DE69519454D1 - Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen - Google Patents
Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegenInfo
- Publication number
- DE69519454D1 DE69519454D1 DE69519454T DE69519454T DE69519454D1 DE 69519454 D1 DE69519454 D1 DE 69519454D1 DE 69519454 T DE69519454 T DE 69519454T DE 69519454 T DE69519454 T DE 69519454T DE 69519454 D1 DE69519454 D1 DE 69519454D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- monoclonal antibodies
- antibodies against
- interferon gamma
- gamma production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP06184162A JP3109018B2 (ja) | 1994-07-14 | 1994-07-14 | インターフェロン−γの産生を誘導する蛋白質 |
JP07045057A JP3122963B2 (ja) | 1995-02-10 | 1995-02-10 | モノクローナル抗体 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69519454D1 true DE69519454D1 (de) | 2000-12-28 |
DE69519454T2 DE69519454T2 (de) | 2001-05-03 |
Family
ID=26385017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69519454T Expired - Lifetime DE69519454T2 (de) | 1994-07-14 | 1995-07-13 | Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen |
Country Status (3)
Country | Link |
---|---|
US (6) | US5912324A (de) |
EP (1) | EP0692536B1 (de) |
DE (1) | DE69519454T2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0692536B1 (de) * | 1994-07-14 | 2000-11-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen |
TW464656B (en) * | 1994-11-15 | 2001-11-21 | Hayashibara Biochem Lab | Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease |
JP2952750B2 (ja) * | 1995-02-23 | 1999-09-27 | 株式会社林原生物化学研究所 | モノクローナル抗体 |
JP2724987B2 (ja) | 1994-11-15 | 1998-03-09 | 株式会社林原生物化学研究所 | インターフェロン−γの産生を誘導するポリペプチド |
JP4004088B2 (ja) * | 1995-09-26 | 2007-11-07 | 株式会社林原生物化学研究所 | 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 |
US7135458B1 (en) * | 1995-11-15 | 2006-11-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use |
EP0816499A3 (de) * | 1996-06-27 | 1999-10-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomische DNS, die für ein Polypeptid kodiert welches die Fähigkeit besitzt die Interferon-Gamma Herstellung zu induzieren |
US6790442B1 (en) | 1996-06-27 | 2004-09-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ |
JPH1080270A (ja) * | 1996-07-19 | 1998-03-31 | Hayashibara Biochem Lab Inc | ポリペプチドをプロセッシングする酵素 |
TW515843B (en) * | 1996-07-25 | 2003-01-01 | Hayashibara Biochem Lab | Process for producing an active polypeptide inducing interferon-γ production |
AU4260497A (en) * | 1996-09-09 | 1998-03-26 | Cornell Research Foundation Inc. | Interferon-gamma inducing factor in neuroendocrine cells |
JP4024366B2 (ja) * | 1996-11-29 | 2007-12-19 | 株式会社林原生物化学研究所 | ポリペプチド |
US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
JP3955352B2 (ja) * | 1997-02-25 | 2007-08-08 | 株式会社林原生物化学研究所 | 破骨細胞形成阻害剤 |
US6087116A (en) * | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
US6432678B1 (en) * | 1999-06-21 | 2002-08-13 | Smithkline Beecham Corporation | Macaca cynomolgus IL 18 |
CN102206277A (zh) * | 2000-02-10 | 2011-10-05 | 雅培制药有限公司 | 结合人白介素-18的抗体及制备和使用方法 |
DE60139316D1 (de) | 2000-06-15 | 2009-09-03 | Smithkline Beecham Corp | Verfahren zur herstellung eines physiologisch aktiven il-18 polypeptids |
US6818444B2 (en) | 2000-08-04 | 2004-11-16 | Heska Corporation | Canine and feline proteins, nucleic acid molecules and uses thereof |
WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
