DK0706799T3 - Immunkonjugater II - Google Patents
Immunkonjugater IIInfo
- Publication number
- DK0706799T3 DK0706799T3 DK95113956T DK95113956T DK0706799T3 DK 0706799 T3 DK0706799 T3 DK 0706799T3 DK 95113956 T DK95113956 T DK 95113956T DK 95113956 T DK95113956 T DK 95113956T DK 0706799 T3 DK0706799 T3 DK 0706799T3
- Authority
- DK
- Denmark
- Prior art keywords
- immunoconjugates
- family
- immune conjugates
- interleukin
- fragment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94114572 | 1994-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0706799T3 true DK0706799T3 (da) | 2002-02-25 |
Family
ID=8216289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95113956T DK0706799T3 (da) | 1994-09-16 | 1995-09-06 | Immunkonjugater II |
Country Status (20)
Country | Link |
---|---|
US (1) | US5824782A (fr) |
EP (1) | EP0706799B1 (fr) |
JP (2) | JP3865802B2 (fr) |
KR (1) | KR100386171B1 (fr) |
CN (1) | CN1123185A (fr) |
AT (1) | ATE208633T1 (fr) |
AU (1) | AU702184B2 (fr) |
CA (1) | CA2158322C (fr) |
CZ (1) | CZ289641B6 (fr) |
DE (1) | DE69523857T2 (fr) |
DK (1) | DK0706799T3 (fr) |
ES (1) | ES2167391T3 (fr) |
HU (1) | HU221989B1 (fr) |
NO (1) | NO315976B1 (fr) |
PL (1) | PL182636B1 (fr) |
PT (1) | PT706799E (fr) |
RU (1) | RU2157701C2 (fr) |
SK (1) | SK282263B6 (fr) |
UA (1) | UA40611C2 (fr) |
ZA (1) | ZA957808B (fr) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055607A2 (fr) * | 1997-06-04 | 1998-12-10 | Oxford Biomedica (Uk) Limited | Vecteur |
US7276488B2 (en) * | 1997-06-04 | 2007-10-02 | Oxford Biomedica (Uk) Limited | Vector system |
US7635687B2 (en) * | 1997-06-04 | 2009-12-22 | Oxford Biomedica (Uk) Limited | Vector system |
DE69824039T2 (de) | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
WO1999046392A1 (fr) * | 1998-03-12 | 1999-09-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methodes et compositions utilisant des proteines de fusion chemokine-antigene tumoral comme vaccins anti-cancer |
CA2326427A1 (fr) * | 1998-03-31 | 1999-10-07 | Koichiro Yamada | Agents prophylactiques/therapeutiques contre les troubles urinaires |
WO1999052562A2 (fr) * | 1998-04-15 | 1999-10-21 | Lexigen Pharmaceuticals Corp. | Co-administration d'un inhibiteur de l'angiogenese pour renforcer la reponse immunitaire a mediation de proteine de fusion d'une cytokine d'anticorps |
CN1305387A (zh) * | 1998-04-17 | 2001-07-25 | 利思进药品公司 | 通过共同给予前列腺素抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 |
US6869606B1 (en) | 1999-02-22 | 2005-03-22 | Millennium Pharmaceuticals, Inc. | Biotinylated-chemokine antibody complexes |
WO2000078334A1 (fr) * | 1999-06-17 | 2000-12-28 | University Of Maryland Biotechnology Institute | Polypeptides chimeres antigeniques de chemokine et leurs utilisations |
GB9915074D0 (en) * | 1999-06-28 | 1999-08-25 | Cortecs Plc | Ligand-binding composition |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US6617135B1 (en) | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
JP2003515323A (ja) * | 1999-11-18 | 2003-05-07 | オックスフォード バイオメディカ(ユーケイ)リミテッド | 抗 体 |
US7208152B2 (en) * | 1999-11-24 | 2007-04-24 | Millennium Pharmaceuticals, Inc. | Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof |
US6319675B1 (en) | 1999-11-24 | 2001-11-20 | Millennium Pharmaceuticals, Inc. | Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor |
WO2001058957A2 (fr) | 2000-02-11 | 2001-08-16 | Lexigen Pharmaceuticals Corp. | Amelioration de la demi-vie circulante de proteines de fusion a base d'anticorps |
