WO2007014054A3 - Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 - Google Patents

Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 Download PDF

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Publication number
WO2007014054A3
WO2007014054A3 PCT/US2006/028419 US2006028419W WO2007014054A3 WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3 US 2006028419 W US2006028419 W US 2006028419W WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3
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WIPO (PCT)
Prior art keywords
benzenesulfonamide
inhibitor
chemokine receptor
ccr2 chemokine
ccr2
Prior art date
Application number
PCT/US2006/028419
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English (en)
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WO2007014054A2 (fr
Inventor
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
Original Assignee
Glaxo Group Limted
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
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Publication date
Priority claimed from GB0515194A external-priority patent/GB0515194D0/en
Priority claimed from GB0519492A external-priority patent/GB0519492D0/en
Application filed by Glaxo Group Limted, Carl Brooks, Pamela A Cleary, Krista B Goodman, Simon Peace, Joanne Philp, Clark A Sehon, Christian Smethurst, Stephen Paul Watson filed Critical Glaxo Group Limted
Publication of WO2007014054A2 publication Critical patent/WO2007014054A2/fr
Publication of WO2007014054A3 publication Critical patent/WO2007014054A3/fr

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    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I): ou un sel acceptable sur le plan pharmaceutique, un solvate ou une combinaison de ceux-ci, ainsi que des compositions de procédés d'utilisation de ces composés, R1, R2, R3 et m y étant décrits.
PCT/US2006/028419 2005-07-22 2006-07-21 Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 WO2007014054A2 (fr)

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EP1748989A2 (fr) 2004-05-12 2007-02-07 ChemoCentryx Inc Sulfonamides aryle
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
CN101511800B (zh) 2006-07-14 2013-02-27 坎莫森特里克斯公司 三唑基苯基苯磺酰胺
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
US8273738B2 (en) 2006-09-05 2012-09-25 Kyowa Hakko Kirin Co., Ltd. Imidazole derivatives
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
CA2692761C (fr) 2007-07-12 2013-04-30 Chemocentryx, Inc. Heteroaryl-pyridyl- et phenyl-benzenesulfonamides condenses en tant que modulateurs du ccr2 pour le traitement de l'inflammation
EP2204366A1 (fr) * 2008-12-19 2010-07-07 Bayer CropScience AG Pyridazinones substitués par phényle agissant en tant qu'herbicide et insecticide
WO2011051198A2 (fr) 2009-10-30 2011-05-05 Bayer Cropscience Ag Dérivés de pyridine en tant qu'agents phytoprotecteurs
DK2588465T3 (en) 2010-06-30 2017-05-01 Ironwood Pharmaceuticals Inc SGC stimulators
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
US8524745B2 (en) 2011-12-12 2013-09-03 Allergan, Inc. Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators
CA2861804C (fr) 2011-12-27 2021-10-26 Ironwood Pharmaceuticals, Inc. Pyrazoles 2-benzyle, 3-(pyrimidin-2-yle)-substitues utiles comme stimulateurs de scg
JP6132853B2 (ja) * 2011-12-27 2017-05-24 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 全身性抗炎症反応を提供する、複数のプロスタグランジン受容体で作用する化合物
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