DK0915835T3 - Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benze - Google Patents
Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benzeInfo
- Publication number
- DK0915835T3 DK0915835T3 DK98928291T DK98928291T DK0915835T3 DK 0915835 T3 DK0915835 T3 DK 0915835T3 DK 98928291 T DK98928291 T DK 98928291T DK 98928291 T DK98928291 T DK 98928291T DK 0915835 T3 DK0915835 T3 DK 0915835T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- amino
- dihydroxypropyl
- reaction
- triiodo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2,3-dihydroxypropyl Chemical group 0.000 title 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 2
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 abstract 1
- KQIGMPWTAHJUMN-UHFFFAOYSA-N 3-aminopropane-1,2-diol Chemical compound NCC(O)CO KQIGMPWTAHJUMN-UHFFFAOYSA-N 0.000 abstract 1
- SSZWWUDQMAHNAQ-UHFFFAOYSA-N 3-chloropropane-1,2-diol Chemical compound OCC(O)CCl SSZWWUDQMAHNAQ-UHFFFAOYSA-N 0.000 abstract 1
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 abstract 1
- KBZFDRWPMZESDI-UHFFFAOYSA-N 5-aminobenzene-1,3-dicarboxylic acid Chemical compound NC1=CC(C(O)=O)=CC(C(O)=O)=C1 KBZFDRWPMZESDI-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- LQIIRBFXBIGGAZ-UHFFFAOYSA-L calcium;sodium;dihydroxide Chemical compound [OH-].[OH-].[Na+].[Ca+2] LQIIRBFXBIGGAZ-UHFFFAOYSA-L 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001268A IT1292037B1 (it) | 1997-05-30 | 1997-05-30 | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
| PCT/EP1998/002927 WO1998054124A1 (en) | 1997-05-30 | 1998-05-19 | A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-n,n'-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0915835T3 true DK0915835T3 (da) | 2001-02-05 |
Family
ID=11377250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98928291T DK0915835T3 (da) | 1997-05-30 | 1998-05-19 | Fremgangsmåde til fremstilling af 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiod-1,3-benze |
Country Status (18)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE520688C2 (sv) * | 2000-04-11 | 2003-08-12 | Bone Support Ab | Ett injicerbart ersättningsmaterial för benmineral |
| SE517168C2 (sv) * | 2000-07-17 | 2002-04-23 | Bone Support Ab | En komposition för ett injicerbart ersättningsmaterial för benmineral |
| SE522098C2 (sv) | 2001-12-20 | 2004-01-13 | Bone Support Ab | Ett nytt benmineralsubstitut |
| SE0300620D0 (sv) | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
| WO2004087637A1 (en) * | 2003-03-31 | 2004-10-14 | Takasago International Corporation | Production of n-alkylamide compounds |
| SE0302983D0 (sv) * | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
| SE527528C2 (sv) | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
| PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| CN100344606C (zh) * | 2005-12-28 | 2007-10-24 | 江苏省原子医学研究所 | 一种碘昔兰的制备方法 |
| CN101663260B (zh) * | 2007-04-25 | 2013-02-13 | 弗·哈夫曼-拉罗切有限公司 | 制备酰基氯的方法 |
| WO2009121789A1 (en) | 2008-04-04 | 2009-10-08 | F. Hoffmann-La Roche Ag | New process for the preparation of cyclohexanecarboxylic acid derivatives via the corresponding cyclohexanecarboxamide derivative |
| WO2009121788A1 (en) | 2008-04-04 | 2009-10-08 | F. Hoffmann-La Roche Ag | New process for the preparatiion of cyclohexanecarboxylic acid dericatives |
| KR101098553B1 (ko) * | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
| ES2624716T3 (es) | 2008-06-17 | 2017-07-17 | F. Hoffmann-La Roche Ag | Éster del ácido 1-(2-etil-butil)-ciclohexanocarboxílico como intermedio en la preparación de amidas farmacéuticamente activas |