DE10019157A1 (de) * | 2000-04-18 | 2001-11-15 | Stefan Duebel | Verfahren zum Einbringen von Liganden in lebende Zellen |
US20040091485A1 (en) * | 2000-05-19 | 2004-05-13 | Ellis John Robert Maxwell | Humanised antibodies to the epidermal growth factor receptor |
US7754676B2 (en) | 2000-09-15 | 2010-07-13 | The United States Of America As Represented By The Department Of Health And Human Services | Defensin-antigen fusion proteins |
AU2001291050A1 (en) | 2000-09-15 | 2002-03-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Viral chemokine-tumur antigen fusion proteins |
GB0029407D0 (en) * | 2000-12-01 | 2001-01-17 | Affitech As | Product |
MXPA03008031A (es) | 2001-03-07 | 2003-12-04 | Merck Patent Gmbh | Tecnologia de expresion para proteinas que contienen porcion de anticuerpo isotipo hibrida. |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
CN100503639C (zh) | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
EP1256354A1 (fr) * | 2001-05-11 | 2002-11-13 | Schering Corporation | Methodes pour le traitement du cancer |
US20020193569A1 (en) * | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
BRPI0210405B8 (pt) | 2001-06-13 | 2021-05-25 | Genmab As | anticorpo monoclonal humano, molécula biespecífica, método in vitro para inibir o crescimento de uma célula expressando egfr, para induzir a citólise de uma célula expressando egfr, e para detectar a presença de antígeno egfr ou uma célula expressando egfr em uma amostra, e, vetor de expressão |
US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
DK1399484T3 (da) * | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
GB0126378D0 (en) * | 2001-11-02 | 2002-01-02 | Oxford Biomedica Ltd | Antigen |
WO2003048334A2 (fr) | 2001-12-04 | 2003-06-12 | Merck Patent Gmbh | Immunocytokines a selectivite modulee |
JP4212921B2 (ja) | 2002-03-29 | 2009-01-21 | 独立行政法人科学技術振興機構 | 抗体を提示するタンパク質中空ナノ粒子を用いる治療薬剤およびタンパク質中空ナノ粒子 |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
EP2135879A3 (fr) * | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US20040110929A1 (en) * | 2002-07-12 | 2004-06-10 | Bjorn Soren E. | TF binding compound |
DE60336406D1 (de) | 2002-10-16 | 2011-04-28 | Purdue Pharma Lp | Antikörper, die an zellassoziiertes ca 125/0722p binden, und verfahren zu deren anwendung |
US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
ATE471946T1 (de) | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
CA2511910A1 (fr) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Ligand |
EP1599572A4 (fr) * | 2003-02-14 | 2007-06-13 | Univ Southern California | Compositions et methodes pour immunotherapie anticancereuse |
JP2008502317A (ja) | 2003-12-30 | 2008-01-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Il−7融合タンパク質 |
AU2005203962C1 (en) | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
GB2424886A (en) * | 2005-04-04 | 2006-10-11 | Dxs Ltd | Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations |
US8124095B2 (en) * | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
US8053569B2 (en) * | 2005-10-07 | 2011-11-08 | Armagen Technologies, Inc. | Nucleic acids encoding and methods of producing fusion proteins |
US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
EP1957536A2 (fr) * | 2005-12-01 | 2008-08-20 | Domantis Limited | Formats d'anticorps a domaine non competitif qui lient le recepteur type 1 d'interleukine 1 |
WO2008022349A2 (fr) * | 2006-08-18 | 2008-02-21 | Armagen Technologies, Inc. | Agents pour barrière hémato-encéphalique |
