DK0885210T5 - Tricykliske forbindelser med bindingsaffinitet for melatoninreceptorer, deres fremstilling og anvendelse - Google Patents

Tricykliske forbindelser med bindingsaffinitet for melatoninreceptorer, deres fremstilling og anvendelse

Info

Publication number
DK0885210T5
DK0885210T5 DK97905450T DK97905450T DK0885210T5 DK 0885210 T5 DK0885210 T5 DK 0885210T5 DK 97905450 T DK97905450 T DK 97905450T DK 97905450 T DK97905450 T DK 97905450T DK 0885210 T5 DK0885210 T5 DK 0885210T5
Authority
DK
Denmark
Prior art keywords
group
optionally substituted
substituted hydrocarbon
preparation
binding affinity
Prior art date
Application number
DK97905450T
Other languages
Danish (da)
English (en)
Other versions
DK0885210T4 (da
DK0885210T3 (da
Inventor
Shigenori Ohkawa
Osamu Uchikawa
Kohji Fukatsu
Masaomi Miyamoto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27286462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0885210(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of DK0885210T3 publication Critical patent/DK0885210T3/da
Publication of DK0885210T4 publication Critical patent/DK0885210T4/da
Publication of DK0885210T5 publication Critical patent/DK0885210T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
DK97905450T 1996-03-08 1997-03-05 Tricykliske forbindelser med bindingsaffinitet for melatoninreceptorer, deres fremstilling og anvendelse DK0885210T5 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5149196 1996-03-08
JP18366796 1996-07-12
JP2918597 1997-02-13
PCT/JP1997/000677 WO1997032871A1 (en) 1996-03-08 1997-03-05 Tricyclic compounds, their production and use

Publications (3)

Publication Number Publication Date
DK0885210T3 DK0885210T3 (da) 2002-10-07
DK0885210T4 DK0885210T4 (da) 2008-09-08
DK0885210T5 true DK0885210T5 (da) 2008-10-13

Family

ID=27286462

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97905450T DK0885210T5 (da) 1996-03-08 1997-03-05 Tricykliske forbindelser med bindingsaffinitet for melatoninreceptorer, deres fremstilling og anvendelse

Country Status (19)

Country Link
US (1) US6218429B1 (cs)
EP (2) EP1550655A1 (cs)
JP (1) JP4358917B2 (cs)
KR (1) KR100494214B1 (cs)
CN (3) CN1900067A (cs)
AT (1) ATE219071T1 (cs)
CA (1) CA2241666C (cs)
CZ (1) CZ291626B6 (cs)
DE (1) DE69713294T3 (cs)
DK (1) DK0885210T5 (cs)
ES (1) ES2175350T5 (cs)
HU (1) HU224220B1 (cs)
NO (1) NO322205B1 (cs)
NZ (1) NZ330656A (cs)
PL (1) PL188093B1 (cs)
PT (1) PT885210E (cs)
SK (1) SK283970B6 (cs)
TW (1) TW562803B (cs)
WO (1) WO1997032871A1 (cs)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773798B1 (fr) * 1998-01-16 2001-02-02 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR100642024B1 (ko) * 1998-06-09 2006-11-06 다케다 야쿠힌 고교 가부시키가이샤 수면 장애를 치료 또는 예방하기 위한 약학적 조성물
WO2001014385A1 (en) * 1999-08-20 2001-03-01 Takeda Chemical Industries, Ltd. Dihydrobenzofuran derivatives, process for the preparation thereof and agents
WO2001013950A1 (en) * 1999-08-20 2001-03-01 Takeda Chemical Industries, Ltd. Percutaneous absorption agents
JP4721495B2 (ja) * 1999-08-20 2011-07-13 武田薬品工業株式会社 ジヒドロベンゾフラン誘導体、その製造法及び剤
JP4632499B2 (ja) * 1999-08-26 2011-02-16 武田薬品工業株式会社 鼻粘膜付着マトリックス
CN1197460C (zh) * 1999-09-08 2005-04-20 阿温提斯作物科学英国有限公司 新的除草组合物
AU2002214306A1 (en) * 2000-11-17 2002-05-27 Takeda Chemical Industries Ltd. Pharmaceutical preparation containing talc/barium sulfate
ATE469644T1 (de) * 2000-11-17 2010-06-15 Takeda Pharmaceutical Pharmazeutische zubereitung enthaltend n-ä2-(1,6, 7,8-tetrahydro-2h-indenoä5,4 büfuran-8- yl)ethylüpropionamid ummantelt mit einer copolyvidon-enthaltenden, polyäthylenglykolfreien umhüllung
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
IL149377A (en) * 2002-04-28 2012-10-31 Neurim Pharma 1991 Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
TWI400220B (zh) * 2004-09-13 2013-07-01 Takeda Pharmaceutical 光活性胺衍生物的製法
TW200626137A (en) * 2004-12-13 2006-08-01 Takeda Pharmaceuticals Co Preventive or therapeutic agent for sleep disorder
US20090042861A1 (en) * 2005-04-04 2009-02-12 Takeda Pharmaceutical Company Limited Prophylactic or Therapeutic Agent for Depression or Anxiety Disorder
JP5220408B2 (ja) * 2005-06-22 2013-06-26 武田薬品工業株式会社 難溶性の有効成分を含有する錠剤
KR101187461B1 (ko) 2005-07-29 2012-10-02 반다 파마슈티칼즈, 인코퍼레이티드. 각성을 향상시키는 방법
ZA200807752B (en) * 2006-03-20 2009-12-30 Takeda Pharmaceutical Agent for prevention/treatment of irritable bowel syndrome
AR061478A1 (es) 2006-06-19 2008-08-27 Takeda Pharmaceutical Compuesto triciclico y composicion farmaceutica
EA200970555A1 (ru) 2006-12-08 2010-02-26 Такеда Фармасьютикал Компани Лимитед Трициклическое соединение и его медицинское применение
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
BRPI0722057A2 (pt) 2006-12-28 2014-04-01 Takeda Pharmaceutical Composto, prodroga, composição farmacêutica, método para prevenir ou tratar distúrbio do sono, e, uso do composto.
US20080242877A1 (en) * 2007-02-26 2008-10-02 Vinod Kumar Kansal Intermediates and processes for the synthesis of Ramelteon
JP5289308B2 (ja) 2007-04-26 2013-09-11 武田薬品工業株式会社 二環性化合物およびその医薬用途
WO2008151170A2 (en) 2007-05-31 2008-12-11 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
US20090105490A1 (en) * 2007-07-12 2009-04-23 Nurit Perlman Polymorphic forms of ramelteon and processes for preparation thereof
ES2324849A1 (es) * 2007-10-25 2009-08-17 Ferrer Internacional, S.A. Compuestos de indano.
US7470814B1 (en) * 2007-10-31 2008-12-30 Ferrer Internacional, S.A. Process for the preparation of substituted 7-allyl-6-hydroxy-indanes
US20090281176A1 (en) * 2007-11-01 2009-11-12 Vinod Kumar Kansal Process for the synthesis of ramelteon and its intermediates
CN101983193B (zh) * 2008-01-31 2014-03-12 武田药品工业株式会社 注意缺陷/多动障碍的预防或治疗剂
JP5584194B2 (ja) 2008-03-28 2014-09-03 エコラボ インコーポレイティド スルホペルオキシカルボン酸、それらの製造方法並びに漂白剤および殺菌剤としての使用方法。
US8871807B2 (en) 2008-03-28 2014-10-28 Ecolab Usa Inc. Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids
US12203056B2 (en) 2008-03-28 2025-01-21 Ecolab Usa Inc. Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents
US8809392B2 (en) 2008-03-28 2014-08-19 Ecolab Usa Inc. Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents
EP2350088A1 (en) * 2008-07-30 2011-08-03 Ferrer Internacional, S.A. 1,6-dihydro-2h-3-oxa-6-aza-as-indacene compounds
WO2010045565A1 (en) * 2008-10-16 2010-04-22 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
BRPI0914068A2 (pt) * 2008-11-14 2015-10-13 Watson Pharma Private Ltd processo de resolução de n-[2-(1,6,7,8-tetra-hidro-2h-indeno[5, 4- b]furano-8-il)]etilamina e ramelteon
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
WO2010092107A1 (en) 2009-02-12 2010-08-19 Lek Pharmaceuticals D.D. Synthesis of (s)-n-[2-(1,6,7,8-tetrahydro-2h-indeno-[5,4-b]furan-8-yl)ethyl]propionamide
WO2010103553A1 (en) * 2009-03-10 2010-09-16 Industriale Chimica S.R.L. Process for the preparation of ramelteon
EP2243775A1 (en) 2009-04-07 2010-10-27 LEK Pharmaceuticals d.d. Synthesis of 1-(2,3-Dihydrobenzofuran-4-YL)ethanone as intermediate in the preparation of ramelteon
CN102648192B (zh) * 2009-09-29 2015-08-26 广州南沙龙沙有限公司 1,2,6,7-四氢-8h-茚并[5,4-b] 呋喃-8-酮的制备方法
JP5758395B2 (ja) * 2009-10-15 2015-08-05 ザ チルドレンズ メディカル センター コーポレイション 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬
WO2012035303A2 (en) 2010-09-17 2012-03-22 Cipla Limited Et Al A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon
CN102321056B (zh) * 2011-07-29 2014-05-14 宁波人健药业集团股份有限公司 一种合成雷美替胺的方法
CN102391220A (zh) * 2011-10-10 2012-03-28 四川大学 三环乙醇类化合物及其制备方法和用途
US9321664B2 (en) 2011-12-20 2016-04-26 Ecolab Usa Inc. Stable percarboxylic acid compositions and uses thereof
CN106396037B (zh) 2012-03-30 2019-10-15 艺康美国股份有限公司 过乙酸/过氧化氢和过氧化物还原剂用于处理钻井液、压裂液、回流水和排放水的用途
WO2014010603A1 (ja) 2012-07-10 2014-01-16 アステラス製薬株式会社 腹圧性尿失禁又は混合型尿失禁の治療又は予防用医薬組成物、及び該医薬組成物に含有される化合物のスクリーニング方法
AR091699A1 (es) 2012-07-10 2015-02-25 Astellas Pharma Inc Derivado de indol carboxamida
CN103724357B (zh) * 2012-10-11 2016-06-08 中国药科大学 一种3,4-二氢吡喃并[3,2-b]吲哚-2-酮类化合物的合成方法
CN102924410A (zh) * 2012-10-29 2013-02-13 华润赛科药业有限责任公司 一种雷美替胺的制备方法及其中间体
US10165774B2 (en) 2013-03-05 2019-01-01 Ecolab Usa Inc. Defoamer useful in a peracid composition with anionic surfactants
US8822719B1 (en) 2013-03-05 2014-09-02 Ecolab Usa Inc. Peroxycarboxylic acid compositions suitable for inline optical or conductivity monitoring
US20140256811A1 (en) 2013-03-05 2014-09-11 Ecolab Usa Inc. Efficient stabilizer in controlling self accelerated decomposition temperature of peroxycarboxylic acid compositions with mineral acids
CN105916840B (zh) 2014-01-14 2019-01-08 安斯泰来制药株式会社 吲哚化合物
CA3010804A1 (en) 2016-01-08 2017-07-13 Takeda Pharmaceutical Company Limited Prophylactic or therapeutic agent for autism spectrum disorder
KR20180100627A (ko) 2016-01-08 2018-09-11 다케다 야쿠힌 고교 가부시키가이샤 섬망의 예방 또는 치료제
US12096768B2 (en) 2019-08-07 2024-09-24 Ecolab Usa Inc. Polymeric and solid-supported chelators for stabilization of peracid-containing compositions
CN110776485B (zh) * 2019-11-22 2022-09-30 山东邹平大展新材料有限公司 一种雷美替胺杂质的制备方法
WO2023059546A1 (en) * 2021-10-04 2023-04-13 Psilosterics, Llc Serotonin receptor agonists and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2713636B1 (fr) 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5661186A (en) 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides

Also Published As

Publication number Publication date
JPH11152281A (ja) 1999-06-08
NO983970L (no) 1998-08-28
HUP9900616A2 (hu) 1999-06-28
CN1900067A (zh) 2007-01-24
HUP9900616A3 (en) 2002-11-28
JP4358917B2 (ja) 2009-11-04
AU706610B2 (en) 1999-06-17
NZ330656A (en) 1999-06-29
CZ277598A3 (cs) 1998-12-16
CN1727339A (zh) 2006-02-01
PT885210E (pt) 2002-09-30
CA2241666C (en) 2007-11-06
ES2175350T3 (es) 2002-11-16
EP0885210A1 (en) 1998-12-23
EP0885210B1 (en) 2002-06-12
NO983970D0 (no) 1998-08-28
EP1550655A1 (en) 2005-07-06
CN100441574C (zh) 2008-12-10
CZ291626B6 (cs) 2003-04-16
DE69713294T3 (de) 2009-01-15
KR19990087628A (ko) 1999-12-27
KR100494214B1 (ko) 2005-11-25
DK0885210T4 (da) 2008-09-08
US6218429B1 (en) 2001-04-17
SK283970B6 (sk) 2004-06-08
PL188093B1 (pl) 2004-12-31
AU2231897A (en) 1997-09-22
TW562803B (en) 2003-11-21
DE69713294D1 (de) 2002-07-18
SK115098A3 (en) 1999-03-12
CN1212691A (zh) 1999-03-31
EP0885210B2 (en) 2008-06-18
CA2241666A1 (en) 1997-09-12
CN100443480C (zh) 2008-12-17
NO322205B1 (no) 2006-08-28
DK0885210T3 (da) 2002-10-07
ES2175350T5 (es) 2008-12-16
HU224220B1 (hu) 2005-06-28
HK1087112A1 (zh) 2006-10-06
ATE219071T1 (de) 2002-06-15
WO1997032871A1 (en) 1997-09-12
DE69713294T2 (de) 2003-02-13
PL328726A1 (en) 1999-02-15

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