DK0885888T3 - Isoquinolinderivater og lægemidler - Google Patents
Isoquinolinderivater og lægemidlerInfo
- Publication number
- DK0885888T3 DK0885888T3 DK97901806T DK97901806T DK0885888T3 DK 0885888 T3 DK0885888 T3 DK 0885888T3 DK 97901806 T DK97901806 T DK 97901806T DK 97901806 T DK97901806 T DK 97901806T DK 0885888 T3 DK0885888 T3 DK 0885888T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxy
- halogen
- compound
- amino group
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1794696 | 1996-02-02 | ||
| JP27588696 | 1996-10-18 | ||
| PCT/JP1997/000240 WO1997028130A1 (fr) | 1996-02-02 | 1997-01-31 | Derives de l'isoquinoline et medicaments associes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0885888T3 true DK0885888T3 (da) | 2003-11-24 |
Family
ID=26354541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97901806T DK0885888T3 (da) | 1996-02-02 | 1997-01-31 | Isoquinolinderivater og lægemidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6153608A (de) |
| EP (1) | EP0885888B1 (de) |
| JP (1) | JP3834663B2 (de) |
| KR (1) | KR19990082174A (de) |
| CN (1) | CN1210521A (de) |
| AT (1) | ATE247090T1 (de) |
| AU (1) | AU1557497A (de) |
| DE (1) | DE69724108T2 (de) |
| DK (1) | DK0885888T3 (de) |
| ES (1) | ES2205166T3 (de) |
| PT (1) | PT885888E (de) |
| WO (1) | WO1997028130A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9512298A (en) * | 1997-09-30 | 1999-04-23 | Molecular Design International, Inc. | Beta3-adrenoreceptor agonists, agonist compositions and methods of using |
| AU9646198A (en) * | 1997-10-22 | 1999-05-10 | Nippon Shinyaku Co. Ltd. | Isoquinoline derivative and drug |
| JP4212149B2 (ja) * | 1998-06-11 | 2009-01-21 | 株式会社デ・ウエスタン・セラピテクス研究所 | 医薬 |
| EP1110553B1 (de) * | 1998-08-10 | 2013-03-27 | Asahi Kasei Pharma Corporation | Orale zusammensetzungen zur kontrollierten freisetzung von fasudil hydrochlorid |
| WO2000064478A1 (fr) | 1999-04-27 | 2000-11-02 | Mitsubishi Pharma Corporation | Medicaments destines a soigner et a prevenir les maladies du foie |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| EP1378247B1 (de) * | 2001-04-11 | 2016-08-24 | Senju Pharmaceutical Co., Ltd. | Wirkstoffe zur behandlung von sehfunktionsstörungen |
| US20040242565A1 (en) * | 2001-09-11 | 2004-12-02 | Yoshinori Toshima | Medicinal composition for prevention of or treatment for cerebrovascular disorder and cardiopathy |
| DE10153605A1 (de) * | 2001-11-02 | 2003-05-28 | Morphochem Ag Komb Chemie | Verwendung von Inhibitoren der Rho-Kinasen zur Stimulation des Nervenwachstums, zur Inhibition der Narbengewebsbildung und/oder Reduktion eines Sekundärschadens |
| CN1642546A (zh) * | 2002-03-28 | 2005-07-20 | 帝人株式会社 | 含有单一晶型的固体制剂 |
| US7094789B2 (en) * | 2002-07-22 | 2006-08-22 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivatives |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| US7160894B2 (en) | 2003-06-06 | 2007-01-09 | Asahi Kasei Pharma Corporation | Tricyclic compound |
| TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| ZA200604862B (en) * | 2003-12-22 | 2007-10-31 | Alcon Inc | Agents for treatment of glaucomatous retinopathy and optic neuropathy |
| CA2548146A1 (en) * | 2003-12-22 | 2005-07-14 | Alcon, Inc. | Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration |
| JP4854070B2 (ja) * | 2004-01-29 | 2012-01-11 | 旭化成ファーマ株式会社 | バイパス術に伴う血管攣縮治療剤 |
| US20080096238A1 (en) * | 2004-03-30 | 2008-04-24 | Alcon, Inc. | High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio |
| WO2005102345A1 (en) * | 2004-03-30 | 2005-11-03 | Alcon, Inc. | Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance |
| US20060115870A1 (en) * | 2004-03-30 | 2006-06-01 | Alcon, Inc. | High throughput assay for human Rho kinase activity |
| CN101048393A (zh) * | 2004-06-30 | 2007-10-03 | 先灵公司 | 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺 |
| US20060247266A1 (en) * | 2004-11-26 | 2006-11-02 | Asahi Kasei Pharma Corporation | Nitrogen-containing tricyclic compounds |
| MY139797A (en) * | 2004-11-29 | 2009-10-30 | Kowa Co | (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate |
| WO2006090783A1 (ja) * | 2005-02-25 | 2006-08-31 | Kowa Co., Ltd. | ４－フルオロイソキノリン－５－スルホニルハライド又はその塩の製造方法 |
| WO2006115244A1 (ja) * | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | ４－ブロモイソキノリン誘導体及びこれを含有する医薬 |
| WO2006115245A1 (ja) * | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | ４－エチニルイソキノリン誘導体及びこれを含有する医薬 |
| ATE423779T1 (de) * | 2005-04-25 | 2009-03-15 | Western Therapeutics Inst Inc | Hochselektiver rho-kinase-inhibitor |
| EP1932841B1 (de) | 2005-08-30 | 2014-01-01 | Asahi Kasei Pharma Corporation | Sulfonamidverbindung |
| AU2007272854B2 (en) * | 2006-07-14 | 2013-08-01 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
| US20080064681A1 (en) * | 2006-09-11 | 2008-03-13 | Hiroyoshi Hidaka | Therapeutic agent for treating glaucoma |
| JP5419279B2 (ja) * | 2007-01-17 | 2014-02-19 | ウィスコンシン アラムニ リサーチ ファンデーション | 改良された幹細胞の培養 |
| US8415372B2 (en) | 2007-02-27 | 2013-04-09 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
| AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
| ES2396795T3 (es) | 2007-07-02 | 2013-02-27 | Asahi Kasei Pharma Corporation | Compuesto de sulfonamida y cirstal del mismo |
| WO2010028011A1 (en) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| CN101386617B (zh) * | 2008-11-03 | 2012-06-13 | 中国药科大学 | 取代的四氢异喹啉衍生物、其制备方法及含有它们的药物组合物 |
| CN101429191B (zh) * | 2008-11-03 | 2012-05-23 | 中国药科大学 | 取代的四氢异喹啉衍生物的用途 |
| US8933071B2 (en) * | 2008-11-07 | 2015-01-13 | Northwestern University | Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders |
| KR101732907B1 (ko) | 2009-06-19 | 2017-05-08 | 가부시키가이샤 디. 웨스턴 세라퓨틱스 겡큐쇼 | 치환된 이소퀴놀린 유도체 |
| WO2011021221A2 (en) | 2009-08-17 | 2011-02-24 | Reliance Life Sciences Pvt. Ltd. | Compositions for spinal cord injury |
| EP2610252A4 (de) | 2010-08-26 | 2013-09-04 | Kowa Co | Neues herstellungsverfahren für isochinolinderivate und deren salze |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| EP3138843B1 (de) * | 2014-04-28 | 2019-11-27 | Medshine Discovery Inc. | Isochinolinesulfonylderivate als rho-kinasehemmer |