CN101173008B (zh) * | 2006-11-01 | 2011-06-22 | 复旦大学 | 一种双功能融合蛋白及其制备方法和应用 |
US20090011040A1 (en) * | 2007-05-02 | 2009-01-08 | Naash Muna I | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
WO2008149147A2 (fr) | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, domaines variables d'anticorps et antagonistes |
CA3184105A1 (fr) * | 2007-07-27 | 2009-02-05 | Armagen Inc. | Procedes et compositions destines a augmenter une activite a-iduronidase dans le snc |
WO2009039409A1 (fr) * | 2007-09-21 | 2009-03-26 | The Regents Of The University Of Californina | Interféron ciblé manifestant des activités apoptotiques et anti-tumorales puissantes |
EP2262531A1 (fr) * | 2008-03-08 | 2010-12-22 | Immungene, Inc. | Immunothérapie avec molécules de fusion modifiées utilisées dans le cancer et les maladies inflammatoires |
US20100098693A1 (en) * | 2008-10-07 | 2010-04-22 | Pardridge William M | Compositions and methods for blood-brain barrier delivery of organophosphatases |
CN106995495A (zh) | 2009-01-12 | 2017-08-01 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
JP5873003B2 (ja) | 2009-03-18 | 2016-03-01 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | IgGデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法 |
EP2421896A1 (fr) | 2009-04-22 | 2012-02-29 | Merck Patent GmbH | Protéines de fusion à des anticorps avec des sites de liaison à fcrn modifiés |
DK2485761T3 (da) | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
CN109022465B (zh) | 2011-10-28 | 2022-04-29 | 特瓦制药澳大利亚私人有限公司 | 多肽构建体及其用途 |
EP2785378B1 (fr) | 2011-12-02 | 2020-05-13 | Armagen, Inc. | Méthodes et compositions pour augmenter l'activité arylsulfatase a dans le système nerveux central |
US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
US9803021B2 (en) | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
KR20240023184A (ko) | 2013-03-11 | 2024-02-20 | 젠자임 코포레이션 | 과글리코실화된 결합 폴리펩티드 |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
DK3677591T5 (da) | 2013-04-29 | 2024-08-26 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antistoffer og fusioner til svækket interferon alpha-2b |
WO2014194100A1 (fr) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Fusions anti-cspg4 et interféron utilisables en vue du traitement de tumeurs malignes |
CN106471010A (zh) | 2014-03-19 | 2017-03-01 | 建新公司 | 靶向模块的位点特异性糖工程化 |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
ES2838680T3 (es) | 2014-10-09 | 2021-07-02 | Genzyme Corp | Conjugados de anticuerpo-fármaco glucomodificados |
PE20170908A1 (es) | 2014-10-29 | 2017-07-12 | Teva Pharmaceuticals Australia Pty Ltd | VARIANTES DE INTERFERON a2b |
US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
CN108700565B (zh) * | 2015-10-07 | 2021-10-29 | 善威生物私人有限公司 | 血液制备和图谱分析 |
JP7241677B2 (ja) | 2016-07-19 | 2023-03-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗cd47併用療法 |
CN111164099A (zh) * | 2017-09-29 | 2020-05-15 | 河谷细胞有限公司 | 抗原蛋白及其方法 |
JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | FGFRチロシンキナーゼの阻害剤としての置換ピラゾロ[1,5-a]ピリジン化合物 |
CN113474337A (zh) | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3,5-二甲氧基苯基)氨基)喹喔啉衍生物 |
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US5470571A (en) * | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US5112946A (en) * | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