US20030044398A1 (en) * | 2001-03-20 | 2003-03-06 | Robl James M. | Methods for producing antibodies in mammals |
KR20040023630A (ko) | 2001-06-26 | 2004-03-18 | 아브게닉스, 인크. | Opgl에 결합하는 항체 |
EP1414517A4 (de) * | 2001-06-26 | 2008-02-06 | Photomed Technologies Inc | Mehrfach-wellenlängen-illuminator |
US7253260B2 (en) * | 2002-04-17 | 2007-08-07 | Smithkline Beecham Corporation | Human IL-18 crystal structure |
US20050121254A1 (en) * | 2002-05-29 | 2005-06-09 | Marcus Hofmann | Device for establishing noise in a motor vehicle |
WO2004002519A1 (en) * | 2002-06-27 | 2004-01-08 | Smithkline Beecham Corporation | Methods of treating or preventing ibd with il-18 |
MXPA05007019A (es) * | 2002-12-30 | 2005-08-18 | Amgen Inc | Terapia de combinacion con factores co-estimuladores. |
TW200510454A (en) | 2003-04-15 | 2005-03-16 | Smithkline Beecham Corp | Conjugates comprising human IL-18 and substitution mutants thereof |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
CN101039696B (zh) | 2004-08-20 | 2011-08-17 | 史密丝克莱恩比彻姆公司 | 给药人il-18治疗创伤的方法 |
US7141382B1 (en) | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
CN1850863B (zh) * | 2006-05-23 | 2012-07-04 | 中国科学院生物物理研究所 | 针对自身抗原和/或种属间高度保守抗原的抗体及其制备方法 |
EA017303B1 (ru) | 2006-05-25 | 2012-11-30 | Глаксо Груп Лимитед | Модифицированные гуманизированные антитела против интерлейкина-18 и их применение |
PE20090190A1 (es) | 2007-03-23 | 2009-03-22 | Smithkline Beecham Corp | Combinacion de anticuerpos anti-cd20 y polipeptidos de il-18 |
US8168165B2 (en) | 2008-12-23 | 2012-05-01 | Abbott Laboratories | Alkylated interleukin-18 compositions |
CA2957387A1 (en) | 2014-08-07 | 2016-02-11 | Hyogo College Of Medicine | Therapeutic agent for cancer which comprises combination of il-18 and molecule-targeting antibody |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5134076A (en) * | 1988-09-27 | 1992-07-28 | The Regents Of The University Of California | Monoclonal antibodies specific for protease nexin-1 and puriciation of protease nexin-1 using monoclonal antibodies |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
JP3230531B2 (ja) * | 1991-08-08 | 2001-11-19 | 光信 佐藤 | IFN―γ誘導活性物質 |
EP0692536B1 (de) * | 1994-07-14 | 2000-11-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen |
JP4024366B2 (ja) * | 1996-11-29 | 2007-12-19 | 株式会社林原生物化学研究所 | ポリペプチド |
-
1995
- 1995-07-13 EP EP95304906A patent/EP0692536B1/de not_active Expired - Lifetime
- 1995-07-13 DE DE69519454T patent/DE69519454T2/de not_active Expired - Lifetime
- 1995-07-14 US US08/502,535 patent/US5912324A/en not_active Expired - Lifetime
-
1997
- 1997-08-11 US US08/908,005 patent/US5914253A/en not_active Expired - Lifetime
-
1999
- 1999-02-19 US US09/253,523 patent/US6274709B1/en not_active Expired - Lifetime
- 1999-02-19 US US09/251,911 patent/US6277598B1/en not_active Expired - Lifetime
- 1999-08-12 US US09/373,230 patent/US7758853B2/en not_active Expired - Fee Related
-
2014
- 2014-07-31 US US14/448,002 patent/US20140336364A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0692536A2 (de) | 1996-01-17 |
US7758853B2 (en) | 2010-07-20 |
US6274709B1 (en) | 2001-08-14 |
US6277598B1 (en) | 2001-08-21 |
EP0692536B1 (de) | 2000-11-22 |
US20030099607A1 (en) | 2003-05-29 |
DE69519454T2 (de) | 2001-05-03 |
EP0692536A3 (de) | 1997-03-26 |
US5914253A (en) | 1999-06-22 |
US20140336364A1 (en) | 2014-11-13 |
US5912324A (en) | 1999-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |