DE69430636D1 - Neue imidazol-derivate und verfahren zu deren herstellung - Google Patents

Neue imidazol-derivate und verfahren zu deren herstellung

Info

Publication number
DE69430636D1
DE69430636D1 DE69430636T DE69430636T DE69430636D1 DE 69430636 D1 DE69430636 D1 DE 69430636D1 DE 69430636 T DE69430636 T DE 69430636T DE 69430636 T DE69430636 T DE 69430636T DE 69430636 D1 DE69430636 D1 DE 69430636D1
Authority
DE
Germany
Prior art keywords
group
lower alkyl
alkyl group
substituent
imidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430636T
Other languages
English (en)
Other versions
DE69430636T2 (de
Inventor
Hiroyuki Miyachi
Kei Okazaki
Hiromi Kiyota
Mitsuru Segawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69430636D1 publication Critical patent/DE69430636D1/de
Publication of DE69430636T2 publication Critical patent/DE69430636T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69430636T 1993-12-10 1994-12-01 Neue imidazol-derivate und verfahren zu deren herstellung Expired - Lifetime DE69430636T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34146793 1993-12-10
JP31935594A JP3294961B2 (ja) 1993-12-10 1994-11-29 新規イミダゾール誘導体及びその製造法
PCT/JP1994/002021 WO1995015951A1 (fr) 1993-12-10 1994-12-01 Nouveau derive de l'imidazole et sa methode d'obtention

Publications (2)

Publication Number Publication Date
DE69430636D1 true DE69430636D1 (de) 2002-06-20
DE69430636T2 DE69430636T2 (de) 2003-01-02

Family

ID=26569693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430636T Expired - Lifetime DE69430636T2 (de) 1993-12-10 1994-12-01 Neue imidazol-derivate und verfahren zu deren herstellung

Country Status (15)

Country Link
US (2) US5932607A (de)
EP (1) EP0733621B1 (de)
JP (1) JP3294961B2 (de)
KR (1) KR100362794B1 (de)
CN (2) CN1069098C (de)
AT (1) ATE217614T1 (de)
AU (1) AU680572B2 (de)
CA (1) CA2178604C (de)
DE (1) DE69430636T2 (de)
DK (1) DK0733621T3 (de)
ES (1) ES2176311T3 (de)
HU (1) HU221950B1 (de)
PT (1) PT733621E (de)
TW (1) TW304193B (de)
WO (1) WO1995015951A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7145996A (en) * 1995-10-13 1997-04-30 Banyu Pharmaceutical Co., Ltd. Substituted heteroaromatic derivatives
PE92198A1 (es) * 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
EP1020449A1 (de) * 1997-09-18 2000-07-19 Mitsubishi-Tokyo Pharmaceuticals, Inc. Imidazolinzusammensetzungen
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
JP2003286266A (ja) * 1999-03-24 2003-10-10 Mitsubishi-Tokyo Pharmaceuticals Inc イミダゾール化合物
ATE316375T1 (de) * 1999-11-11 2006-02-15 Kyorin Seiyaku Kk Orale feste zusammensetzung
JPWO2003027060A1 (ja) * 2001-09-20 2005-05-12 杏林製薬株式会社 ジフェニルブタンアミド誘導体
JP5087059B2 (ja) * 2001-10-31 2012-11-28 杏林製薬株式会社 ４−（２−メチル−１−イミダゾリル）−２，２−ジフェニルブタンアミドの製造方法
CN100364990C (zh) * 2002-10-30 2008-01-30 施万制药 取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物
WO2005011683A1 (ja) * 2003-08-04 2005-02-10 Kyorin Pharmaceutical Co., Ltd. 経皮吸収型製剤
CA2532714C (en) 2003-08-04 2010-11-16 Kyorin Pharmaceutical Co., Ltd. Oral sustained-release tablet comprising 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide
SI1677795T1 (sl) * 2003-10-14 2011-04-29 Glaxo Group Ltd Antagonisti muskarinskega acetilholinskega receptorja
AR046225A1 (es) * 2003-11-04 2005-11-30 Glaxo Group Ltd Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion
EP1747219A4 (de) * 2004-05-13 2010-05-26 Glaxo Group Ltd Antagonisten des muscarinischen acetylcholinrezeptors
CA2589146C (en) * 2004-12-14 2011-09-20 Kyorin Pharmaceutical Co., Ltd. Process for producing muscarine receptor antagonist and intermediate therefor
KR20130069764A (ko) * 2005-02-03 2013-06-26 교린 세이야꾸 가부시키 가이샤 경피 흡수형 제제
TW200734310A (en) * 2005-07-25 2007-09-16 Mitsubishi Pharma Corp Novel nitrogenated heterocyclic compound
KR101528953B1 (ko) 2008-01-31 2015-06-15 교린 세이야꾸 가부시키 가이샤 이미다페나신을 유효 성분으로 하는 구강 내 속붕정의 제조 방법
KR101528954B1 (ko) 2008-01-31 2015-06-15 교린 세이야꾸 가부시키 가이샤 이미다페나신 함유 구강 내 속붕괴성 정제
WO2010113952A1 (ja) * 2009-03-31 2010-10-07 杏林製薬株式会社 ムスカリン受容体拮抗薬
ES2604705T3 (es) 2010-03-31 2017-03-08 Ono Pharmaceutical Co., Ltd. Agente preventivo y/o remedio para el síndrome mano-pie
US8748433B2 (en) 2010-04-30 2014-06-10 Merck Sharp & Dohme Corp. β3 adrenergic receptor agonists
CN102746235B (zh) * 2012-07-20 2014-09-03 北京科莱博医药开发有限责任公司 一种改进的制备咪达那新的方法
CN103242214B (zh) * 2013-05-02 2016-04-06 陕西步长高新制药有限公司 一种吲哚衍生物及其制备方法
CN103242230B (zh) * 2013-05-02 2015-02-18 陕西步长高新制药有限公司 一种喹啉酮衍生物及其制备方法
CN112774569B (zh) * 2021-01-11 2022-04-08 江门市华熊新材料有限公司 含氟咪唑表面活性剂及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073921A (en) * 1975-03-12 1978-02-14 Rohm And Haas Company Substituted arylcyanoalkyl and diarylcyanoalkylimidazoles and fungical compositions and methods utilizing them
US4225723A (en) * 1975-03-12 1980-09-30 Rohm And Haas Company Process for the preparation of substituted arylcyanoalkyl and diaryl cyanoalkylimidazoles
JPS6019750B2 (ja) * 1978-02-18 1985-05-17 キツセイ薬品工業株式会社 Ｎ↓−（ω↓−置換アルキル）イミダゾ−ル
GB2016452B (en) * 1978-02-18 1982-07-21 Kissei Pharmaceutical Imidazole compounds
JPS6054307B2 (ja) * 1978-06-09 1985-11-29 小野薬品工業株式会社 イミダゾ−ル誘導体
US4293561A (en) * 1979-03-09 1981-10-06 Syntex (U.S.A.) Inc. 1-(Naphthyl-n-propyl)imidazole derivatives
JPS5756464A (en) * 1980-09-22 1982-04-05 Ono Pharmaceut Co Ltd Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4766140A (en) * 1984-06-18 1988-08-23 Eli Lilly And Company Method of inhibiting aromatase
GB8810067D0 (en) * 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
JPH06112670A (ja) * 1992-09-24 1994-04-22 Mitsubishi Rayon Co Ltd 電気機器組立方法

Also Published As

Publication number Publication date
EP0733621A1 (de) 1996-09-25
AU1120095A (en) 1995-06-27
CA2178604C (en) 2004-06-29
ES2176311T3 (es) 2002-12-01
JPH07215943A (ja) 1995-08-15
DE69430636T2 (de) 2003-01-02
EP0733621B1 (de) 2002-05-15
JP3294961B2 (ja) 2002-06-24
KR100362794B1 (ko) 2003-01-29
AU680572B2 (en) 1997-07-31
HUT74182A (en) 1996-11-28
CN1258673A (zh) 2000-07-05
WO1995015951A1 (fr) 1995-06-15
KR960706477A (ko) 1996-12-09
CN1137270A (zh) 1996-12-04
TW304193B (de) 1997-05-01
HU221950B1 (hu) 2003-03-28
CN1109674C (zh) 2003-05-28
CA2178604A1 (en) 1995-06-15
PT733621E (pt) 2002-09-30
EP0733621A4 (de) 1997-04-02
HU9601505D0 (en) 1996-07-29
US6103747A (en) 2000-08-15
DK0733621T3 (da) 2002-09-09
US5932607A (en) 1999-08-03
CN1069098C (zh) 2001-08-01
ATE217614T1 (de) 2002-06-15

Similar Documents

Publication Publication Date Title
DE69430636T2 (de) Neue imidazol-derivate und verfahren zu deren herstellung
DE69433346D1 (de) Verbindungen verwendbar als Zwischenprodukte zur Herstellung von Piperidinderivate
ATE126219T1 (de) Benzimidazolderivate, verfahren zu deren herstellung und anwendung.
ATE208779T1 (de) Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
DE3785315D1 (de) Erythromycin-a-derivate und verfahren zu ihrer herstellung.
DE69613240T2 (de) N-aminoalkylfluorencarboxamide, neue klasse von dopaminerezeptor subtype spezifische liganden
DE69636439D1 (de) Verfahren zur herstellung von piperidinderivaten
NO982770D0 (no) FremgangsmÕte for fremstilling av piperidinderivater
TW271435B (de)
ATE233764T1 (de) Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel
ATE41423T1 (de) 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ATE214061T1 (de) Azetidinonverbindung und verfahren zu ihrer herstellung
ATE168679T1 (de) Neue tetracyclische verbindungen
DE69311500D1 (de) 2,3-Diphenyl-5-pyrrolyl-furan Derivate, Verfahren und Zwischenprodukte für ihre Herstellung und ihre Verwendung als entzündungshemmende, antiallergische und blutplättchenaggregationshemmende Mittel
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
EP0798304A4 (de) Medikamente gegen trhombocytopenie
DE60116655D1 (de) Carbamatderivate, verfahren zu deren herstellung und deren verwendung
TH14340A (th) กรรมวิธีสำหรับเตรียมสารประกอบคาร์แบเพเนมและเพเนมและสารประกอบชนิดใหม่ที่เกี่ยวข้องในกรรมวิธีดังกล่าว
TH14340EX (th) กรรมวิธีสำหรับเตรียมสารประกอบคาร์แบเพเนมและเพเนมและสารประกอบชนิดใหม่ที่เกี่ยวข้องในกรรมวิธีดังกล่าว

Legal Events

Date Code Title Description
8364 No opposition during term of opposition