AU654811B2 (en) * | 1990-03-20 | 1994-11-24 | Trustees Of Columbia University In The City Of New York, The | Chimeric antibodies with receptor binding ligands in place of their constant region |
CA2095836C (fr) * | 1990-11-09 | 1999-04-06 | Stephen D. Gillies | Immunoconjugues de la cytokine |
ES2204890T3 (es) * | 1991-03-06 | 2004-05-01 | Merck Patent Gmbh | Anticuerpos monoclonales humanizados. |
EP0603194A4 (fr) * | 1991-07-05 | 1994-12-07 | Seragen Inc | Molecules ciblees sur un recepteur du facteur de croissance epidermique, et utilisees dans le traitement de l'arthrite inflammatoire. |
ES2144440T3 (es) * | 1992-08-18 | 2000-06-16 | Centro Inmunologia Molecular | Anticuerpos monoclonales que reconocen el receptor del factor de crecimiento epidermico, celulas y metodos para su produccion y compuestos que los contienen. |
-
1995
- 1995-09-06 EP EP95113956A patent/EP0706799B1/fr not_active Expired - Lifetime
- 1995-09-06 DK DK95113956T patent/DK0706799T3/da active
- 1995-09-06 ES ES95113956T patent/ES2167391T3/es not_active Expired - Lifetime
- 1995-09-06 DE DE69523857T patent/DE69523857T2/de not_active Expired - Fee Related
- 1995-09-06 PT PT95113956T patent/PT706799E/pt unknown
- 1995-09-06 AT AT95113956T patent/ATE208633T1/de not_active IP Right Cessation
- 1995-09-08 AU AU30533/95A patent/AU702184B2/en not_active Ceased
- 1995-09-11 JP JP23283295A patent/JP3865802B2/ja not_active Expired - Fee Related
- 1995-09-13 SK SK1145-95A patent/SK282263B6/sk unknown
- 1995-09-14 CZ CZ19952375A patent/CZ289641B6/cs not_active IP Right Cessation
- 1995-09-14 CN CN95116279A patent/CN1123185A/zh active Pending
- 1995-09-14 UA UA95094164A patent/UA40611C2/uk unknown
- 1995-09-14 CA CA002158322A patent/CA2158322C/fr not_active Expired - Fee Related
- 1995-09-15 ZA ZA957808A patent/ZA957808B/xx unknown
- 1995-09-15 NO NO19953650A patent/NO315976B1/no not_active IP Right Cessation
- 1995-09-15 US US08/528,523 patent/US5824782A/en not_active Expired - Fee Related
- 1995-09-15 HU HU9502711A patent/HU221989B1/hu not_active IP Right Cessation
- 1995-09-15 KR KR1019950030385A patent/KR100386171B1/ko not_active IP Right Cessation
- 1995-09-15 PL PL95310493A patent/PL182636B1/pl not_active IP Right Cessation
- 1995-09-15 RU RU95115976/14A patent/RU2157701C2/ru not_active IP Right Cessation
-
2005
- 2005-11-17 JP JP2005332965A patent/JP2006117684A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CZ237595A3 (en) | 1996-04-17 |
CZ289641B6 (cs) | 2002-03-13 |
EP0706799A3 (fr) | 1996-12-04 |
SK114595A3 (en) | 1997-03-05 |
ATE208633T1 (de) | 2001-11-15 |
JP2006117684A (ja) | 2006-05-11 |
ZA957808B (en) | 1996-05-07 |
AU702184B2 (en) | 1999-02-18 |
RU2157701C2 (ru) | 2000-10-20 |
KR960010023A (ko) | 1996-04-20 |
NO315976B1 (no) | 2003-11-24 |
PL182636B1 (pl) | 2002-02-28 |
DE69523857T2 (de) | 2002-06-13 |
US5824782A (en) | 1998-10-20 |
CN1123185A (zh) | 1996-05-29 |
NO953650D0 (no) | 1995-09-15 |
HUT75836A (en) | 1997-05-28 |
JPH0899901A (ja) | 1996-04-16 |
AU3053395A (en) | 1996-03-28 |
PT706799E (pt) | 2002-05-31 |
UA40611C2 (uk) | 2001-08-15 |
DE69523857D1 (de) | 2001-12-20 |
CA2158322C (fr) | 2009-06-16 |
PL310493A1 (en) | 1996-03-18 |
JP3865802B2 (ja) | 2007-01-10 |
CA2158322A1 (fr) | 1996-03-17 |
SK282263B6 (sk) | 2001-12-03 |
HU9502711D0 (en) | 1995-11-28 |
ES2167391T3 (es) | 2002-05-16 |
EP0706799A2 (fr) | 1996-04-17 |
HU221989B1 (hu) | 2003-03-28 |
KR100386171B1 (ko) | 2003-08-21 |
EP0706799B1 (fr) | 2001-11-14 |
NO953650L (no) | 1996-03-18 |
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