| HRP20171443T1 (hr) | 2008-11-18 | 2017-11-03 | Bracco Imaging S.P.A | Postupak za pripremanje jodiranog kontrastnog sredstva |
| KR101699226B1 (ko) | 2009-11-26 | 2017-01-24 | 호비온 차이나 홀딩 리미티드 | 이오딕사놀의 제조 및 정제 |
| US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
| IT1403988B1 (it) * | 2010-07-15 | 2013-11-08 | Bracco Imaging Spa | Processo per la preparazione di agenti di contrasto. |
| KR102024692B1 (ko) | 2013-02-20 | 2019-11-04 | 본 서포트 아베 | 경화성 뼈 대체물의 향상된 세팅 |
| KR101520187B1 (ko) | 2013-10-25 | 2015-05-13 | 주식회사 대웅제약 | 이오프로마이드의 중간체의 제조방법 |
| CN106316878B (zh) * | 2015-06-15 | 2018-01-19 | 重庆常捷医药有限公司 | 一种碘美普尔杂质的制备方法 |
| EP3548461B1 (en) * | 2016-12-05 | 2021-02-03 | Bracco Imaging SpA | Mechanochemical synthesis of radiographic agents intermediates |
| KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| CN114478298B (zh) * | 2020-11-12 | 2024-09-27 | 成都西岭源药业有限公司 | 一种造影剂碘佛醇的纯化方法 |
| CN113387833A (zh) * | 2021-05-25 | 2021-09-14 | 成都丽璟科技有限公司 | 一种低渗透性泛影酸衍生物造影剂及其制备方法 |
| CN115872894B (zh) * | 2022-11-15 | 2024-12-24 | 上海慧聚药业有限公司 | 非离子型造影剂的合成 |
| CN116332787B (zh) * | 2023-03-03 | 2023-10-27 | 安庆朗坤药业有限公司 | 一种造影剂中间体乙酰碘化物的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| ATE176663T1 (de) * | 1995-05-23 | 1999-02-15 | Fructamine Spa | Verfahren zur herstellung von dicarbonsäurechlorid |
-
1997
- 1997-05-30 IT IT97MI001268A patent/IT1292037B1/it active IP Right Grant
-
1998
- 1998-05-19 DE DE69800434T patent/DE69800434T2/de not_active Expired - Lifetime
- 1998-05-19 EP EP98928291A patent/EP0915835B1/en not_active Expired - Lifetime
- 1998-05-19 ES ES98928291T patent/ES2152747T3/es not_active Expired - Lifetime
- 1998-05-19 CN CN98800714A patent/CN1228079A/zh active Pending
- 1998-05-19 PL PL98331208A patent/PL331208A1/xx unknown
- 1998-05-19 JP JP50018399A patent/JP3437584B2/ja not_active Expired - Lifetime
- 1998-05-19 DK DK98928291T patent/DK0915835T3/da active
- 1998-05-19 AU AU80185/98A patent/AU729759B2/en not_active Ceased
- 1998-05-19 CA CA002261656A patent/CA2261656A1/en not_active Abandoned
- 1998-05-19 AT AT98928291T patent/ATE198191T1/de not_active IP Right Cessation
- 1998-05-19 CZ CZ99253A patent/CZ25399A3/cs unknown
- 1998-05-19 KR KR1019997000722A patent/KR20000029649A/ko not_active Ceased
- 1998-05-19 PT PT98928291T patent/PT915835E/pt unknown
- 1998-05-19 WO PCT/EP1998/002927 patent/WO1998054124A1/en not_active Application Discontinuation
- 1998-05-28 US US09/084,922 patent/US5965772A/en not_active Expired - Lifetime
-
1999
- 1999-01-25 NO NO19990334A patent/NO323475B1/no not_active IP Right Cessation
-
2000
- 2000-12-21 GR GR20000402639T patent/GR3035123T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998054124A1 (en) | 1998-12-03 |
| NO990334D0 (no) | 1999-01-25 |
| KR20000029649A (ko) | 2000-05-25 |
| CZ25399A3 (cs) | 1999-07-14 |
| JP3437584B2 (ja) | 2003-08-18 |
| CN1228079A (zh) | 1999-09-08 |
| CA2261656A1 (en) | 1998-12-03 |
| PL331208A1 (en) | 1999-07-05 |
| DE69800434T2 (de) | 2001-04-19 |
| EP0915835A1 (en) | 1999-05-19 |
| ATE198191T1 (de) | 2001-01-15 |
| GR3035123T3 (en) | 2001-03-30 |
| ITMI971268A1 (it) | 1998-11-30 |
| DE69800434D1 (de) | 2001-01-25 |
| EP0915835B1 (en) | 2000-12-20 |
| ES2152747T3 (es) | 2001-02-01 |
| ITMI971268A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-05-30 |
| NO990334L (no) | 1999-03-26 |
| AU8018598A (en) | 1998-12-30 |
| IT1292037B1 (it) | 1999-01-25 |
| PT915835E (pt) | 2001-03-30 |
| JP2000505820A (ja) | 2000-05-16 |
| AU729759B2 (en) | 2001-02-08 |
| NO323475B1 (no) | 2007-05-21 |
| US5965772A (en) | 1999-10-12 |
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