZ25399A3 (de) |
| DE (1) | DE69800434T2 (de) |
| DK (1) | DK0915835T3 (de) |
| ES (1) | ES2152747T3 (de) |
| GR (1) | GR3035123T3 (de) |
| IT (1) | IT1292037B1 (de) |
| NO (1) | NO323475B1 (de) |
| PL (1) | PL331208A1 (de) |
| PT (1) | PT915835E (de) |
| WO (1) | WO1998054124A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE520688C2 (sv) * | 2000-04-11 | 2003-08-12 | Bone Support Ab | Ett injicerbart ersättningsmaterial för benmineral |
| SE517168C2 (sv) * | 2000-07-17 | 2002-04-23 | Bone Support Ab | En komposition för ett injicerbart ersättningsmaterial för benmineral |
| SE522098C2 (sv) | 2001-12-20 | 2004-01-13 | Bone Support Ab | Ett nytt benmineralsubstitut |
| SE0300620D0 (sv) | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
| WO2004087637A1 (en) * | 2003-03-31 | 2004-10-14 | Takasago International Corporation | Production of n-alkylamide compounds |
| SE0302983D0 (sv) * | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
| SE527528C2 (sv) * | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
| PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| CN100344606C (zh) * | 2005-12-28 | 2007-10-24 | 江苏省原子医学研究所 | 一种碘昔兰的制备方法 |
| CN101663260B (zh) * | 2007-04-25 | 2013-02-13 | 弗·哈夫曼-拉罗切有限公司 | 制备酰基氯的方法 |
| CN101952236B (zh) | 2008-04-04 | 2014-07-02 | 弗·哈夫曼-拉罗切有限公司 | 通过相应的环己烷羧酰胺衍生物制备环己烷羧酸衍生物的新工艺 |
| WO2009121788A1 (en) | 2008-04-04 | 2009-10-08 | F. Hoffmann-La Roche Ag | New process for the preparatiion of cyclohexanecarboxylic acid dericatives |
| KR101098553B1 (ko) * | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
| JP5325980B2 (ja) | 2008-06-17 | 2013-10-23 | エフ．ホフマン−ラ ロシュ アーゲー | 薬学的に活性なアミドの製造における中間体としての１−（２−エチル−ブチル）−シクロヘキサンカルボン酸エステル |
| BRPI0921464B8 (pt) * | 2008-11-18 | 2021-05-25 | Bracco Imaging Spa | processo para preparação de agente de contraste iodado |
| AU2009355814B2 (en) * | 2009-11-26 | 2016-06-30 | Imax Diagnostic Imaging Holding Ltd | Preparation and purification of iodixanol |
| US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
| IT1403988B1 (it) * | 2010-07-15 | 2013-11-08 | Bracco Imaging Spa | Processo per la preparazione di agenti di contrasto. |
| DK2958603T3 (en) | 2013-02-20 | 2018-07-16 | Bone Support Ab | IMPROVED CURE FOR HARDWARE BONE COMPENSATION |
| KR101520187B1 (ko) * | 2013-10-25 | 2015-05-13 | 주식회사 대웅제약 | 이오프로마이드의 중간체의 제조방법 |
| CN106316878B (zh) * | 2015-06-15 | 2018-01-19 | 重庆常捷医药有限公司 | 一种碘美普尔杂质的制备方法 |
| CN110023279B (zh) | 2016-12-05 | 2022-03-11 | 伯拉考成像股份公司 | 放射照相剂中间体的机械化学合成 |
| KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| CN113387833A (zh) * | 2021-05-25 | 2021-09-14 | 成都丽璟科技有限公司 | 一种低渗透性泛影酸衍生物造影剂及其制备方法 |
| CN115872894A (zh) * | 2022-11-15 | 2023-03-31 | 上海慧聚药业有限公司 | 非离子型造影剂的合成 |
| CN116332787B (zh) * | 2023-03-03 | 2023-10-27 | 安庆朗坤药业有限公司 | 一种造影剂中间体乙酰碘化物的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (de) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| JP4012566B2 (ja) * | 1995-05-23 | 2007-11-21 | ブラッコ イメージング エッセ ピ ア | ジカルボン酸二塩化物の製造方法 |
-
1997
- 1997-05-30 IT IT97MI001268A patent/IT1292037B1/it active IP Right Grant
-
1998
- 1998-05-19 JP JP50018399A patent/JP3437584B2/ja not_active Expired - Lifetime
- 1998-05-19 CA CA002261656A patent/CA2261656A1/en not_active Abandoned
- 1998-05-19 AU AU80185/98A patent/AU729759B2/en not_active Ceased
- 1998-05-19 PL PL98331208A patent/PL331208A1/xx unknown
- 1998-05-19 KR KR1019997000722A patent/KR20000029649A/ko not_active Application Discontinuation
- 1998-05-19 ES ES98928291T patent/ES2152747T3/es not_active Expired - Lifetime
- 1998-05-19 AT AT98928291T patent/ATE198191T1/de not_active IP Right Cessation
- 1998-05-19 DE DE69800434T patent/DE69800434T2/de not_active Expired - Lifetime
- 1998-05-19 CN CN98800714A patent/CN1228079A/zh active Pending
- 1998-05-19 PT PT98928291T patent/PT915835E/pt unknown
- 1998-05-19 CZ CZ99253A patent/CZ25399A3/cs unknown
- 1998-05-19 DK DK98928291T patent/DK0915835T3/da active
- 1998-05-19 EP EP98928291A patent/EP0915835B1/de not_active Expired - Lifetime
- 1998-05-19 WO PCT/EP1998/002927 patent/WO1998054124A1/en not_active Application Discontinuation
- 1998-05-28 US US09/084,922 patent/US5965772A/en not_active Expired - Lifetime
-
1999
- 1999-01-25 NO NO19990334A patent/NO323475B1/no not_active IP Right Cessation
-
2000
- 2000-12-21 GR GR20000402639T patent/GR3035123T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0915835B1 (de) | 2000-12-20 |
| CA2261656A1 (en) | 1998-12-03 |
| KR20000029649A (ko) | 2000-05-25 |
| JP3437584B2 (ja) | 2003-08-18 |
| ITMI971268A0 (de) | 1997-05-30 |
| AU729759B2 (en) | 2001-02-08 |
| PT915835E (pt) | 2001-03-30 |
| NO323475B1 (no) | 2007-05-21 |
| DE69800434T2 (de) | 2001-04-19 |
| DE69800434D1 (de) | 2001-01-25 |
| JP2000505820A (ja) | 2000-05-16 |
| GR3035123T3 (en) | 2001-03-30 |
| ITMI971268A1 (it) | 1998-11-30 |
| IT1292037B1 (it) | 1999-01-25 |
| WO1998054124A1 (en) | 1998-12-03 |
| EP0915835A1 (de) | 1999-05-19 |
| AU8018598A (en) | 1998-12-30 |
| ATE198191T1 (de) | 2001-01-15 |
| NO990334D0 (no) | 1999-01-25 |
| PL331208A1 (en) | 1999-07-05 |
| CZ25399A3 (cs) | 1999-07-14 |
| ES2152747T3 (es) | 2001-02-01 |
| CN1228079A (zh) | 1999-09-08 |
| US5965772A (en) | 1999-10-12 |
| NO990334L (no) | 1999-03-26 |
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