DK0733621T3 - Hidtil ukendte imidazolderivater og fremgangsmåde til fremstilling af disse - Google Patents
Hidtil ukendte imidazolderivater og fremgangsmåde til fremstilling af disseInfo
- Publication number
- DK0733621T3 DK0733621T3 DK95902285T DK95902285T DK0733621T3 DK 0733621 T3 DK0733621 T3 DK 0733621T3 DK 95902285 T DK95902285 T DK 95902285T DK 95902285 T DK95902285 T DK 95902285T DK 0733621 T3 DK0733621 T3 DK 0733621T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- lower alkyl
- alkyl group
- imidazole derivatives
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34146793 | 1993-12-10 | ||
| JP31935594A JP3294961B2 (ja) | 1993-12-10 | 1994-11-29 | 新規イミダゾール誘導体及びその製造法 |
| PCT/JP1994/002021 WO1995015951A1 (fr) | 1993-12-10 | 1994-12-01 | Nouveau derive de l'imidazole et sa methode d'obtention |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0733621T3 true DK0733621T3 (da) | 2002-09-09 |
Family
ID=26569693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95902285T DK0733621T3 (da) | 1993-12-10 | 1994-12-01 | Hidtil ukendte imidazolderivater og fremgangsmåde til fremstilling af disse |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5932607A (da) |
| EP (1) | EP0733621B1 (da) |
| JP (1) | JP3294961B2 (da) |
| KR (1) | KR100362794B1 (da) |
| CN (2) | CN1069098C (da) |
| AT (1) | ATE217614T1 (da) |
| AU (1) | AU680572B2 (da) |
| CA (1) | CA2178604C (da) |
| DE (1) | DE69430636T2 (da) |
| DK (1) | DK0733621T3 (da) |
| ES (1) | ES2176311T3 (da) |
| HU (1) | HU221950B1 (da) |
| PT (1) | PT733621E (da) |
| TW (1) | TW304193B (da) |
| WO (1) | WO1995015951A1 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
| PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| CA2303385A1 (en) * | 1997-09-18 | 1999-03-25 | Mitsubishi-Tokyo Pharmaceuticals, Inc. | Imidazoline compounds |
| TW407153B (en) * | 1997-10-27 | 2000-10-01 | Nippon Kayaku Kk | Imidazole compounds and their use |
| JP2003286266A (ja) * | 1999-03-24 | 2003-10-10 | Mitsubishi-Tokyo Pharmaceuticals Inc | イミダゾール化合物 |
| AU1304501A (en) * | 1999-11-11 | 2001-06-06 | Kyorin Pharmaceutical Co. Ltd. | Oral solid preparation |
| WO2003027060A1 (fr) * | 2001-09-20 | 2003-04-03 | Kyorin Pharmaceutical Co., Ltd. | Derives amide de diphenylbutane |
| JP5087059B2 (ja) * | 2001-10-31 | 2012-11-28 | 杏林製薬株式会社 | ４−（２−メチル−１−イミダゾリル）−２，２−ジフェニルブタンアミドの製造方法 |
| CN100364990C (zh) * | 2002-10-30 | 2008-01-30 | 施万制药 | 取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物 |
| KR101175816B1 (ko) | 2003-08-04 | 2012-08-24 | 교린 세이야꾸 가부시키 가이샤 | 경구 서방성 정제 |
| EP1652523A4 (en) * | 2003-08-04 | 2008-11-19 | Kyorin Seiyaku Kk | PREPARATION FOR TRANSDERMAL ABSORPTION |
| EA013689B1 (ru) * | 2003-10-14 | 2010-06-30 | Глэксо Груп Лимитед | Антагонисты мускариновых ацетилхолиновых рецепторов |
| PE20050489A1 (es) * | 2003-11-04 | 2005-09-02 | Glaxo Group Ltd | Antagonistas de receptores de acetilcolina muscarinicos |
| US7598267B2 (en) * | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| EP1845091A4 (en) * | 2004-12-14 | 2009-03-04 | Kyorin Seiyaku Kk | METHOD FOR PRODUCING AN ANTAGONIST OF THE MUSCARIN RECEPTOR AND INTERMEDIATE PRODUCTS THEREFOR |
| EP1844773A4 (en) * | 2005-02-03 | 2010-04-28 | Kyorin Seiyaku Kk | PREPARATION FOR PERCUTANEOUS ABSORPTION |
| EP1939183A4 (en) * | 2005-07-25 | 2009-02-18 | Mitsubishi Tanabe Pharma Corp | NOVEL HETEROCYCLIC NITROGEN COMPOUND |
| CN101983055B (zh) | 2008-01-31 | 2013-05-08 | 杏林制药株式会社 | 以咪达那新为有效成分的口腔内速崩片的制造方法 |
| WO2009096560A1 (ja) | 2008-01-31 | 2009-08-06 | Kyorin Pharmaceutical Co., Ltd. | イミダフェナシン含有口腔内速崩壊性錠剤 |
| WO2010113952A1 (ja) * | 2009-03-31 | 2010-10-07 | 杏林製薬株式会社 | ムスカリン受容体拮抗薬 |
| ES2604705T3 (es) | 2010-03-31 | 2017-03-08 | Ono Pharmaceutical Co., Ltd. | Agente preventivo y/o remedio para el síndrome mano-pie |
| CA2796877A1 (en) | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
