CA2245728A1 - Isoquinoline derivatives and drugs - Google Patents
Isoquinoline derivatives and drugsInfo
- Publication number
- CA2245728A1 CA2245728A1 CA 2245728 CA2245728A CA2245728A1 CA 2245728 A1 CA2245728 A1 CA 2245728A1 CA 2245728 CA2245728 CA 2245728 CA 2245728 A CA2245728 A CA 2245728A CA 2245728 A1 CA2245728 A1 CA 2245728A1
- Authority
- CA
- Canada
- Prior art keywords
- hydroxy
- halogen
- compound
- amino group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, (see formula I) wherein R1 represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogen; R2 represents hydrogen, hydroxy, or halogen; R3 represents hydrogen, alkyl, or amidino; Ring A represents a 5 to 11-membered cyclic amino group which may be substituted, which cyclic amino group may be bridged between two carbon atoms in optional positions.
The compound of this invention is useful for the prevention or treatment of cerebral tissue impairment due to the vasospasm following cerebral hemorrhage.
The compound of this invention is useful for the prevention or treatment of cerebral tissue impairment due to the vasospasm following cerebral hemorrhage.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8/17946 | 1996-02-02 | ||
| JP1794696 | 1996-02-02 | ||
| JP27588696 | 1996-10-18 | ||
| JP8/275886 | 1996-10-18 | ||
| PCT/JP1997/000240 WO1997028130A1 (en) | 1996-02-02 | 1997-01-31 | Isoquinoline derivatives and drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2245728A1 true CA2245728A1 (en) | 1997-08-07 |
| CA2245728C CA2245728C (en) | 2006-12-05 |
Family
ID=29424195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2245728 Expired - Lifetime CA2245728C (en) | 1996-02-02 | 1997-01-31 | Isoquinoline derivatives and drugs |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2245728C (en) |
-
1997
- 1997-01-31 CA CA 2245728 patent/CA2245728C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2245728C (en) | 2006-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170131 |