| CN105085525B (zh) * | 2014-04-28 | 2019-01-04 | 南京明德新药研发股份有限公司 | 作为rho激酶抑制剂的异喹啉磺酰衍生物 |
| JP6755775B2 (ja) * | 2016-11-04 | 2020-09-16 | 富士アミドケミカル株式会社 | ４−フルオロイソキノリンの製法 |
| CN109134433B (zh) * | 2017-06-16 | 2021-05-25 | 成都先导药物开发股份有限公司 | 一种抑制rock的化合物及其应用 |
| WO2019015608A1 (zh) * | 2017-07-19 | 2019-01-24 | 南京明德新药研发股份有限公司 | 异喹啉磺酰衍生物及其应用 |
| WO2019057121A1 (zh) * | 2017-09-25 | 2019-03-28 | 南京明德新药研发股份有限公司 | 一种异喹啉磺酰衍生物的晶型及其制备方法 |
| CN111116555B (zh) * | 2018-10-30 | 2023-06-02 | 北京盈科瑞创新药物研究有限公司 | 一种Rho激酶抑制剂及其制备方法和应用 |
| CN111440150B (zh) * | 2020-05-12 | 2021-04-06 | 中国药科大学 | 一种一氧化氮供体型法舒地尔衍生物及其制备方法和用途 |
| CA3236332A1 (en) | 2021-10-30 | 2023-05-04 | Ziev B. Moses | Treatments for disturbed cerebral homeostasis |
| CN115626925A (zh) * | 2022-12-08 | 2023-01-20 | 山东汇海医药化工有限公司 | 一种双哌啶的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57156463A (en) * | 1981-03-20 | 1982-09-27 | Asahi Chem Ind Co Ltd | Isoquinoline derivative |
| JPH0227992B2 (ja) * | 1982-01-14 | 1990-06-20 | Asahi Kasei Kogyo Kk | Isokinorinsuruhonirukagobutsu |
| US4456757A (en) * | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS5993054A (ja) * | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | イソキノリンスルホン酸アミド誘導体 |
| US4678783B1 (en) * | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| JPS61152658A (ja) * | 1984-12-27 | 1986-07-11 | Asahi Chem Ind Co Ltd | 置換されたイソキノリンスルホンアミド誘導体 |
| JPS61227581A (ja) * | 1985-04-02 | 1986-10-09 | Asahi Chem Ind Co Ltd | 血管拡張剤 |
| JP2720348B2 (ja) * | 1989-03-30 | 1998-03-04 | 旭化成工業株式会社 | 脳細胞機能障害改善剤 |
-
1997
- 1997-01-31 AU AU15574/97A patent/AU1557497A/en not_active Abandoned
- 1997-01-31 AT AT97901806T patent/ATE247090T1/de active
- 1997-01-31 ES ES97901806T patent/ES2205166T3/es not_active Expired - Lifetime
- 1997-01-31 PT PT97901806T patent/PT885888E/pt unknown
- 1997-01-31 DK DK97901806T patent/DK0885888T3/da active
- 1997-01-31 KR KR1019980705899A patent/KR19990082174A/ko not_active Application Discontinuation
- 1997-01-31 CN CN97191967A patent/CN1210521A/zh active Pending
- 1997-01-31 US US09/117,433 patent/US6153608A/en not_active Expired - Lifetime
- 1997-01-31 EP EP97901806A patent/EP0885888B1/de not_active Expired - Lifetime
- 1997-01-31 WO PCT/JP1997/000240 patent/WO1997028130A1/ja active IP Right Grant
- 1997-01-31 DE DE69724108T patent/DE69724108T2/de not_active Expired - Lifetime
- 1997-01-31 JP JP51067397A patent/JP3834663B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT885888E (pt) | 2003-12-31 |
| EP0885888B1 (de) | 2003-08-13 |
| EP0885888A1 (de) | 1998-12-23 |
| EP0885888A4 (de) | 2000-07-19 |
| CN1210521A (zh) | 1999-03-10 |
| ATE247090T1 (de) | 2003-08-15 |
| DE69724108T2 (de) | 2004-06-09 |
| ES2205166T3 (es) | 2004-05-01 |
| JP3834663B2 (ja) | 2006-10-18 |
| KR19990082174A (ko) | 1999-11-25 |
| DE69724108D1 (de) | 2003-09-18 |
| AU1557497A (en) | 1997-08-22 |
| WO1997028130A1 (fr) | 1997-08-07 |
| US6153608A (en) | 2000-11-28 |
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