WO2003027060A1 - Derives amide de diphenylbutane - Google Patents

Derives amide de diphenylbutane Download PDF

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Publication number
WO2003027060A1
WO2003027060A1 PCT/JP2002/009424 JP0209424W WO03027060A1 WO 2003027060 A1 WO2003027060 A1 WO 2003027060A1 JP 0209424 W JP0209424 W JP 0209424W WO 03027060 A1 WO03027060 A1 WO 03027060A1
Authority
WO
WIPO (PCT)
Prior art keywords
diphenylbutane
amide derivatives
deoxy
muscarinic receptor
represents hydrogen
Prior art date
Application number
PCT/JP2002/009424
Other languages
English (en)
Japanese (ja)
Inventor
Ichiro Araya
Takeshi Tsubuki
Makoto Numata
Tatsuhiro Saito
Hiroyuki Miyachi
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to JP2003530651A priority Critical patent/JPWO2003027060A1/ja
Publication of WO2003027060A1 publication Critical patent/WO2003027060A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés représentés par la formule générale (1), des sels et des hydrates de ceux-ci, possédant une sélectivité vis-à-vis du récepteur muscarinique dans les muscles lisses plus élevée que vis-à-vis du récepteur muscarinique du coeur et présentant un antagonisme élevé. Dans ladite formule (1), X représente hydrogène ou hydroxy ; R1 représente hydrogène ou 1-désoxy-D-glucopyranuronate ; et R2 représente, entre autres, 4,5-dioxo-2-méthylimidazolidinyle, 1-(2-méthyl-1-imidazolio)-1-désoxy-β-D-puranuronate.
PCT/JP2002/009424 2001-09-20 2002-09-13 Derives amide de diphenylbutane WO2003027060A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003530651A JPWO2003027060A1 (ja) 2001-09-20 2002-09-13 ジフェニルブタンアミド誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001287712 2001-09-20
JP2001-287712 2001-09-20

Publications (1)

Publication Number Publication Date
WO2003027060A1 true WO2003027060A1 (fr) 2003-04-03

Family

ID=19110478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009424 WO2003027060A1 (fr) 2001-09-20 2002-09-13 Derives amide de diphenylbutane

Country Status (2)

Country Link
JP (1) JPWO2003027060A1 (fr)
WO (1) WO2003027060A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013421A1 (fr) * 2005-07-25 2007-02-01 Mitsubishi Tanabe Pharma Corporation Nouveau composé hétérocyclique azoté
WO2007077510A2 (fr) 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Antagonistes des récepteurs muscariniques
EP2130830A1 (fr) 2008-06-03 2009-12-09 Ranbaxy Laboratories Limited Antagonistes de récepteur muscarinique
CN103242230A (zh) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 一种喹啉酮衍生物及其制备方法
CN103242214A (zh) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 一种吲哚衍生物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015951A1 (fr) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Nouveau derive de l'imidazole et sa methode d'obtention

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015951A1 (fr) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Nouveau derive de l'imidazole et sa methode d'obtention

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013421A1 (fr) * 2005-07-25 2007-02-01 Mitsubishi Tanabe Pharma Corporation Nouveau composé hétérocyclique azoté
WO2007077510A2 (fr) 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Antagonistes des récepteurs muscariniques
EP2130830A1 (fr) 2008-06-03 2009-12-09 Ranbaxy Laboratories Limited Antagonistes de récepteur muscarinique
CN103242230A (zh) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 一种喹啉酮衍生物及其制备方法
CN103242214A (zh) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 一种吲哚衍生物及其制备方法
CN103242230B (zh) * 2013-05-02 2015-02-18 陕西步长高新制药有限公司 一种喹啉酮衍生物及其制备方法
CN103242214B (zh) * 2013-05-02 2016-04-06 陕西步长高新制药有限公司 一种吲哚衍生物及其制备方法

Also Published As

Publication number Publication date
JPWO2003027060A1 (ja) 2005-05-12

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