| CN102746235B (zh) * | 2012-07-20 | 2014-09-03 | 北京科莱博医药开发有限责任公司 | 一种改进的制备咪达那新的方法 |
| CN103242214B (zh) * | 2013-05-02 | 2016-04-06 | 陕西步长高新制药有限公司 | 一种吲哚衍生物及其制备方法 |
| CN103242230B (zh) * | 2013-05-02 | 2015-02-18 | 陕西步长高新制药有限公司 | 一种喹啉酮衍生物及其制备方法 |
| CN112774569B (zh) * | 2021-01-11 | 2022-04-08 | 江门市华熊新材料有限公司 | 含氟咪唑表面活性剂及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4073921A (en) * | 1975-03-12 | 1978-02-14 | Rohm And Haas Company | Substituted arylcyanoalkyl and diarylcyanoalkylimidazoles and fungical compositions and methods utilizing them |
| US4225723A (en) * | 1975-03-12 | 1980-09-30 | Rohm And Haas Company | Process for the preparation of substituted arylcyanoalkyl and diaryl cyanoalkylimidazoles |
| GB2016452B (en) * | 1978-02-18 | 1982-07-21 | Kissei Pharmaceutical | Imidazole compounds |
| JPS6019750B2 (ja) * | 1978-02-18 | 1985-05-17 | キツセイ薬品工業株式会社 | Ｎ↓−（ω↓−置換アルキル）イミダゾ−ル |
| JPS6054307B2 (ja) * | 1978-06-09 | 1985-11-29 | 小野薬品工業株式会社 | イミダゾ−ル誘導体 |
| US4293561A (en) * | 1979-03-09 | 1981-10-06 | Syntex (U.S.A.) Inc. | 1-(Naphthyl-n-propyl)imidazole derivatives |
| JPS5756464A (en) * | 1980-09-22 | 1982-04-05 | Ono Pharmaceut Co Ltd | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
| US4766140A (en) * | 1984-06-18 | 1988-08-23 | Eli Lilly And Company | Method of inhibiting aromatase |
| US4605661A (en) * | 1984-06-18 | 1986-08-12 | Eli Lilly And Company | Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles |
| GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| JPH06112670A (ja) * | 1992-09-24 | 1994-04-22 | Mitsubishi Rayon Co Ltd | 電気機器組立方法 |
-
1994
- 1994-11-29 JP JP31935594A patent/JP3294961B2/ja not_active Expired - Lifetime
- 1994-12-01 AU AU11200/95A patent/AU680572B2/en not_active Expired
- 1994-12-01 KR KR1019960703035A patent/KR100362794B1/ko not_active IP Right Cessation
- 1994-12-01 US US08/652,551 patent/US5932607A/en not_active Expired - Lifetime
- 1994-12-01 DK DK95902285T patent/DK0733621T3/da active
- 1994-12-01 CA CA002178604A patent/CA2178604C/en not_active Expired - Lifetime
- 1994-12-01 PT PT95902285T patent/PT733621E/pt unknown
- 1994-12-01 AT AT95902285T patent/ATE217614T1/de active
- 1994-12-01 DE DE69430636T patent/DE69430636T2/de not_active Expired - Lifetime
- 1994-12-01 ES ES95902285T patent/ES2176311T3/es not_active Expired - Lifetime
- 1994-12-01 EP EP95902285A patent/EP0733621B1/en not_active Expired - Lifetime
- 1994-12-01 WO PCT/JP1994/002021 patent/WO1995015951A1/ja active IP Right Grant
- 1994-12-01 CN CN94194450A patent/CN1069098C/zh not_active Expired - Lifetime
- 1994-12-01 HU HU9601505A patent/HU221950B1/hu active IP Right Grant
- 1994-12-07 TW TW083111362A patent/TW304193B/zh not_active IP Right Cessation
-
1999
- 1999-05-19 US US09/313,979 patent/US6103747A/en not_active Expired - Lifetime
- 1999-10-20 CN CN99123354A patent/CN1109674C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE217614T1 (de) | 2002-06-15 |
| CN1109674C (zh) | 2003-05-28 |
| KR100362794B1 (ko) | 2003-01-29 |
| CN1258673A (zh) | 2000-07-05 |
| CA2178604A1 (en) | 1995-06-15 |
| DE69430636T2 (de) | 2003-01-02 |
| JP3294961B2 (ja) | 2002-06-24 |
| AU1120095A (en) | 1995-06-27 |
| DE69430636D1 (de) | 2002-06-20 |
| TW304193B (da) | 1997-05-01 |
| US6103747A (en) | 2000-08-15 |
| WO1995015951A1 (fr) | 1995-06-15 |
| CN1069098C (zh) | 2001-08-01 |
| ES2176311T3 (es) | 2002-12-01 |
| EP0733621B1 (en) | 2002-05-15 |
| CA2178604C (en) | 2004-06-29 |
| US5932607A (en) | 1999-08-03 |
| EP0733621A4 (en) | 1997-04-02 |
| AU680572B2 (en) | 1997-07-31 |
| HUT74182A (en) | 1996-11-28 |
| PT733621E (pt) | 2002-09-30 |
| CN1137270A (zh) | 1996-12-04 |
| EP0733621A1 (en) | 1996-09-25 |
| HU9601505D0 (en) | 1996-07-29 |
| HU221950B1 (hu) | 2003-03-28 |
| KR960706477A (ko) | 1996-12-09 |
| JPH07215943A (ja) | 1995-08-15 |
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